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The map label for this gene is ghrA [H]

Identifier: 194734338

GI number: 194734338

Start: 1183372

End: 1184310

Strand: Direct

Name: ghrA [H]

Synonym: SeSA_A1200

Alternate gene names: 194734338

Gene position: 1183372-1184310 (Clockwise)

Preceding gene: 194735338

Following gene: 194734997

Centisome position: 25.13

GC content: 55.38

Gene sequence:

>939_bases
ATGGAGATAATTTTTTATCACCCGACATTTAACGCCGCCTGGTGGGTAAATGCACTGGAGAAGGCTCTCCCACATGCGCG
CGTTCGTGAATGGAAGGTCGGTGATAACAACCCCGCAGACTATGCGCTTGTATGGCAGCCCCCGGTTGAAATGCTGGCCG
GAAGACGCTTAAAAGCCGTCTTTGCGCTGGGCGCGGGGGTGGATGCAATTCTGAGTAAATTAAATGCGCATCCGGAAATG
CTGGACGCCTCCATTCCTCTATTCCGTCTGGAAGATACCGGAATGGGCCTGCAAATGCAGGAGTATGCCGTCAGCCAGGT
ATTACACTGGTTCCGTCGTTTCGATGATTATCAGGCGCTGAAGAATCAGGCGCTATGGAAACCGCTGCCGGAATATACCC
GCGAAGAATTTAGCGTCGGTATCATGGGCGCAGGGGTGCTGGGCGCAAAAGTGGCAGAAAGTCTACAGGCGTGGGGGTTC
CCGTTACGTTGCTGGAGTCGTAGCCGCAAATCCTGGCCTGGCGTGGAAAGTTATGTGGGGCGTGAAGAGCTGCGCGCTTT
CCTGAACCAGACGCGGGTGCTGATTAATCTGCTGCCGAATACGGCCCAAACGGTAGGAATTATTAATAGCGAATTGTTGG
ATCAATTGCCGGATGGCGCCTACGTGCTGAATCTCGCGCGCGGCGTTCATGTTCAGGAGGCTGATCTGCTGGCTGCGCTT
GATAGCGGTAAGCTAAAAGGCGCGATGTTGGATGTCTTTAGCCAGGAACCGTTACCGCAGGAAAGCCCATTATGGCGCCA
TCCGCGAGTCGCCATGACGCCGCACATTGCGGCAGTCACCCGTCCGGCGGAAGCCATCGATTATATTAGCCGCACAATTA
CCCAGCTGGAGAAGGGAGAGCCGGTGACGGGGCAGGTGGATCGGGCGAGAGGATATTGA

Upstream 100 bases:

>100_bases
TTTTTTGCCCGCGCCGGGAAATTTGCTATGCTGCACATCCCGTTGAAAACGCTGATAACAGGCGCAATCACATTCCGCAC
CATACTGCTCAGGAGATAAC

Downstream 100 bases:

>100_bases
CATCAACCCGGCGCGGGCCGGGTTTCGCTAAAAAACGCTGGCGATACCTGCTATCCTTGTCGGAAATGACTACAGGAGAG
AGCAATGTATCCCGTTGACC

Product: putative 2-hydroxyacid dehydrogenase YcdW

Products: NA

Alternate protein names: 2-ketoacid reductase [H]

Number of amino acids: Translated: 312; Mature: 312

Protein sequence:

>312_residues
MEIIFYHPTFNAAWWVNALEKALPHARVREWKVGDNNPADYALVWQPPVEMLAGRRLKAVFALGAGVDAILSKLNAHPEM
LDASIPLFRLEDTGMGLQMQEYAVSQVLHWFRRFDDYQALKNQALWKPLPEYTREEFSVGIMGAGVLGAKVAESLQAWGF
PLRCWSRSRKSWPGVESYVGREELRAFLNQTRVLINLLPNTAQTVGIINSELLDQLPDGAYVLNLARGVHVQEADLLAAL
DSGKLKGAMLDVFSQEPLPQESPLWRHPRVAMTPHIAAVTRPAEAIDYISRTITQLEKGEPVTGQVDRARGY

Sequences:

>Translated_312_residues
MEIIFYHPTFNAAWWVNALEKALPHARVREWKVGDNNPADYALVWQPPVEMLAGRRLKAVFALGAGVDAILSKLNAHPEM
LDASIPLFRLEDTGMGLQMQEYAVSQVLHWFRRFDDYQALKNQALWKPLPEYTREEFSVGIMGAGVLGAKVAESLQAWGF
PLRCWSRSRKSWPGVESYVGREELRAFLNQTRVLINLLPNTAQTVGIINSELLDQLPDGAYVLNLARGVHVQEADLLAAL
DSGKLKGAMLDVFSQEPLPQESPLWRHPRVAMTPHIAAVTRPAEAIDYISRTITQLEKGEPVTGQVDRARGY
>Mature_312_residues
MEIIFYHPTFNAAWWVNALEKALPHARVREWKVGDNNPADYALVWQPPVEMLAGRRLKAVFALGAGVDAILSKLNAHPEM
LDASIPLFRLEDTGMGLQMQEYAVSQVLHWFRRFDDYQALKNQALWKPLPEYTREEFSVGIMGAGVLGAKVAESLQAWGF
PLRCWSRSRKSWPGVESYVGREELRAFLNQTRVLINLLPNTAQTVGIINSELLDQLPDGAYVLNLARGVHVQEADLLAAL
DSGKLKGAMLDVFSQEPLPQESPLWRHPRVAMTPHIAAVTRPAEAIDYISRTITQLEKGEPVTGQVDRARGY

Specific function: Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively [H]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GhrA subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=270, Percent_Identity=28.1481481481481, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI6912396, Length=237, Percent_Identity=29.957805907173, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI145580578, Length=237, Percent_Identity=27.0042194092827, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4557499, Length=237, Percent_Identity=27.0042194092827, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI145580575, Length=237, Percent_Identity=27.0042194092827, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87081824, Length=312, Percent_Identity=78.2051282051282, Blast_Score=523, Evalue=1e-150,
Organism=Escherichia coli, GI87082289, Length=146, Percent_Identity=30.8219178082192, Blast_Score=71, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=257, Percent_Identity=28.7937743190661, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324055, Length=179, Percent_Identity=31.2849162011173, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324980, Length=175, Percent_Identity=30.8571428571429, Blast_Score=71, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324964, Length=175, Percent_Identity=30.8571428571429, Blast_Score=71, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28574286, Length=260, Percent_Identity=26.9230769230769, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24585514, Length=241, Percent_Identity=24.896265560166, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574282, Length=241, Percent_Identity=24.896265560166, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45552429, Length=241, Percent_Identity=24.896265560166, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI28574284, Length=241, Percent_Identity=24.896265560166, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45551003, Length=241, Percent_Identity=24.896265560166, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24585516, Length=237, Percent_Identity=26.1603375527426, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921140, Length=154, Percent_Identity=30.5194805194805, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.79; =1.1.1.81 [H]

Molecular weight: Translated: 35007; Mature: 35007

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIIFYHPTFNAAWWVNALEKALPHARVREWKVGDNNPADYALVWQPPVEMLAGRRLKAV
CEEEEECCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCEEEEECCCHHHHCCCHHHHH
FALGAGVDAILSKLNAHPEMLDASIPLFRLEDTGMGLQMQEYAVSQVLHWFRRFDDYQAL
HHHCCCHHHHHHHHCCCHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KNQALWKPLPEYTREEFSVGIMGAGVLGAKVAESLQAWGFPLRCWSRSRKSWPGVESYVG
HHHHHCCCCHHHHHHHHCEEEECCCHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHHHCC
REELRAFLNQTRVLINLLPNTAQTVGIINSELLDQLPDGAYVLNLARGVHVQEADLLAAL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEHHHHHCCCCCHHHHHHHH
DSGKLKGAMLDVFSQEPLPQESPLWRHPRVAMTPHIAAVTRPAEAIDYISRTITQLEKGE
CCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEECCCHHHHCCHHHHHHHHHHHHHHHHCCC
PVTGQVDRARGY
CCCCCCHHCCCC
>Mature Secondary Structure
MEIIFYHPTFNAAWWVNALEKALPHARVREWKVGDNNPADYALVWQPPVEMLAGRRLKAV
CEEEEECCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCEEEEECCCHHHHCCCHHHHH
FALGAGVDAILSKLNAHPEMLDASIPLFRLEDTGMGLQMQEYAVSQVLHWFRRFDDYQAL
HHHCCCHHHHHHHHCCCHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHH
KNQALWKPLPEYTREEFSVGIMGAGVLGAKVAESLQAWGFPLRCWSRSRKSWPGVESYVG
HHHHHCCCCHHHHHHHHCEEEECCCHHHHHHHHHHHHCCCCHHHHHCCCCCCCCHHHHCC
REELRAFLNQTRVLINLLPNTAQTVGIINSELLDQLPDGAYVLNLARGVHVQEADLLAAL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEHHHHHCCCCCHHHHHHHH
DSGKLKGAMLDVFSQEPLPQESPLWRHPRVAMTPHIAAVTRPAEAIDYISRTITQLEKGE
CCCCCCHHHHHHHCCCCCCCCCCCCCCCCEEECCCHHHHCCHHHHHHHHHHHHHHHHCCC
PVTGQVDRARGY
CCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA