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The map label for this gene is pagC [H]

Identifier: 194733957

GI number: 194733957

Start: 1298903

End: 1299460

Strand: Direct

Name: pagC [H]

Synonym: SeSA_A1333

Alternate gene names: 194733957

Gene position: 1298903-1299460 (Clockwise)

Preceding gene: 194734593

Following gene: 194737709

Centisome position: 27.58

GC content: 43.19

Gene sequence:

>558_bases
ATGAAAAATATTATTTTATCCACTTTAGTTATTACTACAGGCGTTTTGGTTGTAAATGTTGCACAGGCCGATACTAACGC
CTTTTCCGTGGGGTATGCACAAAGTAAAGTTCAGGATTTCAAAAATATCCGAGGGGTAAATGTGAAATATCGTTATGAGG
ATGACTCTCCGGTAAGTTTTATTTCCTCGCTAAGTTACTTATATGGAGACAGCCAGGCTTCCGGGTCTGTTGAGTCTGAA
GGTATTCATTACCATGACAAGTTTGAGGTGAAGTACGGCTCTTTTATGGTTGGGCCAGCCTATCGATTGTCTGACAATTT
TTCGTTATACGCGCTGGCAGGTGTCGGCACGGTAAAGGCGACGTTTAAAGAACATTCCACTCAGGATGGCGATTCTTTTT
CTAACAAAATTTCCTCAAGGAAAACGGGATTTGCCTGGGGCGCAGGTGTACAGATGAATCCGCTGGAGAATATCGTCGTC
GATGTTGGGTATGAAGGAAGCAACATCTCCTCTACAAAAATAAACGGCTTCAACGTCGGGGTTGGATACCGTTTCTGA

Upstream 100 bases:

>100_bases
TGGTTTTGTCGATTCGGCATAGTGGCGATAACTGAATGCCGGATCGGTACCGCAGGTGTTTAAACACACCGTAAATAATA
AGTAGTATTAAGGAGTTGTT

Downstream 100 bases:

>100_bases
AAAGCATAAGCTATGCGGAAGGTTCGCCTTCCGCACCGCCAGTCAATAAAACAGGGCTTCTTTACCAGTGACACGTACCT
GCCTGACTTTTCTCTCTTCG

Product: outer membrane invasion protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 185; Mature: 185

Protein sequence:

>185_residues
MKNIILSTLVITTGVLVVNVAQADTNAFSVGYAQSKVQDFKNIRGVNVKYRYEDDSPVSFISSLSYLYGDSQASGSVESE
GIHYHDKFEVKYGSFMVGPAYRLSDNFSLYALAGVGTVKATFKEHSTQDGDSFSNKISSRKTGFAWGAGVQMNPLENIVV
DVGYEGSNISSTKINGFNVGVGYRF

Sequences:

>Translated_185_residues
MKNIILSTLVITTGVLVVNVAQADTNAFSVGYAQSKVQDFKNIRGVNVKYRYEDDSPVSFISSLSYLYGDSQASGSVESE
GIHYHDKFEVKYGSFMVGPAYRLSDNFSLYALAGVGTVKATFKEHSTQDGDSFSNKISSRKTGFAWGAGVQMNPLENIVV
DVGYEGSNISSTKINGFNVGVGYRF
>Mature_185_residues
MKNIILSTLVITTGVLVVNVAQADTNAFSVGYAQSKVQDFKNIRGVNVKYRYEDDSPVSFISSLSYLYGDSQASGSVESE
GIHYHDKFEVKYGSFMVGPAYRLSDNFSLYALAGVGTVKATFKEHSTQDGDSFSNKISSRKTGFAWGAGVQMNPLENIVV
DVGYEGSNISSTKINGFNVGVGYRF

Specific function: Essential for full virulence and survival within macrophages [H]

COG id: COG3637

COG function: function code M; Opacity protein and related surface antigens

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ail/ompX/pagC/lom family [H]

Homologues:

Organism=Escherichia coli, GI1787034, Length=187, Percent_Identity=35.2941176470588, Blast_Score=96, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000758
- InterPro:   IPR011250 [H]

Pfam domain/function: PF06316 Ail_Lom [H]

EC number: NA

Molecular weight: Translated: 20109; Mature: 20109

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00694 ENT_VIR_OMP_1 ; PS00695 ENT_VIR_OMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNIILSTLVITTGVLVVNVAQADTNAFSVGYAQSKVQDFKNIRGVNVKYRYEDDSPVSF
CCCHHHHHHHHHCCEEEEEEECCCCCEEEECHHHHHHHHHHHCCCCEEEEEECCCCHHHH
ISSLSYLYGDSQASGSVESEGIHYHDKFEVKYGSFMVGPAYRLSDNFSLYALAGVGTVKA
HHHHHHHHCCCCCCCCCCCCCCEECEEEEEEECCEEECCCEEECCCCEEEEEECCCEEEE
TFKEHSTQDGDSFSNKISSRKTGFAWGAGVQMNPLENIVVDVGYEGSNISSTKINGFNVG
HHHHCCCCCCCHHHHHHHCCCCCEEECCCCEECCCCEEEEEECCCCCCCCCEEECCEEEC
VGYRF
CEECC
>Mature Secondary Structure
MKNIILSTLVITTGVLVVNVAQADTNAFSVGYAQSKVQDFKNIRGVNVKYRYEDDSPVSF
CCCHHHHHHHHHCCEEEEEEECCCCCEEEECHHHHHHHHHHHCCCCEEEEEECCCCHHHH
ISSLSYLYGDSQASGSVESEGIHYHDKFEVKYGSFMVGPAYRLSDNFSLYALAGVGTVKA
HHHHHHHHCCCCCCCCCCCCCCEECEEEEEEECCEEECCCEEECCCCEEEEEECCCEEEE
TFKEHSTQDGDSFSNKISSRKTGFAWGAGVQMNPLENIVVDVGYEGSNISSTKINGFNVG
HHHHCCCCCCCHHHHHHHCCCCCEEECCCCEECCCCEEEEEECCCCCCCCCEEECCEEEC
VGYRF
CEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1846140; 11677609 [H]