Click here to switch to the map view.

The map label for this gene is apt

Identifier: 194334589

GI number: 194334589

Start: 1953631

End: 1954164

Strand: Reverse

Name: apt

Synonym: Paes_1789

Alternate gene names: 194334589

Gene position: 1954164-1953631 (Counterclockwise)

Preceding gene: 194334590

Following gene: 194334588

Centisome position: 77.76

GC content: 51.87

Gene sequence:

>534_bases
ATGCCTATCAAATCCCGTATCCGGACCATTCCGGATTATCCGAAAAAGGGAATCATGTTCCGCGACATTACCACCCTCCT
CAAGGACCCGGTAGGTTTCAGGCTCGTGATTGACCAGATTACCCAGCACTACCTGGAAAACGGCATCAATTTCGATATGA
TCATCGGTATGGAAGCCCGAGGATTCATTATCGGCGGTGCACTCTCCTACACGCTTGGCAAAGGGTTTGTCCCGATCAGA
AAACCCGGCAAGCTGCCCGGCGAAACGGTCAATCAGGAATACCAGCTTGAGTACGGTACCGATAAGGTTGAGATGCATAT
CGACGCTCTCGAAAAAGGTACTCGCGTTCTGCTTGTCGACGATCTTCTTGCCACCGGAGGCACCGCTCTTGCCGGCGCAG
CGCTCATAGAAAAAGTCGGCGGGGTTGTTGCAGATATGGCCTTCATCGTCAATCTTCCTGATATCGGCGGCCAGAAAAAG
CTTGAGGAGAAAGGCTATAGCCTCTTCTCTCTCACTGAGTTCGAAGGAGACTGA

Upstream 100 bases:

>100_bases
AAAATCTGTTTTGCCTTAGTACGTTCCAGCCGACAGAGCTCTCTTTTTGAGACGGCTGGCGGTTGTTGCAGTTTCACTAA
CCCGAAAACATATAGCATCA

Downstream 100 bases:

>100_bases
GCCCTGAAATCACCTTGACAGGTGACCGTGAGCCTGACGCAGGAAAGGTTGTATCCGCTGCGTCAGGTTCAGCTGTTCAG
CGCTTCGTTTCAAAGGAGCC

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MPIKSRIRTIPDYPKKGIMFRDITTLLKDPVGFRLVIDQITQHYLENGINFDMIIGMEARGFIIGGALSYTLGKGFVPIR
KPGKLPGETVNQEYQLEYGTDKVEMHIDALEKGTRVLLVDDLLATGGTALAGAALIEKVGGVVADMAFIVNLPDIGGQKK
LEEKGYSLFSLTEFEGD

Sequences:

>Translated_177_residues
MPIKSRIRTIPDYPKKGIMFRDITTLLKDPVGFRLVIDQITQHYLENGINFDMIIGMEARGFIIGGALSYTLGKGFVPIR
KPGKLPGETVNQEYQLEYGTDKVEMHIDALEKGTRVLLVDDLLATGGTALAGAALIEKVGGVVADMAFIVNLPDIGGQKK
LEEKGYSLFSLTEFEGD
>Mature_176_residues
PIKSRIRTIPDYPKKGIMFRDITTLLKDPVGFRLVIDQITQHYLENGINFDMIIGMEARGFIIGGALSYTLGKGFVPIRK
PGKLPGETVNQEYQLEYGTDKVEMHIDALEKGTRVLLVDDLLATGGTALAGAALIEKVGGVVADMAFIVNLPDIGGQKKL
EEKGYSLFSLTEFEGD

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=174, Percent_Identity=43.6781609195402, Blast_Score=143, Evalue=8e-35,
Organism=Homo sapiens, GI71773201, Length=125, Percent_Identity=49.6, Blast_Score=125, Evalue=3e-29,
Organism=Escherichia coli, GI1786675, Length=174, Percent_Identity=52.8735632183908, Blast_Score=192, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI17509087, Length=161, Percent_Identity=42.8571428571429, Blast_Score=126, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6323619, Length=170, Percent_Identity=36.4705882352941, Blast_Score=113, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320649, Length=168, Percent_Identity=35.7142857142857, Blast_Score=96, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17136334, Length=167, Percent_Identity=43.1137724550898, Blast_Score=138, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_PROA2 (B4S410)

Other databases:

- EMBL:   CP001108
- RefSeq:   YP_002016449.1
- ProteinModelPortal:   B4S410
- SMR:   B4S410
- GeneID:   6458817
- GenomeReviews:   CP001108_GR
- KEGG:   paa:Paes_1789
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19391; Mature: 19260

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIKSRIRTIPDYPKKGIMFRDITTLLKDPVGFRLVIDQITQHYLENGINFDMIIGMEAR
CCCHHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCC
GFIIGGALSYTLGKGFVPIRKPGKLPGETVNQEYQLEYGTDKVEMHIDALEKGTRVLLVD
CEEEECHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEEEHHCCCCEEEEEE
DLLATGGTALAGAALIEKVGGVVADMAFIVNLPDIGGQKKLEEKGYSLFSLTEFEGD
CHHHCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHCCCEEEEEECCCCC
>Mature Secondary Structure 
PIKSRIRTIPDYPKKGIMFRDITTLLKDPVGFRLVIDQITQHYLENGINFDMIIGMEAR
CCHHHHCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCC
GFIIGGALSYTLGKGFVPIRKPGKLPGETVNQEYQLEYGTDKVEMHIDALEKGTRVLLVD
CEEEECHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEEEHHCCCCEEEEEE
DLLATGGTALAGAALIEKVGGVVADMAFIVNLPDIGGQKKLEEKGYSLFSLTEFEGD
CHHHCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA