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The map label for this gene is trpF

Identifier: 194333639

GI number: 194333639

Start: 882388

End: 883056

Strand: Reverse

Name: trpF

Synonym: Paes_0806

Alternate gene names: 194333639

Gene position: 883056-882388 (Counterclockwise)

Preceding gene: 194333640

Following gene: 194333636

Centisome position: 35.14

GC content: 51.42

Gene sequence:

>669_bases
ATGACCCGTATCAAAATCTGCGGCATTACAACGCTTGAAGATGCCCTGGCCGCTGTCGAAGCAGGGGCTCATGCTCTTGG
CTTTAACTTCAGCACAACAAGCCCGAGAGCGGTAACGCCCCAAACTGCCAGAAGCATCATATCGGCAATCCCGCCATTCA
TTACAACAACAGGTATCTTCGTTGAGCAGTCGCCTGATGAGATCAACAGCATATGCGAACGCTGCAATCTTCATTGCGCG
CAATTGCACAGTGAAGCCTATGATGCCCAATCATCGCTTGCGGTAAGCGCCCCATCAATTATCAGAGTATTCCGTGCAGG
ACCATCTTTTCACATGGATCAGGTCAGAAGCTATGCCGGGAAAACAGGAATCAGAAACTTCCTCTTCGATGCGTTCAGAG
AGGGCCAGCCAGGAGGAACGGGTGAAAGCATTGAAGACACGACAGCTATCCGGATATTCAAAGAAACCGCATCGATAGGA
TCAGCTATTCTTGCAGGAGGGCTGAAGCCCGAAAATGTAGGCAGGGCAATCCGTCTTGTCAGCCCCTATGCCGTCGATAC
GGCAAGCGGCGTTGAATCAGTGCCGGGGCGAAAAGACCATGATAAAATACGGGCATTTGTAAGGGCAGTTCAGGAAGCCG
ATAACGACTCATCGTCGCCGGAAGCATGA

Upstream 100 bases:

>100_bases
CTGAGTACCCGAATCAGCGCATACCGCGTTACCGCCAATTGATATCATGGAACAATGCCAGCCTTAAAAACACCACCATT
CACCACTTCTTTTTCCTATC

Downstream 100 bases:

>100_bases
ACCTGTTCCAGAATCAGCACTGAAGTTGCTGCAGAAAATTGAATGATAAGACAATGGCTCCTGGCAAGAAGCACAACAAC
AGAATGTTGTGCCATATTCT

Product: phosphoribosylanthranilate isomerase

Products: NA

Alternate protein names: PRAI

Number of amino acids: Translated: 222; Mature: 221

Protein sequence:

>222_residues
MTRIKICGITTLEDALAAVEAGAHALGFNFSTTSPRAVTPQTARSIISAIPPFITTTGIFVEQSPDEINSICERCNLHCA
QLHSEAYDAQSSLAVSAPSIIRVFRAGPSFHMDQVRSYAGKTGIRNFLFDAFREGQPGGTGESIEDTTAIRIFKETASIG
SAILAGGLKPENVGRAIRLVSPYAVDTASGVESVPGRKDHDKIRAFVRAVQEADNDSSSPEA

Sequences:

>Translated_222_residues
MTRIKICGITTLEDALAAVEAGAHALGFNFSTTSPRAVTPQTARSIISAIPPFITTTGIFVEQSPDEINSICERCNLHCA
QLHSEAYDAQSSLAVSAPSIIRVFRAGPSFHMDQVRSYAGKTGIRNFLFDAFREGQPGGTGESIEDTTAIRIFKETASIG
SAILAGGLKPENVGRAIRLVSPYAVDTASGVESVPGRKDHDKIRAFVRAVQEADNDSSSPEA
>Mature_221_residues
TRIKICGITTLEDALAAVEAGAHALGFNFSTTSPRAVTPQTARSIISAIPPFITTTGIFVEQSPDEINSICERCNLHCAQ
LHSEAYDAQSSLAVSAPSIIRVFRAGPSFHMDQVRSYAGKTGIRNFLFDAFREGQPGGTGESIEDTTAIRIFKETASIGS
AILAGGLKPENVGRAIRLVSPYAVDTASGVESVPGRKDHDKIRAFVRAVQEADNDSSSPEA

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0135

COG function: function code E; Phosphoribosylanthranilate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpF family

Homologues:

Organism=Escherichia coli, GI87081863, Length=196, Percent_Identity=28.5714285714286, Blast_Score=63, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320210, Length=222, Percent_Identity=28.8288288288288, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPF_PROA2 (B4S715)

Other databases:

- EMBL:   CP001108
- RefSeq:   YP_002015499.1
- ProteinModelPortal:   B4S715
- SMR:   B4S715
- GeneID:   6460160
- GenomeReviews:   CP001108_GR
- KEGG:   paa:Paes_0806
- HOGENOM:   HBG554803
- OMA:   SKICGIT
- ProtClustDB:   CLSK637437
- HAMAP:   MF_00135_B
- InterPro:   IPR013785
- InterPro:   IPR001240
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00697 PRAI; SSF51366 RibP_bind_barrel

EC number: =5.3.1.24

Molecular weight: Translated: 23597; Mature: 23465

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRIKICGITTLEDALAAVEAGAHALGFNFSTTSPRAVTPQTARSIISAIPPFITTTGIF
CCEEEEECCHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHCCEE
VEQSPDEINSICERCNLHCAQLHSEAYDAQSSLAVSAPSIIRVFRAGPSFHMDQVRSYAG
EECCHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHH
KTGIRNFLFDAFREGQPGGTGESIEDTTAIRIFKETASIGSAILAGGLKPENVGRAIRLV
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCEEEEE
SPYAVDTASGVESVPGRKDHDKIRAFVRAVQEADNDSSSPEA
CCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TRIKICGITTLEDALAAVEAGAHALGFNFSTTSPRAVTPQTARSIISAIPPFITTTGIF
CEEEEECCHHHHHHHHHHHHCCHHCCCCCCCCCCCCCCHHHHHHHHHHHCHHHHHCCEE
VEQSPDEINSICERCNLHCAQLHSEAYDAQSSLAVSAPSIIRVFRAGPSFHMDQVRSYAG
EECCHHHHHHHHHHHCCHHHHHHHHHHCCHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHH
KTGIRNFLFDAFREGQPGGTGESIEDTTAIRIFKETASIGSAILAGGLKPENVGRAIRLV
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHCCEEEEE
SPYAVDTASGVESVPGRKDHDKIRAFVRAVQEADNDSSSPEA
CCCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA