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The map label for this gene is czcD [H]

Identifier: 194333546

GI number: 194333546

Start: 758667

End: 759572

Strand: Reverse

Name: czcD [H]

Synonym: Paes_0712

Alternate gene names: 194333546

Gene position: 759572-758667 (Counterclockwise)

Preceding gene: 194333551

Following gene: 194333545

Centisome position: 30.23

GC content: 47.13

Gene sequence:

>906_bases
ATGGAACATAACGAACAGGTTCTGTCGGAAAGAACATTTAAAGGAAGAAAAGCCAAAAAAGGGCTTCGGTTCGCTGTCAG
CGTCACCGGCCTCATCTTTCTTGTTGAGCTGATAGGCGGGTGGGTGTCAGGCAGCCTTGCCCTGATGGCCGATGCAGGCC
ATATGGCAACAGACCTTTTCGCCTTATCTATCAGCTATCTCGCTATCCGATTGAGTGCCAGGCCATCGACAAAAAAAAGA
TCCTACGGCTATTTCCGGATCGAAATCATCGCAGCCCTCATCAACGGAGTCATTCTCTGTATCACAGCTCTTTTTATCAC
CATTGAAGCGTGGAAAAGAATTTCCCTGCCGAAAGAAATCGATAGCGCCCAAATGCTGGTTTTCGGAATTATCGGCCTGA
CTGCCAACATAGCCAGCGCAATCATGCTGCACAGGGAACAGAAAAACAGTGTCAACGTCAAAGCAGCTTATATCCACATT
CTGAGCGATCTTGCCGGATCTGTTGGTGTTGTGGCAGGATCGATCCTCATCAGTCTTACCCGAATCACGACAATCGACAG
CATAATAAGCTTTATCATAGCAATCCTGATTGTGCAAAGCGCACTGAAAATTATCAGAGAAGCCGTCGATGTCCTCATGG
AGTCAGTACCTCCTGAGCTCGACATTCAGGAAATTGAAGAGGCTCTGCTTAACTTCAGGCATGTCGAAGGACTGCACGAT
CTTCATGTCTGGGCCCTGACCAGCGGGGTCAACGCCCTCAGCTGTCACCTTCTTGTCAAGAATCTTGACGCAGGGCAAAA
TATCCTTGTGCCGATTCATAGAGAGTTGAAGGAAAAATACAATATTGATCATGTAACCATTCAGCTTGAAGATGAACGCT
TTATTGCAGCTCATAATAAAGGGTAG

Upstream 100 bases:

>100_bases
AATCCCGATCTCTTGACGACAATTCCCCCTCCTGCCGGACGATTGCATGGCGAAGCGACAAGCCATCCCGAGCCGGGTAT
CAATCAATGCTGTTAAGCAC

Downstream 100 bases:

>100_bases
CGTTATTCATTGTCGTGAGCGAGCTGAAGACAAGGCCGACGGAGCACAGAAACCCGAATCCCGACAAGTCGGGATGAGGA
TTTCGAGCACCGACGAACGA

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MEHNEQVLSERTFKGRKAKKGLRFAVSVTGLIFLVELIGGWVSGSLALMADAGHMATDLFALSISYLAIRLSARPSTKKR
SYGYFRIEIIAALINGVILCITALFITIEAWKRISLPKEIDSAQMLVFGIIGLTANIASAIMLHREQKNSVNVKAAYIHI
LSDLAGSVGVVAGSILISLTRITTIDSIISFIIAILIVQSALKIIREAVDVLMESVPPELDIQEIEEALLNFRHVEGLHD
LHVWALTSGVNALSCHLLVKNLDAGQNILVPIHRELKEKYNIDHVTIQLEDERFIAAHNKG

Sequences:

>Translated_301_residues
MEHNEQVLSERTFKGRKAKKGLRFAVSVTGLIFLVELIGGWVSGSLALMADAGHMATDLFALSISYLAIRLSARPSTKKR
SYGYFRIEIIAALINGVILCITALFITIEAWKRISLPKEIDSAQMLVFGIIGLTANIASAIMLHREQKNSVNVKAAYIHI
LSDLAGSVGVVAGSILISLTRITTIDSIISFIIAILIVQSALKIIREAVDVLMESVPPELDIQEIEEALLNFRHVEGLHD
LHVWALTSGVNALSCHLLVKNLDAGQNILVPIHRELKEKYNIDHVTIQLEDERFIAAHNKG
>Mature_301_residues
MEHNEQVLSERTFKGRKAKKGLRFAVSVTGLIFLVELIGGWVSGSLALMADAGHMATDLFALSISYLAIRLSARPSTKKR
SYGYFRIEIIAALINGVILCITALFITIEAWKRISLPKEIDSAQMLVFGIIGLTANIASAIMLHREQKNSVNVKAAYIHI
LSDLAGSVGVVAGSILISLTRITTIDSIISFIIAILIVQSALKIIREAVDVLMESVPPELDIQEIEEALLNFRHVEGLHD
LHVWALTSGVNALSCHLLVKNLDAGQNILVPIHRELKEKYNIDHVTIQLEDERFIAAHNKG

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI52352805, Length=292, Percent_Identity=34.2465753424658, Blast_Score=164, Evalue=7e-41,
Organism=Homo sapiens, GI21359890, Length=310, Percent_Identity=29.3548387096774, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI21361112, Length=300, Percent_Identity=27, Blast_Score=125, Evalue=3e-29,
Organism=Homo sapiens, GI289803013, Length=299, Percent_Identity=30.4347826086957, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI289803009, Length=299, Percent_Identity=30.4347826086957, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI289803007, Length=299, Percent_Identity=30.4347826086957, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI289803003, Length=299, Percent_Identity=30.4347826086957, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI64762489, Length=299, Percent_Identity=30.4347826086957, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI20070323, Length=307, Percent_Identity=27.6872964169381, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI14210520, Length=219, Percent_Identity=33.3333333333333, Blast_Score=111, Evalue=7e-25,
Organism=Homo sapiens, GI52351208, Length=134, Percent_Identity=32.089552238806, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI222080086, Length=109, Percent_Identity=33.9449541284404, Blast_Score=68, Evalue=1e-11,
Organism=Homo sapiens, GI40255009, Length=109, Percent_Identity=33.9449541284404, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1786966, Length=274, Percent_Identity=36.4963503649635, Blast_Score=158, Evalue=4e-40,
Organism=Escherichia coli, GI1790349, Length=236, Percent_Identity=25.4237288135593, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17555794, Length=306, Percent_Identity=31.0457516339869, Blast_Score=156, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI17555796, Length=307, Percent_Identity=30.9446254071661, Blast_Score=154, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI193210990, Length=310, Percent_Identity=27.4193548387097, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI32564488, Length=285, Percent_Identity=28.0701754385965, Blast_Score=110, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17550440, Length=141, Percent_Identity=31.9148936170213, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17550442, Length=141, Percent_Identity=31.9148936170213, Blast_Score=75, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6323899, Length=124, Percent_Identity=34.6774193548387, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6324892, Length=120, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6320411, Length=191, Percent_Identity=31.9371727748691, Blast_Score=69, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24583858, Length=301, Percent_Identity=29.2358803986711, Blast_Score=115, Evalue=3e-26,
Organism=Drosophila melanogaster, GI24656728, Length=340, Percent_Identity=27.0588235294118, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24656724, Length=340, Percent_Identity=27.0588235294118, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24656720, Length=340, Percent_Identity=27.0588235294118, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24656715, Length=340, Percent_Identity=27.0588235294118, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI21357035, Length=340, Percent_Identity=27.0588235294118, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24585900, Length=137, Percent_Identity=31.3868613138686, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24585898, Length=137, Percent_Identity=31.3868613138686, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24585896, Length=137, Percent_Identity=31.3868613138686, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI19921672, Length=137, Percent_Identity=31.3868613138686, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24584409, Length=148, Percent_Identity=33.1081081081081, Blast_Score=81, Evalue=9e-16,
Organism=Drosophila melanogaster, GI28574430, Length=148, Percent_Identity=33.1081081081081, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24645863, Length=145, Percent_Identity=31.0344827586207, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 33102; Mature: 33102

Theoretical pI: Translated: 7.41; Mature: 7.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHNEQVLSERTFKGRKAKKGLRFAVSVTGLIFLVELIGGWVSGSLALMADAGHMATDLF
CCCCHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHH
ALSISYLAIRLSARPSTKKRSYGYFRIEIIAALINGVILCITALFITIEAWKRISLPKEI
HHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DSAQMLVFGIIGLTANIASAIMLHREQKNSVNVKAAYIHILSDLAGSVGVVAGSILISLT
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RITTIDSIISFIIAILIVQSALKIIREAVDVLMESVPPELDIQEIEEALLNFRHVEGLHD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHH
LHVWALTSGVNALSCHLLVKNLDAGQNILVPIHRELKEKYNIDHVTIQLEDERFIAAHNK
HHHHHHHCCCCHHHHHHHEECCCCCCCEEEHHHHHHHHHCCCCEEEEEEECCEEEECCCC
G
C
>Mature Secondary Structure
MEHNEQVLSERTFKGRKAKKGLRFAVSVTGLIFLVELIGGWVSGSLALMADAGHMATDLF
CCCCHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHH
ALSISYLAIRLSARPSTKKRSYGYFRIEIIAALINGVILCITALFITIEAWKRISLPKEI
HHHHHHHHEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
DSAQMLVFGIIGLTANIASAIMLHREQKNSVNVKAAYIHILSDLAGSVGVVAGSILISLT
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHH
RITTIDSIISFIIAILIVQSALKIIREAVDVLMESVPPELDIQEIEEALLNFRHVEGLHD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHH
LHVWALTSGVNALSCHLLVKNLDAGQNILVPIHRELKEKYNIDHVTIQLEDERFIAAHNK
HHHHHHHCCCCHHHHHHHEECCCCCCCEEEHHHHHHHHHCCCCEEEEEEECCEEEECCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA