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The map label for this gene is argD [H]

Identifier: 194333436

GI number: 194333436

Start: 631809

End: 633002

Strand: Reverse

Name: argD [H]

Synonym: Paes_0593

Alternate gene names: 194333436

Gene position: 633002-631809 (Counterclockwise)

Preceding gene: 194333437

Following gene: 194333435

Centisome position: 25.19

GC content: 49.08

Gene sequence:

>1194_bases
ATGACCAGCATACTCAATAAAGAGACTGAACACGAACTGTTCTTCCATAATTATGCAAGGCTTCCCCTCGCTATTACTCA
CGGCAAAGGGGTCTACCTCTTTGACGAAAACAGCAACCGCTACCTCGACATGATATCGGGCATCGGTGTCAACGCGCTGG
GATACGGTGACGAGAGGCTTATCGAAGCCATTCATGATCAGGCAAAAAAGATCATTCATGCCTCCAATCTCTTCATGCTT
GAACCTCAATTCAAACTGGCATCGAAGCTGCTCGACATCTCGGGACTTTCGAAAGTATTTTTTGCAAACAGCGGAACCGA
GGCGATAGAAGCAGCCATGAAACTGTCAAGAAAATGGGCATCTCTTTCAGGCAGCACCGGAAAAAAAGAGATCCTCTCCC
TTTCAAACTGCTTTCATGGAAGAACCTACGGAGCAATGTCTCTGACTGCAAAACCGAAATATCTGGAAGGTTTCGACCCG
CTTCTGCCGGGCACAGGCAGTATCGCCTTCAATGATATTGAGGATCTGAAAAGAAAGATCACCAGCAACACAGCCGCTGT
CTTTATCGAATTCGTTCAGGGAGAAGGCGGCATTCATCAGATATCCCGTGAGTTTGTCGAAGAGCTGAAAAAGCTCCGGG
AAACCCACAATTTTCTCATCGTTGCCGACGAGATACAGGCTGGTTGCGGAAGAACCGGGAAATTTTTCAGCTACATGCAT
TTCGACATCGATCCGGACCTTGTCTGCGTTGCCAAACCGCTTGGTGGAGGTTTGCCGCTGGGTGCGGTTATCGGAAGCAG
GAAAGTGCAGGATGTCTTTGCAGCCGGTAATCACGGAACGACATTCGGAGGAAACCCTGTAGCCTGCGCTGCCGGCCACG
CACTGATCGAAACCCTCTACAGCAAGAAGATCATGGAGCACGCTCTTGCAACAGGATCATGGATCAAAGCAGCTCTGACG
AAACTGGCCGAAACGCATACACAGATTCAGGAAATCCGTCAGTACGGATTGATGATCGGCATCACGGTTAACCGTGATGC
CGCATATTATGTCCAGGAGTCTCTGAAAAGGAGGGTTCTCGTCAATGCCACAAGCCAGAACGTCATCCGACTGCTTCCGC
CACTGACCATAACAGTCGAAGAAGCGCAACAATGTATTGATTGTCTCGATGAAATCTTCAGCGAAGAACAGTAA

Upstream 100 bases:

>100_bases
ACGGAGCAGTACGGCTCTGGAGAGCTATACTCTCCATAAGGAATCGTCAGTAATTGTTTACCAGGATCACCGCGTCACCC
TAATTCTATCGTTATCGACC

Downstream 100 bases:

>100_bases
AACAAAAAAAGCCGCTCCACAGCCGATGCCGCTCGAAAAGACCAACTATATCTTTCTCGGCATCGGTATCGCAATCATTG
CGTTCGGCTACAGCGGCATG

Product: acetylornithine aminotransferase

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MTSILNKETEHELFFHNYARLPLAITHGKGVYLFDENSNRYLDMISGIGVNALGYGDERLIEAIHDQAKKIIHASNLFML
EPQFKLASKLLDISGLSKVFFANSGTEAIEAAMKLSRKWASLSGSTGKKEILSLSNCFHGRTYGAMSLTAKPKYLEGFDP
LLPGTGSIAFNDIEDLKRKITSNTAAVFIEFVQGEGGIHQISREFVEELKKLRETHNFLIVADEIQAGCGRTGKFFSYMH
FDIDPDLVCVAKPLGGGLPLGAVIGSRKVQDVFAAGNHGTTFGGNPVACAAGHALIETLYSKKIMEHALATGSWIKAALT
KLAETHTQIQEIRQYGLMIGITVNRDAAYYVQESLKRRVLVNATSQNVIRLLPPLTITVEEAQQCIDCLDEIFSEEQ

Sequences:

>Translated_397_residues
MTSILNKETEHELFFHNYARLPLAITHGKGVYLFDENSNRYLDMISGIGVNALGYGDERLIEAIHDQAKKIIHASNLFML
EPQFKLASKLLDISGLSKVFFANSGTEAIEAAMKLSRKWASLSGSTGKKEILSLSNCFHGRTYGAMSLTAKPKYLEGFDP
LLPGTGSIAFNDIEDLKRKITSNTAAVFIEFVQGEGGIHQISREFVEELKKLRETHNFLIVADEIQAGCGRTGKFFSYMH
FDIDPDLVCVAKPLGGGLPLGAVIGSRKVQDVFAAGNHGTTFGGNPVACAAGHALIETLYSKKIMEHALATGSWIKAALT
KLAETHTQIQEIRQYGLMIGITVNRDAAYYVQESLKRRVLVNATSQNVIRLLPPLTITVEEAQQCIDCLDEIFSEEQ
>Mature_396_residues
TSILNKETEHELFFHNYARLPLAITHGKGVYLFDENSNRYLDMISGIGVNALGYGDERLIEAIHDQAKKIIHASNLFMLE
PQFKLASKLLDISGLSKVFFANSGTEAIEAAMKLSRKWASLSGSTGKKEILSLSNCFHGRTYGAMSLTAKPKYLEGFDPL
LPGTGSIAFNDIEDLKRKITSNTAAVFIEFVQGEGGIHQISREFVEELKKLRETHNFLIVADEIQAGCGRTGKFFSYMHF
DIDPDLVCVAKPLGGGLPLGAVIGSRKVQDVFAAGNHGTTFGGNPVACAAGHALIETLYSKKIMEHALATGSWIKAALTK
LAETHTQIQEIRQYGLMIGITVNRDAAYYVQESLKRRVLVNATSQNVIRLLPPLTITVEEAQQCIDCLDEIFSEEQ

Specific function: Catalyzes The Transmination Of N(2)-Succinylornithine And Alpha-Ketoglutarate Into N(2)-Succinylglutamate Semialdehyde And Glutamate. Can Also Act As A Acetylornithine Aminotransferase. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=392, Percent_Identity=30.8673469387755, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI284507298, Length=297, Percent_Identity=32.3232323232323, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI37574042, Length=423, Percent_Identity=27.1867612293144, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI13994255, Length=371, Percent_Identity=28.8409703504043, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI226442705, Length=423, Percent_Identity=27.4231678486998, Blast_Score=145, Evalue=8e-35,
Organism=Homo sapiens, GI24119277, Length=415, Percent_Identity=26.5060240963855, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI226442709, Length=343, Percent_Identity=28.2798833819242, Blast_Score=129, Evalue=7e-30,
Organism=Homo sapiens, GI188536080, Length=450, Percent_Identity=23.1111111111111, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI38679950, Length=450, Percent_Identity=23.1111111111111, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI38679946, Length=450, Percent_Identity=23.1111111111111, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1788044, Length=391, Percent_Identity=37.0843989769821, Blast_Score=275, Evalue=5e-75,
Organism=Escherichia coli, GI1789759, Length=382, Percent_Identity=34.2931937172775, Blast_Score=245, Evalue=3e-66,
Organism=Escherichia coli, GI145693181, Length=372, Percent_Identity=35.4838709677419, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI1789016, Length=408, Percent_Identity=29.4117647058824, Blast_Score=177, Evalue=7e-46,
Organism=Escherichia coli, GI1787560, Length=395, Percent_Identity=31.8987341772152, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1786991, Length=419, Percent_Identity=27.6849642004773, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1786349, Length=342, Percent_Identity=26.0233918128655, Blast_Score=103, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25144271, Length=388, Percent_Identity=29.3814432989691, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI32564660, Length=427, Percent_Identity=29.03981264637, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI25144274, Length=258, Percent_Identity=31.7829457364341, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI71992977, Length=428, Percent_Identity=26.1682242990654, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI71981843, Length=169, Percent_Identity=26.0355029585799, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17541228, Length=425, Percent_Identity=23.5294117647059, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6324432, Length=388, Percent_Identity=32.7319587628866, Blast_Score=222, Evalue=6e-59,
Organism=Saccharomyces cerevisiae, GI6323470, Length=414, Percent_Identity=32.3671497584541, Blast_Score=202, Evalue=9e-53,
Organism=Saccharomyces cerevisiae, GI6324386, Length=487, Percent_Identity=25.8726899383984, Blast_Score=106, Evalue=8e-24,
Organism=Saccharomyces cerevisiae, GI6321456, Length=431, Percent_Identity=24.3619489559165, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI21357415, Length=386, Percent_Identity=31.3471502590674, Blast_Score=206, Evalue=2e-53,
Organism=Drosophila melanogaster, GI28574759, Length=429, Percent_Identity=29.3706293706294, Blast_Score=173, Evalue=2e-43,
Organism=Drosophila melanogaster, GI161085790, Length=427, Percent_Identity=29.03981264637, Blast_Score=171, Evalue=7e-43,
Organism=Drosophila melanogaster, GI21356575, Length=426, Percent_Identity=27.9342723004695, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI281366494, Length=355, Percent_Identity=25.9154929577465, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24667139, Length=355, Percent_Identity=25.9154929577465, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24667143, Length=355, Percent_Identity=25.9154929577465, Blast_Score=86, Evalue=3e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 43660; Mature: 43528

Theoretical pI: Translated: 6.70; Mature: 6.70

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSILNKETEHELFFHNYARLPLAITHGKGVYLFDENSNRYLDMISGIGVNALGYGDERL
CCCCCCCCHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCHHHHHHCCCCCEECCCHHHH
IEAIHDQAKKIIHASNLFMLEPQFKLASKLLDISGLSKVFFANSGTEAIEAAMKLSRKWA
HHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHH
SLSGSTGKKEILSLSNCFHGRTYGAMSLTAKPKYLEGFDPLLPGTGSIAFNDIEDLKRKI
HCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCHHCCCCCCCCCCCCEEECCHHHHHHHH
TSNTAAVFIEFVQGEGGIHQISREFVEELKKLRETHNFLIVADEIQAGCGRTGKFFSYMH
HCCCHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHEEEE
FDIDPDLVCVAKPLGGGLPLGAVIGSRKVQDVFAAGNHGTTFGGNPVACAAGHALIETLY
ECCCCCEEEEECCCCCCCCHHHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
SKKIMEHALATGSWIKAALTKLAETHTQIQEIRQYGLMIGITVNRDAAYYVQESLKRRVL
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHEEE
VNATSQNVIRLLPPLTITVEEAQQCIDCLDEIFSEEQ
EECCCCCHHHHCCCCEEEHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TSILNKETEHELFFHNYARLPLAITHGKGVYLFDENSNRYLDMISGIGVNALGYGDERL
CCCCCCCHHHHHHHHHHCCCEEEEECCCEEEEEECCCCCHHHHHHCCCCCEECCCHHHH
IEAIHDQAKKIIHASNLFMLEPQFKLASKLLDISGLSKVFFANSGTEAIEAAMKLSRKWA
HHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHH
SLSGSTGKKEILSLSNCFHGRTYGAMSLTAKPKYLEGFDPLLPGTGSIAFNDIEDLKRKI
HCCCCCCHHHHHHHHHHCCCCCCCEEEECCCCCHHCCCCCCCCCCCCEEECCHHHHHHHH
TSNTAAVFIEFVQGEGGIHQISREFVEELKKLRETHNFLIVADEIQAGCGRTGKFFSYMH
HCCCHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCHHEEEE
FDIDPDLVCVAKPLGGGLPLGAVIGSRKVQDVFAAGNHGTTFGGNPVACAAGHALIETLY
ECCCCCEEEEECCCCCCCCHHHHHCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
SKKIMEHALATGSWIKAALTKLAETHTQIQEIRQYGLMIGITVNRDAAYYVQESLKRRVL
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCHHHHHHHHHHHEEE
VNATSQNVIRLLPPLTITVEEAQQCIDCLDEIFSEEQ
EECCCCCHHHHCCCCEEEHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]