Click here to switch to the map view.

The map label for this gene is dapA

Identifier: 194333379

GI number: 194333379

Start: 578995

End: 579888

Strand: Reverse

Name: dapA

Synonym: Paes_0536

Alternate gene names: 194333379

Gene position: 579888-578995 (Counterclockwise)

Preceding gene: 194333380

Following gene: 194333375

Centisome position: 23.08

GC content: 50.89

Gene sequence:

>894_bases
ATGTCAAACACTTCAATTTCCGGTTCGGCAGTGGCACTTGTCACACCGTTCAGACAGGATACATCGATCGATACCGATGC
GCTGCGGCGCCTCGTGCAGTTCCATCTCGCCTCAGGCACCGATATCCTCATCCCCTGTGGCACCACCGGTGAATCACCAA
CGCTCTGTCAGGAAGAACAGGCAGCAATCATCAGGATCGTCAAGGAAGAAGCCGGGAACCATATCCTGGTCGCTGCCGGA
GCAGGCACCAACGATACCCGCAAAGCAGTCGAACTGGCACTCAATGCCCGGAAAGCAGGCGCAGAAGCAATTCTGTCCGT
CGCTCCATATTACAACAAACCCTCGCAGGAAGGCTTTTACCAGCATTATCGTCATATAGCCGAAGCGCTCGATATTCCGG
TTATTATTTATAATGTGCCAGGCAGAACAGGCAGCAATATTGCCGCAGAAACCATTCTCCGGCTTGCTTCGGATTTCCAG
AACATCGCAGCGGTCAAGGAAGCTTCAGACAATATAGGCCAGATCATGGAGCTGCTTGCCGATCGTCCGGACCATTTTTC
CGTTCTCACCGGTGAAGACACACTCATACTGCCGTTCATGGCAATGGGCGGTGATGGCGTTATTTCCGTCGCGGCAAATC
AGGTACCTGCAGAGATCAAGCAGCTCATCACCCTTGTACAGGAAGGAAACCTGCCGGAAGCAAGAAGACTCAATAACAGG
TTGCGTAAACTCTTCAGACTGAACTTTATTGAAAGCAATCCTGTACCGGTCAAATATGCTCTGTCATTGATGGGAATGAT
AGAAGAAGTCTATCGCCTTCCTCTCCTGGCTATGGAAGAAAAGCATAAGAAAATCCTGAAACAGGAACTCGAAACCCTGG
GGCTGATCAGCTGA

Upstream 100 bases:

>100_bases
TTTTTTACGGTAGTGATTTAGCAAAATCAATAAGTTTGCCTTATACTATCTACCATTCTCTATTGTTTTCCAAACACACG
TAAACAGAGACGTTCTGTCT

Downstream 100 bases:

>100_bases
TCGCCCCGAGGTTTTCGACAAAACTATCCATCTCCGCTCTGCTCCTCTTCTCCGTTACGGCGATCAACAGCCCTGAATCG
TCATGAATGCCGAGATCGTA

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 297; Mature: 296

Protein sequence:

>297_residues
MSNTSISGSAVALVTPFRQDTSIDTDALRRLVQFHLASGTDILIPCGTTGESPTLCQEEQAAIIRIVKEEAGNHILVAAG
AGTNDTRKAVELALNARKAGAEAILSVAPYYNKPSQEGFYQHYRHIAEALDIPVIIYNVPGRTGSNIAAETILRLASDFQ
NIAAVKEASDNIGQIMELLADRPDHFSVLTGEDTLILPFMAMGGDGVISVAANQVPAEIKQLITLVQEGNLPEARRLNNR
LRKLFRLNFIESNPVPVKYALSLMGMIEEVYRLPLLAMEEKHKKILKQELETLGLIS

Sequences:

>Translated_297_residues
MSNTSISGSAVALVTPFRQDTSIDTDALRRLVQFHLASGTDILIPCGTTGESPTLCQEEQAAIIRIVKEEAGNHILVAAG
AGTNDTRKAVELALNARKAGAEAILSVAPYYNKPSQEGFYQHYRHIAEALDIPVIIYNVPGRTGSNIAAETILRLASDFQ
NIAAVKEASDNIGQIMELLADRPDHFSVLTGEDTLILPFMAMGGDGVISVAANQVPAEIKQLITLVQEGNLPEARRLNNR
LRKLFRLNFIESNPVPVKYALSLMGMIEEVYRLPLLAMEEKHKKILKQELETLGLIS
>Mature_296_residues
SNTSISGSAVALVTPFRQDTSIDTDALRRLVQFHLASGTDILIPCGTTGESPTLCQEEQAAIIRIVKEEAGNHILVAAGA
GTNDTRKAVELALNARKAGAEAILSVAPYYNKPSQEGFYQHYRHIAEALDIPVIIYNVPGRTGSNIAAETILRLASDFQN
IAAVKEASDNIGQIMELLADRPDHFSVLTGEDTLILPFMAMGGDGVISVAANQVPAEIKQLITLVQEGNLPEARRLNNRL
RKLFRLNFIESNPVPVKYALSLMGMIEEVYRLPLLAMEEKHKKILKQELETLGLIS

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=306, Percent_Identity=25.1633986928105, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI13540533, Length=306, Percent_Identity=22.5490196078431, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI1788823, Length=295, Percent_Identity=40.6779661016949, Blast_Score=228, Evalue=3e-61,
Organism=Escherichia coli, GI87082415, Length=287, Percent_Identity=32.0557491289199, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1789620, Length=286, Percent_Identity=29.020979020979, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1786463, Length=265, Percent_Identity=27.9245283018868, Blast_Score=118, Evalue=6e-28,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_PROA2 (B4S5J5)

Other databases:

- EMBL:   CP001108
- RefSeq:   YP_002015239.1
- ProteinModelPortal:   B4S5J5
- SMR:   B4S5J5
- GeneID:   6459895
- GenomeReviews:   CP001108_GR
- KEGG:   paa:Paes_0536
- HOGENOM:   HBG358848
- OMA:   GMYRHFK
- ProtClustDB:   PRK03170
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 32384; Mature: 32253

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 166-166 BINDING 110-110

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTSISGSAVALVTPFRQDTSIDTDALRRLVQFHLASGTDILIPCGTTGESPTLCQEEQ
CCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHH
AAIIRIVKEEAGNHILVAAGAGTNDTRKAVELALNARKAGAEAILSVAPYYNKPSQEGFY
HHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
QHYRHIAEALDIPVIIYNVPGRTGSNIAAETILRLASDFQNIAAVKEASDNIGQIMELLA
HHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
DRPDHFSVLTGEDTLILPFMAMGGDGVISVAANQVPAEIKQLITLVQEGNLPEARRLNNR
CCCCCEEEEECCCEEEEEHHHCCCCCEEEEHHHHCHHHHHHHHHHHHCCCCCHHHHHHHH
LRKLFRLNFIESNPVPVKYALSLMGMIEEVYRLPLLAMEEKHKKILKQELETLGLIS
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SNTSISGSAVALVTPFRQDTSIDTDALRRLVQFHLASGTDILIPCGTTGESPTLCQEEQ
CCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHH
AAIIRIVKEEAGNHILVAAGAGTNDTRKAVELALNARKAGAEAILSVAPYYNKPSQEGFY
HHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHH
QHYRHIAEALDIPVIIYNVPGRTGSNIAAETILRLASDFQNIAAVKEASDNIGQIMELLA
HHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
DRPDHFSVLTGEDTLILPFMAMGGDGVISVAANQVPAEIKQLITLVQEGNLPEARRLNNR
CCCCCEEEEECCCEEEEEHHHCCCCCEEEEHHHHCHHHHHHHHHHHHCCCCCHHHHHHHH
LRKLFRLNFIESNPVPVKYALSLMGMIEEVYRLPLLAMEEKHKKILKQELETLGLIS
HHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA