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The map label for this gene is lpxK [H]

Identifier: 194333328

GI number: 194333328

Start: 522552

End: 523631

Strand: Reverse

Name: lpxK [H]

Synonym: Paes_0485

Alternate gene names: 194333328

Gene position: 523631-522552 (Counterclockwise)

Preceding gene: 194333329

Following gene: 194333326

Centisome position: 20.84

GC content: 51.3

Gene sequence:

>1080_bases
GTGCATAAGAGCCCGAGCAGTCTGCTCTTCTTTCCCGCTCTTGTCTACAGAGGGATCATTGCGCTGCGCAATCTCCTGTT
CGATACCAGCATCTTCCGAAGCAGCGCTTCCCCCATCCCTGTCGTATCAATAGGCAATATCACGGCAGGGGGAACCGGTA
AAACCCCCATGACCGACCTTATCGTCAACTACTACCTCAAAAAAGGGATCCTGCCTGCTGTCATCTCAAGGGGGTATAAA
AGGAGCACAAAAGGGGTACAGCTTGTCTCCGATGGCAAGAGGGTCCTGCTCAACAGCAGAGAGGCCGGCGATGAAACGGT
CATGCTTGCATGGAAAAACAGAGCCGCCGTTGTCGTGGTCGCTGAACAACGGCGTCAAGGCGTGGAATTTATCGTGAAAC
ACTTTCAGGAGAAAACGCCTGACGTTATCATTCTTGACGACGCTTTTCAGCACCGCCAGATTCAGAGGGACCTGAACATT
GTGCTCATCAACGCCTCTGTCCCCTTCTGGAATGACCGCATGCTTCCGAAGGGACGCCTGAGGGAACCGACAAAGAATAT
CGGCCGTGCCGATCTTGCCGTCATCACGAAACTCCGACCCAATGAAACCGGCGAAACGCTTGCAGCACCGCTTCGAAAAA
AAGGGATTCCTGTCATCAAATCAAGAATCAAAACCGGAAAGCTCGTTGCCATTGCTCCTGTCGACAAAACGTCATCAGCA
CCATGCGACAGATCAAGAACCGGCTTTTTCGCCGTGGCCGGTATCGCCAACCCCGACAGTTTTCTCCAATCGCTCATCGA
ATGCGGTATTACGGTCAGCATGCACACCTTTTTTGACGACCATGAAGAATTTCCCCTGCAGGAGCTCCGAAACATCATAA
AAAAAGCCAGGTCGCATAACCTGGCTATCGTGACAACAGAAAAAGATTACTACAGAATACTGGGCAACACGGAGCAACTT
GCGCTGCTCACACAAATCCCGAGCTGCTATCTGACCATTGAACCTGACATTTTCGAAGGCCGGGAGATCCTTGAAAGCAT
GCTCGATAACGTCCTGAAAAACCGTAAGACTATCGGATGA

Upstream 100 bases:

>100_bases
AGCAGAGTCTCCATTACGCTGCACAGCATCACTATTCCCCTCTTCACCAATGAACAGGAGTTGCGAGATTTTGAACAGAA
ACTTTCAGAAAAATTCGCAG

Downstream 100 bases:

>100_bases
ACTACGCTTTGATAATGGCCGAGATCTCCTTGAATTTCTCACCTTGAGCCACCCGAAGAAGTTCAAAAATAGCCATTTCC
GTACTTTTGAGCCATGCCCC

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MHKSPSSLLFFPALVYRGIIALRNLLFDTSIFRSSASPIPVVSIGNITAGGTGKTPMTDLIVNYYLKKGILPAVISRGYK
RSTKGVQLVSDGKRVLLNSREAGDETVMLAWKNRAAVVVVAEQRRQGVEFIVKHFQEKTPDVIILDDAFQHRQIQRDLNI
VLINASVPFWNDRMLPKGRLREPTKNIGRADLAVITKLRPNETGETLAAPLRKKGIPVIKSRIKTGKLVAIAPVDKTSSA
PCDRSRTGFFAVAGIANPDSFLQSLIECGITVSMHTFFDDHEEFPLQELRNIIKKARSHNLAIVTTEKDYYRILGNTEQL
ALLTQIPSCYLTIEPDIFEGREILESMLDNVLKNRKTIG

Sequences:

>Translated_359_residues
MHKSPSSLLFFPALVYRGIIALRNLLFDTSIFRSSASPIPVVSIGNITAGGTGKTPMTDLIVNYYLKKGILPAVISRGYK
RSTKGVQLVSDGKRVLLNSREAGDETVMLAWKNRAAVVVVAEQRRQGVEFIVKHFQEKTPDVIILDDAFQHRQIQRDLNI
VLINASVPFWNDRMLPKGRLREPTKNIGRADLAVITKLRPNETGETLAAPLRKKGIPVIKSRIKTGKLVAIAPVDKTSSA
PCDRSRTGFFAVAGIANPDSFLQSLIECGITVSMHTFFDDHEEFPLQELRNIIKKARSHNLAIVTTEKDYYRILGNTEQL
ALLTQIPSCYLTIEPDIFEGREILESMLDNVLKNRKTIG
>Mature_359_residues
MHKSPSSLLFFPALVYRGIIALRNLLFDTSIFRSSASPIPVVSIGNITAGGTGKTPMTDLIVNYYLKKGILPAVISRGYK
RSTKGVQLVSDGKRVLLNSREAGDETVMLAWKNRAAVVVVAEQRRQGVEFIVKHFQEKTPDVIILDDAFQHRQIQRDLNI
VLINASVPFWNDRMLPKGRLREPTKNIGRADLAVITKLRPNETGETLAAPLRKKGIPVIKSRIKTGKLVAIAPVDKTSSA
PCDRSRTGFFAVAGIANPDSFLQSLIECGITVSMHTFFDDHEEFPLQELRNIIKKARSHNLAIVTTEKDYYRILGNTEQL
ALLTQIPSCYLTIEPDIFEGREILESMLDNVLKNRKTIG

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=321, Percent_Identity=27.7258566978193, Blast_Score=109, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 40019; Mature: 40019

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKSPSSLLFFPALVYRGIIALRNLLFDTSIFRSSASPIPVVSIGNITAGGTGKTPMTDL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCEECCCCCCCHHHHH
IVNYYLKKGILPAVISRGYKRSTKGVQLVSDGKRVLLNSREAGDETVMLAWKNRAAVVVV
HHHHHHHHCCHHHHHHCCCCCCCCCEEEECCCCEEEEECCCCCCCEEEEEECCCEEEEEE
AEQRRQGVEFIVKHFQEKTPDVIILDDAFQHRQIQRDLNIVLINASVPFWNDRMLPKGRL
EHHHHCCHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCC
REPTKNIGRADLAVITKLRPNETGETLAAPLRKKGIPVIKSRIKTGKLVAIAPVDKTSSA
CCCHHHCCCHHEHEEEECCCCCCCHHHHHHHHHCCCHHHHHHCCCCCEEEEEECCCCCCC
PCDRSRTGFFAVAGIANPDSFLQSLIECGITVSMHTFFDDHEEFPLQELRNIIKKARSHN
CCCCCCCCEEEEEECCCHHHHHHHHHHCCCEEEEEEHHCCCCCCCHHHHHHHHHHHHCCC
LAIVTTEKDYYRILGNTEQLALLTQIPSCYLTIEPDIFEGREILESMLDNVLKNRKTIG
EEEEEECCHHHHCCCCCHHHHHEECCCCEEEEECCCHHCHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MHKSPSSLLFFPALVYRGIIALRNLLFDTSIFRSSASPIPVVSIGNITAGGTGKTPMTDL
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCEECCCCCCCHHHHH
IVNYYLKKGILPAVISRGYKRSTKGVQLVSDGKRVLLNSREAGDETVMLAWKNRAAVVVV
HHHHHHHHCCHHHHHHCCCCCCCCCEEEECCCCEEEEECCCCCCCEEEEEECCCEEEEEE
AEQRRQGVEFIVKHFQEKTPDVIILDDAFQHRQIQRDLNIVLINASVPFWNDRMLPKGRL
EHHHHCCHHHHHHHHHHCCCCEEEECCCHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCC
REPTKNIGRADLAVITKLRPNETGETLAAPLRKKGIPVIKSRIKTGKLVAIAPVDKTSSA
CCCHHHCCCHHEHEEEECCCCCCCHHHHHHHHHCCCHHHHHHCCCCCEEEEEECCCCCCC
PCDRSRTGFFAVAGIANPDSFLQSLIECGITVSMHTFFDDHEEFPLQELRNIIKKARSHN
CCCCCCCCEEEEEECCCHHHHHHHHHHCCCEEEEEEHHCCCCCCCHHHHHHHHHHHHCCC
LAIVTTEKDYYRILGNTEQLALLTQIPSCYLTIEPDIFEGREILESMLDNVLKNRKTIG
EEEEEECCHHHHCCCCCHHHHHEECCCCEEEEECCCHHCHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA