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The map label for this gene is thrS

Identifier: 194333013

GI number: 194333013

Start: 172946

End: 174919

Strand: Reverse

Name: thrS

Synonym: Paes_0167

Alternate gene names: 194333013

Gene position: 174919-172946 (Counterclockwise)

Preceding gene: 194333014

Following gene: 194333012

Centisome position: 6.96

GC content: 51.52

Gene sequence:

>1974_bases
ATGTCCGAACATACTACATCGCAGACCCAGGTAACGGTAACTCTGCCTGATGGTGAAAGCAGATCTTTCCCCTTCGGCAC
GACCGGTTACGATATTGCCCGTTCAATCGGGAAAAAACTTGCACAGGATGCCCTCGCCGTCGTCATTAACGGCAGAGCAC
AGGACCTCGATTCCCCTGTCAGCGAAGATGCCTCGATTGAAATCGTCACATTCGACCACCCACTGGGAAAGGAAATTTTC
TGGCACAGTGCCAGTCATATCATGGCCCACGCCATCGAAGAACTGTTTCCCGGCTCAAGATTCGGCGCAGGGCCAGCAAT
TGAACAGGGATTCTACTACGATATCGCCTCCAGTCACCGCTTCACAGAAAGTGACCTCCACGATATCGAAACCAGGATGA
TCGAGATCGGCCGGCGCGCTATCGACGTGCGGCGCGAGGAACTCTCGCGTCAGGCAGCCATCGATTTTTTCTCATCGACC
AGAAAGGACCCCTACAAGGTTGAAATCCTCGAAGATACCCTGAAGGATACTCCGACGGTTTCGATCTATCACCAGGGCGA
ATTTGCCGATCTTTGCACCGGTCCGCACCTGCCGAACACCTCGAAGCTCAAAGCAGTCAAGCTGACCAATATTTCAGCAT
CGTTCTGGAGAGGAGACTCGTCACGTGAAAGCATGCAGAGAATTTACGGTATAGCGTTTCCTTCCGAAAAACTCCTCAAA
CAGCACCTTGCTCATATCGAAGAAGCAAAAAAACGCGATCATCGCAAGCTCGGCGCTGAACTTGAACTCTTCATGCTCTC
GCCCGAAGTAGGCAGCGGTCTACCGATCTGGCTTCCGAAAGGCGCGATCGTTCGAAACGAACTGGAATCATTCCTCAGAG
AAGAACAGAGAAAACGCGGCTATGTACCGGTATACACGCCTCATATAGGAAATATAGGATTGTACAAACGATCCGGTCAT
TATCCGTATTACAGTGAATCACAGTTTCCGCCACTAACCTATACCGATGATCTCGGAAGAGAGGAACAGTATCTGCTCAA
ACCGATGAACTGTCCGCATCATCACATGATCTACAGTTCAAAGCTTCGCAGCTATCGCGATCTGCCGATACGACTGACCG
AGTTCGGCACCGTCTACCGCCACGAACAGTCAGGAGAACTCAACGGCCTTATTCGCGCAAGAGGCTTTACGCAGGATGAT
TCTCATATCTACTGCCGTCCGGACCAGCTCGTCGACGAGATCTGCAATGCTATCGATCTCACAAAATTCGTCTTCGCGAC
ACTCGGCTTCGACGACATCCAGATTCGCCTGTCGCTCCACGACCCTGAAAACCAGGACAAATACGGCGGAACGAAAGAGG
TATGGGAACAGGCAGAAAAAGACGTTCGCGAAGCTGCAGACAGAATGAACATCGACTACTTCACGGGCATTGGTGAAGCC
AGTTTCTATGGGCCGAAAATTGACTTTATCGTCCGCGATGCCATTGGAAGAAAATGGCAGCTCGGCACCGTTCAGGTAGA
CTACGTCATGCCCGAACGATTCGATCTCTCATATATTGGAAGTGATGGACAGCCCCACAGGCCGGTCATCATCCACCGGG
CACCATTTGGATCGATGGAGCGTTTTATCGGTGTTCTGATTGAGCATACCGGCGGAAATTTCCCGCTATGGCTTGCGCCT
GTTCAGATCGCTGTTCTCCCGATCACGGATGAAGTGCACGACTATGCCGTACAGGTTCGCGATACGCTCCATGCTGCCGG
CATGCGCGTCGAGCTCGACACCCGCAGTGAAAAAATAGGGAAAAAAATCCGCGAATCGGAAGTCGCAAAAATCCCGTACA
TGGTCATTATCGGCCAGAAGGAAGCTGCTGCCGGAGAGGTCTCGCTGAGACGACACCGCGAGGGTGATCAGGGCAACATG
ACCGTAGAAGAACTGAAAGAAAAATTAGCTAAGGAAATTAACGACAAATCCTGA

Upstream 100 bases:

>100_bases
GATAATACACTGACAAAAAGCGGCTGATAATCCTGAAATCAGGGTATAAACAGGCACCCGATAGGGTACCTGCCAAGATC
TAGAAGAGACAGCGTCTTAC

Downstream 100 bases:

>100_bases
GACCGCAGCAAGAATTGTTCTGATAGCGGCCGTCACACAAATCCAGACCATATGAGAAAAAAGAGAAGCGCTCCTCAAAA
GCCAAAACTAACCTACAGGG

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 657; Mature: 656

Protein sequence:

>657_residues
MSEHTTSQTQVTVTLPDGESRSFPFGTTGYDIARSIGKKLAQDALAVVINGRAQDLDSPVSEDASIEIVTFDHPLGKEIF
WHSASHIMAHAIEELFPGSRFGAGPAIEQGFYYDIASSHRFTESDLHDIETRMIEIGRRAIDVRREELSRQAAIDFFSST
RKDPYKVEILEDTLKDTPTVSIYHQGEFADLCTGPHLPNTSKLKAVKLTNISASFWRGDSSRESMQRIYGIAFPSEKLLK
QHLAHIEEAKKRDHRKLGAELELFMLSPEVGSGLPIWLPKGAIVRNELESFLREEQRKRGYVPVYTPHIGNIGLYKRSGH
YPYYSESQFPPLTYTDDLGREEQYLLKPMNCPHHHMIYSSKLRSYRDLPIRLTEFGTVYRHEQSGELNGLIRARGFTQDD
SHIYCRPDQLVDEICNAIDLTKFVFATLGFDDIQIRLSLHDPENQDKYGGTKEVWEQAEKDVREAADRMNIDYFTGIGEA
SFYGPKIDFIVRDAIGRKWQLGTVQVDYVMPERFDLSYIGSDGQPHRPVIIHRAPFGSMERFIGVLIEHTGGNFPLWLAP
VQIAVLPITDEVHDYAVQVRDTLHAAGMRVELDTRSEKIGKKIRESEVAKIPYMVIIGQKEAAAGEVSLRRHREGDQGNM
TVEELKEKLAKEINDKS

Sequences:

>Translated_657_residues
MSEHTTSQTQVTVTLPDGESRSFPFGTTGYDIARSIGKKLAQDALAVVINGRAQDLDSPVSEDASIEIVTFDHPLGKEIF
WHSASHIMAHAIEELFPGSRFGAGPAIEQGFYYDIASSHRFTESDLHDIETRMIEIGRRAIDVRREELSRQAAIDFFSST
RKDPYKVEILEDTLKDTPTVSIYHQGEFADLCTGPHLPNTSKLKAVKLTNISASFWRGDSSRESMQRIYGIAFPSEKLLK
QHLAHIEEAKKRDHRKLGAELELFMLSPEVGSGLPIWLPKGAIVRNELESFLREEQRKRGYVPVYTPHIGNIGLYKRSGH
YPYYSESQFPPLTYTDDLGREEQYLLKPMNCPHHHMIYSSKLRSYRDLPIRLTEFGTVYRHEQSGELNGLIRARGFTQDD
SHIYCRPDQLVDEICNAIDLTKFVFATLGFDDIQIRLSLHDPENQDKYGGTKEVWEQAEKDVREAADRMNIDYFTGIGEA
SFYGPKIDFIVRDAIGRKWQLGTVQVDYVMPERFDLSYIGSDGQPHRPVIIHRAPFGSMERFIGVLIEHTGGNFPLWLAP
VQIAVLPITDEVHDYAVQVRDTLHAAGMRVELDTRSEKIGKKIRESEVAKIPYMVIIGQKEAAAGEVSLRRHREGDQGNM
TVEELKEKLAKEINDKS
>Mature_656_residues
SEHTTSQTQVTVTLPDGESRSFPFGTTGYDIARSIGKKLAQDALAVVINGRAQDLDSPVSEDASIEIVTFDHPLGKEIFW
HSASHIMAHAIEELFPGSRFGAGPAIEQGFYYDIASSHRFTESDLHDIETRMIEIGRRAIDVRREELSRQAAIDFFSSTR
KDPYKVEILEDTLKDTPTVSIYHQGEFADLCTGPHLPNTSKLKAVKLTNISASFWRGDSSRESMQRIYGIAFPSEKLLKQ
HLAHIEEAKKRDHRKLGAELELFMLSPEVGSGLPIWLPKGAIVRNELESFLREEQRKRGYVPVYTPHIGNIGLYKRSGHY
PYYSESQFPPLTYTDDLGREEQYLLKPMNCPHHHMIYSSKLRSYRDLPIRLTEFGTVYRHEQSGELNGLIRARGFTQDDS
HIYCRPDQLVDEICNAIDLTKFVFATLGFDDIQIRLSLHDPENQDKYGGTKEVWEQAEKDVREAADRMNIDYFTGIGEAS
FYGPKIDFIVRDAIGRKWQLGTVQVDYVMPERFDLSYIGSDGQPHRPVIIHRAPFGSMERFIGVLIEHTGGNFPLWLAPV
QIAVLPITDEVHDYAVQVRDTLHAAGMRVELDTRSEKIGKKIRESEVAKIPYMVIIGQKEAAAGEVSLRRHREGDQGNMT
VEELKEKLAKEINDKS

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38202255, Length=645, Percent_Identity=38.2945736434108, Blast_Score=471, Evalue=1e-133,
Organism=Homo sapiens, GI38570111, Length=643, Percent_Identity=37.0139968895801, Blast_Score=457, Evalue=1e-128,
Organism=Homo sapiens, GI20070344, Length=661, Percent_Identity=37.6701966717095, Blast_Score=442, Evalue=1e-124,
Organism=Escherichia coli, GI1788013, Length=646, Percent_Identity=40.7120743034056, Blast_Score=527, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI71984192, Length=644, Percent_Identity=35.8695652173913, Blast_Score=456, Evalue=1e-128,
Organism=Caenorhabditis elegans, GI71984184, Length=644, Percent_Identity=35.8695652173913, Blast_Score=456, Evalue=1e-128,
Organism=Saccharomyces cerevisiae, GI6322112, Length=662, Percent_Identity=35.3474320241692, Blast_Score=439, Evalue=1e-124,
Organism=Saccharomyces cerevisiae, GI6322654, Length=412, Percent_Identity=33.9805825242718, Blast_Score=251, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24583839, Length=644, Percent_Identity=38.1987577639752, Blast_Score=476, Evalue=1e-134,
Organism=Drosophila melanogaster, GI24583842, Length=644, Percent_Identity=38.1987577639752, Blast_Score=476, Evalue=1e-134,
Organism=Drosophila melanogaster, GI28574141, Length=644, Percent_Identity=38.1987577639752, Blast_Score=476, Evalue=1e-134,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_PROA2 (B4S3D2)

Other databases:

- EMBL:   CP001108
- RefSeq:   YP_002014873.1
- ProteinModelPortal:   B4S3D2
- SMR:   B4S3D2
- GeneID:   6460184
- GenomeReviews:   CP001108_GR
- KEGG:   paa:Paes_0167
- HOGENOM:   HBG352811
- OMA:   GRKWQLG
- ProtClustDB:   PRK00413
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- Gene3D:   G3DSA:3.10.20.30
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF81271 TGS-like; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 74610; Mature: 74479

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHTTSQTQVTVTLPDGESRSFPFGTTGYDIARSIGKKLAQDALAVVINGRAQDLDSPV
CCCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCHHCCCCCC
SEDASIEIVTFDHPLGKEIFWHSASHIMAHAIEELFPGSRFGAGPAIEQGFYYDIASSHR
CCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCC
FTESDLHDIETRMIEIGRRAIDVRREELSRQAAIDFFSSTRKDPYKVEILEDTLKDTPTV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCCE
SIYHQGEFADLCTGPHLPNTSKLKAVKLTNISASFWRGDSSRESMQRIYGIAFPSEKLLK
EEEECCCCHHHCCCCCCCCCCCEEEEEEECCCHHHHCCCCHHHHHHHHHHCCCCHHHHHH
QHLAHIEEAKKRDHRKLGAELELFMLSPEVGSGLPIWLPKGAIVRNELESFLREEQRKRG
HHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCC
YVPVYTPHIGNIGLYKRSGHYPYYSESQFPPLTYTDDLGREEQYLLKPMNCPHHHMIYSS
CCEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHH
KLRSYRDLPIRLTEFGTVYRHEQSGELNGLIRARGFTQDDSHIYCRPDQLVDEICNAIDL
HHHHHCCCCEEEECCCHHEEECCCCCCCEEEEECCCCCCCCEEEECHHHHHHHHHHHHHH
TKFVFATLGFDDIQIRLSLHDPENQDKYGGTKEVWEQAEKDVREAADRMNIDYFTGIGEA
HHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHEECCCCC
SFYGPKIDFIVRDAIGRKWQLGTVQVDYVMPERFDLSYIGSDGQPHRPVIIHRAPFGSME
CCCCCCEEEEEEHHCCCEEEECEEEEEEECCCCCCEEEECCCCCCCCCEEEEECCCCHHH
RFIGVLIEHTGGNFPLWLAPVQIAVLPITDEVHDYAVQVRDTLHAAGMRVELDTRSEKIG
HHHHHEEEECCCCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCHHHHH
KKIRESEVAKIPYMVIIGQKEAAAGEVSLRRHREGDQGNMTVEELKEKLAKEINDKS
HHHHHHHHHHCCEEEEECCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SEHTTSQTQVTVTLPDGESRSFPFGTTGYDIARSIGKKLAQDALAVVINGRAQDLDSPV
CCCCCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCHHCCCCCC
SEDASIEIVTFDHPLGKEIFWHSASHIMAHAIEELFPGSRFGAGPAIEQGFYYDIASSHR
CCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCC
FTESDLHDIETRMIEIGRRAIDVRREELSRQAAIDFFSSTRKDPYKVEILEDTLKDTPTV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHCCCCCE
SIYHQGEFADLCTGPHLPNTSKLKAVKLTNISASFWRGDSSRESMQRIYGIAFPSEKLLK
EEEECCCCHHHCCCCCCCCCCCEEEEEEECCCHHHHCCCCHHHHHHHHHHCCCCHHHHHH
QHLAHIEEAKKRDHRKLGAELELFMLSPEVGSGLPIWLPKGAIVRNELESFLREEQRKRG
HHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCC
YVPVYTPHIGNIGLYKRSGHYPYYSESQFPPLTYTDDLGREEQYLLKPMNCPHHHMIYSS
CCEEECCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCHHHHHHH
KLRSYRDLPIRLTEFGTVYRHEQSGELNGLIRARGFTQDDSHIYCRPDQLVDEICNAIDL
HHHHHCCCCEEEECCCHHEEECCCCCCCEEEEECCCCCCCCEEEECHHHHHHHHHHHHHH
TKFVFATLGFDDIQIRLSLHDPENQDKYGGTKEVWEQAEKDVREAADRMNIDYFTGIGEA
HHHHHHHCCCCEEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHEECCCCC
SFYGPKIDFIVRDAIGRKWQLGTVQVDYVMPERFDLSYIGSDGQPHRPVIIHRAPFGSME
CCCCCCEEEEEEHHCCCEEEECEEEEEEECCCCCCEEEECCCCCCCCCEEEEECCCCHHH
RFIGVLIEHTGGNFPLWLAPVQIAVLPITDEVHDYAVQVRDTLHAAGMRVELDTRSEKIG
HHHHHEEEECCCCCCEEEEEEEEEEEECCCHHHHHHHHHHHHHHHCCCEEEECCCHHHHH
KKIRESEVAKIPYMVIIGQKEAAAGEVSLRRHREGDQGNMTVEELKEKLAKEINDKS
HHHHHHHHHHCCEEEEECCCCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA