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The map label for this gene is recQ [H]

Identifier: 194332913

GI number: 194332913

Start: 66923

End: 68776

Strand: Reverse

Name: recQ [H]

Synonym: Paes_0060

Alternate gene names: 194332913

Gene position: 68776-66923 (Counterclockwise)

Preceding gene: 194332921

Following gene: 194332907

Centisome position: 2.74

GC content: 56.47

Gene sequence:

>1854_bases
ATGACCCACGATACGCTACCCGCATCACCATCAGCTTCCGTCTTGAACACCCTCCACAAAGTCTTTGGTTTCAATGCCTT
CCGCCCGAATCAGGGGGAGGTTGTACAGGCCATACTTTCCGGCAGGGATGCGTTTGCGGTGATGCCGACTGGCGGGGGAA
AGTCGCTGTGTTATCAGCTGCCCGCGGTGGTGATGGAGGGGACGTGCGTGGTGATCAGTCCGTTGATCGCGCTGATGAAG
GATCAGGTGGACGGGGCGAGGGTAAACGGGATCAGGGCTGCGTATCTGAACAGTTCGCTCTCTCCTGATGAGCAGTCGCT
GGTGATGAGCGAACTGACGTCGAACAGGCTGGATCTGCTCTATGTGGCGCCGGAGCGGTTTTCGCTGGAGCATTTCCAGA
CAGTGCTGAAAGAGGTGAAGATCAGTATGGCGGTGATCGACGAGGCGCACTGCATTTCGGAATGGGGGCATGATTTCCGG
CCGGACTATCTCTCCCTTTCTGCGCTCGTGGAGCTCTTTCCCGATGTTCCTGTTGCGGCCTTCACGGCGACGGCGACACA
CAAGGTGCAGGCCGATATTCTCCGGAAGCTTGGTCTGCGCGATCCGTTCGTCGTCCGGGCCTCGTTTGACAGACCGAACC
TGACCTACGATGTCCGCTTCAAGGACAATGTTTCAGAGCAGCTTGTCGGGCTCCTGAAGAGCAGCCCCGGCAAGGCGGGG
ATCATCTACCGGACCAGTCGCAAAAGCGTCAACGAGACGACTGCCATGCTGCAGGCGAAGGGATTCCGGGCGCTGCCGTA
CCATGCGGGGCTCGGCGATGAGGAGCGAAAAAAGAACCAGGAGACGTTTATCCGCGACGAGGCGGATGTGATCGTGGCAA
CAGTGGCGTTCGGGATGGGAATCGACAAGTCCAACATCCGCTTCGTGATTCATGCCGACCTGCCGAAAAGCATCGAGAAC
TACTACCAGGAGACGGGACGTGCAGGACGCGACGGCGAACCGGCACACTGCACGCTCCTCTTTTCACAGGGCGATATTCC
CAAGGTCCGCTTCTTCATCGATACGATCATTGACGAAACTGAACGAAACAAAGCGCTCGATGCCCTGCAGCGGGTTGTCT
CTTTTGCATCAACGTCAGTCTGCCGCCGCATAACCCTGCTGGACTATTTCGGGGAGAGCTATCCGAAGGAGAACTGCGGA
TCCTGCGACATCTGCCTCGGCACACGCGAAGTGACTGACTGCACACGGGAGGCGCAGATGCTGCTATCGGCAATTGCCCG
AACGGAAGGGCGGTTCGGCGCAACCCATATCATCGATATCGTCATGGGAAGCAAGAACAAAAAGATTCTCGAACTCGGTC
ACGACCGCCTGAAAACCTACGGGGTAGGCAAAGAGAAGAACAAAAAATTCTGGCGCCATCTGATCGACGAACTGCTGGCT
CAGAAGATGATCGCAAAAGCAGAAGGGCTCTACCCGACGCTCTATCTTCTTGAACAGTCTGTGCCGGTCCTGAAAGGCGA
AGCGAGGCTGGAGATGGTGAGAGTGATTGAGAAGAAAACCCCGAAACCCTCAAGAACCATGGAGCATGGGGACTATGATC
ACGAACTCTTTGAACAGCTGAGAACGCTGCGTAAACAGCTGGCCGACGAACAGGATATACCGCCCTACATCGTTTTTTCA
GACCGCTCGCTGCGCGACATGGCAGCTCTGCTCCCGAAAGACGACGAGACAATGCTTGAGGTCTCAGGGGTAGGGGAGGT
CAAGCTCGAACGCTATGGACGGATCTTCCTCGACTGGATCAGGAGGTATTGCCAACGCCAGCCTGAGCAATCCGAAGCAA
CCCAATCTTCATAA

Upstream 100 bases:

>100_bases
CTCCTCATCACTCCTGACCTTATGCATTTATTTTAACGTGGTGAACAGCTATATTCCTATCCTAAGCGATTTGCCAATCC
CCCGACCTTGAACACTGATC

Downstream 100 bases:

>100_bases
ACTGAACCGCATACTGTAACAGCAGAAGCCTCAGCCATCGCACGCTCTGGAACGGAAGCTGCGCTGCCGAAAAAACAACA
GCCCGCCCTGCTTGTCGGGC

Product: ATP-dependent DNA helicase RecQ

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 617; Mature: 616

Protein sequence:

>617_residues
MTHDTLPASPSASVLNTLHKVFGFNAFRPNQGEVVQAILSGRDAFAVMPTGGGKSLCYQLPAVVMEGTCVVISPLIALMK
DQVDGARVNGIRAAYLNSSLSPDEQSLVMSELTSNRLDLLYVAPERFSLEHFQTVLKEVKISMAVIDEAHCISEWGHDFR
PDYLSLSALVELFPDVPVAAFTATATHKVQADILRKLGLRDPFVVRASFDRPNLTYDVRFKDNVSEQLVGLLKSSPGKAG
IIYRTSRKSVNETTAMLQAKGFRALPYHAGLGDEERKKNQETFIRDEADVIVATVAFGMGIDKSNIRFVIHADLPKSIEN
YYQETGRAGRDGEPAHCTLLFSQGDIPKVRFFIDTIIDETERNKALDALQRVVSFASTSVCRRITLLDYFGESYPKENCG
SCDICLGTREVTDCTREAQMLLSAIARTEGRFGATHIIDIVMGSKNKKILELGHDRLKTYGVGKEKNKKFWRHLIDELLA
QKMIAKAEGLYPTLYLLEQSVPVLKGEARLEMVRVIEKKTPKPSRTMEHGDYDHELFEQLRTLRKQLADEQDIPPYIVFS
DRSLRDMAALLPKDDETMLEVSGVGEVKLERYGRIFLDWIRRYCQRQPEQSEATQSS

Sequences:

>Translated_617_residues
MTHDTLPASPSASVLNTLHKVFGFNAFRPNQGEVVQAILSGRDAFAVMPTGGGKSLCYQLPAVVMEGTCVVISPLIALMK
DQVDGARVNGIRAAYLNSSLSPDEQSLVMSELTSNRLDLLYVAPERFSLEHFQTVLKEVKISMAVIDEAHCISEWGHDFR
PDYLSLSALVELFPDVPVAAFTATATHKVQADILRKLGLRDPFVVRASFDRPNLTYDVRFKDNVSEQLVGLLKSSPGKAG
IIYRTSRKSVNETTAMLQAKGFRALPYHAGLGDEERKKNQETFIRDEADVIVATVAFGMGIDKSNIRFVIHADLPKSIEN
YYQETGRAGRDGEPAHCTLLFSQGDIPKVRFFIDTIIDETERNKALDALQRVVSFASTSVCRRITLLDYFGESYPKENCG
SCDICLGTREVTDCTREAQMLLSAIARTEGRFGATHIIDIVMGSKNKKILELGHDRLKTYGVGKEKNKKFWRHLIDELLA
QKMIAKAEGLYPTLYLLEQSVPVLKGEARLEMVRVIEKKTPKPSRTMEHGDYDHELFEQLRTLRKQLADEQDIPPYIVFS
DRSLRDMAALLPKDDETMLEVSGVGEVKLERYGRIFLDWIRRYCQRQPEQSEATQSS
>Mature_616_residues
THDTLPASPSASVLNTLHKVFGFNAFRPNQGEVVQAILSGRDAFAVMPTGGGKSLCYQLPAVVMEGTCVVISPLIALMKD
QVDGARVNGIRAAYLNSSLSPDEQSLVMSELTSNRLDLLYVAPERFSLEHFQTVLKEVKISMAVIDEAHCISEWGHDFRP
DYLSLSALVELFPDVPVAAFTATATHKVQADILRKLGLRDPFVVRASFDRPNLTYDVRFKDNVSEQLVGLLKSSPGKAGI
IYRTSRKSVNETTAMLQAKGFRALPYHAGLGDEERKKNQETFIRDEADVIVATVAFGMGIDKSNIRFVIHADLPKSIENY
YQETGRAGRDGEPAHCTLLFSQGDIPKVRFFIDTIIDETERNKALDALQRVVSFASTSVCRRITLLDYFGESYPKENCGS
CDICLGTREVTDCTREAQMLLSAIARTEGRFGATHIIDIVMGSKNKKILELGHDRLKTYGVGKEKNKKFWRHLIDELLAQ
KMIAKAEGLYPTLYLLEQSVPVLKGEARLEMVRVIEKKTPKPSRTMEHGDYDHELFEQLRTLRKQLADEQDIPPYIVFSD
RSLRDMAALLPKDDETMLEVSGVGEVKLERYGRIFLDWIRRYCQRQPEQSEATQSS

Specific function: Involved in the recF recombination pathway; its gene expression is under the regulation of the SOS system. It is a DNA helicase [H]

COG id: COG0514

COG function: function code L; Superfamily II DNA helicase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HRDC domain [H]

Homologues:

Organism=Homo sapiens, GI4557365, Length=635, Percent_Identity=35.2755905511811, Blast_Score=349, Evalue=4e-96,
Organism=Homo sapiens, GI148612816, Length=431, Percent_Identity=41.0672853828306, Blast_Score=310, Evalue=3e-84,
Organism=Homo sapiens, GI14591902, Length=473, Percent_Identity=37.6321353065539, Blast_Score=304, Evalue=2e-82,
Organism=Homo sapiens, GI14591904, Length=473, Percent_Identity=37.6321353065539, Blast_Score=304, Evalue=2e-82,
Organism=Homo sapiens, GI51242947, Length=389, Percent_Identity=42.4164524421594, Blast_Score=298, Evalue=1e-80,
Organism=Homo sapiens, GI51242943, Length=389, Percent_Identity=42.4164524421594, Blast_Score=297, Evalue=2e-80,
Organism=Homo sapiens, GI110735439, Length=510, Percent_Identity=34.7058823529412, Blast_Score=291, Evalue=2e-78,
Organism=Homo sapiens, GI169218196, Length=510, Percent_Identity=34.7058823529412, Blast_Score=290, Evalue=2e-78,
Organism=Homo sapiens, GI284005309, Length=409, Percent_Identity=34.718826405868, Blast_Score=204, Evalue=3e-52,
Organism=Homo sapiens, GI21071032, Length=443, Percent_Identity=25.7336343115124, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI222352149, Length=355, Percent_Identity=23.943661971831, Blast_Score=77, Evalue=7e-14,
Organism=Homo sapiens, GI20149629, Length=340, Percent_Identity=23.2352941176471, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI148613856, Length=370, Percent_Identity=23.7837837837838, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI38201710, Length=370, Percent_Identity=23.7837837837838, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI4758138, Length=354, Percent_Identity=24.5762711864407, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI38569503, Length=361, Percent_Identity=23.5457063711911, Blast_Score=69, Evalue=2e-11,
Organism=Homo sapiens, GI38569505, Length=361, Percent_Identity=23.5457063711911, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI41327771, Length=383, Percent_Identity=22.4543080939948, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI48994977, Length=605, Percent_Identity=44.7933884297521, Blast_Score=538, Evalue=1e-154,
Organism=Escherichia coli, GI87082221, Length=347, Percent_Identity=23.9193083573487, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1787016, Length=356, Percent_Identity=25.8426966292135, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI25145561, Length=668, Percent_Identity=35.0299401197605, Blast_Score=353, Evalue=1e-97,
Organism=Caenorhabditis elegans, GI71987997, Length=554, Percent_Identity=36.101083032491, Blast_Score=309, Evalue=2e-84,
Organism=Caenorhabditis elegans, GI71987993, Length=554, Percent_Identity=36.101083032491, Blast_Score=309, Evalue=4e-84,
Organism=Caenorhabditis elegans, GI32564293, Length=675, Percent_Identity=30.3703703703704, Blast_Score=307, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI17552866, Length=475, Percent_Identity=34.5263157894737, Blast_Score=272, Evalue=4e-73,
Organism=Caenorhabditis elegans, GI17507945, Length=460, Percent_Identity=25.2173913043478, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17508543, Length=412, Percent_Identity=24.0291262135922, Blast_Score=76, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17537549, Length=356, Percent_Identity=24.7191011235955, Blast_Score=75, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17552642, Length=351, Percent_Identity=25.9259259259259, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17555296, Length=330, Percent_Identity=24.8484848484848, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI115533224, Length=408, Percent_Identity=23.5294117647059, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI32565321, Length=379, Percent_Identity=23.4828496042216, Blast_Score=72, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6323844, Length=545, Percent_Identity=38.1651376146789, Blast_Score=360, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6320224, Length=351, Percent_Identity=22.7920227920228, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324778, Length=355, Percent_Identity=25.6338028169014, Blast_Score=70, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323021, Length=386, Percent_Identity=23.8341968911917, Blast_Score=64, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6325138, Length=255, Percent_Identity=25.8823529411765, Blast_Score=64, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24646066, Length=639, Percent_Identity=35.8372456964006, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24664226, Length=434, Percent_Identity=36.1751152073733, Blast_Score=275, Evalue=9e-74,
Organism=Drosophila melanogaster, GI24664230, Length=432, Percent_Identity=35.8796296296296, Blast_Score=271, Evalue=1e-72,
Organism=Drosophila melanogaster, GI62472181, Length=432, Percent_Identity=35.8796296296296, Blast_Score=271, Evalue=1e-72,
Organism=Drosophila melanogaster, GI21358123, Length=372, Percent_Identity=35.752688172043, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24585582, Length=340, Percent_Identity=24.4117647058824, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24584994, Length=383, Percent_Identity=24.8041775456919, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI18857967, Length=381, Percent_Identity=24.6719160104987, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24666101, Length=351, Percent_Identity=23.9316239316239, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI28574962, Length=370, Percent_Identity=24.0540540540541, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR011545
- InterPro:   IPR004589
- InterPro:   IPR006293
- InterPro:   IPR002121
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR010997
- InterPro:   IPR018982 [H]

Pfam domain/function: PF00270 DEAD; PF00271 Helicase_C; PF00570 HRDC; PF09382 RQC [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 69224; Mature: 69093

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS50967 HRDC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHDTLPASPSASVLNTLHKVFGFNAFRPNQGEVVQAILSGRDAFAVMPTGGGKSLCYQL
CCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHH
PAVVMEGTCVVISPLIALMKDQVDGARVNGIRAAYLNSSLSPDEQSLVMSELTSNRLDLL
HHHHHCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEE
YVAPERFSLEHFQTVLKEVKISMAVIDEAHCISEWGHDFRPDYLSLSALVELFPDVPVAA
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHH
FTATATHKVQADILRKLGLRDPFVVRASFDRPNLTYDVRFKDNVSEQLVGLLKSSPGKAG
HHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHCCCCCEE
IIYRTSRKSVNETTAMLQAKGFRALPYHAGLGDEERKKNQETFIRDEADVIVATVAFGMG
EEEECCCCCHHHHHHHHHHCCCEECCCCCCCCHHHHHCCHHHHHCCCHHEEEHHHHHHCC
IDKSNIRFVIHADLPKSIENYYQETGRAGRDGEPAHCTLLFSQGDIPKVRFFIDTIIDET
CCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHH
ERNKALDALQRVVSFASTSVCRRITLLDYFGESYPKENCGSCDICLGTREVTDCTREAQM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHH
LLSAIARTEGRFGATHIIDIVMGSKNKKILELGHDRLKTYGVGKEKNKKFWRHLIDELLA
HHHHHHHCCCCCCHHHHEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
QKMIAKAEGLYPTLYLLEQSVPVLKGEARLEMVRVIEKKTPKPSRTMEHGDYDHELFEQL
HHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
RTLRKQLADEQDIPPYIVFSDRSLRDMAALLPKDDETMLEVSGVGEVKLERYGRIFLDWI
HHHHHHHCCCCCCCCEEEECCCCHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHH
RRYCQRQPEQSEATQSS
HHHHHCCCCHHHHCCCC
>Mature Secondary Structure 
THDTLPASPSASVLNTLHKVFGFNAFRPNQGEVVQAILSGRDAFAVMPTGGGKSLCYQL
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCHHHHHHH
PAVVMEGTCVVISPLIALMKDQVDGARVNGIRAAYLNSSLSPDEQSLVMSELTSNRLDLL
HHHHHCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCEEEE
YVAPERFSLEHFQTVLKEVKISMAVIDEAHCISEWGHDFRPDYLSLSALVELFPDVPVAA
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHH
FTATATHKVQADILRKLGLRDPFVVRASFDRPNLTYDVRFKDNVSEQLVGLLKSSPGKAG
HHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHCCCCCEE
IIYRTSRKSVNETTAMLQAKGFRALPYHAGLGDEERKKNQETFIRDEADVIVATVAFGMG
EEEECCCCCHHHHHHHHHHCCCEECCCCCCCCHHHHHCCHHHHHCCCHHEEEHHHHHHCC
IDKSNIRFVIHADLPKSIENYYQETGRAGRDGEPAHCTLLFSQGDIPKVRFFIDTIIDET
CCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHH
ERNKALDALQRVVSFASTSVCRRITLLDYFGESYPKENCGSCDICLGTREVTDCTREAQM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHH
LLSAIARTEGRFGATHIIDIVMGSKNKKILELGHDRLKTYGVGKEKNKKFWRHLIDELLA
HHHHHHHCCCCCCHHHHEEEEECCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
QKMIAKAEGLYPTLYLLEQSVPVLKGEARLEMVRVIEKKTPKPSRTMEHGDYDHELFEQL
HHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
RTLRKQLADEQDIPPYIVFSDRSLRDMAALLPKDDETMLEVSGVGEVKLERYGRIFLDWI
HHHHHHHCCCCCCCCEEEECCCCHHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHH
RRYCQRQPEQSEATQSS
HHHHHCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3027506; 1379743; 9278503; 2164680 [H]