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The map label for this gene is glyQS [H]

Identifier: 194332877

GI number: 194332877

Start: 27054

End: 28520

Strand: Reverse

Name: glyQS [H]

Synonym: Paes_0024

Alternate gene names: 194332877

Gene position: 28520-27054 (Counterclockwise)

Preceding gene: 194332898

Following gene: 194332876

Centisome position: 1.13

GC content: 52.22

Gene sequence:

>1467_bases
ATGAGCAATTCGGATACACGGGTACAGGGCAAGAAGCTCTCGCCTGAGAAAGTGATGAATAAACTGGTCTCGCTGGCTAA
ACGCCGCGGCTTTATTTTCCCCTCTTCGGAGATCTACGGAGGGCTCTCCTCCTGCTTCGATTACGGGCCGCTGGGCAGCG
AGATGAAAAAGAATATCAAAGACCTCTGGTGGACGTCGATGACAAGAAAACACCAGAATATTGTTGGCATTGACGCCTCG
ATCATGATGAACCCGACAGTCTGGGAAGCGTCAGGGCATGTGTCGAGCTTCAACGACCCGATGATCGACGACAAAACAAC
CAAACGTCGCTACCGGGCGGATCACCTGATAGAAAACCACATCGAAAAACTTCGCCGTGACGGAAAAACGGACGAAGCCC
AGAGAATAAGCTCCAGCTACGAACAGGCAGCAGATGCCGAAGATTCGAACAAGGCGTTCTACGACATCATCATCGCCGAG
GAGATCAAAGCCCCTGATACAGGATCGTCTGACTGGACCGAAGTCAGACAGTTTAACCTGATGTTCAAGTGCAACATGGG
CGCGCTTGCCGACTCAGCGGGCAGCGTCTACCTCAGGCCGGAGACAGCCCAGGGGATTTTTGTGAACTTCCACAACGTGC
GCGAATCAAACCGCATGAAGGTACCGTTCGGCATTGCCCAGATAGGCAAGGCGTTCCGCAACGAGATCGTGAAAGGAAAC
TTCATCTTCCGCATGGTGGAATTCGAGCAGATGGAAATGCAGTATTTCGTCAAACCGGGCACGCAGAAAGAGACCTTCGA
GGCCTGGAGAGAAGAGCGCTTCAACTGGTATAAAGAACGCCTCGGCCTTACTCCAGGCAAACTGCACTGGTATAAGCACG
ACAAACTCGCCCACTATGCCGATCTTGCCTACGATATCAAATTCGAGTTTCCTTTCGGCATCGAAGAGATCGAGGGAATT
CACTCCCGAACCGATTTTGACCTGAAACAGCACCAGGAGTTTTCGGGCAAAAATATGGAGTATATCGACCAGGCGACAAA
CGAGCGATACATTCCCTATGTGGTTGAAACCTCAGCCGGTGCCGACAGGCTCTTCCTCGCATTGCTCTGCGACGCCTATA
CCGAGGATGTCATCGACGGCGAAGAGCGGGTCATGATGAAGTTTTCGCCGACAATCGCCCCGGTCAAAGCAGCGGTGCTG
CCACTGATGAAAAAAGGCGAAATGGGCGAAAAAGCTTCGAAATTCCGTAACGACCTTGCCGAACAGTTTCTTGTCCAGTA
CGATGATGCCGGATCGATCGGCAAACGATACCGCCGGCAGGATGAAATCGGCACGCCATTCTGCTTTACGGTTGACCATC
AAACGCTTGAAGATGACACCGTCACGGTCCGCTACCGCGACACGGCAGAACAGCAGAGAATGGAGATGTCGAAGGTTCCG
GAATTTCTCGCTGCAGAAATTGTTTAA

Upstream 100 bases:

>100_bases
ATCAGGGAGAACCGATTTTCAACCTTGGATTGTTATATTGAGTGTTTTATCATACTGGACTGACAATCCGCTGGACTTTA
CCACAACCTTTTGAGCAACC

Downstream 100 bases:

>100_bases
GTAACAACCCGGTCACGGCCATTGCAGAGCCACCGGATAAACCTGAAACGTTCCGTTATATCATGCGTTACGATGTCGCT
GTCATAGGAGGAGGGCCATC

Product: glycyl-tRNA synthetase

Products: NA

Alternate protein names: Glycine--tRNA ligase; GlyRS [H]

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MSNSDTRVQGKKLSPEKVMNKLVSLAKRRGFIFPSSEIYGGLSSCFDYGPLGSEMKKNIKDLWWTSMTRKHQNIVGIDAS
IMMNPTVWEASGHVSSFNDPMIDDKTTKRRYRADHLIENHIEKLRRDGKTDEAQRISSSYEQAADAEDSNKAFYDIIIAE
EIKAPDTGSSDWTEVRQFNLMFKCNMGALADSAGSVYLRPETAQGIFVNFHNVRESNRMKVPFGIAQIGKAFRNEIVKGN
FIFRMVEFEQMEMQYFVKPGTQKETFEAWREERFNWYKERLGLTPGKLHWYKHDKLAHYADLAYDIKFEFPFGIEEIEGI
HSRTDFDLKQHQEFSGKNMEYIDQATNERYIPYVVETSAGADRLFLALLCDAYTEDVIDGEERVMMKFSPTIAPVKAAVL
PLMKKGEMGEKASKFRNDLAEQFLVQYDDAGSIGKRYRRQDEIGTPFCFTVDHQTLEDDTVTVRYRDTAEQQRMEMSKVP
EFLAAEIV

Sequences:

>Translated_488_residues
MSNSDTRVQGKKLSPEKVMNKLVSLAKRRGFIFPSSEIYGGLSSCFDYGPLGSEMKKNIKDLWWTSMTRKHQNIVGIDAS
IMMNPTVWEASGHVSSFNDPMIDDKTTKRRYRADHLIENHIEKLRRDGKTDEAQRISSSYEQAADAEDSNKAFYDIIIAE
EIKAPDTGSSDWTEVRQFNLMFKCNMGALADSAGSVYLRPETAQGIFVNFHNVRESNRMKVPFGIAQIGKAFRNEIVKGN
FIFRMVEFEQMEMQYFVKPGTQKETFEAWREERFNWYKERLGLTPGKLHWYKHDKLAHYADLAYDIKFEFPFGIEEIEGI
HSRTDFDLKQHQEFSGKNMEYIDQATNERYIPYVVETSAGADRLFLALLCDAYTEDVIDGEERVMMKFSPTIAPVKAAVL
PLMKKGEMGEKASKFRNDLAEQFLVQYDDAGSIGKRYRRQDEIGTPFCFTVDHQTLEDDTVTVRYRDTAEQQRMEMSKVP
EFLAAEIV
>Mature_487_residues
SNSDTRVQGKKLSPEKVMNKLVSLAKRRGFIFPSSEIYGGLSSCFDYGPLGSEMKKNIKDLWWTSMTRKHQNIVGIDASI
MMNPTVWEASGHVSSFNDPMIDDKTTKRRYRADHLIENHIEKLRRDGKTDEAQRISSSYEQAADAEDSNKAFYDIIIAEE
IKAPDTGSSDWTEVRQFNLMFKCNMGALADSAGSVYLRPETAQGIFVNFHNVRESNRMKVPFGIAQIGKAFRNEIVKGNF
IFRMVEFEQMEMQYFVKPGTQKETFEAWREERFNWYKERLGLTPGKLHWYKHDKLAHYADLAYDIKFEFPFGIEEIEGIH
SRTDFDLKQHQEFSGKNMEYIDQATNERYIPYVVETSAGADRLFLALLCDAYTEDVIDGEERVMMKFSPTIAPVKAAVLP
LMKKGEMGEKASKFRNDLAEQFLVQYDDAGSIGKRYRRQDEIGTPFCFTVDHQTLEDDTVTVRYRDTAEQQRMEMSKVPE
FLAAEIV

Specific function: Catalyzes the attachment of glycine to tRNA(Gly) [H]

COG id: COG0423

COG function: function code J; Glycyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI116805340, Length=354, Percent_Identity=31.638418079096, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI70887790, Length=308, Percent_Identity=23.3766233766234, Blast_Score=82, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI32564541, Length=403, Percent_Identity=32.5062034739454, Blast_Score=175, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI17554996, Length=403, Percent_Identity=32.5062034739454, Blast_Score=174, Evalue=7e-44,
Organism=Saccharomyces cerevisiae, GI6325338, Length=370, Percent_Identity=30, Blast_Score=149, Evalue=8e-37,
Organism=Saccharomyces cerevisiae, GI6319597, Length=394, Percent_Identity=28.1725888324873, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI21357965, Length=361, Percent_Identity=33.5180055401662, Blast_Score=172, Evalue=6e-43,
Organism=Drosophila melanogaster, GI24664462, Length=361, Percent_Identity=33.5180055401662, Blast_Score=171, Evalue=8e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR022961
- InterPro:   IPR002315 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.14 [H]

Molecular weight: Translated: 56299; Mature: 56168

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSDTRVQGKKLSPEKVMNKLVSLAKRRGFIFPSSEIYGGLSSCFDYGPLGSEMKKNIK
CCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHCCCCCCHHHHHHHH
DLWWTSMTRKHQNIVGIDASIMMNPTVWEASGHVSSFNDPMIDDKTTKRRYRADHLIENH
HHHHHHHHHHCCCEEECCCEEEECCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
IEKLRRDGKTDEAQRISSSYEQAADAEDSNKAFYDIIIAEEIKAPDTGSSDWTEVRQFNL
HHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEEHHCCCCCCCCCHHHHHHHEEE
MFKCNMGALADSAGSVYLRPETAQGIFVNFHNVRESNRMKVPFGIAQIGKAFRNEIVKGN
EEEECCCCCCCCCCEEEECCCCCCEEEEEEECCCCCCCEECCCCHHHHHHHHHHHHCCCC
FIFRMVEFEQMEMQYFVKPGTQKETFEAWREERFNWYKERLGLTPGKLHWYKHDKLAHYA
EEEEEHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHH
DLAYDIKFEFPFGIEEIEGIHSRTDFDLKQHQEFSGKNMEYIDQATNERYIPYVVETSAG
CEEEEEEEECCCCHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHCCCCCCCCEEEECCCC
ADRLFLALLCDAYTEDVIDGEERVMMKFSPTIAPVKAAVLPLMKKGEMGEKASKFRNDLA
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
EQFLVQYDDAGSIGKRYRRQDEIGTPFCFTVDHQTLEDDTVTVRYRDTAEQQRMEMSKVP
HHHHHCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHH
EFLAAEIV
HHHHHHCC
>Mature Secondary Structure 
SNSDTRVQGKKLSPEKVMNKLVSLAKRRGFIFPSSEIYGGLSSCFDYGPLGSEMKKNIK
CCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHHHCCCCCCHHHHHHHH
DLWWTSMTRKHQNIVGIDASIMMNPTVWEASGHVSSFNDPMIDDKTTKRRYRADHLIENH
HHHHHHHHHHCCCEEECCCEEEECCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
IEKLRRDGKTDEAQRISSSYEQAADAEDSNKAFYDIIIAEEIKAPDTGSSDWTEVRQFNL
HHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEEEHHCCCCCCCCCHHHHHHHEEE
MFKCNMGALADSAGSVYLRPETAQGIFVNFHNVRESNRMKVPFGIAQIGKAFRNEIVKGN
EEEECCCCCCCCCCEEEECCCCCCEEEEEEECCCCCCCEECCCCHHHHHHHHHHHHCCCC
FIFRMVEFEQMEMQYFVKPGTQKETFEAWREERFNWYKERLGLTPGKLHWYKHDKLAHYA
EEEEEHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHH
DLAYDIKFEFPFGIEEIEGIHSRTDFDLKQHQEFSGKNMEYIDQATNERYIPYVVETSAG
CEEEEEEEECCCCHHHHHHHHCCCCCCHHHHHHCCCCCHHHHHHCCCCCCCCEEEECCCC
ADRLFLALLCDAYTEDVIDGEERVMMKFSPTIAPVKAAVLPLMKKGEMGEKASKFRNDLA
HHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHH
EQFLVQYDDAGSIGKRYRRQDEIGTPFCFTVDHQTLEDDTVTVRYRDTAEQQRMEMSKVP
HHHHHCCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEEEECCCHHHHHHHHHHHH
EFLAAEIV
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]