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The map label for this gene is thrC [H]

Identifier: 193213550

GI number: 193213550

Start: 2111156

End: 2112472

Strand: Direct

Name: thrC [H]

Synonym: Cpar_1911

Alternate gene names: 193213550

Gene position: 2111156-2112472 (Clockwise)

Preceding gene: 193213549

Following gene: 193213551

Centisome position: 92.22

GC content: 60.21

Gene sequence:

>1317_bases
ATGATTTTCTACAGCACCACGAAAGCTTCCGCTCCCGTCACGATGAAAAAAGCTACCCTCGAAGGCCTCGCGCCCGATGG
GGGGTTGTACGTGCCATCCGAAATGCCGCGCTTCTCCGCCGAGGAGATTTCGCTGCTGGAGAGCGGCTCGTTCACCAATA
TCGCCTTTGCCATCGCCAAGAAGTTCGTAGGTGATGAAATTCCGCTCGACCGCCTCTCGGCGCTGATCGACGACTGCTTC
ACCTTCGAAACGCCTCTGCACGAACTCGATGCCGATACCTTTGTCGAAGAACTGTTCCACGGCCCGACGCTCGCGTTCAA
GGATTATGGCGCACGCTTCCTGGCAAGGATGACCGGCTTTTACGCCGCCGAAGAGAGCCGGATGATCACCGTGCTGGTGG
CCACCTCCGGCGACACCGGCAGCGCGGTAGCTTACGGCTTCCACGGCATTCCCAACACCCGGGTGGTGCTGCTCTACCCG
TCGGGCAAGGTGAGCCATTTGCAGGAGCAGCAGCTCACCACGGCGGGCGACAACGTCCATGCTCTCGAAGTCAAGGGCGA
TTTCGATGACTGCCAGCGCCTGGTCAAGCAGGCCTTCGTCGATCAGTCGCTTCGGCAGAAGCTGACGCTGACCTCGGCCA
ACTCCATCAACATCTCGCGCCTCATTCCGCAGTCGTTCTACTACGCCTGGGCTGCCCTGCAACTCCGCCAGCACCAATCG
AATGCGCTGCCGACCTTCTCGGTGCCGAGCGGCAACTACGGCAACCTGACCGCCGGCGTGATGGCGAAAATGATGGGCTT
CCCGATCGGCGGATTCATCGCGGCCTCGAACGCCAACGACAGCGTCACACGCTATCTCGACGAGGGACGCTTCGAACCGC
GGCCGACCATCAAGACCCTGACCACGGCGATGGACGTCGGCAACCCGAGCAACTTCGCCCGCCTGCTGCACTTCTACGAA
GGCGACTTCCGCAAAATGGGTGTTGACATTGCAGGCATCGCAGTCTCGGACGCTGAAACCGTTGAAACGATCCGTGCTGT
ACATGATCGATACGGCTACATCATGGATCCCCATACCGCCGTCGGATATCGGGCGCTCGAACACTTCCGCGATACCCGCT
CAGGTGCCGGGAAACCGGCGGTCGTGCTCTCCACGGCGCATCCGGTCAAGTTCGACGAAGCGATCAGGACGGCCACCGGC
AAGGAGGTGCCGATCCCGGAATCGATGCACGACATCATGAACAAGCCGAAACAGGCTACGCTGATCGGTAACAGATACGA
AGATCTTGCCGGATTCCTTGGCAATCTCGACCGGTAA

Upstream 100 bases:

>100_bases
AAACTCTCGAAAGCCGAGCTGGATTCCGACATGTGGGTCTCGCCCGTGTGCAGCCAGGGCGCACGCGTCATCAGCTCAAC
TCTTTGAAACGCATCACGAT

Downstream 100 bases:

>100_bases
GCAACCAGACCCCGACAGAACCCATGAATCTCCAGACGATTCTCTTTTTCCTGGTGATCATCCCGGTCATGTTCTTCGGG
ATGCTCTTTGCGCTCATCCT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 438; Mature: 438

Protein sequence:

>438_residues
MIFYSTTKASAPVTMKKATLEGLAPDGGLYVPSEMPRFSAEEISLLESGSFTNIAFAIAKKFVGDEIPLDRLSALIDDCF
TFETPLHELDADTFVEELFHGPTLAFKDYGARFLARMTGFYAAEESRMITVLVATSGDTGSAVAYGFHGIPNTRVVLLYP
SGKVSHLQEQQLTTAGDNVHALEVKGDFDDCQRLVKQAFVDQSLRQKLTLTSANSINISRLIPQSFYYAWAALQLRQHQS
NALPTFSVPSGNYGNLTAGVMAKMMGFPIGGFIAASNANDSVTRYLDEGRFEPRPTIKTLTTAMDVGNPSNFARLLHFYE
GDFRKMGVDIAGIAVSDAETVETIRAVHDRYGYIMDPHTAVGYRALEHFRDTRSGAGKPAVVLSTAHPVKFDEAIRTATG
KEVPIPESMHDIMNKPKQATLIGNRYEDLAGFLGNLDR

Sequences:

>Translated_438_residues
MIFYSTTKASAPVTMKKATLEGLAPDGGLYVPSEMPRFSAEEISLLESGSFTNIAFAIAKKFVGDEIPLDRLSALIDDCF
TFETPLHELDADTFVEELFHGPTLAFKDYGARFLARMTGFYAAEESRMITVLVATSGDTGSAVAYGFHGIPNTRVVLLYP
SGKVSHLQEQQLTTAGDNVHALEVKGDFDDCQRLVKQAFVDQSLRQKLTLTSANSINISRLIPQSFYYAWAALQLRQHQS
NALPTFSVPSGNYGNLTAGVMAKMMGFPIGGFIAASNANDSVTRYLDEGRFEPRPTIKTLTTAMDVGNPSNFARLLHFYE
GDFRKMGVDIAGIAVSDAETVETIRAVHDRYGYIMDPHTAVGYRALEHFRDTRSGAGKPAVVLSTAHPVKFDEAIRTATG
KEVPIPESMHDIMNKPKQATLIGNRYEDLAGFLGNLDR
>Mature_438_residues
MIFYSTTKASAPVTMKKATLEGLAPDGGLYVPSEMPRFSAEEISLLESGSFTNIAFAIAKKFVGDEIPLDRLSALIDDCF
TFETPLHELDADTFVEELFHGPTLAFKDYGARFLARMTGFYAAEESRMITVLVATSGDTGSAVAYGFHGIPNTRVVLLYP
SGKVSHLQEQQLTTAGDNVHALEVKGDFDDCQRLVKQAFVDQSLRQKLTLTSANSINISRLIPQSFYYAWAALQLRQHQS
NALPTFSVPSGNYGNLTAGVMAKMMGFPIGGFIAASNANDSVTRYLDEGRFEPRPTIKTLTTAMDVGNPSNFARLLHFYE
GDFRKMGVDIAGIAVSDAETVETIRAVHDRYGYIMDPHTAVGYRALEHFRDTRSGAGKPAVVLSTAHPVKFDEAIRTATG
KEVPIPESMHDIMNKPKQATLIGNRYEDLAGFLGNLDR

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=434, Percent_Identity=33.1797235023041, Blast_Score=199, Evalue=6e-51,
Organism=Homo sapiens, GI149193323, Length=458, Percent_Identity=30.3493449781659, Blast_Score=193, Evalue=2e-49,
Organism=Escherichia coli, GI1786185, Length=416, Percent_Identity=42.5480769230769, Blast_Score=325, Evalue=5e-90,
Organism=Saccharomyces cerevisiae, GI6319901, Length=457, Percent_Identity=35.6673960612691, Blast_Score=246, Evalue=7e-66,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 47978; Mature: 47978

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFYSTTKASAPVTMKKATLEGLAPDGGLYVPSEMPRFSAEEISLLESGSFTNIAFAIAK
CEEEECCCCCCCEEEHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHCCCCCHHHHHHHHH
KFVGDEIPLDRLSALIDDCFTFETPLHELDADTFVEELFHGPTLAFKDYGARFLARMTGF
HHCCCCCCHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHH
YAAEESRMITVLVATSGDTGSAVAYGFHGIPNTRVVLLYPSGKVSHLQEQQLTTAGDNVH
HCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEE
ALEVKGDFDDCQRLVKQAFVDQSLRQKLTLTSANSINISRLIPQSFYYAWAALQLRQHQS
EEEECCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHC
NALPTFSVPSGNYGNLTAGVMAKMMGFPIGGFIAASNANDSVTRYLDEGRFEPRPTIKTL
CCCCEEECCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHCCCCCCCCHHHHH
TTAMDVGNPSNFARLLHFYEGDFRKMGVDIAGIAVSDAETVETIRAVHDRYGYIMDPHTA
HHHHCCCCHHHHHHHHHHHCCCHHHCCCEEEEEEECCHHHHHHHHHHHHHCCCEECCCHH
VGYRALEHFRDTRSGAGKPAVVLSTAHPVKFDEAIRTATGKEVPIPESMHDIMNKPKQAT
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCHHHHHHHCCCCCEE
LIGNRYEDLAGFLGNLDR
EECCHHHHHHHHHCCCCC
>Mature Secondary Structure
MIFYSTTKASAPVTMKKATLEGLAPDGGLYVPSEMPRFSAEEISLLESGSFTNIAFAIAK
CEEEECCCCCCCEEEHHHHHHCCCCCCCEECCCCCCCCCHHHHHHHCCCCCHHHHHHHHH
KFVGDEIPLDRLSALIDDCFTFETPLHELDADTFVEELFHGPTLAFKDYGARFLARMTGF
HHCCCCCCHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHH
YAAEESRMITVLVATSGDTGSAVAYGFHGIPNTRVVLLYPSGKVSHLQEQQLTTAGDNVH
HCCCCCCEEEEEEEECCCCCCEEEEEECCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEE
ALEVKGDFDDCQRLVKQAFVDQSLRQKLTLTSANSINISRLIPQSFYYAWAALQLRQHQS
EEEECCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHC
NALPTFSVPSGNYGNLTAGVMAKMMGFPIGGFIAASNANDSVTRYLDEGRFEPRPTIKTL
CCCCEEECCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHCCCCCCCCHHHHH
TTAMDVGNPSNFARLLHFYEGDFRKMGVDIAGIAVSDAETVETIRAVHDRYGYIMDPHTA
HHHHCCCCHHHHHHHHHHHCCCHHHCCCEEEEEEECCHHHHHHHHHHHHHCCCEECCCHH
VGYRALEHFRDTRSGAGKPAVVLSTAHPVKFDEAIRTATGKEVPIPESMHDIMNKPKQAT
HHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCCHHHHHHHCCCCCEE
LIGNRYEDLAGFLGNLDR
EECCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8423151 [H]