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The map label for this gene is thrB [H]

Identifier: 193213549

GI number: 193213549

Start: 2110168

End: 2111142

Strand: Direct

Name: thrB [H]

Synonym: Cpar_1910

Alternate gene names: 193213549

Gene position: 2110168-2111142 (Clockwise)

Preceding gene: 193213543

Following gene: 193213550

Centisome position: 92.18

GC content: 59.59

Gene sequence:

>975_bases
ATGAAAACCGTCACTGGATTTGCGTCGGCAACAGTAGGAAATGTTGCCTGCGGTTTTGACGTCCTCGGTTTTGCCATTAC
CGAACCCGGTGATGAAGTTATCCTGACGCTTCATGACGAACCCCGGAGCGGCAGCCCTGTCACGATCACCTCGATTTCGG
GGGACGGAGGCGCCTTGCCGCTCGACCCGAAAAAGAACACGTCGAGCTTCGTCGTGCTCAAGTTTCTCGAATATATCCGT
TCGACCAAGGGCATCGACTTCAAGGGGCATATTGACCTGGAACTGAAAAAGCATCTGCCGCTCTCAAGCGGCATGGGCAG
CAGTGCGGCCAGTGCCGCAGCGGCGCTCGTTGCGGCCAACGAACTGCTCGGTTCGCCCTGTTCCAAGATGGAGCTGGTAC
ATTTCGCCATCGAAGGCGAGCGCGTCGCGTGCGGCTCGGCCCATGCCGATAATGCCGCGCCGGCCATGCTGGGCAATTTT
ATCCTGATCCGCAGCTATCATCCGCTCGACCTGATCACCATCAGGCCACCCAAAGACCTGTTCTGCACGCTCGTACATCC
GCACACCGAAGTAAAAACCTCGTTCGCCCGCTCCGTGCTGCCAAAATCGATTCCGCTTTCCATGGCTATTCAGCAGTGGG
GCAATGTTGGCGCACTGGTCTCCGGACTGCTGATGGAGGATTACGACCTGATCGGCCGCGCGCTGGTGGATGTGGTCGCC
GAACCGAAGCGCGCACCGCTCATTCCCGGCTTCAACGAGGTCAAACAGGCCGCGCTCGACGCCGGAGCTTTGGGATGCAG
CATCGCCGGATCCGGCCCGTCAGTCTTCGCATTCTCCTCATCCCGCGCGACAGCCGAAACGGTCGGCGCGGCCATGCAGG
AAACCTTCAAACTCTCGAAAGCCGAGCTGGATTCCGACATGTGGGTCTCGCCCGTGTGCAGCCAGGGCGCACGCGTCATC
AGCTCAACTCTTTGA

Upstream 100 bases:

>100_bases
AGCTTCCAGTTATTCAAATGCACAAGACAATTTGGATAAGAGACTTTTCCGGAGCAACCCGTCGCCGTACCGTTTCAGCA
ATCATGCCCCCTATCACGCT

Downstream 100 bases:

>100_bases
AACGCATCACGATATGATTTTCTACAGCACCACGAAAGCTTCCGCTCCCGTCACGATGAAAAAAGCTACCCTCGAAGGCC
TCGCGCCCGATGGGGGGTTG

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MKTVTGFASATVGNVACGFDVLGFAITEPGDEVILTLHDEPRSGSPVTITSISGDGGALPLDPKKNTSSFVVLKFLEYIR
STKGIDFKGHIDLELKKHLPLSSGMGSSAASAAAALVAANELLGSPCSKMELVHFAIEGERVACGSAHADNAAPAMLGNF
ILIRSYHPLDLITIRPPKDLFCTLVHPHTEVKTSFARSVLPKSIPLSMAIQQWGNVGALVSGLLMEDYDLIGRALVDVVA
EPKRAPLIPGFNEVKQAALDAGALGCSIAGSGPSVFAFSSSRATAETVGAAMQETFKLSKAELDSDMWVSPVCSQGARVI
SSTL

Sequences:

>Translated_324_residues
MKTVTGFASATVGNVACGFDVLGFAITEPGDEVILTLHDEPRSGSPVTITSISGDGGALPLDPKKNTSSFVVLKFLEYIR
STKGIDFKGHIDLELKKHLPLSSGMGSSAASAAAALVAANELLGSPCSKMELVHFAIEGERVACGSAHADNAAPAMLGNF
ILIRSYHPLDLITIRPPKDLFCTLVHPHTEVKTSFARSVLPKSIPLSMAIQQWGNVGALVSGLLMEDYDLIGRALVDVVA
EPKRAPLIPGFNEVKQAALDAGALGCSIAGSGPSVFAFSSSRATAETVGAAMQETFKLSKAELDSDMWVSPVCSQGARVI
SSTL
>Mature_324_residues
MKTVTGFASATVGNVACGFDVLGFAITEPGDEVILTLHDEPRSGSPVTITSISGDGGALPLDPKKNTSSFVVLKFLEYIR
STKGIDFKGHIDLELKKHLPLSSGMGSSAASAAAALVAANELLGSPCSKMELVHFAIEGERVACGSAHADNAAPAMLGNF
ILIRSYHPLDLITIRPPKDLFCTLVHPHTEVKTSFARSVLPKSIPLSMAIQQWGNVGALVSGLLMEDYDLIGRALVDVVA
EPKRAPLIPGFNEVKQAALDAGALGCSIAGSGPSVFAFSSSRATAETVGAAMQETFKLSKAELDSDMWVSPVCSQGARVI
SSTL

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=321, Percent_Identity=29.2834890965732, Blast_Score=132, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 33851; Mature: 33851

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTVTGFASATVGNVACGFDVLGFAITEPGDEVILTLHDEPRSGSPVTITSISGDGGALP
CCCCCCCHHHHHCCHHHCHHHHEEEEECCCCEEEEEEECCCCCCCCEEEEEECCCCCCCC
LDPKKNTSSFVVLKFLEYIRSTKGIDFKGHIDLELKKHLPLSSGMGSSAASAAAALVAAN
CCCCCCCCHHHHHHHHHHHHHCCCCCEECEEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
ELLGSPCSKMELVHFAIEGERVACGSAHADNAAPAMLGNFILIRSYHPLDLITIRPPKDL
HHHCCCCCCEEEEEEEECCCEEEECCCCCCCCCHHHHCCEEEEEECCCEEEEEECCCHHH
FCTLVHPHTEVKTSFARSVLPKSIPLSMAIQQWGNVGALVSGLLMEDYDLIGRALVDVVA
EEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHC
EPKRAPLIPGFNEVKQAALDAGALGCSIAGSGPSVFAFSSSRATAETVGAAMQETFKLSK
CCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHH
AELDSDMWVSPVCSQGARVISSTL
HHCCCCCCCCHHHHCCHHHHHHCC
>Mature Secondary Structure
MKTVTGFASATVGNVACGFDVLGFAITEPGDEVILTLHDEPRSGSPVTITSISGDGGALP
CCCCCCCHHHHHCCHHHCHHHHEEEEECCCCEEEEEEECCCCCCCCEEEEEECCCCCCCC
LDPKKNTSSFVVLKFLEYIRSTKGIDFKGHIDLELKKHLPLSSGMGSSAASAAAALVAAN
CCCCCCCCHHHHHHHHHHHHHCCCCCEECEEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
ELLGSPCSKMELVHFAIEGERVACGSAHADNAAPAMLGNFILIRSYHPLDLITIRPPKDL
HHHCCCCCCEEEEEEEECCCEEEECCCCCCCCCHHHHCCEEEEEECCCEEEEEECCCHHH
FCTLVHPHTEVKTSFARSVLPKSIPLSMAIQQWGNVGALVSGLLMEDYDLIGRALVDVVA
EEEEECCCHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHC
EPKRAPLIPGFNEVKQAALDAGALGCSIAGSGPSVFAFSSSRATAETVGAAMQETFKLSK
CCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHH
AELDSDMWVSPVCSQGARVISSTL
HHCCCCCCCCHHHHCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12093901 [H]