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The map label for this gene is drrB [H]

Identifier: 193213499

GI number: 193213499

Start: 2043800

End: 2044645

Strand: Direct

Name: drrB [H]

Synonym: Cpar_1860

Alternate gene names: 193213499

Gene position: 2043800-2044645 (Clockwise)

Preceding gene: 193213498

Following gene: 193213505

Centisome position: 89.28

GC content: 62.65

Gene sequence:

>846_bases
GTGACAGCAAGCCAAACTTCCGCGACATCAACCGCACTCGCCGGACGGCCAAACGGCTGGGCTGAAAAGTTCGACCCCGC
CGGGTTCCTGCGCGACACGGCGGCCATCGTCGCCACCGAGCTGGCCAAGCTGCGCCGCGACCCGTCGGAAATCCTCAGCC
GCTCGATCCAGCCCGCGCTCTGGCTGCTGGTCTTCGGCCAGGTCTTCGGGCGGATGCGCGCCATCCCCACCGGCAAGCTC
GACTACTTCAGCTTCCTCGCGCCGGGCATCCTCGCGCAGAGCGTGCTCTTCATCGCGATCTTTTACGGCATCAACGTCAT
CTGGGAAAAAGACCTCGGCATTTTGCAGAAGCTGCTCGCCAGCCCCGCCCCGCGCAGCGCGCTCGTCTTCGGCAAGGCGG
TCTCGGCGGGAATGCGCGCCATAGCGCAGGCAGCCATCGTCTATCTGATGGCGCTCGTCGCAGGCGTTCATCTGAACTGG
TCGCCGCTCGCGCTCGGCGGCGTGCTCGTCGCCATCGTGCTCGGCGCGGCGCTCTTTTCGACCTTCTCGCTCATGATCGC
CTGCCTCGTCCGGTCGCGCGAACGCTTCATGGGCATCGGTCAGGTCATGACCATGCCGCTCTTCTTCGCCAGTAACGCCA
TCTACCCGATCTCCATCATGCCCACCTGGCTCAAAATCGTCGCCCATATCAACCCACTCTCCTACCAGGTTGACCTCCTC
CGCGCGTTGATGGTCGTCGGCGGCACGAGCACTTTCGGCATCGGGATGGATTTTCTGATGTTGATTGGAATGCTTGTTGC
GCTGATCGTCGTGACATCGAAATTGTATCCGACGATTGTGCAGTAA

Upstream 100 bases:

>100_bases
GAGGGAGTCATCGCCGCCGAAGGGTCGGCGAAAGAGCTGAAGCACCGCGCCGGAACAGACTCGATGAACCAGGTTTTCAT
TCACTTTGCAGGAGAGTTCA

Downstream 100 bases:

>100_bases
CACCCCCTCACTCCCCCTGCTTTTCAGTGAGATACTTCCAGTACTTCGCAGGCATGTTGGATTGCTGAAGGCGGGGGTTT
TTGCGTTCGGGAATGGCGAT

Product: ABC-2 type transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 281; Mature: 280

Protein sequence:

>281_residues
MTASQTSATSTALAGRPNGWAEKFDPAGFLRDTAAIVATELAKLRRDPSEILSRSIQPALWLLVFGQVFGRMRAIPTGKL
DYFSFLAPGILAQSVLFIAIFYGINVIWEKDLGILQKLLASPAPRSALVFGKAVSAGMRAIAQAAIVYLMALVAGVHLNW
SPLALGGVLVAIVLGAALFSTFSLMIACLVRSRERFMGIGQVMTMPLFFASNAIYPISIMPTWLKIVAHINPLSYQVDLL
RALMVVGGTSTFGIGMDFLMLIGMLVALIVVTSKLYPTIVQ

Sequences:

>Translated_281_residues
MTASQTSATSTALAGRPNGWAEKFDPAGFLRDTAAIVATELAKLRRDPSEILSRSIQPALWLLVFGQVFGRMRAIPTGKL
DYFSFLAPGILAQSVLFIAIFYGINVIWEKDLGILQKLLASPAPRSALVFGKAVSAGMRAIAQAAIVYLMALVAGVHLNW
SPLALGGVLVAIVLGAALFSTFSLMIACLVRSRERFMGIGQVMTMPLFFASNAIYPISIMPTWLKIVAHINPLSYQVDLL
RALMVVGGTSTFGIGMDFLMLIGMLVALIVVTSKLYPTIVQ
>Mature_280_residues
TASQTSATSTALAGRPNGWAEKFDPAGFLRDTAAIVATELAKLRRDPSEILSRSIQPALWLLVFGQVFGRMRAIPTGKLD
YFSFLAPGILAQSVLFIAIFYGINVIWEKDLGILQKLLASPAPRSALVFGKAVSAGMRAIAQAAIVYLMALVAGVHLNWS
PLALGGVLVAIVLGAALFSTFSLMIACLVRSRERFMGIGQVMTMPLFFASNAIYPISIMPTWLKIVAHINPLSYQVDLLR
ALMVVGGTSTFGIGMDFLMLIGMLVALIVVTSKLYPTIVQ

Specific function: Part of the ABC transporter complex drrAB involved in daunorubicin and doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000412
- InterPro:   IPR013525 [H]

Pfam domain/function: PF01061 ABC2_membrane [H]

EC number: NA

Molecular weight: Translated: 30224; Mature: 30092

Theoretical pI: Translated: 10.49; Mature: 10.49

Prosite motif: PS51012 ABC_TM2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTASQTSATSTALAGRPNGWAEKFDPAGFLRDTAAIVATELAKLRRDPSEILSRSIQPAL
CCCCCCCCHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHH
WLLVFGQVFGRMRAIPTGKLDYFSFLAPGILAQSVLFIAIFYGINVIWEKDLGILQKLLA
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SPAPRSALVFGKAVSAGMRAIAQAAIVYLMALVAGVHLNWSPLALGGVLVAIVLGAALFS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
TFSLMIACLVRSRERFMGIGQVMTMPLFFASNAIYPISIMPTWLKIVAHINPLSYQVDLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHCCCHHHHHHHH
RALMVVGGTSTFGIGMDFLMLIGMLVALIVVTSKLYPTIVQ
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TASQTSATSTALAGRPNGWAEKFDPAGFLRDTAAIVATELAKLRRDPSEILSRSIQPAL
CCCCCCCHHHHHCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHCCHHHH
WLLVFGQVFGRMRAIPTGKLDYFSFLAPGILAQSVLFIAIFYGINVIWEKDLGILQKLLA
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SPAPRSALVFGKAVSAGMRAIAQAAIVYLMALVAGVHLNWSPLALGGVLVAIVLGAALFS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHH
TFSLMIACLVRSRERFMGIGQVMTMPLFFASNAIYPISIMPTWLKIVAHINPLSYQVDLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEHHHHHHHHHHHCCCHHHHHHHH
RALMVVGGTSTFGIGMDFLMLIGMLVALIVVTSKLYPTIVQ
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1924314 [H]