Click here to switch to the map view.

The map label for this gene is thiL [H]

Identifier: 193213474

GI number: 193213474

Start: 2017236

End: 2018306

Strand: Direct

Name: thiL [H]

Synonym: Cpar_1835

Alternate gene names: 193213474

Gene position: 2017236-2018306 (Clockwise)

Preceding gene: 193213472

Following gene: 193213475

Centisome position: 88.12

GC content: 61.06

Gene sequence:

>1071_bases
ATGGCATTCAAACCTATTTCCGAGATTGGTGAATTCGGTCTGATCGACCGGCTCGCAAAGATTACCGCCCCCTCCGCGAA
CCAGCGACCGGAACTCATCGAGGGCATCGGCGACGACTGCGCGGTATGGCAAAGCGACGAGTCGGCGGTGCAGGTGGTCA
CGACCGACATCCTGACCGAGCACGTCCACTTCGACCTGTTGACCACACCCTTGCACCACCTCGGCAGCAAGGCGATCAGC
GTCAACGTCTCGGATATCTGCGCAATGAACGCCATGCCGGACTACGCAGTGATCTCGATCGCCGTGCCGCCGAAGATGCC
GGTGGAGATGGTCGAGGAGCTGTACAAGGGAATGAACCACGCCGCCGAAGTGTATGGACTCGCCATCGTGGGCGGCGACA
CCTCGTCTTCGGCATCGGGCCTGTTCATCTCGGTTTCGATGACCGGAACGACAACGCCGGAACTCCTTGCGCTGCGCAAA
GGCGCGTCGCCGAGCGATTTGATCTGTGTAACGGGAACGCTCGGCGGCTCGACCGCCGGACTGCACCTCTTGCAGCGCGA
AAAGGCGACCATGATCGAGCAGATGCGCAACAACGAGCCGTACAACAAGGAGGTGATGGCCGAGTTGCAGGAGTACGCCG
AAGCGATCCGCTGCCACCTGCTGCCCGAAGCGCGCATCGACATCATCGACTTTTTCAGCGAAGAGGGCATCGTGCCGACC
GCCATGATCGACATCTCCGACGGCCTGGTCTCCGACCTCGGCCACCTCTGCCGCCGCTCCAACGTCGGCGCGAAGATCGA
CGAAAGCAAGCTGCCCGTGCTGCCCGAAGCGCGAACCGTGGCCGAAGAGTTCCAGCAGGACGTCTTCGACTGGGCGCTCA
CCGGCGGCGAAGACTACCAGCTCCTCTTCACCGTGCCGAAAAAGGACTACGACCTCATCGCCGCCCACCGCGACATCACG
GTCATCGGCGAAATTACCGAGAAGGAAGCGGGCATGATGCTCACCGACATCTTCGGCATGACGATTGATATGACGGACAT
GAAACGGGGATTCGATCACTTCGCGGAGTGA

Upstream 100 bases:

>100_bases
TCAAAAAAGCCCATGGAAAAAGAGAAATTGGCTATGTTTATGGACGATTGGGCCGGAGAAATTCCGGAAAACCCGCTTGA
ATTTTAATGTAGCTAAATAT

Downstream 100 bases:

>100_bases
GGTGGACAGGATTGGCAAGCACAGATCATTTGCCATCCCGTAGGGGCAGACCTGCGTGTCTGCCCTCCCCGGAAACCCGA
CAAATCAGAAATTTCCCAAC

Product: thiamine-monophosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 356; Mature: 355

Protein sequence:

>356_residues
MAFKPISEIGEFGLIDRLAKITAPSANQRPELIEGIGDDCAVWQSDESAVQVVTTDILTEHVHFDLLTTPLHHLGSKAIS
VNVSDICAMNAMPDYAVISIAVPPKMPVEMVEELYKGMNHAAEVYGLAIVGGDTSSSASGLFISVSMTGTTTPELLALRK
GASPSDLICVTGTLGGSTAGLHLLQREKATMIEQMRNNEPYNKEVMAELQEYAEAIRCHLLPEARIDIIDFFSEEGIVPT
AMIDISDGLVSDLGHLCRRSNVGAKIDESKLPVLPEARTVAEEFQQDVFDWALTGGEDYQLLFTVPKKDYDLIAAHRDIT
VIGEITEKEAGMMLTDIFGMTIDMTDMKRGFDHFAE

Sequences:

>Translated_356_residues
MAFKPISEIGEFGLIDRLAKITAPSANQRPELIEGIGDDCAVWQSDESAVQVVTTDILTEHVHFDLLTTPLHHLGSKAIS
VNVSDICAMNAMPDYAVISIAVPPKMPVEMVEELYKGMNHAAEVYGLAIVGGDTSSSASGLFISVSMTGTTTPELLALRK
GASPSDLICVTGTLGGSTAGLHLLQREKATMIEQMRNNEPYNKEVMAELQEYAEAIRCHLLPEARIDIIDFFSEEGIVPT
AMIDISDGLVSDLGHLCRRSNVGAKIDESKLPVLPEARTVAEEFQQDVFDWALTGGEDYQLLFTVPKKDYDLIAAHRDIT
VIGEITEKEAGMMLTDIFGMTIDMTDMKRGFDHFAE
>Mature_355_residues
AFKPISEIGEFGLIDRLAKITAPSANQRPELIEGIGDDCAVWQSDESAVQVVTTDILTEHVHFDLLTTPLHHLGSKAISV
NVSDICAMNAMPDYAVISIAVPPKMPVEMVEELYKGMNHAAEVYGLAIVGGDTSSSASGLFISVSMTGTTTPELLALRKG
ASPSDLICVTGTLGGSTAGLHLLQREKATMIEQMRNNEPYNKEVMAELQEYAEAIRCHLLPEARIDIIDFFSEEGIVPTA
MIDISDGLVSDLGHLCRRSNVGAKIDESKLPVLPEARTVAEEFQQDVFDWALTGGEDYQLLFTVPKKDYDLIAAHRDITV
IGEITEKEAGMMLTDIFGMTIDMTDMKRGFDHFAE

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786619, Length=352, Percent_Identity=32.9545454545455, Blast_Score=142, Evalue=3e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 38822; Mature: 38691

Theoretical pI: Translated: 4.27; Mature: 4.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFKPISEIGEFGLIDRLAKITAPSANQRPELIEGIGDDCAVWQSDESAVQVVTTDILTE
CCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCEEECCCCCCEEHHHHHHHHH
HVHFDLLTTPLHHLGSKAISVNVSDICAMNAMPDYAVISIAVPPKMPVEMVEELYKGMNH
HHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHH
AAEVYGLAIVGGDTSSSASGLFISVSMTGTTTPELLALRKGASPSDLICVTGTLGGSTAG
HHHHEEEEEECCCCCCCCCEEEEEEEECCCCCHHHHHHHCCCCCCCEEEEEECCCCCHHH
LHLLQREKATMIEQMRNNEPYNKEVMAELQEYAEAIRCHLLPEARIDIIDFFSEEGIVPT
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCEE
AMIDISDGLVSDLGHLCRRSNVGAKIDESKLPVLPEARTVAEEFQQDVFDWALTGGEDYQ
EEEECCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEE
LLFTVPKKDYDLIAAHRDITVIGEITEKEAGMMLTDIFGMTIDMTDMKRGFDHFAE
EEEEECCCCCEEEEECCCEEEEEECHHCCCCEEEEHHHCCEEEHHHHHHHHHHHCC
>Mature Secondary Structure 
AFKPISEIGEFGLIDRLAKITAPSANQRPELIEGIGDDCAVWQSDESAVQVVTTDILTE
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCCCCEEECCCCCCEEHHHHHHHHH
HVHFDLLTTPLHHLGSKAISVNVSDICAMNAMPDYAVISIAVPPKMPVEMVEELYKGMNH
HHHHHHHHHHHHHCCCCEEEEEHHHHHHHCCCCCCEEEEEECCCCCCHHHHHHHHHHHHH
AAEVYGLAIVGGDTSSSASGLFISVSMTGTTTPELLALRKGASPSDLICVTGTLGGSTAG
HHHHEEEEEECCCCCCCCCEEEEEEEECCCCCHHHHHHHCCCCCCCEEEEEECCCCCHHH
LHLLQREKATMIEQMRNNEPYNKEVMAELQEYAEAIRCHLLPEARIDIIDFFSEEGIVPT
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCEE
AMIDISDGLVSDLGHLCRRSNVGAKIDESKLPVLPEARTVAEEFQQDVFDWALTGGEDYQ
EEEECCCHHHHHHHHHHHHCCCCCEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCEE
LLFTVPKKDYDLIAAHRDITVIGEITEKEAGMMLTDIFGMTIDMTDMKRGFDHFAE
EEEEECCCCCEEEEECCCEEEEEECHHCCCCEEEEHHHCCEEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9202461; 9384377; 8419296 [H]