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The map label for this gene is copA [H]

Identifier: 193213306

GI number: 193213306

Start: 1814885

End: 1817308

Strand: Direct

Name: copA [H]

Synonym: Cpar_1664

Alternate gene names: 193213306

Gene position: 1814885-1817308 (Clockwise)

Preceding gene: 193213305

Following gene: 193213307

Centisome position: 79.28

GC content: 63.66

Gene sequence:

>2424_bases
ATGTCCGTGACTGAACGGCGAAACAAAGAAAAGCTCCACTGCGACCACTGCCAGCAGGAGATGGAATACTCGGCAGCCGT
CACAGCAGTGATCGACGGGCAAACACGATACTTCTGCTGCCACGGCTGCCTCGGCGTCTATGAACTGATTCACAGCGAGT
CGCTCGACGCCTTCTATCAGCAGCGCTGCGACTGGCAACCGGGCCGCCCGGCGTTCGGCAAAGTGGATGCGCGGGAATTC
GAAGGTAACGTTCGCAACGACGGCTCGTCCAGCAAGATCGATCTGCTGCTCTCGGGCATCCGCTGCGCCTCGTGCGTCTG
GCTGGTTGAAAAGGCGCTGGCGCGGCTCGACGGCATCGTCTCGGCGAGGGTAAACTACGCAACCCACCGGGCGACTATCC
AGTGGCGTACCGGCGAGATCACCCTTGAGACGATCCTGAACACCCTCGCAGGCCTTGGCTACCTTCCACGCCCGGTCCGG
CATGGTGCGCAGGTCGAGGCGTTCACGGAGGAAAAGCGCGACCTGCTGCTGCGCTTCGGCACGGCGGGCTTCTTTTCGAT
GCAGTTGATGCTCATCATCGCCGCGCTCTACGCAGGCTTTTTTCAGGGCATCGAAACCACCTACCGCCTGACTTTCCAGA
TTATTTCCTGGGCGTTGGCCACGCCGGTGGTCTTCTACTCCGGCTGGCCATTCATCTCCAACGCCCTGCGCTCGCTACGA
AACCGATCGCTGAACATGGACGCGCTGGTGGCGCTCGGCTCGCTCTCGGCCTACTTCTACAGCGTGGCGATGATCTTCAC
CGGCGGCGAAGTGTTCTTTGACACCTCGGCGATGATTATCACCTTCATCCTGCTCGGTCGATTCCTCGAAGCCGGTTCGC
GTTTGAAGGCGGGCAGCGCTCTCGCGGCACTGGCCGACCTGCAACCATCCGAAGCGCTGCTGGTCGGAGAGGATGGGCAC
GCAGCCCCGGCACCACTCGAACAGATCAACGCAGGCGCGGTGATCGAGGTTCTACCCGGCGGACGGGTGCCGCTGGACGG
CACGGTGACGGCAGGCGAGTCGGATGTCGATGAGTCGATGCTCACCGGCGAGTCAGCGCCCGTAGCCAAAGCGCCGGGCA
GCACGGTCTATGCGGGCACGCTGGCCATCACCGGACGCCTGCTGGTGTCGGTCACGGGCAATGCGCACGAAACGCTGCTG
TCTGGCATCATCCGCACCGTCGAGGAGGCGCAGGCGCGCAAAGCCCCGATCCAGGGCGTGGCCGACCGCGTTGCTGGATG
GTTCGTGCCAGCGATCATCCTTCTTGCGGCCGGCACCTTCGCTTGGTGGCGGATTGACGGAGCGCCGACGGTAACGGCGC
TCATGACCGCCGTTTCGGTGCTGGTGATCGCCTGCCCCTGCGCGCTGGGGCTTGCAACGCCGCTGGCGATCCTCGTCGGC
ACCACGGCGGTCAGCCGCAAAGGCATCCTCGTCAAGGGTGGCGATATTTTCGAAACCGTCTCCAAAACCACCACCGTCGT
GCTCGACAAAACCGGCACCATCACGCGCGGCAAGCCGTCCGTGACCGACACTTTCGACTACGGCATTTCCAACCGTTTCA
TGCAGTGCTGCGCCTCGCTCGAAGCGTGGTCGAGCCATCCGGCCGGTCAGGCAATCACCGACGCATGGCTCGGCGAGAGG
CTGCCGCTCGACGGACTCCGGGTGATTCCCGGCATGGGAGTCTCAGGAAAAATCGAGGGCGAAACGTGGCTTGCAGGTTC
ACGCGTCCTGCTCGAAAAGAAAGGGGTGACGCTCGACGACAAATGCCTCGAAACCACCGACCGGCTCGAAGCCGAGGGGA
AGACCACGGTGCTCGTCGCCTGCAACGGCCATGTGGCAGGCCTCTTCGGCCTGATCGACGACCTGCGCGACGATGCCGAA
CGGATGATCGAGGCACTCCGGGCGCAAGGACTGGGGCTGATGATCCTCACCGGCGACAACGCTGGCGTAGCACGCTACAT
CGCCGAAAAATGCGGCATCACGCAAGTGCGCTCCGGCCTCGATCCGCTCGGCAAGGCCGAAGCGATCAGGGAGCTGAAGC
GCTCGGGCGAAACCGTGCTGATGGCCGGGGACGGCATCAACGACGCCCCGGCGCTTACTGAAGCCGACACTGGCGTCTCG
TTCGGCACGGCCACGGCGGTGGCGATCGACAGCGCCGGAGTGACCATCATGAACGACGATTTGACGCTGCTCGACACGCT
CGTCGCCCACTCTCGCCGCTGCTTCGCCATCATCCGCCAGAACCTCGCCTGGGCGTTCGGCTACAACCTGATCGCCCTGC
CGCTGGCCGTCACCGGCGTGCTGCACCCGATTGTTTCAGCGCTCCTCATGGCAACCAGTTCGCTCGTAGTGGTCAGTAAC
TCGCTCCGACTCCGAAAACTCTGA

Upstream 100 bases:

>100_bases
TGGGTCGGCAAAGGGCTGATCGTCAAGTGCATGAGTGGCCGCAAACTCTGGCAGGCGACCATCCTCTCGCCGGAACTCGG
CAATCCCGCGTTCACCTTCA

Downstream 100 bases:

>100_bases
ACCTGCAATCATGGCAAGCACCTTCTTTCTCATAGGCATCGGCTTCGTCATCGGCCTTGCCGGATGGGCTCTCTTCCTCT
GGGCAGTACGCAGCGGACAG

Product: heavy metal translocating P-type ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: NA

Number of amino acids: Translated: 807; Mature: 806

Protein sequence:

>807_residues
MSVTERRNKEKLHCDHCQQEMEYSAAVTAVIDGQTRYFCCHGCLGVYELIHSESLDAFYQQRCDWQPGRPAFGKVDAREF
EGNVRNDGSSSKIDLLLSGIRCASCVWLVEKALARLDGIVSARVNYATHRATIQWRTGEITLETILNTLAGLGYLPRPVR
HGAQVEAFTEEKRDLLLRFGTAGFFSMQLMLIIAALYAGFFQGIETTYRLTFQIISWALATPVVFYSGWPFISNALRSLR
NRSLNMDALVALGSLSAYFYSVAMIFTGGEVFFDTSAMIITFILLGRFLEAGSRLKAGSALAALADLQPSEALLVGEDGH
AAPAPLEQINAGAVIEVLPGGRVPLDGTVTAGESDVDESMLTGESAPVAKAPGSTVYAGTLAITGRLLVSVTGNAHETLL
SGIIRTVEEAQARKAPIQGVADRVAGWFVPAIILLAAGTFAWWRIDGAPTVTALMTAVSVLVIACPCALGLATPLAILVG
TTAVSRKGILVKGGDIFETVSKTTTVVLDKTGTITRGKPSVTDTFDYGISNRFMQCCASLEAWSSHPAGQAITDAWLGER
LPLDGLRVIPGMGVSGKIEGETWLAGSRVLLEKKGVTLDDKCLETTDRLEAEGKTTVLVACNGHVAGLFGLIDDLRDDAE
RMIEALRAQGLGLMILTGDNAGVARYIAEKCGITQVRSGLDPLGKAEAIRELKRSGETVLMAGDGINDAPALTEADTGVS
FGTATAVAIDSAGVTIMNDDLTLLDTLVAHSRRCFAIIRQNLAWAFGYNLIALPLAVTGVLHPIVSALLMATSSLVVVSN
SLRLRKL

Sequences:

>Translated_807_residues
MSVTERRNKEKLHCDHCQQEMEYSAAVTAVIDGQTRYFCCHGCLGVYELIHSESLDAFYQQRCDWQPGRPAFGKVDAREF
EGNVRNDGSSSKIDLLLSGIRCASCVWLVEKALARLDGIVSARVNYATHRATIQWRTGEITLETILNTLAGLGYLPRPVR
HGAQVEAFTEEKRDLLLRFGTAGFFSMQLMLIIAALYAGFFQGIETTYRLTFQIISWALATPVVFYSGWPFISNALRSLR
NRSLNMDALVALGSLSAYFYSVAMIFTGGEVFFDTSAMIITFILLGRFLEAGSRLKAGSALAALADLQPSEALLVGEDGH
AAPAPLEQINAGAVIEVLPGGRVPLDGTVTAGESDVDESMLTGESAPVAKAPGSTVYAGTLAITGRLLVSVTGNAHETLL
SGIIRTVEEAQARKAPIQGVADRVAGWFVPAIILLAAGTFAWWRIDGAPTVTALMTAVSVLVIACPCALGLATPLAILVG
TTAVSRKGILVKGGDIFETVSKTTTVVLDKTGTITRGKPSVTDTFDYGISNRFMQCCASLEAWSSHPAGQAITDAWLGER
LPLDGLRVIPGMGVSGKIEGETWLAGSRVLLEKKGVTLDDKCLETTDRLEAEGKTTVLVACNGHVAGLFGLIDDLRDDAE
RMIEALRAQGLGLMILTGDNAGVARYIAEKCGITQVRSGLDPLGKAEAIRELKRSGETVLMAGDGINDAPALTEADTGVS
FGTATAVAIDSAGVTIMNDDLTLLDTLVAHSRRCFAIIRQNLAWAFGYNLIALPLAVTGVLHPIVSALLMATSSLVVVSN
SLRLRKL
>Mature_806_residues
SVTERRNKEKLHCDHCQQEMEYSAAVTAVIDGQTRYFCCHGCLGVYELIHSESLDAFYQQRCDWQPGRPAFGKVDAREFE
GNVRNDGSSSKIDLLLSGIRCASCVWLVEKALARLDGIVSARVNYATHRATIQWRTGEITLETILNTLAGLGYLPRPVRH
GAQVEAFTEEKRDLLLRFGTAGFFSMQLMLIIAALYAGFFQGIETTYRLTFQIISWALATPVVFYSGWPFISNALRSLRN
RSLNMDALVALGSLSAYFYSVAMIFTGGEVFFDTSAMIITFILLGRFLEAGSRLKAGSALAALADLQPSEALLVGEDGHA
APAPLEQINAGAVIEVLPGGRVPLDGTVTAGESDVDESMLTGESAPVAKAPGSTVYAGTLAITGRLLVSVTGNAHETLLS
GIIRTVEEAQARKAPIQGVADRVAGWFVPAIILLAAGTFAWWRIDGAPTVTALMTAVSVLVIACPCALGLATPLAILVGT
TAVSRKGILVKGGDIFETVSKTTTVVLDKTGTITRGKPSVTDTFDYGISNRFMQCCASLEAWSSHPAGQAITDAWLGERL
PLDGLRVIPGMGVSGKIEGETWLAGSRVLLEKKGVTLDDKCLETTDRLEAEGKTTVLVACNGHVAGLFGLIDDLRDDAER
MIEALRAQGLGLMILTGDNAGVARYIAEKCGITQVRSGLDPLGKAEAIRELKRSGETVLMAGDGINDAPALTEADTGVSF
GTATAVAIDSAGVTIMNDDLTLLDTLVAHSRRCFAIIRQNLAWAFGYNLIALPLAVTGVLHPIVSALLMATSSLVVVSNS
LRLRKL

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI55743071, Length=798, Percent_Identity=33.9598997493734, Blast_Score=405, Evalue=1e-113,
Organism=Homo sapiens, GI115529486, Length=818, Percent_Identity=33.2518337408313, Blast_Score=402, Evalue=1e-112,
Organism=Homo sapiens, GI55743073, Length=577, Percent_Identity=34.1421143847487, Blast_Score=287, Evalue=3e-77,
Organism=Homo sapiens, GI22748667, Length=246, Percent_Identity=24.7967479674797, Blast_Score=70, Evalue=1e-11,
Organism=Homo sapiens, GI51944966, Length=253, Percent_Identity=24.901185770751, Blast_Score=67, Evalue=7e-11,
Organism=Escherichia coli, GI1786691, Length=739, Percent_Identity=36.9418132611637, Blast_Score=387, Evalue=1e-108,
Organism=Escherichia coli, GI1789879, Length=733, Percent_Identity=30.8321964529332, Blast_Score=255, Evalue=9e-69,
Organism=Escherichia coli, GI1786914, Length=449, Percent_Identity=28.0623608017817, Blast_Score=129, Evalue=8e-31,
Organism=Escherichia coli, GI2367363, Length=658, Percent_Identity=23.2522796352584, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17556548, Length=793, Percent_Identity=32.0302648171501, Blast_Score=320, Evalue=1e-87,
Organism=Caenorhabditis elegans, GI17559224, Length=255, Percent_Identity=24.3137254901961, Blast_Score=68, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320475, Length=741, Percent_Identity=32.1187584345479, Blast_Score=315, Evalue=2e-86,
Organism=Saccharomyces cerevisiae, GI6319772, Length=596, Percent_Identity=32.7181208053691, Blast_Score=288, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6325221, Length=581, Percent_Identity=22.7194492254733, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6321430, Length=528, Percent_Identity=22.9166666666667, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI221329854, Length=521, Percent_Identity=32.4376199616123, Blast_Score=244, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR000695
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 86109; Mature: 85978

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00154 ATPASE_E1_E2 ; PS01047 HMA_1 ; PS50846 HMA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTERRNKEKLHCDHCQQEMEYSAAVTAVIDGQTRYFCCHGCLGVYELIHSESLDAFYQ
CCCCCCCCCCCCCHHHHHHHHHHHHEEEEEECCCCEEEEHHHHHHHHHHHHHCCHHHHHH
QRCDWQPGRPAFGKVDAREFEGNVRNDGSSSKIDLLLSGIRCASCVWLVEKALARLDGIV
HHCCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SARVNYATHRATIQWRTGEITLETILNTLAGLGYLPRPVRHGAQVEAFTEEKRDLLLRFG
HHHHEEEEEEEEEEEECCCEEHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHCC
TAGFFSMQLMLIIAALYAGFFQGIETTYRLTFQIISWALATPVVFYSGWPFISNALRSLR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHH
NRSLNMDALVALGSLSAYFYSVAMIFTGGEVFFDTSAMIITFILLGRFLEAGSRLKAGSA
CCCCCHHHHHHHHHHHHHHHHHHHHEECCEEEECCHHHHHHHHHHHHHHHCCCCCCCCHH
LAALADLQPSEALLVGEDGHAAPAPLEQINAGAVIEVLPGGRVPLDGTVTAGESDVDESM
HHHHHCCCCCCEEEECCCCCCCCCCHHHCCCCCEEEECCCCCCCCCCEEECCCCCHHHHH
LTGESAPVAKAPGSTVYAGTLAITGRLLVSVTGNAHETLLSGIIRTVEEAQARKAPIQGV
HCCCCCCCCCCCCCEEEEEHHEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHH
ADRVAGWFVPAIILLAAGTFAWWRIDGAPTVTALMTAVSVLVIACPCALGLATPLAILVG
HHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TTAVSRKGILVKGGDIFETVSKTTTVVLDKTGTITRGKPSVTDTFDYGISNRFMQCCASL
HHHHCCCCEEEECCHHHHHHHCCEEEEEECCCCEECCCCCCCCHHHCCHHHHHHHHHHHH
EAWSSHPAGQAITDAWLGERLPLDGLRVIPGMGVSGKIEGETWLAGSRVLLEKKGVTLDD
HHHCCCCCCCHHHHHHHCCCCCCCCCEECCCCCCCCEECCCEEECCCEEEEEECCCCCCH
KCLETTDRLEAEGKTTVLVACNGHVAGLFGLIDDLRDDAERMIEALRAQGLGLMILTGDN
HHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
AGVARYIAEKCGITQVRSGLDPLGKAEAIRELKRSGETVLMAGDGINDAPALTEADTGVS
CHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCC
FGTATAVAIDSAGVTIMNDDLTLLDTLVAHSRRCFAIIRQNLAWAFGYNLIALPLAVTGV
CCCEEEEEEECCCCEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LHPIVSALLMATSSLVVVSNSLRLRKL
HHHHHHHHHHHCCCEEEEECCEEECCC
>Mature Secondary Structure 
SVTERRNKEKLHCDHCQQEMEYSAAVTAVIDGQTRYFCCHGCLGVYELIHSESLDAFYQ
CCCCCCCCCCCCHHHHHHHHHHHHEEEEEECCCCEEEEHHHHHHHHHHHHHCCHHHHHH
QRCDWQPGRPAFGKVDAREFEGNVRNDGSSSKIDLLLSGIRCASCVWLVEKALARLDGIV
HHCCCCCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SARVNYATHRATIQWRTGEITLETILNTLAGLGYLPRPVRHGAQVEAFTEEKRDLLLRFG
HHHHEEEEEEEEEEEECCCEEHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHHHHCC
TAGFFSMQLMLIIAALYAGFFQGIETTYRLTFQIISWALATPVVFYSGWPFISNALRSLR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHHHHH
NRSLNMDALVALGSLSAYFYSVAMIFTGGEVFFDTSAMIITFILLGRFLEAGSRLKAGSA
CCCCCHHHHHHHHHHHHHHHHHHHHEECCEEEECCHHHHHHHHHHHHHHHCCCCCCCCHH
LAALADLQPSEALLVGEDGHAAPAPLEQINAGAVIEVLPGGRVPLDGTVTAGESDVDESM
HHHHHCCCCCCEEEECCCCCCCCCCHHHCCCCCEEEECCCCCCCCCCEEECCCCCHHHHH
LTGESAPVAKAPGSTVYAGTLAITGRLLVSVTGNAHETLLSGIIRTVEEAQARKAPIQGV
HCCCCCCCCCCCCCEEEEEHHEEEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCHHHH
ADRVAGWFVPAIILLAAGTFAWWRIDGAPTVTALMTAVSVLVIACPCALGLATPLAILVG
HHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TTAVSRKGILVKGGDIFETVSKTTTVVLDKTGTITRGKPSVTDTFDYGISNRFMQCCASL
HHHHCCCCEEEECCHHHHHHHCCEEEEEECCCCEECCCCCCCCHHHCCHHHHHHHHHHHH
EAWSSHPAGQAITDAWLGERLPLDGLRVIPGMGVSGKIEGETWLAGSRVLLEKKGVTLDD
HHHCCCCCCCHHHHHHHCCCCCCCCCEECCCCCCCCEECCCEEECCCEEEEEECCCCCCH
KCLETTDRLEAEGKTTVLVACNGHVAGLFGLIDDLRDDAERMIEALRAQGLGLMILTGDN
HHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCC
AGVARYIAEKCGITQVRSGLDPLGKAEAIRELKRSGETVLMAGDGINDAPALTEADTGVS
CHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCC
FGTATAVAIDSAGVTIMNDDLTLLDTLVAHSRRCFAIIRQNLAWAFGYNLIALPLAVTGV
CCCEEEEEEECCCCEEECCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
LHPIVSALLMATSSLVVVSNSLRLRKL
HHHHHHHHHHHCCCEEEEECCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA