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The map label for this gene is pyrB

Identifier: 193213284

GI number: 193213284

Start: 1793404

End: 1794330

Strand: Direct

Name: pyrB

Synonym: Cpar_1641

Alternate gene names: 193213284

Gene position: 1793404-1794330 (Clockwise)

Preceding gene: 193213274

Following gene: 193213285

Centisome position: 78.34

GC content: 60.41

Gene sequence:

>927_bases
TTGAACCACCTCACGGGACTTTTCGGATTACCGGCAAGCACGCTGGTCGAGCTGCTCGACCTTGCCGCCGGATACAGAGA
GGGGCTCAACAGAGAGCCTGAAACCTTCGCCCCGTTGCTCTCGAACCGGCGAATCGCCCTTGTTTTCTTTGAGAATTCCA
CCCGCACCCGCTTTTCGTTCGAGCTCGCCGCACGGCATCTTGGCGCGGGAACGCTGAGCTTCACGGCAGCATCGAGCAGC
GTCAGCAAAGGCGAAACCCTGTCGGACACCATCCGCAACCTCGAAGCGATGAAAGTCGATGCGTTTGTGTTGCGGCACCC
ATCATCGGGCGCGGCGGACTTCGTGACATCGATTACCAACCGGCCGGTCATCAACGCCGGAGACGGCACGCACGAGCACC
CGACCCAGGCGCTGCTTGACATTCTCACTCTCAGAAGCTACTTCGGAAAGATCGAAGGGCTAAAAATCATGATTCTCGGC
GACATCCTGCACAGCCGGGTTGCCCGCTCGAACATCCTCGGCCTGAAAACCCTCGGCGCAGAGATCGCCGTCTGCGCGCC
TTCGACGCTGCTCCCCGGCCGGATTGACCAGCTTGGCGTGCAGGTCTTCACCAATCTCGACAAAGCGCTGGCCTGGGCCG
ATGCGGCCATCGTGCTGCGCCTCCAGCTCGAACGGGCCACCGGCGGCTACATTCCGTCGCTCGAAGAGTACTCTGCGGGA
TACGGCCTGACTGACGAGAAATTCGACCGCCTGAAACGGCTCATGCCGGTGCTGCATCCCGGGCCGATCAACCGTGAAAT
TGAAATTTCAAACATGGTAGCCGACCGGATTCAGCCGCCCGGCTATTCAAGCAGCATGCTGATGGAACAGGTAACCAACG
GCGTAGCGGTTCGAATGGCCGTGCTGCATCGCCTGCTGGCCAAGTGA

Upstream 100 bases:

>100_bases
GGTCATCGGATAACAGCGTGACTGCATAGTGCTATGATCGTTAAATTTTTCTTAATTTTCGAAACAACATTCATTTCAAC
GCATAAACGTCCATGAAGTA

Downstream 100 bases:

>100_bases
AACGGCGGCAGACAGTCAACGAATATTTATTAACATCACCATACCCCTGAAAAACGACAAACCATGAACAAACGCTTTTC
GATAGTGACCGCCGCGCTGT

Product: aspartate carbamoyltransferase catalytic subunit

Products: NA

Alternate protein names: Aspartate transcarbamylase; ATCase

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MNHLTGLFGLPASTLVELLDLAAGYREGLNREPETFAPLLSNRRIALVFFENSTRTRFSFELAARHLGAGTLSFTAASSS
VSKGETLSDTIRNLEAMKVDAFVLRHPSSGAADFVTSITNRPVINAGDGTHEHPTQALLDILTLRSYFGKIEGLKIMILG
DILHSRVARSNILGLKTLGAEIAVCAPSTLLPGRIDQLGVQVFTNLDKALAWADAAIVLRLQLERATGGYIPSLEEYSAG
YGLTDEKFDRLKRLMPVLHPGPINREIEISNMVADRIQPPGYSSSMLMEQVTNGVAVRMAVLHRLLAK

Sequences:

>Translated_308_residues
MNHLTGLFGLPASTLVELLDLAAGYREGLNREPETFAPLLSNRRIALVFFENSTRTRFSFELAARHLGAGTLSFTAASSS
VSKGETLSDTIRNLEAMKVDAFVLRHPSSGAADFVTSITNRPVINAGDGTHEHPTQALLDILTLRSYFGKIEGLKIMILG
DILHSRVARSNILGLKTLGAEIAVCAPSTLLPGRIDQLGVQVFTNLDKALAWADAAIVLRLQLERATGGYIPSLEEYSAG
YGLTDEKFDRLKRLMPVLHPGPINREIEISNMVADRIQPPGYSSSMLMEQVTNGVAVRMAVLHRLLAK
>Mature_308_residues
MNHLTGLFGLPASTLVELLDLAAGYREGLNREPETFAPLLSNRRIALVFFENSTRTRFSFELAARHLGAGTLSFTAASSS
VSKGETLSDTIRNLEAMKVDAFVLRHPSSGAADFVTSITNRPVINAGDGTHEHPTQALLDILTLRSYFGKIEGLKIMILG
DILHSRVARSNILGLKTLGAEIAVCAPSTLLPGRIDQLGVQVFTNLDKALAWADAAIVLRLQLERATGGYIPSLEEYSAG
YGLTDEKFDRLKRLMPVLHPGPINREIEISNMVADRIQPPGYSSSMLMEQVTNGVAVRMAVLHRLLAK

Specific function: Pyrimidine biosynthesis; second step. [C]

COG id: COG0540

COG function: function code F; Aspartate carbamoyltransferase, catalytic chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATCase/OTCase family

Homologues:

Organism=Homo sapiens, GI18105007, Length=280, Percent_Identity=35.7142857142857, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI38788445, Length=161, Percent_Identity=31.055900621118, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI2367364, Length=296, Percent_Identity=36.4864864864865, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1790703, Length=192, Percent_Identity=27.6041666666667, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI193204318, Length=315, Percent_Identity=33.968253968254, Blast_Score=119, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6322331, Length=279, Percent_Identity=31.8996415770609, Blast_Score=115, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24642586, Length=278, Percent_Identity=37.0503597122302, Blast_Score=140, Evalue=1e-33,

Paralogues:

None

Copy number: 2080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 14328 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): PYRB_CHLP8 (B3QQ34)

Other databases:

- EMBL:   CP001099
- RefSeq:   YP_001999237.1
- GeneID:   6420582
- GenomeReviews:   CP001099_GR
- KEGG:   cpc:Cpar_1641
- HOGENOM:   HBG579429
- OMA:   MNRGLEI
- ProtClustDB:   PRK00856
- HAMAP:   MF_00001
- InterPro:   IPR006132
- InterPro:   IPR006130
- InterPro:   IPR006131
- InterPro:   IPR002082
- PRINTS:   PR00100
- PRINTS:   PR00101
- TIGRFAMs:   TIGR00670

Pfam domain/function: PF00185 OTCace; PF02729 OTCace_N; SSF53671 Asp/Orn_carbamoyltranf

EC number: =2.1.3.2

Molecular weight: Translated: 33505; Mature: 33505

Theoretical pI: Translated: 7.83; Mature: 7.83

Prosite motif: PS00097 CARBAMOYLTRANSFERASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHLTGLFGLPASTLVELLDLAAGYREGLNREPETFAPLLSNRRIALVFFENSTRTRFSF
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEEECCCCCEEHH
ELAARHLGAGTLSFTAASSSVSKGETLSDTIRNLEAMKVDAFVLRHPSSGAADFVTSITN
HHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHEEHEEECCCCCHHHHHHHHCC
RPVINAGDGTHEHPTQALLDILTLRSYFGKIEGLKIMILGDILHSRVARSNILGLKTLGA
CCEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCHHHHCCC
EIAVCAPSTLLPGRIDQLGVQVFTNLDKALAWADAAIVLRLQLERATGGYIPSLEEYSAG
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCHHHHCCC
YGLTDEKFDRLKRLMPVLHPGPINREIEISNMVADRIQPPGYSSSMLMEQVTNGVAVRMA
CCCCHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHH
VLHRLLAK
HHHHHHCC
>Mature Secondary Structure
MNHLTGLFGLPASTLVELLDLAAGYREGLNREPETFAPLLSNRRIALVFFENSTRTRFSF
CCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCEEEEEEECCCCCEEHH
ELAARHLGAGTLSFTAASSSVSKGETLSDTIRNLEAMKVDAFVLRHPSSGAADFVTSITN
HHHHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHEEHEEECCCCCHHHHHHHHCC
RPVINAGDGTHEHPTQALLDILTLRSYFGKIEGLKIMILGDILHSRVARSNILGLKTLGA
CCEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHCCHHHHCCC
EIAVCAPSTLLPGRIDQLGVQVFTNLDKALAWADAAIVLRLQLERATGGYIPSLEEYSAG
EEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEEEEECCCCCCCCCHHHHCCC
YGLTDEKFDRLKRLMPVLHPGPINREIEISNMVADRIQPPGYSSSMLMEQVTNGVAVRMA
CCCCHHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHH
VLHRLLAK
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA