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The map label for this gene is dctA [H]

Identifier: 193213050

GI number: 193213050

Start: 1531415

End: 1532926

Strand: Direct

Name: dctA [H]

Synonym: Cpar_1403

Alternate gene names: 193213050

Gene position: 1531415-1532926 (Clockwise)

Preceding gene: 193213049

Following gene: 193213051

Centisome position: 66.9

GC content: 62.57

Gene sequence:

>1512_bases
ATGGAGGAGCGCAAAGAAATGCAGCAGTCACCAGTCAAAAAGAGCAACCACAACAACAGACTCCTTATCGGGATTATTAC
CGGCATCGTGGCGGGGGCGCTGCTCGGCGGCTTCTGGCCGGAAGGCGGCCTCACGGTAAAATTTGTTGGCGACCTGTTCA
TCCGGTTCCTGATGATGATTGTCATGCCGCTCATCATCGCAGCGATGGTCAGCGGCATCGCGCGGCTCGGCGACGTCCGC
AAGCTTGGCTCGCTCGGCACGCGGACGCTCGGCTACTACATCGGCACCACGGCGCTGTCGGTCTTCACCGGCATTCTACT
GGTGCTCTGGATTCAACCGGGCAAAGCTGGACTGGAGAACTCGAAGGCTTCGATCACGCAGGCCAACGTCCAGTACCGCA
TCGAAGGCAACACCGTCCGGATAGACTCGGCGGCGCTTCCGGACAGCGATCTGACGACCTCGACCCTGCACCTGCTCGAC
CGGAACCTCTCGGCCTCGATCGACTCGACTCGGCAATCCGGCGACACGATTGTCATCACGACATCCGGATGGAAACGGCG
GGCTGAAGCAGTGACGCCGGAGAACGGCGAGGGAAAAGGCATCCGACTCGACCGACAGCCTGACAAGCGTTTCATGCAGG
AGAAGCGAGCCATCGGTGACATTCTCAAGGAAGTCGTGAGCGGCCTCGTGCCGTCGAACATCTTCAAGGCGATGGCGAAC
AACGAAATCCTGCCGGTCATCACCTTTTCGCTGCTGCTCGGCGCAGCGCTCTCCATGACCGGCGAGGCGGGCCGCACGGC
CATCCTGTTTTTCAACAGCCTCAACGAGGCGATGATGAAGATCATCCACCTCGGGATGTACGTCGCGCCGGTGGGCATCG
GGGCGCTGATCGCCGGGCGACTCAGCGAAGCGGGCGGCTTCAGCGGCTTCTGGCCGGAGCTGCAACAGCTCGGCAAGTAC
GCCGCGACGGTCATCGGCGGCCTCGCGATCCACAGCCTCGTCACGCTGCCGCTGCTCCTGAAATTCTTCGGCAAACGCTC
GCCGTCGGGCTACGCCGTCCGAACCTTCCCCGCGCTGCTCACCGCCTTTTCGACCGCGTCGAGTTCAGCCACCCTGCCGC
TCACCATCGAGTGCGCCGAGGAGAACAACGGCATCTCAAAACGCACCGCCGGATTCGTGCTGCCGCTCGGCGCAACGGTC
AACATGGACGGCACCGCACTCTACGAAGCGGTTGCGGTGATCTTCATCGCGCAGATGAATGGCATCACGCTCGGCACGCC
GGAGCTCGTCGTCGTCTTCCTCACGGCGACGCTCGCCGCCATCGGTGCGGCAGGCATTCCCGAAGCGGGGCTGGTGACGA
TGGTGCTGGTGCTCAAAGCGGTGAACCTCCCAGTCGAAGGCATTGCGCTGATCTTGGCCATCGACTGGTTCCTCGACCGC
TGCCGAACCACCGTCAACGTCTGGGGCGACAGCGTCGGTGCGGGTATTATCGACCGGAAGGTGAAGAGGTAG

Upstream 100 bases:

>100_bases
CTGAACTGAAAACCTCGTACAACGGCGACGCCCCGGAAGGCACCGTGCCCTGGGACACAACCTACCGCCTGAAGCTGGGA
TACCAGTGGTAAAACAATCG

Downstream 100 bases:

>100_bases
GTTGAGACTGGAGTGAAAATGGATTAACTCTCCCTCTGTTGATTGCGGGATGGTACGCTCATTATCCTATATTCTTTTTA
CGCCATTTCCCGAGCCATTC

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: C4-dicarboxylate permease [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MEERKEMQQSPVKKSNHNNRLLIGIITGIVAGALLGGFWPEGGLTVKFVGDLFIRFLMMIVMPLIIAAMVSGIARLGDVR
KLGSLGTRTLGYYIGTTALSVFTGILLVLWIQPGKAGLENSKASITQANVQYRIEGNTVRIDSAALPDSDLTTSTLHLLD
RNLSASIDSTRQSGDTIVITTSGWKRRAEAVTPENGEGKGIRLDRQPDKRFMQEKRAIGDILKEVVSGLVPSNIFKAMAN
NEILPVITFSLLLGAALSMTGEAGRTAILFFNSLNEAMMKIIHLGMYVAPVGIGALIAGRLSEAGGFSGFWPELQQLGKY
AATVIGGLAIHSLVTLPLLLKFFGKRSPSGYAVRTFPALLTAFSTASSSATLPLTIECAEENNGISKRTAGFVLPLGATV
NMDGTALYEAVAVIFIAQMNGITLGTPELVVVFLTATLAAIGAAGIPEAGLVTMVLVLKAVNLPVEGIALILAIDWFLDR
CRTTVNVWGDSVGAGIIDRKVKR

Sequences:

>Translated_503_residues
MEERKEMQQSPVKKSNHNNRLLIGIITGIVAGALLGGFWPEGGLTVKFVGDLFIRFLMMIVMPLIIAAMVSGIARLGDVR
KLGSLGTRTLGYYIGTTALSVFTGILLVLWIQPGKAGLENSKASITQANVQYRIEGNTVRIDSAALPDSDLTTSTLHLLD
RNLSASIDSTRQSGDTIVITTSGWKRRAEAVTPENGEGKGIRLDRQPDKRFMQEKRAIGDILKEVVSGLVPSNIFKAMAN
NEILPVITFSLLLGAALSMTGEAGRTAILFFNSLNEAMMKIIHLGMYVAPVGIGALIAGRLSEAGGFSGFWPELQQLGKY
AATVIGGLAIHSLVTLPLLLKFFGKRSPSGYAVRTFPALLTAFSTASSSATLPLTIECAEENNGISKRTAGFVLPLGATV
NMDGTALYEAVAVIFIAQMNGITLGTPELVVVFLTATLAAIGAAGIPEAGLVTMVLVLKAVNLPVEGIALILAIDWFLDR
CRTTVNVWGDSVGAGIIDRKVKR
>Mature_503_residues
MEERKEMQQSPVKKSNHNNRLLIGIITGIVAGALLGGFWPEGGLTVKFVGDLFIRFLMMIVMPLIIAAMVSGIARLGDVR
KLGSLGTRTLGYYIGTTALSVFTGILLVLWIQPGKAGLENSKASITQANVQYRIEGNTVRIDSAALPDSDLTTSTLHLLD
RNLSASIDSTRQSGDTIVITTSGWKRRAEAVTPENGEGKGIRLDRQPDKRFMQEKRAIGDILKEVVSGLVPSNIFKAMAN
NEILPVITFSLLLGAALSMTGEAGRTAILFFNSLNEAMMKIIHLGMYVAPVGIGALIAGRLSEAGGFSGFWPELQQLGKY
AATVIGGLAIHSLVTLPLLLKFFGKRSPSGYAVRTFPALLTAFSTASSSATLPLTIECAEENNGISKRTAGFVLPLGATV
NMDGTALYEAVAVIFIAQMNGITLGTPELVVVFLTATLAAIGAAGIPEAGLVTMVLVLKAVNLPVEGIALILAIDWFLDR
CRTTVNVWGDSVGAGIIDRKVKR

Specific function: Responsible for the transport of succinate and fumarate, but not malate, across the membrane (Probable) [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI66773030, Length=500, Percent_Identity=37.8, Blast_Score=283, Evalue=4e-76,
Organism=Homo sapiens, GI169790839, Length=525, Percent_Identity=37.1428571428571, Blast_Score=281, Evalue=7e-76,
Organism=Homo sapiens, GI194239697, Length=501, Percent_Identity=36.7265469061876, Blast_Score=278, Evalue=1e-74,
Organism=Homo sapiens, GI4827012, Length=464, Percent_Identity=39.4396551724138, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI40254478, Length=498, Percent_Identity=38.3534136546185, Blast_Score=276, Evalue=3e-74,
Organism=Homo sapiens, GI21314632, Length=452, Percent_Identity=34.7345132743363, Blast_Score=235, Evalue=6e-62,
Organism=Homo sapiens, GI223468566, Length=261, Percent_Identity=45.2107279693487, Blast_Score=230, Evalue=3e-60,
Organism=Homo sapiens, GI223468564, Length=261, Percent_Identity=45.2107279693487, Blast_Score=229, Evalue=3e-60,
Organism=Homo sapiens, GI5032093, Length=261, Percent_Identity=45.2107279693487, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI262359914, Length=525, Percent_Identity=31.2380952380952, Blast_Score=199, Evalue=7e-51,
Organism=Homo sapiens, GI301601644, Length=132, Percent_Identity=49.2424242424242, Blast_Score=149, Evalue=9e-36,
Organism=Escherichia coli, GI1790514, Length=281, Percent_Identity=36.6548042704626, Blast_Score=151, Evalue=9e-38,
Organism=Escherichia coli, GI1789947, Length=281, Percent_Identity=29.5373665480427, Blast_Score=108, Evalue=6e-25,
Organism=Escherichia coli, GI1789473, Length=297, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1788024, Length=307, Percent_Identity=26.3843648208469, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71983099, Length=507, Percent_Identity=38.4615384615385, Blast_Score=303, Evalue=2e-82,
Organism=Caenorhabditis elegans, GI71983106, Length=493, Percent_Identity=38.7423935091278, Blast_Score=300, Evalue=9e-82,
Organism=Caenorhabditis elegans, GI71996953, Length=494, Percent_Identity=38.663967611336, Blast_Score=270, Evalue=2e-72,
Organism=Caenorhabditis elegans, GI17537407, Length=496, Percent_Identity=35.4838709677419, Blast_Score=255, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI193206505, Length=507, Percent_Identity=32.3471400394477, Blast_Score=241, Evalue=8e-64,
Organism=Caenorhabditis elegans, GI193206654, Length=495, Percent_Identity=29.6969696969697, Blast_Score=217, Evalue=1e-56,
Organism=Caenorhabditis elegans, GI17541374, Length=257, Percent_Identity=47.8599221789883, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI24583025, Length=509, Percent_Identity=34.1846758349705, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI17137668, Length=509, Percent_Identity=34.1846758349705, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI24583023, Length=509, Percent_Identity=34.1846758349705, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI281360481, Length=509, Percent_Identity=30.8447937131631, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI281360483, Length=509, Percent_Identity=30.8447937131631, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI17137666, Length=509, Percent_Identity=30.8447937131631, Blast_Score=189, Evalue=4e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 53513; Mature: 53513

Theoretical pI: Translated: 9.78; Mature: 9.78

Prosite motif: PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEERKEMQQSPVKKSNHNNRLLIGIITGIVAGALLGGFWPEGGLTVKFVGDLFIRFLMMI
CCHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHH
VMPLIIAAMVSGIARLGDVRKLGSLGTRTLGYYIGTTALSVFTGILLVLWIQPGKAGLEN
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCC
SKASITQANVQYRIEGNTVRIDSAALPDSDLTTSTLHLLDRNLSASIDSTRQSGDTIVIT
CCCCEEEECEEEEECCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCCHHHHCCCCEEEEE
TSGWKRRAEAVTPENGEGKGIRLDRQPDKRFMQEKRAIGDILKEVVSGLVPSNIFKAMAN
CCCCHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
NEILPVITFSLLLGAALSMTGEAGRTAILFFNSLNEAMMKIIHLGMYVAPVGIGALIAGR
CCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSEAGGFSGFWPELQQLGKYAATVIGGLAIHSLVTLPLLLKFFGKRSPSGYAVRTFPALL
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
TAFSTASSSATLPLTIECAEENNGISKRTAGFVLPLGATVNMDGTALYEAVAVIFIAQMN
HHHHCCCCCCCEEEEEEECCCCCCCCHHCCCEEEECCCEECCCHHHHHHHHHHHHHHHCC
GITLGTPELVVVFLTATLAAIGAAGIPEAGLVTMVLVLKAVNLPVEGIALILAIDWFLDR
CCEECCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
CRTTVNVWGDSVGAGIIDRKVKR
HHHHHHHCCCCCCCCHHHHHCCC
>Mature Secondary Structure
MEERKEMQQSPVKKSNHNNRLLIGIITGIVAGALLGGFWPEGGLTVKFVGDLFIRFLMMI
CCHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHH
VMPLIIAAMVSGIARLGDVRKLGSLGTRTLGYYIGTTALSVFTGILLVLWIQPGKAGLEN
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCC
SKASITQANVQYRIEGNTVRIDSAALPDSDLTTSTLHLLDRNLSASIDSTRQSGDTIVIT
CCCCEEEECEEEEECCCEEEECCCCCCCCCCHHHHHHHHHCCCCCCCHHHHCCCCEEEEE
TSGWKRRAEAVTPENGEGKGIRLDRQPDKRFMQEKRAIGDILKEVVSGLVPSNIFKAMAN
CCCCHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
NEILPVITFSLLLGAALSMTGEAGRTAILFFNSLNEAMMKIIHLGMYVAPVGIGALIAGR
CCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSEAGGFSGFWPELQQLGKYAATVIGGLAIHSLVTLPLLLKFFGKRSPSGYAVRTFPALL
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
TAFSTASSSATLPLTIECAEENNGISKRTAGFVLPLGATVNMDGTALYEAVAVIFIAQMN
HHHHCCCCCCCEEEEEEECCCCCCCCHHCCCEEEECCCEECCCHHHHHHHHHHHHHHHCC
GITLGTPELVVVFLTATLAAIGAAGIPEAGLVTMVLVLKAVNLPVEGIALILAIDWFLDR
CCEECCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHH
CRTTVNVWGDSVGAGIIDRKVKR
HHHHHHHCCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 10708364 [H]