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The map label for this gene is htrA [H]

Identifier: 193213026

GI number: 193213026

Start: 1496721

End: 1498331

Strand: Direct

Name: htrA [H]

Synonym: Cpar_1378

Alternate gene names: 193213026

Gene position: 1496721-1498331 (Clockwise)

Preceding gene: 193213025

Following gene: 193213029

Centisome position: 65.38

GC content: 47.05

Gene sequence:

>1611_bases
ATGATCCAGCATCTTCTTAGAGCACTTATCCTGCTTGTGATGGTGTCAGCAAGCCAAGCCTTTCCAGGACTGCTTTATGC
CAAATCGGCAAGCGAGATCTTTGCGCAAGCATCCCAAAGCATCGTCGTTGTCTACAATTACGATAACAAAGGTATCAAGC
AACAACTTGGCAGTGGCGTTGTCATGCCTGACGGCAAGGTCGCAACCAATTTTCATGTTGTCAACAGGGCAAATAAAATC
ACGGTTCTCTTTAACGGAAAAGAGTTCGAAGCCAAAGCAACCCACTCCGATCCAAAGCGTGATATATGCCTGCTGGACGT
CGAGGGGCTGAACGCACCAGGTGCCGTTATAGGCAATGCCAGCCAGCTCAAGGTGGGAGAAAAGGTCTATGCAATAGGAG
CACCGGAAGGCTTTGAAAAAACACTTTCCGACGGAATTGTTTCAGGATTCAGGACTGTCGATGGCGGAAACTATATTCAG
ACGACAACTCCGATATCTCCCGGTTCAAGCGGTGGAGGTTTGTTCGATGAAGAAGGTCGTTTGGTAGGACTCCCCACGTT
TTACATGGTCAGCGGCAAAAGCCTCAATTTCGCCGTTCCGGTCGAATGGGTGCTTGAAGCCTCCAAGCCACAACTAAGCC
ATGCGAAAAAGACGAGGCAATGCTCCGAGTGGCTTAACAAAGCTGCCGCTTATGAAAAAAACAAGGATTGGTCAGGCATG
ATCAGGCATTGTACCCTGTGGACCAAGACCCAGCCAAAAAACTGTGATGCCTGGTACTGCTTAGGTATTGCCTACAACCG
CATTCAAAATGCACAAAACGCCATCAGTGCGTTTCAAAATGCGGTGCAGATCAAACCGGATAACTCTAAAGCATGGAATG
ACCTTGGTTTTGCTTATGTCGTTGCAGGGATGAAACTCGAAGCCATCGAGGCCTATAAAAAATCGATCCTCACGAACCAG
AACAATGCTGCAGCATGGCAAAACATAGGGATACTGTACCTAAAAAAAGGCGACCTTGATATGGCTACAGAATCTTTCCA
GCAGGCAGTACAAATCAAGCCTGATTATCTCTCAGCATGGGTCAACCTCGGAATATCGCTGCAAGCAAACGGAAGTCCGA
AAGAAGCCATCCAAGCCTTCACAAAAGCCATCAGTATTAATGGCAACAACTCTGTTATATGGAATAACCTTGGCTTAGCC
TACAGGGATAACGGCAATGTCGACCAATCGATCGATGCCTTCAGGCATGCACTGCAAATCAATCCAAATTATGATACCGC
ACGAAACAACCTGGCCGAAACCTATCGTCTGACAGGACGTGTGGATGAAAGCATCAATACCTACATTCAGTCGACAGAAA
TAAATCTGAACGATTCAACAGCATGGCAAGCCCTCGGGGATGCATATACGAAGAACCATCAAAGCGACAAAGCTTTAGAG
GCCTTCAAACAGGCATTGCGATGCGACCCGAACAATGTTAAAGCACTGGTCGGTTTAGGCAGACATTACGCAACCAAAAA
AAATCGTGTCGTAGCTATGGACGTATACCGTCGGCTGAAAAATATCGACTCTGGAGTGGCAAAGGATTATCTCAAGAATT
ACCTCCTCTGA

Upstream 100 bases:

>100_bases
CCCGTATTACGACAAGAGCATGTATATCAATTGAAAATACCGACCTTCGTAAGCTGATTGCGCTTCTTGTATTGCGGCAA
AACCATTAAAGCAAACGGCA

Downstream 100 bases:

>100_bases
AAACTACCAACTCAAACAGCTTTTTTCACGAAGCAAAATCATCGCCCCTCAAGGTCGCGCAAGCAACAAAAAAAGAGGGT
GTTCCGGATTTACCTCCCGG

Product: TPR repeat-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 536; Mature: 536

Protein sequence:

>536_residues
MIQHLLRALILLVMVSASQAFPGLLYAKSASEIFAQASQSIVVVYNYDNKGIKQQLGSGVVMPDGKVATNFHVVNRANKI
TVLFNGKEFEAKATHSDPKRDICLLDVEGLNAPGAVIGNASQLKVGEKVYAIGAPEGFEKTLSDGIVSGFRTVDGGNYIQ
TTTPISPGSSGGGLFDEEGRLVGLPTFYMVSGKSLNFAVPVEWVLEASKPQLSHAKKTRQCSEWLNKAAAYEKNKDWSGM
IRHCTLWTKTQPKNCDAWYCLGIAYNRIQNAQNAISAFQNAVQIKPDNSKAWNDLGFAYVVAGMKLEAIEAYKKSILTNQ
NNAAAWQNIGILYLKKGDLDMATESFQQAVQIKPDYLSAWVNLGISLQANGSPKEAIQAFTKAISINGNNSVIWNNLGLA
YRDNGNVDQSIDAFRHALQINPNYDTARNNLAETYRLTGRVDESINTYIQSTEINLNDSTAWQALGDAYTKNHQSDKALE
AFKQALRCDPNNVKALVGLGRHYATKKNRVVAMDVYRRLKNIDSGVAKDYLKNYLL

Sequences:

>Translated_536_residues
MIQHLLRALILLVMVSASQAFPGLLYAKSASEIFAQASQSIVVVYNYDNKGIKQQLGSGVVMPDGKVATNFHVVNRANKI
TVLFNGKEFEAKATHSDPKRDICLLDVEGLNAPGAVIGNASQLKVGEKVYAIGAPEGFEKTLSDGIVSGFRTVDGGNYIQ
TTTPISPGSSGGGLFDEEGRLVGLPTFYMVSGKSLNFAVPVEWVLEASKPQLSHAKKTRQCSEWLNKAAAYEKNKDWSGM
IRHCTLWTKTQPKNCDAWYCLGIAYNRIQNAQNAISAFQNAVQIKPDNSKAWNDLGFAYVVAGMKLEAIEAYKKSILTNQ
NNAAAWQNIGILYLKKGDLDMATESFQQAVQIKPDYLSAWVNLGISLQANGSPKEAIQAFTKAISINGNNSVIWNNLGLA
YRDNGNVDQSIDAFRHALQINPNYDTARNNLAETYRLTGRVDESINTYIQSTEINLNDSTAWQALGDAYTKNHQSDKALE
AFKQALRCDPNNVKALVGLGRHYATKKNRVVAMDVYRRLKNIDSGVAKDYLKNYLL
>Mature_536_residues
MIQHLLRALILLVMVSASQAFPGLLYAKSASEIFAQASQSIVVVYNYDNKGIKQQLGSGVVMPDGKVATNFHVVNRANKI
TVLFNGKEFEAKATHSDPKRDICLLDVEGLNAPGAVIGNASQLKVGEKVYAIGAPEGFEKTLSDGIVSGFRTVDGGNYIQ
TTTPISPGSSGGGLFDEEGRLVGLPTFYMVSGKSLNFAVPVEWVLEASKPQLSHAKKTRQCSEWLNKAAAYEKNKDWSGM
IRHCTLWTKTQPKNCDAWYCLGIAYNRIQNAQNAISAFQNAVQIKPDNSKAWNDLGFAYVVAGMKLEAIEAYKKSILTNQ
NNAAAWQNIGILYLKKGDLDMATESFQQAVQIKPDYLSAWVNLGISLQANGSPKEAIQAFTKAISINGNNSVIWNNLGLA
YRDNGNVDQSIDAFRHALQINPNYDTARNNLAETYRLTGRVDESINTYIQSTEINLNDSTAWQALGDAYTKNHQSDKALE
AFKQALRCDPNNVKALVGLGRHYATKKNRVVAMDVYRRLKNIDSGVAKDYLKNYLL

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0457

COG function: function code R; FOG: TPR repeat

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI32307150, Length=338, Percent_Identity=25.1479289940828, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI32307148, Length=338, Percent_Identity=25.1479289940828, Blast_Score=119, Evalue=8e-27,
Organism=Homo sapiens, GI4506141, Length=160, Percent_Identity=36.875, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI118766330, Length=215, Percent_Identity=27.4418604651163, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI118766328, Length=215, Percent_Identity=27.4418604651163, Blast_Score=83, Evalue=8e-16,
Organism=Homo sapiens, GI301336134, Length=264, Percent_Identity=23.1060606060606, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI83415184, Length=264, Percent_Identity=23.1060606060606, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI170784867, Length=269, Percent_Identity=23.4200743494424, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI224809432, Length=347, Percent_Identity=21.6138328530259, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI296531396, Length=199, Percent_Identity=24.1206030150754, Blast_Score=75, Evalue=2e-13,
Organism=Homo sapiens, GI7706671, Length=221, Percent_Identity=23.9819004524887, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI22129776, Length=166, Percent_Identity=33.1325301204819, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI21361204, Length=218, Percent_Identity=23.8532110091743, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI24308541, Length=160, Percent_Identity=33.125, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI22749211, Length=234, Percent_Identity=23.0769230769231, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI196259776, Length=218, Percent_Identity=23.8532110091743, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI196259774, Length=218, Percent_Identity=23.8532110091743, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI196259772, Length=218, Percent_Identity=23.8532110091743, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI196259770, Length=218, Percent_Identity=23.8532110091743, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI301898023, Length=172, Percent_Identity=22.6744186046512, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI42476022, Length=172, Percent_Identity=22.6744186046512, Blast_Score=69, Evalue=9e-12,
Organism=Homo sapiens, GI7662078, Length=242, Percent_Identity=25.2066115702479, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI7019477, Length=161, Percent_Identity=34.7826086956522, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI167466177, Length=186, Percent_Identity=22.5806451612903, Blast_Score=67, Evalue=5e-11,
Organism=Homo sapiens, GI167466175, Length=186, Percent_Identity=22.5806451612903, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1789629, Length=157, Percent_Identity=37.5796178343949, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1786356, Length=161, Percent_Identity=36.0248447204969, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI1789630, Length=188, Percent_Identity=31.3829787234043, Blast_Score=74, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI115532690, Length=347, Percent_Identity=25.3602305475504, Blast_Score=125, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI115532692, Length=347, Percent_Identity=25.3602305475504, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI25147174, Length=271, Percent_Identity=24.7232472324723, Blast_Score=78, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI71983711, Length=212, Percent_Identity=26.8867924528302, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71983707, Length=212, Percent_Identity=26.8867924528302, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI25146105, Length=272, Percent_Identity=22.0588235294118, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319589, Length=349, Percent_Identity=22.0630372492837, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6320450, Length=197, Percent_Identity=26.3959390862944, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319387, Length=227, Percent_Identity=23.3480176211454, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17647755, Length=314, Percent_Identity=25.796178343949, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24585827, Length=314, Percent_Identity=25.796178343949, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24585829, Length=314, Percent_Identity=25.796178343949, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24647123, Length=250, Percent_Identity=25.6, Blast_Score=92, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24585440, Length=225, Percent_Identity=24, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24656717, Length=269, Percent_Identity=22.6765799256506, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI18110006, Length=269, Percent_Identity=22.6765799256506, Blast_Score=73, Evalue=6e-13,
Organism=Drosophila melanogaster, GI19920486, Length=247, Percent_Identity=27.1255060728745, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161076610, Length=247, Percent_Identity=27.1255060728745, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24646839, Length=161, Percent_Identity=31.055900621118, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 58939; Mature: 58939

Theoretical pI: Translated: 9.18; Mature: 9.18

Prosite motif: PS50005 TPR ; PS50293 TPR_REGION

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQHLLRALILLVMVSASQAFPGLLYAKSASEIFAQASQSIVVVYNYDNKGIKQQLGSGV
CHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHCCCCEEEEEECCCCCHHHHHCCCE
VMPDGKVATNFHVVNRANKITVLFNGKEFEAKATHSDPKRDICLLDVEGLNAPGAVIGNA
ECCCCCEEEEEEEEECCCEEEEEECCCEEECCCCCCCCCCCEEEEEECCCCCCCCEECCC
SQLKVGEKVYAIGAPEGFEKTLSDGIVSGFRTVDGGNYIQTTTPISPGSSGGGLFDEEGR
HHEEECCEEEEECCCCHHHHHHHHHHHHCCEECCCCCEEEEECCCCCCCCCCCCCCCCCC
LVGLPTFYMVSGKSLNFAVPVEWVLEASKPQLSHAKKTRQCSEWLNKAAAYEKNKDWSGM
EEECCEEEEEECCCCEEECCHHHEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
IRHCTLWTKTQPKNCDAWYCLGIAYNRIQNAQNAISAFQNAVQIKPDNSKAWNDLGFAYV
HHEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCEEECCCCCCCHHHCCHHHH
VAGMKLEAIEAYKKSILTNQNNAAAWQNIGILYLKKGDLDMATESFQQAVQIKPDYLSAW
HCCCHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHH
VNLGISLQANGSPKEAIQAFTKAISINGNNSVIWNNLGLAYRDNGNVDQSIDAFRHALQI
HHCCEEEEECCCHHHHHHHHHHEEEECCCCEEEEECCCEEECCCCCCCHHHHHHHHHEEC
NPNYDTARNNLAETYRLTGRVDESINTYIQSTEINLNDSTAWQALGDAYTKNHQSDKALE
CCCCCHHHHHHHHHHHCCCCCCHHHHHEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHH
AFKQALRCDPNNVKALVGLGRHYATKKNRVVAMDVYRRLKNIDSGVAKDYLKNYLL
HHHHHHCCCCCCHHHHHHCCHHHCCCCCCEEEHHHHHHHHHCCCHHHHHHHHHHCC
>Mature Secondary Structure
MIQHLLRALILLVMVSASQAFPGLLYAKSASEIFAQASQSIVVVYNYDNKGIKQQLGSGV
CHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHCCCCEEEEEECCCCCHHHHHCCCE
VMPDGKVATNFHVVNRANKITVLFNGKEFEAKATHSDPKRDICLLDVEGLNAPGAVIGNA
ECCCCCEEEEEEEEECCCEEEEEECCCEEECCCCCCCCCCCEEEEEECCCCCCCCEECCC
SQLKVGEKVYAIGAPEGFEKTLSDGIVSGFRTVDGGNYIQTTTPISPGSSGGGLFDEEGR
HHEEECCEEEEECCCCHHHHHHHHHHHHCCEECCCCCEEEEECCCCCCCCCCCCCCCCCC
LVGLPTFYMVSGKSLNFAVPVEWVLEASKPQLSHAKKTRQCSEWLNKAAAYEKNKDWSGM
EEECCEEEEEECCCCEEECCHHHEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHH
IRHCTLWTKTQPKNCDAWYCLGIAYNRIQNAQNAISAFQNAVQIKPDNSKAWNDLGFAYV
HHEEEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHCEEECCCCCCCHHHCCHHHH
VAGMKLEAIEAYKKSILTNQNNAAAWQNIGILYLKKGDLDMATESFQQAVQIKPDYLSAW
HCCCHHHHHHHHHHHHHCCCCCCCHHHCCCEEEEECCCCHHHHHHHHHHHCCCHHHHHHH
VNLGISLQANGSPKEAIQAFTKAISINGNNSVIWNNLGLAYRDNGNVDQSIDAFRHALQI
HHCCEEEEECCCHHHHHHHHHHEEEECCCCEEEEECCCEEECCCCCCCHHHHHHHHHEEC
NPNYDTARNNLAETYRLTGRVDESINTYIQSTEINLNDSTAWQALGDAYTKNHQSDKALE
CCCCCHHHHHHHHHHHCCCCCCHHHHHEEEEEEECCCCCHHHHHHHHHHHCCCCCHHHHH
AFKQALRCDPNNVKALVGLGRHYATKKNRVVAMDVYRRLKNIDSGVAKDYLKNYLL
HHHHHHCCCCCCHHHHHHCCHHHCCCCCCEEEHHHHHHHHHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]