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The map label for this gene is pyrD [H]

Identifier: 190571468

GI number: 190571468

Start: 1154063

End: 1155130

Strand: Direct

Name: pyrD [H]

Synonym: WPa_1083

Alternate gene names: 190571468

Gene position: 1154063-1155130 (Clockwise)

Preceding gene: 190571467

Following gene: 190571469

Centisome position: 77.85

GC content: 33.9

Gene sequence:

>1068_bases
ATGGTAAAAAATAAACTAAAAATAAGCAAAGTGTTTTACAAAATGATATTACGTAATTTATTGTTTTTACTGCCGCCTGA
AATCGCTCACTCCTTGGTAATAACGGCGTTAAAAAAGATGCCCTGTAGGAAACCTATAGAACTACCTAAGTCTTTAAATG
TAAACTTTTTTGGTAATAAAATTAGGAGTCCTGTAGGTCTTGCTGCAGGTTTTGATAAAAATGCGGAAGTTGTAAAGCCG
ATGCTCTCATTTGGTTTTGGATTTATTGAGGCTGGTACTGTAACTAAACATCCCCAATATGGAAACAAAAAACCGAGAAT
TTTTCGATTAATTAAAGATGAAGGAATAATTAATAGATTGGGATTTAATAATAAAGGAGTAGACTATTTTCTTAAACAGA
TAAGTGAAACTAAACTTGGTAATTGTATTTTTGGTATAAATATAGGAAGAAACAGTACATCAAAGGACCAAATCAGCGAT
TATGTTGACTTAATAAAGATAGTATATGGAAAGAGCAATTATATAGTACTGAACATCTCATCCCCAAACACACCTAACTT
GCGCGATTTGCACAATAAACAAGAATTATCCAAATTGTTGAAATCTATCACTCTAACCCGGAAATCAATCGATAGCTCTG
AATCCATACCGATAATATTAAAAATTTCTCCAGATATAGATCAGCAAACAAAAGAAAATATCGCTGAGCTTACACTAGAA
TATAAAATTGACGGCTTAATAGTAAGCAACACTACGATAAGTCGAGATTCTTACTATAATGAGAGTGGTGGGTTGAGCGG
CAGGCCATTATTTCAACTTTCAACCGAGTTATTGAGTGACATGTACAAGCTTACTAAAAGCAGAATTCTATTGATAGGAT
GCGGAGGAATTTCAAGTGGTGTTGATGCATATGAAAAAATAAAGGCAGGAGCCTCTTTAGTACAACTGTACACTGCTCTT
GTATACCAGGGGCATCAAGTTGTGAACAAAATCAATCTGGAGCTTGCAGAATTGGTAAAAAGAGATGGATTTAGTAACAT
TACTGAAGCAGTGGGTTGTATACATTAA

Upstream 100 bases:

>100_bases
AGTTCTGGTTTCCCTTCAGAAAAATTAGTTTTTACTACCCATAGAAACTATATACTTACTATTTTGATAAACCTCAAGCT
TTCTAAGTTATTCTTGTTGC

Downstream 100 bases:

>100_bases
TTTTGGAAGTTATTGATATTGTTTTAGTAAAGTAGAGCTAACTTTTTAGTGTAGAGGTATGATAGAGAGTGCTTTTCTAT
TGAATGATTAATATGAGAGT

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MVKNKLKISKVFYKMILRNLLFLLPPEIAHSLVITALKKMPCRKPIELPKSLNVNFFGNKIRSPVGLAAGFDKNAEVVKP
MLSFGFGFIEAGTVTKHPQYGNKKPRIFRLIKDEGIINRLGFNNKGVDYFLKQISETKLGNCIFGINIGRNSTSKDQISD
YVDLIKIVYGKSNYIVLNISSPNTPNLRDLHNKQELSKLLKSITLTRKSIDSSESIPIILKISPDIDQQTKENIAELTLE
YKIDGLIVSNTTISRDSYYNESGGLSGRPLFQLSTELLSDMYKLTKSRILLIGCGGISSGVDAYEKIKAGASLVQLYTAL
VYQGHQVVNKINLELAELVKRDGFSNITEAVGCIH

Sequences:

>Translated_355_residues
MVKNKLKISKVFYKMILRNLLFLLPPEIAHSLVITALKKMPCRKPIELPKSLNVNFFGNKIRSPVGLAAGFDKNAEVVKP
MLSFGFGFIEAGTVTKHPQYGNKKPRIFRLIKDEGIINRLGFNNKGVDYFLKQISETKLGNCIFGINIGRNSTSKDQISD
YVDLIKIVYGKSNYIVLNISSPNTPNLRDLHNKQELSKLLKSITLTRKSIDSSESIPIILKISPDIDQQTKENIAELTLE
YKIDGLIVSNTTISRDSYYNESGGLSGRPLFQLSTELLSDMYKLTKSRILLIGCGGISSGVDAYEKIKAGASLVQLYTAL
VYQGHQVVNKINLELAELVKRDGFSNITEAVGCIH
>Mature_355_residues
MVKNKLKISKVFYKMILRNLLFLLPPEIAHSLVITALKKMPCRKPIELPKSLNVNFFGNKIRSPVGLAAGFDKNAEVVKP
MLSFGFGFIEAGTVTKHPQYGNKKPRIFRLIKDEGIINRLGFNNKGVDYFLKQISETKLGNCIFGINIGRNSTSKDQISD
YVDLIKIVYGKSNYIVLNISSPNTPNLRDLHNKQELSKLLKSITLTRKSIDSSESIPIILKISPDIDQQTKENIAELTLE
YKIDGLIVSNTTISRDSYYNESGGLSGRPLFQLSTELLSDMYKLTKSRILLIGCGGISSGVDAYEKIKAGASLVQLYTAL
VYQGHQVVNKINLELAELVKRDGFSNITEAVGCIH

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=360, Percent_Identity=44.1666666666667, Blast_Score=303, Evalue=2e-82,
Organism=Escherichia coli, GI1787177, Length=335, Percent_Identity=38.5074626865672, Blast_Score=226, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17509475, Length=366, Percent_Identity=40.9836065573771, Blast_Score=275, Evalue=3e-74,
Organism=Saccharomyces cerevisiae, GI6322633, Length=329, Percent_Identity=24.6200607902736, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI281361352, Length=364, Percent_Identity=43.6813186813187, Blast_Score=300, Evalue=1e-81,
Organism=Drosophila melanogaster, GI17137316, Length=364, Percent_Identity=43.6813186813187, Blast_Score=300, Evalue=1e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 39532; Mature: 39532

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKNKLKISKVFYKMILRNLLFLLPPEIAHSLVITALKKMPCRKPIELPKSLNVNFFGNK
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCHH
IRSPVGLAAGFDKNAEVVKPMLSFGFGFIEAGTVTKHPQYGNKKPRIFRLIKDEGIINRL
HCCCCCEECCCCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCEEEEECCCCCHHHC
GFNNKGVDYFLKQISETKLGNCIFGINIGRNSTSKDQISDYVDLIKIVYGKSNYIVLNIS
CCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEC
SPNTPNLRDLHNKQELSKLLKSITLTRKSIDSSESIPIILKISPDIDQQTKENIAELTLE
CCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHEEEE
YKIDGLIVSNTTISRDSYYNESGGLSGRPLFQLSTELLSDMYKLTKSRILLIGCGGISSG
EEECEEEEECCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCC
VDAYEKIKAGASLVQLYTALVYQGHQVVNKINLELAELVKRDGFSNITEAVGCIH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
>Mature Secondary Structure
MVKNKLKISKVFYKMILRNLLFLLPPEIAHSLVITALKKMPCRKPIELPKSLNVNFFGNK
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEECCHH
IRSPVGLAAGFDKNAEVVKPMLSFGFGFIEAGTVTKHPQYGNKKPRIFRLIKDEGIINRL
HCCCCCEECCCCCCHHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCEEEEECCCCCHHHC
GFNNKGVDYFLKQISETKLGNCIFGINIGRNSTSKDQISDYVDLIKIVYGKSNYIVLNIS
CCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEC
SPNTPNLRDLHNKQELSKLLKSITLTRKSIDSSESIPIILKISPDIDQQTKENIAELTLE
CCCCCCHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHEEEE
YKIDGLIVSNTTISRDSYYNESGGLSGRPLFQLSTELLSDMYKLTKSRILLIGCGGISSG
EEECEEEEECCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCC
VDAYEKIKAGASLVQLYTALVYQGHQVVNKINLELAELVKRDGFSNITEAVGCIH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA