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The map label for this gene is clpA [C]

Identifier: 190571464

GI number: 190571464

Start: 1148725

End: 1151004

Strand: Direct

Name: clpA [C]

Synonym: WPa_1079

Alternate gene names: 190571464

Gene position: 1148725-1151004 (Clockwise)

Preceding gene: 190571463

Following gene: 190571465

Centisome position: 77.49

GC content: 34.12

Gene sequence:

>2280_bases
ATGATTTCTAAAAATTTAGAGGCAAGTTTAAATAGAGCGTTACAGATTGCTTCTGATTGTAAGCTTAAATATGCAAAAGT
GGAACATTTGTTGCTAGCATTAACCAAAGATGTGGATGTAAATTATGTTTTATCAAGATGTAACATCAGAGCTGGTGAAA
TCATAAATATAGATAATATTATATTAAGGAATGATCGTGGTAATAATGCAAAAGGTTTTTTACAAGACAACTCCGAATTA
ACTGTCAATAAAGTTGAGCCTGATGTGCTATTTCAACGCATAATACATAAAGCCATGATACGAGCTCATCGTCTGGGAAG
AAAAGAAATAAATGGAGCAAGTATTCTATTAGAGATTCTGTCTGAGCAAGATTTATACATTGAAGAGCTATTATGCAAAC
AGAATGCAAAGGATTCTAATTTGATTTATAACATATCCAATATAAAATATTCAGGTGATATAGAAGAATATGTAACTAAT
CGCAAGATAAAACTTGATAAGAATAACGATATCTCTACTGTAGCAAATAAAGGTGAATTATTAAAAGATGAAGAAGTTCT
ACAAAATTATTGTAGAAATTTAAATGATTATGCAAGAAGCAAAAAAATAGATTATGTCATTGGTCGTGATTATGAATTAA
ATCGCACTATAGAAATCTTGCTAAGACGCAGAAAAAATAACCCTTTATATGTCGGAGAACCAGGTGTTGGTAAAACAACA
ATAGTTGAAGGCTTGGTATTGAAAATTATTGAAGGTAGTGTTCCGAGTGCACTGAGATCCAGCATAATTTATGCTTTGGA
TTTAGGATCACTTCTTGCAGGAACACGCTATAGAGGTGACTTCGAAGAGAGAATAAAATCTATAATAAAAGTAATTGAGG
CAAAACCTGGCGCTATTCTTTTCATTGATGAAATACACACTATTATTGGAGCAGGTTCAACAAGTGGCAGCTTTCTTGAT
GCTGGCAATCTGCTCAAACCTGCACTTGCAAGAGGTGCGTTGCGTTGTATAGGTGCAACTACATATAGAGAATATAGCAA
TAGCTTTGAAAAGGATAAAGCATTAGCAAGGAGGTTTCAAAAAATTAATGTAAAAGAGTCTTCTATTAATGATACAGTAA
AGATACTAGATGGTATAAAGCATTACTATGAAAGGTATCATGGAGTATATTACACGAAACATGCCATTAAATCTGCAGCT
GAACTTTCACACAAGTATATTACTGGGCGAATATTACCCGATAAAGCAGTTGATGTTATAGATGAAGCAGGGGCATATTG
TAAGTTACAAAAAAGCAGGCGAAAAATTATAAACAGTAGAGACATTAAGAGTACTATCGCTAGGATTACAAACGTACCTT
GCGGGTTTGATGATATGCAAAGAGTAAAATCTTTGAAAGAAAATCTCAATAGGGCCATTTTTGGTCAAGAGCAAGCGATA
GAGTTTCTCGTTAATTCTATTAAAATTGCTAAATCTGGTCTGAGAAGTTACAATAAACCCTTGGCAAAGTATCTTTTTGC
AGGGCCAACTGGTGTAGGTAAGACTGAGCTTGCGAAGCAGCTAGCACAAAATATGGGTATGAACCTTATTCGGTTTGATA
TGTCTGAGTATATGGAACCTCACACAATATCTAGAATGATTGGTTCCCCTCCTGGATATGTGGGTTACGACCAAGGTGGA
TTGCTTACAGAATCTGTATCTAATAATCAATATAGCGTAGTACTTCTTGATGAAATTGAGAAAGCTCATAGTGATATTTA
TAATATATTACTACAAATCATGGATTATGGTTGTGTTACAGACACTTACGGACGTAAGGTTAATTTTTCCAATACGATTT
TAATTATGACAACCAATGCAGGGGCATTTGAACGTAACAAAAGTTCTATTGGCTTTGGGTATAAAAACTTTAACATCAGT
GACAGCGAAAAAGCAATGGAACGGGTTTTTAGCCCCGAATTTCGTAATCGTCTTGATGCAGTCATTTCCTTTTCTGATTT
GGATGCGGATGTCATTTTGCACATTGTGGATAAATTTATTCAGGAATTAAAAAAACAACTTGTGCAAAAGGGTATAAGCT
GCTCAGTGGAAGAAGAAGTAAAGTCTTATCTTGCGCAAACAGGTTATAGCAAAGAAATGGGAGCACGCCCAATAGAGAGG
CTGATTGAAAAAGAGATAAAAAGTCATTTGGCTGAAGAAATACTGAATCGTCGATTAATTAAAGGAAAGAAATTAAGGAT
TTATATTGGTAAACACGGAATTGCTTTTGATATAGTTTAA

Upstream 100 bases:

>100_bases
AGCTTAATTCAATTTGGCTACAACGAGCTGCTAGATTTCAGTTTTTTTAATAATTGTGTGCTACTAATTATATATAAATT
TACACTTTTAAAGAGAATAG

Downstream 100 bases:

>100_bases
ATTCTTGCTTGAGTATTAAATTTGTAGTATAGTCACTATTTTTTAATGAGGCTATAGTGGCAAGTTTAACCAGAAATCAA
TATTACAGTAATCAAGATTT

Product: ATP-dependent Clp protease, ATP-binding subunit ClpA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 759; Mature: 759

Protein sequence:

>759_residues
MISKNLEASLNRALQIASDCKLKYAKVEHLLLALTKDVDVNYVLSRCNIRAGEIINIDNIILRNDRGNNAKGFLQDNSEL
TVNKVEPDVLFQRIIHKAMIRAHRLGRKEINGASILLEILSEQDLYIEELLCKQNAKDSNLIYNISNIKYSGDIEEYVTN
RKIKLDKNNDISTVANKGELLKDEEVLQNYCRNLNDYARSKKIDYVIGRDYELNRTIEILLRRRKNNPLYVGEPGVGKTT
IVEGLVLKIIEGSVPSALRSSIIYALDLGSLLAGTRYRGDFEERIKSIIKVIEAKPGAILFIDEIHTIIGAGSTSGSFLD
AGNLLKPALARGALRCIGATTYREYSNSFEKDKALARRFQKINVKESSINDTVKILDGIKHYYERYHGVYYTKHAIKSAA
ELSHKYITGRILPDKAVDVIDEAGAYCKLQKSRRKIINSRDIKSTIARITNVPCGFDDMQRVKSLKENLNRAIFGQEQAI
EFLVNSIKIAKSGLRSYNKPLAKYLFAGPTGVGKTELAKQLAQNMGMNLIRFDMSEYMEPHTISRMIGSPPGYVGYDQGG
LLTESVSNNQYSVVLLDEIEKAHSDIYNILLQIMDYGCVTDTYGRKVNFSNTILIMTTNAGAFERNKSSIGFGYKNFNIS
DSEKAMERVFSPEFRNRLDAVISFSDLDADVILHIVDKFIQELKKQLVQKGISCSVEEEVKSYLAQTGYSKEMGARPIER
LIEKEIKSHLAEEILNRRLIKGKKLRIYIGKHGIAFDIV

Sequences:

>Translated_759_residues
MISKNLEASLNRALQIASDCKLKYAKVEHLLLALTKDVDVNYVLSRCNIRAGEIINIDNIILRNDRGNNAKGFLQDNSEL
TVNKVEPDVLFQRIIHKAMIRAHRLGRKEINGASILLEILSEQDLYIEELLCKQNAKDSNLIYNISNIKYSGDIEEYVTN
RKIKLDKNNDISTVANKGELLKDEEVLQNYCRNLNDYARSKKIDYVIGRDYELNRTIEILLRRRKNNPLYVGEPGVGKTT
IVEGLVLKIIEGSVPSALRSSIIYALDLGSLLAGTRYRGDFEERIKSIIKVIEAKPGAILFIDEIHTIIGAGSTSGSFLD
AGNLLKPALARGALRCIGATTYREYSNSFEKDKALARRFQKINVKESSINDTVKILDGIKHYYERYHGVYYTKHAIKSAA
ELSHKYITGRILPDKAVDVIDEAGAYCKLQKSRRKIINSRDIKSTIARITNVPCGFDDMQRVKSLKENLNRAIFGQEQAI
EFLVNSIKIAKSGLRSYNKPLAKYLFAGPTGVGKTELAKQLAQNMGMNLIRFDMSEYMEPHTISRMIGSPPGYVGYDQGG
LLTESVSNNQYSVVLLDEIEKAHSDIYNILLQIMDYGCVTDTYGRKVNFSNTILIMTTNAGAFERNKSSIGFGYKNFNIS
DSEKAMERVFSPEFRNRLDAVISFSDLDADVILHIVDKFIQELKKQLVQKGISCSVEEEVKSYLAQTGYSKEMGARPIER
LIEKEIKSHLAEEILNRRLIKGKKLRIYIGKHGIAFDIV
>Mature_759_residues
MISKNLEASLNRALQIASDCKLKYAKVEHLLLALTKDVDVNYVLSRCNIRAGEIINIDNIILRNDRGNNAKGFLQDNSEL
TVNKVEPDVLFQRIIHKAMIRAHRLGRKEINGASILLEILSEQDLYIEELLCKQNAKDSNLIYNISNIKYSGDIEEYVTN
RKIKLDKNNDISTVANKGELLKDEEVLQNYCRNLNDYARSKKIDYVIGRDYELNRTIEILLRRRKNNPLYVGEPGVGKTT
IVEGLVLKIIEGSVPSALRSSIIYALDLGSLLAGTRYRGDFEERIKSIIKVIEAKPGAILFIDEIHTIIGAGSTSGSFLD
AGNLLKPALARGALRCIGATTYREYSNSFEKDKALARRFQKINVKESSINDTVKILDGIKHYYERYHGVYYTKHAIKSAA
ELSHKYITGRILPDKAVDVIDEAGAYCKLQKSRRKIINSRDIKSTIARITNVPCGFDDMQRVKSLKENLNRAIFGQEQAI
EFLVNSIKIAKSGLRSYNKPLAKYLFAGPTGVGKTELAKQLAQNMGMNLIRFDMSEYMEPHTISRMIGSPPGYVGYDQGG
LLTESVSNNQYSVVLLDEIEKAHSDIYNILLQIMDYGCVTDTYGRKVNFSNTILIMTTNAGAFERNKSSIGFGYKNFNIS
DSEKAMERVFSPEFRNRLDAVISFSDLDADVILHIVDKFIQELKKQLVQKGISCSVEEEVKSYLAQTGYSKEMGARPIER
LIEKEIKSHLAEEILNRRLIKGKKLRIYIGKHGIAFDIV

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=317, Percent_Identity=33.1230283911672, Blast_Score=157, Evalue=5e-38,
Organism=Escherichia coli, GI1787109, Length=761, Percent_Identity=46.3863337713535, Blast_Score=695, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=247, Percent_Identity=54.251012145749, Blast_Score=279, Evalue=5e-76,
Organism=Saccharomyces cerevisiae, GI6320464, Length=249, Percent_Identity=52.2088353413655, Blast_Score=256, Evalue=1e-68,
Organism=Saccharomyces cerevisiae, GI6323002, Length=238, Percent_Identity=48.3193277310924, Blast_Score=230, Evalue=7e-61,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 85636; Mature: 85636

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS00870 CLPAB_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISKNLEASLNRALQIASDCKLKYAKVEHLLLALTKDVDVNYVLSRCNIRAGEIINIDNI
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEECCCE
ILRNDRGNNAKGFLQDNSELTVNKVEPDVLFQRIIHKAMIRAHRLGRKEINGASILLEIL
EEECCCCCCCCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHH
SEQDLYIEELLCKQNAKDSNLIYNISNIKYSGDIEEYVTNRKIKLDKNNDISTVANKGEL
CCCCHHHHHHHHHCCCCCCCEEEEECCEEECCCHHHHHCCCEEEECCCCCHHHHHCCCCC
LKDEEVLQNYCRNLNDYARSKKIDYVIGRDYELNRTIEILLRRRKNNPLYVGEPGVGKTT
CCHHHHHHHHHHCHHHHHHHCCCCEEECCCCCCHHHHHHHHHHCCCCCEEECCCCCCHHH
IVEGLVLKIIEGSVPSALRSSIIYALDLGSLLAGTRYRGDFEERIKSIIKVIEAKPGAIL
HHHHHHHHHHCCCCCHHHHHHHHHHEEHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEE
FIDEIHTIIGAGSTSGSFLDAGNLLKPALARGALRCIGATTYREYSNSFEKDKALARRFQ
EHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KINVKESSINDTVKILDGIKHYYERYHGVYYTKHAIKSAAELSHKYITGRILPDKAVDVI
HCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEECCHHHHHHH
DEAGAYCKLQKSRRKIINSRDIKSTIARITNVPCGFDDMQRVKSLKENLNRAIFGQEQAI
HHCCCCEEEHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHH
EFLVNSIKIAKSGLRSYNKPLAKYLFAGPTGVGKTELAKQLAQNMGMNLIRFDMSEYMEP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEECHHHHCCH
HTISRMIGSPPGYVGYDQGGLLTESVSNNQYSVVLLDEIEKAHSDIYNILLQIMDYGCVT
HHHHHHHCCCCCCCCCCCCCCEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCC
DTYGRKVNFSNTILIMTTNAGAFERNKSSIGFGYKNFNISDSEKAMERVFSPEFRNRLDA
CCCCCEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHH
VISFSDLDADVILHIVDKFIQELKKQLVQKGISCSVEEEVKSYLAQTGYSKEMGARPIER
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHCCCHHHHH
LIEKEIKSHLAEEILNRRLIKGKKLRIYIGKHGIAFDIV
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEECC
>Mature Secondary Structure
MISKNLEASLNRALQIASDCKLKYAKVEHLLLALTKDVDVNYVLSRCNIRAGEIINIDNI
CCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCEEECCCE
ILRNDRGNNAKGFLQDNSELTVNKVEPDVLFQRIIHKAMIRAHRLGRKEINGASILLEIL
EEECCCCCCCCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHH
SEQDLYIEELLCKQNAKDSNLIYNISNIKYSGDIEEYVTNRKIKLDKNNDISTVANKGEL
CCCCHHHHHHHHHCCCCCCCEEEEECCEEECCCHHHHHCCCEEEECCCCCHHHHHCCCCC
LKDEEVLQNYCRNLNDYARSKKIDYVIGRDYELNRTIEILLRRRKNNPLYVGEPGVGKTT
CCHHHHHHHHHHCHHHHHHHCCCCEEECCCCCCHHHHHHHHHHCCCCCEEECCCCCCHHH
IVEGLVLKIIEGSVPSALRSSIIYALDLGSLLAGTRYRGDFEERIKSIIKVIEAKPGAIL
HHHHHHHHHHCCCCCHHHHHHHHHHEEHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCEEE
FIDEIHTIIGAGSTSGSFLDAGNLLKPALARGALRCIGATTYREYSNSFEKDKALARRFQ
EHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KINVKESSINDTVKILDGIKHYYERYHGVYYTKHAIKSAAELSHKYITGRILPDKAVDVI
HCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHEEEECCHHHHHHH
DEAGAYCKLQKSRRKIINSRDIKSTIARITNVPCGFDDMQRVKSLKENLNRAIFGQEQAI
HHCCCCEEEHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCHHHHH
EFLVNSIKIAKSGLRSYNKPLAKYLFAGPTGVGKTELAKQLAQNMGMNLIRFDMSEYMEP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCEEEEECHHHHCCH
HTISRMIGSPPGYVGYDQGGLLTESVSNNQYSVVLLDEIEKAHSDIYNILLQIMDYGCVT
HHHHHHHCCCCCCCCCCCCCCEEECCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHCCCCC
DTYGRKVNFSNTILIMTTNAGAFERNKSSIGFGYKNFNISDSEKAMERVFSPEFRNRLDA
CCCCCEECCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCHHHHHHHHH
VISFSDLDADVILHIVDKFIQELKKQLVQKGISCSVEEEVKSYLAQTGYSKEMGARPIER
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHCCCHHHHH
LIEKEIKSHLAEEILNRRLIKGKKLRIYIGKHGIAFDIV
HHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6209404 [H]