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The map label for this gene is lolC [H]

Identifier: 190571458

GI number: 190571458

Start: 1141179

End: 1142408

Strand: Direct

Name: lolC [H]

Synonym: WPa_1072

Alternate gene names: 190571458

Gene position: 1141179-1142408 (Clockwise)

Preceding gene: 190571457

Following gene: 190571459

Centisome position: 76.98

GC content: 33.98

Gene sequence:

>1230_bases
ATGTCTATTGCCTTTGAATTTACTATGGCTATTCGCTATTTGCGAGCAAAGAATTCTAGATTTTGCTCTATAATGGCCTT
GTTTTCTATTATTGGTATTGCTCTTGGAGTTGCAACGCTAATAGTAGTAATGTCTGTAATGAATGGGTTCAGAGCAAAGC
TGCTCGACTCTGTACTTGGCATTAATGGTCATATTAATGTTTACTTTGATAGAAGCATAAATTCAGATTACCACGCAGTG
TTAAAATCTATTGAGAAAATCCCAGGTGTATTAAAAGCTACTTCTATGACCAATGATCAAGTGATCGTTGCAGCAAATAG
TGGAATTGTGGGTAGCGTAGTCCGTGGTGTGTCAACTAAAGACTTACTTAATAATACTATCGTTAAGAATAATGTAATTA
TGGGTAACGTGGAAAAATTCGATGAAGGTATCATAATAGGGGCAAGATTAGCAGAAGCTTTGAATATTGATTATGGTGAT
AACATTATGCTTATATCACCTGAAGGATTTGATGCACTGTCTGGTGAAATACCAAAAATGAAAGAATATAAAGTTGTAGC
AATATTTGATATGGGTATGTTTGAGTACGACAATACCTTAATGTATATGCCCATAAAGTCAGCTAAAGCTTTTTTTAATT
ATAAAGATAATGTGAGAAATATAGAAGTGTTTGTAGATGATATTGCTATGGCTAATAAGCTAGCAAACGCTATAGCAAAA
GAAACAGGAATGAGAGCTGAAAGTTGGCAGTCTCAGCAAAGCCATTATGTTAATGCTTTAAAGACTGAAAGAAATGTGAT
GTTTTTAATTCTCACTTTAATTATAGTTGTAGCAGCATTTAATATTGTTTCAAATTTGATGATGATAGTGCAAGAAAAGA
AATCTGCAATTGCAATTATGCGTACGTTTGGTGCAACAAGCGGAAGCATTATGCGCATATTTTGTGCTTGTGGATTGCTG
ATTGGTTTTACAGGAACTTGTCTTGGCTCTATTATAGGGGTTGTTTTTTCTCTCAATATTGAAAGTATTAGAGTGTTTTT
AGAAAACATTACCAACATCAAACTGTTTGATCCTATGATATACTTTTTTTCAAGTTTGCCAGTGATATTAGTCTCTCAAG
ATGTGATTAACATTTCTGCACTTGCATTGTTCTTATCATTTTTAGCGACAATTCCTCCTGCATTACAAGCAGCTGCTCAA
GATCCTGTGGAGATATTACGTTATGAATGA

Upstream 100 bases:

>100_bases
TATTCTATAAGCTTGCTAAATTTAGACAACCTCATTTGAGGTAAAGGAAAAATTACAGTTATATGAAGCATAAAAAGTAT
GATATTTAAATCTTAGTATA

Downstream 100 bases:

>100_bases
TACTTGGAGAAAATGCATAGGTTGGTTCTTAATTATATTGTTGTTTGTTAGCTATATTACAATAAATAACATAATATTTT
TTAAAATAAATCAGCAAGAG

Product: lipoprotein releasing system transmembrane protein lolc

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MSIAFEFTMAIRYLRAKNSRFCSIMALFSIIGIALGVATLIVVMSVMNGFRAKLLDSVLGINGHINVYFDRSINSDYHAV
LKSIEKIPGVLKATSMTNDQVIVAANSGIVGSVVRGVSTKDLLNNTIVKNNVIMGNVEKFDEGIIIGARLAEALNIDYGD
NIMLISPEGFDALSGEIPKMKEYKVVAIFDMGMFEYDNTLMYMPIKSAKAFFNYKDNVRNIEVFVDDIAMANKLANAIAK
ETGMRAESWQSQQSHYVNALKTERNVMFLILTLIIVVAAFNIVSNLMMIVQEKKSAIAIMRTFGATSGSIMRIFCACGLL
IGFTGTCLGSIIGVVFSLNIESIRVFLENITNIKLFDPMIYFFSSLPVILVSQDVINISALALFLSFLATIPPALQAAAQ
DPVEILRYE

Sequences:

>Translated_409_residues
MSIAFEFTMAIRYLRAKNSRFCSIMALFSIIGIALGVATLIVVMSVMNGFRAKLLDSVLGINGHINVYFDRSINSDYHAV
LKSIEKIPGVLKATSMTNDQVIVAANSGIVGSVVRGVSTKDLLNNTIVKNNVIMGNVEKFDEGIIIGARLAEALNIDYGD
NIMLISPEGFDALSGEIPKMKEYKVVAIFDMGMFEYDNTLMYMPIKSAKAFFNYKDNVRNIEVFVDDIAMANKLANAIAK
ETGMRAESWQSQQSHYVNALKTERNVMFLILTLIIVVAAFNIVSNLMMIVQEKKSAIAIMRTFGATSGSIMRIFCACGLL
IGFTGTCLGSIIGVVFSLNIESIRVFLENITNIKLFDPMIYFFSSLPVILVSQDVINISALALFLSFLATIPPALQAAAQ
DPVEILRYE
>Mature_408_residues
SIAFEFTMAIRYLRAKNSRFCSIMALFSIIGIALGVATLIVVMSVMNGFRAKLLDSVLGINGHINVYFDRSINSDYHAVL
KSIEKIPGVLKATSMTNDQVIVAANSGIVGSVVRGVSTKDLLNNTIVKNNVIMGNVEKFDEGIIIGARLAEALNIDYGDN
IMLISPEGFDALSGEIPKMKEYKVVAIFDMGMFEYDNTLMYMPIKSAKAFFNYKDNVRNIEVFVDDIAMANKLANAIAKE
TGMRAESWQSQQSHYVNALKTERNVMFLILTLIIVVAAFNIVSNLMMIVQEKKSAIAIMRTFGATSGSIMRIFCACGLLI
GFTGTCLGSIIGVVFSLNIESIRVFLENITNIKLFDPMIYFFSSLPVILVSQDVINISALALFLSFLATIPPALQAAAQD
PVEILRYE

Specific function: Part of an ATP-dependent transport system responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprotein) and

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=389, Percent_Identity=31.3624678663239, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1787360, Length=413, Percent_Identity=28.3292978208232, Blast_Score=154, Evalue=8e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 44972; Mature: 44840

Theoretical pI: Translated: 6.78; Mature: 6.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
5.1 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIAFEFTMAIRYLRAKNSRFCSIMALFSIIGIALGVATLIVVMSVMNGFRAKLLDSVLG
CCEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
INGHINVYFDRSINSDYHAVLKSIEKIPGVLKATSMTNDQVIVAANSGIVGSVVRGVSTK
CCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEEECCCCHHHHHHCCCHH
DLLNNTIVKNNVIMGNVEKFDEGIIIGARLAEALNIDYGDNIMLISPEGFDALSGEIPKM
HHHHCCCEECCEEECCHHHHCCCEEEHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCC
KEYKVVAIFDMGMFEYDNTLMYMPIKSAKAFFNYKDNVRNIEVFVDDIAMANKLANAIAK
CCEEEEEEEECCEEEECCEEEEEEEHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHH
ETGMRAESWQSQQSHYVNALKTERNVMFLILTLIIVVAAFNIVSNLMMIVQEKKSAIAIM
HHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTFGATSGSIMRIFCACGLLIGFTGTCLGSIIGVVFSLNIESIRVFLENITNIKLFDPMI
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHH
YFFSSLPVILVSQDVINISALALFLSFLATIPPALQAAAQDPVEILRYE
HHHCCCCEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHCCC
>Mature Secondary Structure 
SIAFEFTMAIRYLRAKNSRFCSIMALFSIIGIALGVATLIVVMSVMNGFRAKLLDSVLG
CEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
INGHINVYFDRSINSDYHAVLKSIEKIPGVLKATSMTNDQVIVAANSGIVGSVVRGVSTK
CCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEEECCCCHHHHHHCCCHH
DLLNNTIVKNNVIMGNVEKFDEGIIIGARLAEALNIDYGDNIMLISPEGFDALSGEIPKM
HHHHCCCEECCEEECCHHHHCCCEEEHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCC
KEYKVVAIFDMGMFEYDNTLMYMPIKSAKAFFNYKDNVRNIEVFVDDIAMANKLANAIAK
CCEEEEEEEECCEEEECCEEEEEEEHHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHHH
ETGMRAESWQSQQSHYVNALKTERNVMFLILTLIIVVAAFNIVSNLMMIVQEKKSAIAIM
HHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTFGATSGSIMRIFCACGLLIGFTGTCLGSIIGVVFSLNIESIRVFLENITNIKLFDPMI
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHH
YFFSSLPVILVSQDVINISALALFLSFLATIPPALQAAAQDPVEILRYE
HHHCCCCEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10761919 [H]