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The map label for this gene is birA [H]

Identifier: 190571390

GI number: 190571390

Start: 1066400

End: 1067236

Strand: Direct

Name: birA [H]

Synonym: WPa_0998

Alternate gene names: 190571390

Gene position: 1066400-1067236 (Clockwise)

Preceding gene: 190571389

Following gene: 190571391

Centisome position: 71.93

GC content: 35.01

Gene sequence:

>837_bases
GTGATCCTTGAAGGTTTTCGTATTTATCATTACAAAGAAGTTCCAAGTACTAATAAAGAAGCATTGGGTTTAATTGAGAA
AGGGATATCAAATGAAACTGTCATTATTGCTGATAAACAAACAGAAGGCAGGGGACGCACTGGAAAAAGCTGGATTTCTC
CAGAGGGTAATCTCTATGCGAGTTTGATAATTAACCAAGAAAAGGATGTCAGCAAATTGACAGAATTGACTTTTGTGACT
GCTCTTGCTGTTGGAAATACTTTATTATCGTTAAATTTCTTGAATAATCAAACCCACTGCGGTGTCATTCCAGTGCGTGA
CACTGGAATCCATACTTTTTCTTCTGGATCCCAGTGTCAAAGCACTGGGATGACAAGAGATCAATTCATAAACGATCTCA
ATCTTCAACATAAATGGCCAAATGACATTCTAATCGATGGCAAGAAAATAAGCGGAATATTGGTTGAAAAAAAATCCAAT
TCAAATTGGCTCATTATAGGAATTGGAATTAATGTCAATCATGCGCCACTTCCAGGCACAACGTGCATTAGCAATTACGG
TGAATCTGTGTCTAACATGGATCTGTTAAAGGAATTAATAATAAATTTTAATAAGCTAAGAAAGCAATGGCTATTTGATG
GGTTTTATGCTATAAGAGAAATGTGGTTAAAAAAAGCATTCAAAATGAATGAGCAAATCAGTGTAAAGTTAGCTGACAAA
TTGTATGAAGGAATTTTTGCTGATATAGATAAAAGTGGTAAATTGGTGTTGCAGCAAAAGGATGGAAGCTTAATTTATTT
TGATGCAGGTGAGTTATTTATTGGCAGTGCATTATGA

Upstream 100 bases:

>100_bases
AGTCTATTCATTATCACTTCAGTGGCTTCACTGATCAATCTCGTTCTTTTCTTGTATGTAGAAGATCTTGACTCACTCAT
TAAACTAAAGGGCTGACAAG

Downstream 100 bases:

>100_bases
ATACATATGTAATTTTTGCTTACCTTATTAGTTTCATACTGATTGGTGGAAATTTGATTTTTACCGTTTCTTGCTATACT
AAAAGTAAAAAAATTCTAGA

Product: biotin-[acetyl-coa-carboxylase] ligase

Products: NA

Alternate protein names: Biotin--protein ligase [H]

Number of amino acids: Translated: 278; Mature: 278

Protein sequence:

>278_residues
MILEGFRIYHYKEVPSTNKEALGLIEKGISNETVIIADKQTEGRGRTGKSWISPEGNLYASLIINQEKDVSKLTELTFVT
ALAVGNTLLSLNFLNNQTHCGVIPVRDTGIHTFSSGSQCQSTGMTRDQFINDLNLQHKWPNDILIDGKKISGILVEKKSN
SNWLIIGIGINVNHAPLPGTTCISNYGESVSNMDLLKELIINFNKLRKQWLFDGFYAIREMWLKKAFKMNEQISVKLADK
LYEGIFADIDKSGKLVLQQKDGSLIYFDAGELFIGSAL

Sequences:

>Translated_278_residues
MILEGFRIYHYKEVPSTNKEALGLIEKGISNETVIIADKQTEGRGRTGKSWISPEGNLYASLIINQEKDVSKLTELTFVT
ALAVGNTLLSLNFLNNQTHCGVIPVRDTGIHTFSSGSQCQSTGMTRDQFINDLNLQHKWPNDILIDGKKISGILVEKKSN
SNWLIIGIGINVNHAPLPGTTCISNYGESVSNMDLLKELIINFNKLRKQWLFDGFYAIREMWLKKAFKMNEQISVKLADK
LYEGIFADIDKSGKLVLQQKDGSLIYFDAGELFIGSAL
>Mature_278_residues
MILEGFRIYHYKEVPSTNKEALGLIEKGISNETVIIADKQTEGRGRTGKSWISPEGNLYASLIINQEKDVSKLTELTFVT
ALAVGNTLLSLNFLNNQTHCGVIPVRDTGIHTFSSGSQCQSTGMTRDQFINDLNLQHKWPNDILIDGKKISGILVEKKSN
SNWLIIGIGINVNHAPLPGTTCISNYGESVSNMDLLKELIINFNKLRKQWLFDGFYAIREMWLKKAFKMNEQISVKLADK
LYEGIFADIDKSGKLVLQQKDGSLIYFDAGELFIGSAL

Specific function: Activates biotin to form biotinyl-5'-adenylate and transfers the biotin moiety to biotin-accepting proteins [H]

COG id: COG0340

COG function: function code H; Biotin-(acetyl-CoA carboxylase) ligase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biotin--protein ligase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004408
- InterPro:   IPR003142
- InterPro:   IPR004143 [H]

Pfam domain/function: PF02237 BPL_C; PF03099 BPL_LipA_LipB [H]

EC number: =6.3.4.15 [H]

Molecular weight: Translated: 31048; Mature: 31048

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILEGFRIYHYKEVPSTNKEALGLIEKGISNETVIIADKQTEGRGRTGKSWISPEGNLYA
CEECCEEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEE
SLIINQEKDVSKLTELTFVTALAVGNTLLSLNFLNNQTHCGVIPVRDTGIHTFSSGSQCQ
EEEEECCHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCEEEEECCCCEECCCCCCHH
STGMTRDQFINDLNLQHKWPNDILIDGKKISGILVEKKSNSNWLIIGIGINVNHAPLPGT
HCCCCHHHHHHHCCCCCCCCCCEEEECCEEEEEEEEECCCCCEEEEEEEECCCCCCCCCH
TCISNYGESVSNMDLLKELIINFNKLRKQWLFDGFYAIREMWLKKAFKMNEQISVKLADK
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHH
LYEGIFADIDKSGKLVLQQKDGSLIYFDAGELFIGSAL
HHHHHHHCCCCCCCEEEEECCCCEEEEECCCEEEECCC
>Mature Secondary Structure
MILEGFRIYHYKEVPSTNKEALGLIEKGISNETVIIADKQTEGRGRTGKSWISPEGNLYA
CEECCEEEEEEECCCCCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEE
SLIINQEKDVSKLTELTFVTALAVGNTLLSLNFLNNQTHCGVIPVRDTGIHTFSSGSQCQ
EEEEECCHHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCEEEEECCCCEECCCCCCHH
STGMTRDQFINDLNLQHKWPNDILIDGKKISGILVEKKSNSNWLIIGIGINVNHAPLPGT
HCCCCHHHHHHHCCCCCCCCCCEEEECCEEEEEEEEECCCCCEEEEEEEECCCCCCCCCH
TCISNYGESVSNMDLLKELIINFNKLRKQWLFDGFYAIREMWLKKAFKMNEQISVKLADK
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHH
LYEGIFADIDKSGKLVLQQKDGSLIYFDAGELFIGSAL
HHHHHHHCCCCCCCEEEEECCCCEEEEECCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8422400 [H]