Click here to switch to the map view.

The map label for this gene is mdmC [H]

Identifier: 190571337

GI number: 190571337

Start: 1010048

End: 1010725

Strand: Reverse

Name: mdmC [H]

Synonym: WPa_0942

Alternate gene names: 190571337

Gene position: 1010725-1010048 (Counterclockwise)

Preceding gene: 190571339

Following gene: 190571334

Centisome position: 68.18

GC content: 30.38

Gene sequence:

>678_bases
ATGCGTCATAACTTTAGCAGAAAATCGTTGTACATAAGAAGCTTATTTGCAAAAGAGTATAAAAAAATAGAAGAACATTG
TACTCTTGATAAGAAACAACGTATTCAAATCACTCCTGAAGAAGGAAAATTATTAAATTTATTTATCAAAATCCATAAAG
TTAAAAGCATAGTTGAAATTGGCACTTTATATGGTTATTCGTCAATTTGTATGGTAAAAGCTTTACCGAAAGATGGTCAT
ATATATACAATAGAAAATAATCCTCAACACTCAAGAATAGCAAAAAAAAATTTTAGTGCTTTTAATCTAAGTGATAAAAT
TACTCTAATAGAAGGTGATGCACTGGAAAAAATTAATGAATTATCAGCAAAGGCACCATTTGACATGATATTCATCGATG
CTGACAAAAGTAGTTATCCTAAGTATTTAGATTGGGCAGAGTCATACATTAAACAAGATGGGCTAATCGTTGCAGATAAC
ACTCTATTATTTGATACAGTATTTTTAGAATCTCCTCCAAAAGAAGTATCAGAAAAGTCATGGCATGCTATGAGAGAGTT
TAACGATAGATTGTCAGATGAAAAAAAATATTTCTCCATATTGATTCCTACTGACGAAGGAATGACTGTAGCTTTAAAAC
TAACGCAAGTTAAAAATCAAGGTCAGCGTAATGTCTAG

Upstream 100 bases:

>100_bases
ATAACAACTTAAAATAAAAATTTTTATTATTCTTAACTCTATTGTTATATCTATAAATCTTATATAGATTAAACCTCCTT
AGTTTATATTATAAAACTTA

Downstream 100 bases:

>100_bases
GGGGAGTTAAGCCAAAAACTCTCTCTAATAATATTTCGCGAAAACAAGGCCTTGATTTAACAATGGAGTACCATTCTTTT
AAAATCTTACTTTTTTCCCA

Product: O-methyltransferase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MRHNFSRKSLYIRSLFAKEYKKIEEHCTLDKKQRIQITPEEGKLLNLFIKIHKVKSIVEIGTLYGYSSICMVKALPKDGH
IYTIENNPQHSRIAKKNFSAFNLSDKITLIEGDALEKINELSAKAPFDMIFIDADKSSYPKYLDWAESYIKQDGLIVADN
TLLFDTVFLESPPKEVSEKSWHAMREFNDRLSDEKKYFSILIPTDEGMTVALKLTQVKNQGQRNV

Sequences:

>Translated_225_residues
MRHNFSRKSLYIRSLFAKEYKKIEEHCTLDKKQRIQITPEEGKLLNLFIKIHKVKSIVEIGTLYGYSSICMVKALPKDGH
IYTIENNPQHSRIAKKNFSAFNLSDKITLIEGDALEKINELSAKAPFDMIFIDADKSSYPKYLDWAESYIKQDGLIVADN
TLLFDTVFLESPPKEVSEKSWHAMREFNDRLSDEKKYFSILIPTDEGMTVALKLTQVKNQGQRNV
>Mature_225_residues
MRHNFSRKSLYIRSLFAKEYKKIEEHCTLDKKQRIQITPEEGKLLNLFIKIHKVKSIVEIGTLYGYSSICMVKALPKDGH
IYTIENNPQHSRIAKKNFSAFNLSDKITLIEGDALEKINELSAKAPFDMIFIDADKSSYPKYLDWAESYIKQDGLIVADN
TLLFDTVFLESPPKEVSEKSWHAMREFNDRLSDEKKYFSILIPTDEGMTVALKLTQVKNQGQRNV

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI31542747, Length=181, Percent_Identity=27.0718232044199, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI25148771, Length=178, Percent_Identity=29.7752808988764, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI72001127, Length=187, Percent_Identity=29.4117647058824, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17565612, Length=174, Percent_Identity=29.3103448275862, Blast_Score=78, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI72001028, Length=188, Percent_Identity=30.8510638297872, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 26013; Mature: 26013

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHNFSRKSLYIRSLFAKEYKKIEEHCTLDKKQRIQITPEEGKLLNLFIKIHKVKSIVEI
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEHHHHHHHHHHHHHH
GTLYGYSSICMVKALPKDGHIYTIENNPQHSRIAKKNFSAFNLSDKITLIEGDALEKINE
HHHHCCCCEEEEEECCCCCCEEEECCCCCHHHHHHCCCCEECCCCEEEEEECHHHHHHHH
LSAKAPFDMIFIDADKSSYPKYLDWAESYIKQDGLIVADNTLLFDTVFLESPPKEVSEKS
HHCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCEEEECCEEEEEEEECCCCCHHHHHHH
WHAMREFNDRLSDEKKYFSILIPTDEGMTVALKLTQVKNQGQRNV
HHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEEEEHHCCCCCCC
>Mature Secondary Structure
MRHNFSRKSLYIRSLFAKEYKKIEEHCTLDKKQRIQITPEEGKLLNLFIKIHKVKSIVEI
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCEEEHHHHHHHHHHHHHH
GTLYGYSSICMVKALPKDGHIYTIENNPQHSRIAKKNFSAFNLSDKITLIEGDALEKINE
HHHHCCCCEEEEEECCCCCCEEEECCCCCHHHHHHCCCCEECCCCEEEEEECHHHHHHHH
LSAKAPFDMIFIDADKSSYPKYLDWAESYIKQDGLIVADNTLLFDTVFLESPPKEVSEKS
HHCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCEEEECCEEEEEEEECCCCCHHHHHHH
WHAMREFNDRLSDEKKYFSILIPTDEGMTVALKLTQVKNQGQRNV
HHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEEEEHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]