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The map label for this gene is dnaX [H]

Identifier: 190571334

GI number: 190571334

Start: 1007289

End: 1008872

Strand: Reverse

Name: dnaX [H]

Synonym: WPa_0939

Alternate gene names: 190571334

Gene position: 1008872-1007289 (Counterclockwise)

Preceding gene: 190571337

Following gene: 190571333

Centisome position: 68.05

GC content: 33.33

Gene sequence:

>1584_bases
ATGAACATAGCATTAAAATATCGTCCTAGTAGCTTTAAAGATTTAGTAGGTCAAGATATATTGGTGCGTATACTAGAAAA
TGCTTTTACTCTCAACAAAATTCCACAATCTATACTGCTTTCTGGTAGCAGTGGAATTGGTAAAACCACCACTGCAAGAA
TAATAGCTTTATGTTTGAACTGCTCATTGGGGCCAACTTTTGAACCTTGTGGATCATGTACAAGTTGTCTGGCAATAAAA
AATTCAAGCCATCCAGATGTAGTTGAAATCGATGCGGCAAGTCACACTAGTGTTGAGGATGTTAGAGCGATCTTGGGAGA
TATTTGCTATTTACCAATAAGTTCTAAATTTAAAGTTTACATTATAGATGAAGTACACATGTTATCCAGTAATGCATTTA
ATGCATTACTTAAAACTCTAGAAGAACCACCATCTAGCGTAAAGTTTATTCTAGCAACTACAGAAATAAAAAAGATACCA
ATAACTGTTATTGCACGTTGTCAAAGGTTTGACTTACATAACATTCCTTCAGCTAAGATAATGGAGCGTTTAAATGATAT
TGCACAAAAAGAAAATTATTTTATTGAAAAAGAAGCATCGGAATTAATTGCTCACCACTGTAGCAATTCAATGCGTAACG
CTTTATTTTTGATGAATCAAGCATTGCTATATAGCAAAGATGGTACAATATCCACTCAAAGTGTTACAGACATACTTGGT
CTAGTAGATAGAAACGTTATATTTGATCTACTGGAAGCAGTATTAGATAGTGATTTACAGAAGGCTTTGTTAGTATTCGA
CAATGTGGTAAAAACAGCAAATCCGCTCAATATTTTTGAAGATCTGCTGCAAACAATCCAGTTAATATGCCGTTTTTTAA
TTACAAAAGAGATTGATACAGAATATGAGAAGAGCAGAGTAAAAGATTTGAGTGCAAAAAAGTCTTTAATATTTTTTTCG
AGATTGTGGAAGGTGCTGCTTAAGGGTATTCAAGATATAAAAATTTCAACATGCAATGAGGTTGCTGCTGAAATGATGTT
AATTAGCCTTTGTTATCTTTCTGATTTGCCTTCTCCGGAACAGGTGATCAAAAAAATTCTTTCACAGAATGTAGAGCAAG
GAAATAGACAGGGCAGACCTGTTGCACCTTCCCCCTCTGTCATCCAAGTAACTGACTACTCGGATCCAAAAAAATATGTG
GAAAAACCCCACTCTGTCATCCCAGTGCGTGACACTGGGATCCATGTGAAAAATAAACAACAAAATTACGATTTTGATAA
GATTTTGCAACTATTAAGGCGGAGTAACCAAATTTATCTTTACAAACAACTGTGTAGTAATCTAAAATTAATAGATTGTA
AATTTGGGTATTTAAAATTAAAAGCTGTATCTAACTTGAACAGTAATTTTTGTAATGACTTGAAAAGTTACTTAAATCAA
GCTACTAATCAGGAGTGGGTTATTATAGTTGATACGAGTTATATGAATAGGGAAGTGAGTAATTTAAATTATGCACCTGT
AGTTAAGGATATATTAAATACGTTTAAAGGTGCAAAGGTAGTTAATATAGAAAATAAGGAGTAG

Upstream 100 bases:

>100_bases
GGCAAAAATTCTGTAACTTGGTCAGGTCAGAAATGAAGCAACCATATCAGAATCTTTTTGGGTTGCATACCTATTTGTAC
TATTTGTTTTATTCTAGGCT

Downstream 100 bases:

>100_bases
GTTGTGGATTTCAGTCAAATAATGAAGCAAGCGCAAGAAATGCAAAAAAAGCTTGCGGAAGCCCAAGAAAAATATATTGG
AAAAGAGTTTCAAGGTATTT

Product: DNA polymerase III, gamma and tau subunits

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MNIALKYRPSSFKDLVGQDILVRILENAFTLNKIPQSILLSGSSGIGKTTTARIIALCLNCSLGPTFEPCGSCTSCLAIK
NSSHPDVVEIDAASHTSVEDVRAILGDICYLPISSKFKVYIIDEVHMLSSNAFNALLKTLEEPPSSVKFILATTEIKKIP
ITVIARCQRFDLHNIPSAKIMERLNDIAQKENYFIEKEASELIAHHCSNSMRNALFLMNQALLYSKDGTISTQSVTDILG
LVDRNVIFDLLEAVLDSDLQKALLVFDNVVKTANPLNIFEDLLQTIQLICRFLITKEIDTEYEKSRVKDLSAKKSLIFFS
RLWKVLLKGIQDIKISTCNEVAAEMMLISLCYLSDLPSPEQVIKKILSQNVEQGNRQGRPVAPSPSVIQVTDYSDPKKYV
EKPHSVIPVRDTGIHVKNKQQNYDFDKILQLLRRSNQIYLYKQLCSNLKLIDCKFGYLKLKAVSNLNSNFCNDLKSYLNQ
ATNQEWVIIVDTSYMNREVSNLNYAPVVKDILNTFKGAKVVNIENKE

Sequences:

>Translated_527_residues
MNIALKYRPSSFKDLVGQDILVRILENAFTLNKIPQSILLSGSSGIGKTTTARIIALCLNCSLGPTFEPCGSCTSCLAIK
NSSHPDVVEIDAASHTSVEDVRAILGDICYLPISSKFKVYIIDEVHMLSSNAFNALLKTLEEPPSSVKFILATTEIKKIP
ITVIARCQRFDLHNIPSAKIMERLNDIAQKENYFIEKEASELIAHHCSNSMRNALFLMNQALLYSKDGTISTQSVTDILG
LVDRNVIFDLLEAVLDSDLQKALLVFDNVVKTANPLNIFEDLLQTIQLICRFLITKEIDTEYEKSRVKDLSAKKSLIFFS
RLWKVLLKGIQDIKISTCNEVAAEMMLISLCYLSDLPSPEQVIKKILSQNVEQGNRQGRPVAPSPSVIQVTDYSDPKKYV
EKPHSVIPVRDTGIHVKNKQQNYDFDKILQLLRRSNQIYLYKQLCSNLKLIDCKFGYLKLKAVSNLNSNFCNDLKSYLNQ
ATNQEWVIIVDTSYMNREVSNLNYAPVVKDILNTFKGAKVVNIENKE
>Mature_527_residues
MNIALKYRPSSFKDLVGQDILVRILENAFTLNKIPQSILLSGSSGIGKTTTARIIALCLNCSLGPTFEPCGSCTSCLAIK
NSSHPDVVEIDAASHTSVEDVRAILGDICYLPISSKFKVYIIDEVHMLSSNAFNALLKTLEEPPSSVKFILATTEIKKIP
ITVIARCQRFDLHNIPSAKIMERLNDIAQKENYFIEKEASELIAHHCSNSMRNALFLMNQALLYSKDGTISTQSVTDILG
LVDRNVIFDLLEAVLDSDLQKALLVFDNVVKTANPLNIFEDLLQTIQLICRFLITKEIDTEYEKSRVKDLSAKKSLIFFS
RLWKVLLKGIQDIKISTCNEVAAEMMLISLCYLSDLPSPEQVIKKILSQNVEQGNRQGRPVAPSPSVIQVTDYSDPKKYV
EKPHSVIPVRDTGIHVKNKQQNYDFDKILQLLRRSNQIYLYKQLCSNLKLIDCKFGYLKLKAVSNLNSNFCNDLKSYLNQ
ATNQEWVIIVDTSYMNREVSNLNYAPVVKDILNTFKGAKVVNIENKE

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=270, Percent_Identity=25.1851851851852, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI31881687, Length=270, Percent_Identity=25.1851851851852, Blast_Score=80, Evalue=6e-15,
Organism=Homo sapiens, GI194306571, Length=317, Percent_Identity=24.9211356466877, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI194306567, Length=317, Percent_Identity=24.9211356466877, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI6677723, Length=317, Percent_Identity=24.9211356466877, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI31563534, Length=304, Percent_Identity=23.0263157894737, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1786676, Length=370, Percent_Identity=35.6756756756757, Blast_Score=245, Evalue=7e-66,
Organism=Caenorhabditis elegans, GI17554730, Length=288, Percent_Identity=20.8333333333333, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322528, Length=285, Percent_Identity=23.1578947368421, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6324039, Length=317, Percent_Identity=24.2902208201893, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI18859927, Length=266, Percent_Identity=24.0601503759398, Blast_Score=76, Evalue=7e-14,
Organism=Drosophila melanogaster, GI17647857, Length=292, Percent_Identity=23.2876712328767, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 59298; Mature: 59298

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIALKYRPSSFKDLVGQDILVRILENAFTLNKIPQSILLSGSSGIGKTTTARIIALCLN
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCCCCCCHHHHHHHHHHHC
CSLGPTFEPCGSCTSCLAIKNSSHPDVVEIDAASHTSVEDVRAILGDICYLPISSKFKVY
CCCCCCCCCCCCHHHHHEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEEE
IIDEVHMLSSNAFNALLKTLEEPPSSVKFILATTEIKKIPITVIARCQRFDLHNIPSAKI
EEECHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHCCHHHHHHHHHCCCCCCCHHHH
MERLNDIAQKENYFIEKEASELIAHHCSNSMRNALFLMNQALLYSKDGTISTQSVTDILG
HHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHH
LVDRNVIFDLLEAVLDSDLQKALLVFDNVVKTANPLNIFEDLLQTIQLICRFLITKEIDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCH
EYEKSRVKDLSAKKSLIFFSRLWKVLLKGIQDIKISTCNEVAAEMMLISLCYLSDLPSPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHH
QVIKKILSQNVEQGNRQGRPVAPSPSVIQVTDYSDPKKYVEKPHSVIPVRDTGIHVKNKQ
HHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHCCCCCEEEEECCCEEECCCC
QNYDFDKILQLLRRSNQIYLYKQLCSNLKLIDCKFGYLKLKAVSNLNSNFCNDLKSYLNQ
CCCCHHHHHHHHHCCCCEEEHHHHHCCCEEEEECCCEEEEEEHHCCCHHHHHHHHHHHHH
ATNQEWVIIVDTSYMNREVSNLNYAPVVKDILNTFKGAKVVNIENKE
CCCCCEEEEEECHHHHHHHCCCCCHHHHHHHHHHHCCCEEEECCCCC
>Mature Secondary Structure
MNIALKYRPSSFKDLVGQDILVRILENAFTLNKIPQSILLSGSSGIGKTTTARIIALCLN
CCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHEECCCCCCCCHHHHHHHHHHHC
CSLGPTFEPCGSCTSCLAIKNSSHPDVVEIDAASHTSVEDVRAILGDICYLPISSKFKVY
CCCCCCCCCCCCHHHHHEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCCCCEEEE
IIDEVHMLSSNAFNALLKTLEEPPSSVKFILATTEIKKIPITVIARCQRFDLHNIPSAKI
EEECHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCHHHCCHHHHHHHHHCCCCCCCHHHH
MERLNDIAQKENYFIEKEASELIAHHCSNSMRNALFLMNQALLYSKDGTISTQSVTDILG
HHHHHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHH
LVDRNVIFDLLEAVLDSDLQKALLVFDNVVKTANPLNIFEDLLQTIQLICRFLITKEIDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCH
EYEKSRVKDLSAKKSLIFFSRLWKVLLKGIQDIKISTCNEVAAEMMLISLCYLSDLPSPE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHH
QVIKKILSQNVEQGNRQGRPVAPSPSVIQVTDYSDPKKYVEKPHSVIPVRDTGIHVKNKQ
HHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCHHHHHCCCCCEEEEECCCEEECCCC
QNYDFDKILQLLRRSNQIYLYKQLCSNLKLIDCKFGYLKLKAVSNLNSNFCNDLKSYLNQ
CCCCHHHHHHHHHCCCCEEEHHHHHCCCEEEEECCCEEEEEEHHCCCHHHHHHHHHHHHH
ATNQEWVIIVDTSYMNREVSNLNYAPVVKDILNTFKGAKVVNIENKE
CCCCCEEEEEECHHHHHHHCCCCCHHHHHHHHHHHCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12089438 [H]