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The map label for this gene is hisS [H]

Identifier: 190571128

GI number: 190571128

Start: 792002

End: 793225

Strand: Reverse

Name: hisS [H]

Synonym: WPa_0726

Alternate gene names: 190571128

Gene position: 793225-792002 (Counterclockwise)

Preceding gene: 190571129

Following gene: 190571125

Centisome position: 53.51

GC content: 34.64

Gene sequence:

>1224_bases
ATGACTAATCAAACAGTTAGAGGAACAAAAGATCTCCTGTTTGATGAATGGTACAAGTTTAAACACATAGAGCAAACAGC
AAGCAGAATCTCAAGTTTATACGGCTTTTTACCTGTTCAAACTCCGATATTTGAATACACAGAAGTCTTTACAAAGACTT
TAGGTGATAGCTCAGATATTATCACTAAAGAGATGTATACTTTTATTGATAAAGGGGGAAAGAGCATAACTCTGCGTCCT
GAGTTCACTGCAGCTATTGTTAGGTTACTCATTGAAAAAAAACTACAAGCGCCGATAAAATTATTTTCAATAGGGCCTGC
ATTTCGCTATGAAAGACCGCAAAAGGGAAGACAAAGGCAATTTCATCAGATAAATTTTGAGGTTTTTGGCATAGAAGATC
CAAAAGCTGATATTGAATTGATATCACTCGCTCAGCACTTACTAACTGAATTTGGCATCAATAAAAATGTAAAGCTGGAA
ATCAACTCTCTGGGTGATAGTGAAACAATAACTCAGTATAGAGAAGCTTTGATATCGTATTTAAAAAAGTTTCAAAATGA
CCTATCAGAAGATAGTCAAAATAGATTGATTAAAAACCCACTCAGAATATTAGACTCTAAGGATAAGACAGATAAAGAAA
TAATCTCTGACGCACCAAAAATCAGTGATTATTATACAAAAGAATCTTCATATTTCTTTGACCAGGTGTTAAATGGACTG
CAAGCTCTTGGCATACCTTACACTGTAAATAGCAAATTAGTTCGAGGTCTAGACTATTATTGTCACACAGTATTTGAATT
TGTCACAGAAGATTTAGGTGCACAAGGAGCAGTTTTTGCCGGTGGAAGATACGATAATCTAGTATCTTCAGTAGGTGGAA
AACACACTCCAGCAATAGGATTTGCAGGGGGGATTGAGCGTATAATGGAATTAATCAACTATGCTGAAAAAAAAGAGAGG
CCTATTTATATAATTCCAATCGGTGGAGAAGCTGAAGAACATGCTCTAACACTTGCAAGTGAATTACGCAGAAATGGTTT
ATATGTGATTTACGAATATAGTGGAACTCTAAAAACCCGAATGAAAAAAGCAAATCAAGCAAATGCAAAAGTTGTATTAA
TCTTTGGTGATGAAGAGCTAAGCAGTAAAACTTTAAAAATTAAAAATATGGACACGGGTGAAGAAAAAATGATTGCTCGC
GATAAAACCGTAGAAAATATCTAA

Upstream 100 bases:

>100_bases
CTTGCTCTGGGTGCCCAAGTGCTGCAATTACCTTAAAACAAGGAGTGCAGAATATGCTAAGCTATCACATACCAGAAGTT
TCAGGTATAGAGACTATGCT

Downstream 100 bases:

>100_bases
TCAGAAGCAATAGGAGTGTTAGCTATAGAAGAAAATTCCTCTGCACAAGAATTTTTCATAGCATTTAATATATCATAATC
TGTAAAATCTAATTTTATCG

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS [H]

Number of amino acids: Translated: 407; Mature: 406

Protein sequence:

>407_residues
MTNQTVRGTKDLLFDEWYKFKHIEQTASRISSLYGFLPVQTPIFEYTEVFTKTLGDSSDIITKEMYTFIDKGGKSITLRP
EFTAAIVRLLIEKKLQAPIKLFSIGPAFRYERPQKGRQRQFHQINFEVFGIEDPKADIELISLAQHLLTEFGINKNVKLE
INSLGDSETITQYREALISYLKKFQNDLSEDSQNRLIKNPLRILDSKDKTDKEIISDAPKISDYYTKESSYFFDQVLNGL
QALGIPYTVNSKLVRGLDYYCHTVFEFVTEDLGAQGAVFAGGRYDNLVSSVGGKHTPAIGFAGGIERIMELINYAEKKER
PIYIIPIGGEAEEHALTLASELRRNGLYVIYEYSGTLKTRMKKANQANAKVVLIFGDEELSSKTLKIKNMDTGEEKMIAR
DKTVENI

Sequences:

>Translated_407_residues
MTNQTVRGTKDLLFDEWYKFKHIEQTASRISSLYGFLPVQTPIFEYTEVFTKTLGDSSDIITKEMYTFIDKGGKSITLRP
EFTAAIVRLLIEKKLQAPIKLFSIGPAFRYERPQKGRQRQFHQINFEVFGIEDPKADIELISLAQHLLTEFGINKNVKLE
INSLGDSETITQYREALISYLKKFQNDLSEDSQNRLIKNPLRILDSKDKTDKEIISDAPKISDYYTKESSYFFDQVLNGL
QALGIPYTVNSKLVRGLDYYCHTVFEFVTEDLGAQGAVFAGGRYDNLVSSVGGKHTPAIGFAGGIERIMELINYAEKKER
PIYIIPIGGEAEEHALTLASELRRNGLYVIYEYSGTLKTRMKKANQANAKVVLIFGDEELSSKTLKIKNMDTGEEKMIAR
DKTVENI
>Mature_406_residues
TNQTVRGTKDLLFDEWYKFKHIEQTASRISSLYGFLPVQTPIFEYTEVFTKTLGDSSDIITKEMYTFIDKGGKSITLRPE
FTAAIVRLLIEKKLQAPIKLFSIGPAFRYERPQKGRQRQFHQINFEVFGIEDPKADIELISLAQHLLTEFGINKNVKLEI
NSLGDSETITQYREALISYLKKFQNDLSEDSQNRLIKNPLRILDSKDKTDKEIISDAPKISDYYTKESSYFFDQVLNGLQ
ALGIPYTVNSKLVRGLDYYCHTVFEFVTEDLGAQGAVFAGGRYDNLVSSVGGKHTPAIGFAGGIERIMELINYAEKKERP
IYIIPIGGEAEEHALTLASELRRNGLYVIYEYSGTLKTRMKKANQANAKVVLIFGDEELSSKTLKIKNMDTGEEKMIARD
KTVENI

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI6996014, Length=461, Percent_Identity=25.8134490238612, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI15029520, Length=452, Percent_Identity=24.3362831858407, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI1788861, Length=414, Percent_Identity=41.5458937198068, Blast_Score=338, Evalue=4e-94,
Organism=Saccharomyces cerevisiae, GI6325290, Length=461, Percent_Identity=26.4642082429501, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24643061, Length=464, Percent_Identity=23.4913793103448, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.21 [H]

Molecular weight: Translated: 46260; Mature: 46129

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNQTVRGTKDLLFDEWYKFKHIEQTASRISSLYGFLPVQTPIFEYTEVFTKTLGDSSDI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHH
ITKEMYTFIDKGGKSITLRPEFTAAIVRLLIEKKLQAPIKLFSIGPAFRYERPQKGRQRQ
HHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCEEEEECCCHHCCCCCCCHHHHH
FHQINFEVFGIEDPKADIELISLAQHLLTEFGINKNVKLEINSLGDSETITQYREALISY
HHEECEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHH
LKKFQNDLSEDSQNRLIKNPLRILDSKDKTDKEIISDAPKISDYYTKESSYFFDQVLNGL
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHCCCCHHHHHHHHHHH
QALGIPYTVNSKLVRGLDYYCHTVFEFVTEDLGAQGAVFAGGRYDNLVSSVGGKHTPAIG
HHCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCCCCCCC
FAGGIERIMELINYAEKKERPIYIIPIGGEAEEHALTLASELRRNGLYVIYEYSGTLKTR
CHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCEEEEEEECCHHHHH
MKKANQANAKVVLIFGDEELSSKTLKIKNMDTGEEKMIARDKTVENI
HHHCCCCCCEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TNQTVRGTKDLLFDEWYKFKHIEQTASRISSLYGFLPVQTPIFEYTEVFTKTLGDSSDI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCHH
ITKEMYTFIDKGGKSITLRPEFTAAIVRLLIEKKLQAPIKLFSIGPAFRYERPQKGRQRQ
HHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCEEEEECCCHHCCCCCCCHHHHH
FHQINFEVFGIEDPKADIELISLAQHLLTEFGINKNVKLEINSLGDSETITQYREALISY
HHEECEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHH
LKKFQNDLSEDSQNRLIKNPLRILDSKDKTDKEIISDAPKISDYYTKESSYFFDQVLNGL
HHHHHHHHCCCHHHHHHHHHHHHHCCCCCCHHHHHHCCCCCHHHHCCCCHHHHHHHHHHH
QALGIPYTVNSKLVRGLDYYCHTVFEFVTEDLGAQGAVFAGGRYDNLVSSVGGKHTPAIG
HHCCCCEECCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHCCCCCCCCCC
FAGGIERIMELINYAEKKERPIYIIPIGGEAEEHALTLASELRRNGLYVIYEYSGTLKTR
CHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCEEEEEEECCHHHHH
MKKANQANAKVVLIFGDEELSSKTLKIKNMDTGEEKMIARDKTVENI
HHHCCCCCCEEEEEECCCCCCCCEEEEECCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA