Click here to switch to the map view.

The map label for this gene is sdhA [H]

Identifier: 190571086

GI number: 190571086

Start: 750239

End: 752038

Strand: Reverse

Name: sdhA [H]

Synonym: WPa_0681

Alternate gene names: 190571086

Gene position: 752038-750239 (Counterclockwise)

Preceding gene: 190571087

Following gene: 190571076

Centisome position: 50.73

GC content: 41.5

Gene sequence:

>1800_bases
ATGGATAAGTCAGCGTATGAAATCATAGAGCATGAGTATGATGTGGTGATAGTAGGTGCAGGTGGAGCAGGGCTTAGAGC
AACACTTGGAATGGCTGCAACTAATTTTTCAGTTGCCTGTATTTCTAAGATTTTCCCTACACGGAGTCATACAGTTGCAG
CACAAGGCGGAATTAGTGCAGCCTTGAGCAACATTGCTGAAGATGATTGGCGCTGGCATGCGTATGACACAATAAAAGGT
TCAGACTGGCTTGGCGATCAAGATGCAATAGAGTATATGTGTAAAAATGCTGCCAAAGCTGTGATTGAACTTGAAAATTT
TGGTGTACCCTTTTCTCGTACGGAAGATGGAAAAATATATCAGCGTGCCTTTGGTGGAATGACAACTCACTTTGGTAAAG
GAAAATCGGCTCAGCGTACTTGTGCAGCAGCAGATAAAACTGGGCATGCAATTCTTCATACTCTATATCAGCAATGTCTT
AAATTTAACGCTGAATTTTTTGTCGAATATTTTGTAATCGATTTGATTATGGACAAAGGGACATGCTGTGGGGTGATAGC
TTGGTCGCTGTGTGATGGTACGTTGCATAGATTTCGTGCACATTTTGTGGTAATAGCAACAGGTGGTTATGGACGTGTTT
ATTTTTCTGCAACAAGTGCACACACCTGCACAGGTGATGGTAATGGCATGGTGGTAAGAGCTGGGTTGCCACTTGAAGAT
ATGGAGTTTGTGCAATTTCATCCAACAGGAATATATGGCTCAGGGTGCTTGATGACGGAAGGATGCCGCGGTGAAGGTGG
GTACCTCGTTAATTCTCAGGGTGAGAAGTTTATGGAACGTTATGCGCCAAAGGCAAAAGATTTGGCTTCTCGTGATGTAG
TAAGTCGAGCAATGACAATTGAAATTAGAGAGGGAAGGGGAGTTGGGCCAAAGAAAGATCACATGTACTTGAATATATCG
CATCTTGATCCGGAAGTAATAAAGCTCAGATTGCCAGGTATTAGTGAAACAGCAAAGACCTTTGCAGGAGTTGATGTTAC
TAAAGATCCGATACCTGTTATTCCAACTGTTCACTACAACATGGGCGGTATTCCAACCAACTATCATGGGGAAGTGATCA
CGTTGCAAAAAGGTAAAGAAGAAGTGGTAGAAGGATTATTTGCAATAGGAGAGGCAGCATGTGTTTCTGTACATGGTGCA
AATCGACTAGGTTCCAACTCGCTTCTTGATCTTGTGGTTTTTGGTAGAGCTGCCGCGCTTAGGGCAAAAGAAAAATTGAA
ACCTGATACACCACATAAAAAATTGCATTCAGACTGCACAGACTGGATAGTAGATAGATTTAATAAAATGAGATTTGCTT
CCGGAGAGTTCAAAGTAGCAAAAATACGAAGTGAAATGCAGCACACTATGCAGAAATATGCATCGGTATTCCGTGTTGCT
GAAGTTTTAGAGGAAGGTAAAAAAGCTATAAAAGAAGTAGCAAAAATGATGCCTAACATTGCAGTTGAAGATCGTAGTAT
GATATGGAATAGTGATTTGGTTGAAGCTCTGGAGCTTGCCAATATGATTCCACAAGCAGTTATTACCATGGAATGCGCAG
CTAATCGCGAGGAAAGCAGGGGTGCTCATGCTCGTGAAGATTTCCCTGAACGTGATGATAAAAACTGGATGAAGCATACT
ATAGCATGGCTTAAAGAAGAGAAAAGCCAAGTTAGTGTAGAAATTGACTATAAAAAAGTTGCTGAAAAAACTCTGAGCGA
TGAGATTGATTTCATCGCCCCGGAAAAGAGAATTTATTAG

Upstream 100 bases:

>100_bases
TTTACTATAGATTTGTTTCAGAAGCTTACATCCAGAAAACTTGTATAGATTTTTTCTACTTCTGTGATATTATAAGCCTG
TGATGATAAAATAAGTGGAT

Downstream 100 bases:

>100_bases
TTAACCCATCTGGTTTATTTATAAATTGACGTAGTATTGATACATAGCTCATTTGAGTAGCTGGGCTTTCTGTATGCTCC
GATTGATTTGACGATCTTTG

Product: succinate dehydrogenase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 599; Mature: 599

Protein sequence:

>599_residues
MDKSAYEIIEHEYDVVIVGAGGAGLRATLGMAATNFSVACISKIFPTRSHTVAAQGGISAALSNIAEDDWRWHAYDTIKG
SDWLGDQDAIEYMCKNAAKAVIELENFGVPFSRTEDGKIYQRAFGGMTTHFGKGKSAQRTCAAADKTGHAILHTLYQQCL
KFNAEFFVEYFVIDLIMDKGTCCGVIAWSLCDGTLHRFRAHFVVIATGGYGRVYFSATSAHTCTGDGNGMVVRAGLPLED
MEFVQFHPTGIYGSGCLMTEGCRGEGGYLVNSQGEKFMERYAPKAKDLASRDVVSRAMTIEIREGRGVGPKKDHMYLNIS
HLDPEVIKLRLPGISETAKTFAGVDVTKDPIPVIPTVHYNMGGIPTNYHGEVITLQKGKEEVVEGLFAIGEAACVSVHGA
NRLGSNSLLDLVVFGRAAALRAKEKLKPDTPHKKLHSDCTDWIVDRFNKMRFASGEFKVAKIRSEMQHTMQKYASVFRVA
EVLEEGKKAIKEVAKMMPNIAVEDRSMIWNSDLVEALELANMIPQAVITMECAANREESRGAHAREDFPERDDKNWMKHT
IAWLKEEKSQVSVEIDYKKVAEKTLSDEIDFIAPEKRIY

Sequences:

>Translated_599_residues
MDKSAYEIIEHEYDVVIVGAGGAGLRATLGMAATNFSVACISKIFPTRSHTVAAQGGISAALSNIAEDDWRWHAYDTIKG
SDWLGDQDAIEYMCKNAAKAVIELENFGVPFSRTEDGKIYQRAFGGMTTHFGKGKSAQRTCAAADKTGHAILHTLYQQCL
KFNAEFFVEYFVIDLIMDKGTCCGVIAWSLCDGTLHRFRAHFVVIATGGYGRVYFSATSAHTCTGDGNGMVVRAGLPLED
MEFVQFHPTGIYGSGCLMTEGCRGEGGYLVNSQGEKFMERYAPKAKDLASRDVVSRAMTIEIREGRGVGPKKDHMYLNIS
HLDPEVIKLRLPGISETAKTFAGVDVTKDPIPVIPTVHYNMGGIPTNYHGEVITLQKGKEEVVEGLFAIGEAACVSVHGA
NRLGSNSLLDLVVFGRAAALRAKEKLKPDTPHKKLHSDCTDWIVDRFNKMRFASGEFKVAKIRSEMQHTMQKYASVFRVA
EVLEEGKKAIKEVAKMMPNIAVEDRSMIWNSDLVEALELANMIPQAVITMECAANREESRGAHAREDFPERDDKNWMKHT
IAWLKEEKSQVSVEIDYKKVAEKTLSDEIDFIAPEKRIY
>Mature_599_residues
MDKSAYEIIEHEYDVVIVGAGGAGLRATLGMAATNFSVACISKIFPTRSHTVAAQGGISAALSNIAEDDWRWHAYDTIKG
SDWLGDQDAIEYMCKNAAKAVIELENFGVPFSRTEDGKIYQRAFGGMTTHFGKGKSAQRTCAAADKTGHAILHTLYQQCL
KFNAEFFVEYFVIDLIMDKGTCCGVIAWSLCDGTLHRFRAHFVVIATGGYGRVYFSATSAHTCTGDGNGMVVRAGLPLED
MEFVQFHPTGIYGSGCLMTEGCRGEGGYLVNSQGEKFMERYAPKAKDLASRDVVSRAMTIEIREGRGVGPKKDHMYLNIS
HLDPEVIKLRLPGISETAKTFAGVDVTKDPIPVIPTVHYNMGGIPTNYHGEVITLQKGKEEVVEGLFAIGEAACVSVHGA
NRLGSNSLLDLVVFGRAAALRAKEKLKPDTPHKKLHSDCTDWIVDRFNKMRFASGEFKVAKIRSEMQHTMQKYASVFRVA
EVLEEGKKAIKEVAKMMPNIAVEDRSMIWNSDLVEALELANMIPQAVITMECAANREESRGAHAREDFPERDDKNWMKHT
IAWLKEEKSQVSVEIDYKKVAEKTLSDEIDFIAPEKRIY

Specific function: Two Distinct, Membrane-Bound, FAD-Containing Enzymes Are Responsible For The Catalysis Of Fumarate And Succinate Interconversion; The Fumarate Reductase Is Used In Anaerobic Growth, And The Succinate Dehydrogenase Is Used In Aerobic Growth. [C]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=614, Percent_Identity=57.9804560260586, Blast_Score=726, Evalue=0.0,
Organism=Escherichia coli, GI1786942, Length=569, Percent_Identity=53.2513181019332, Blast_Score=559, Evalue=1e-160,
Organism=Escherichia coli, GI1790597, Length=578, Percent_Identity=40.6574394463668, Blast_Score=403, Evalue=1e-113,
Organism=Escherichia coli, GI1788928, Length=556, Percent_Identity=32.7338129496403, Blast_Score=230, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17550100, Length=618, Percent_Identity=57.9288025889968, Blast_Score=713, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505833, Length=616, Percent_Identity=56.8181818181818, Blast_Score=699, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322701, Length=597, Percent_Identity=63.9865996649916, Blast_Score=788, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6322416, Length=597, Percent_Identity=63.8190954773869, Blast_Score=771, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6320788, Length=482, Percent_Identity=27.5933609958506, Blast_Score=114, Evalue=6e-26,
Organism=Saccharomyces cerevisiae, GI6322511, Length=488, Percent_Identity=25.6147540983607, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI17137288, Length=612, Percent_Identity=60.1307189542484, Blast_Score=758, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655642, Length=612, Percent_Identity=60.1307189542484, Blast_Score=758, Evalue=0.0,
Organism=Drosophila melanogaster, GI24655647, Length=612, Percent_Identity=60.1307189542484, Blast_Score=758, Evalue=0.0,
Organism=Drosophila melanogaster, GI24663005, Length=617, Percent_Identity=54.9432739059968, Blast_Score=689, Evalue=0.0,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR011281
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 66268; Mature: 66268

Theoretical pI: Translated: 6.67; Mature: 6.67

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKSAYEIIEHEYDVVIVGAGGAGLRATLGMAATNFSVACISKIFPTRSHTVAAQGGISA
CCCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCEEEECCCHHH
ALSNIAEDDWRWHAYDTIKGSDWLGDQDAIEYMCKNAAKAVIELENFGVPFSRTEDGKIY
HHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCHHH
QRAFGGMTTHFGKGKSAQRTCAAADKTGHAILHTLYQQCLKFNAEFFVEYFVIDLIMDKG
HHHHCCCCEECCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCC
TCCGVIAWSLCDGTLHRFRAHFVVIATGGYGRVYFSATSAHTCTGDGNGMVVRAGLPLED
CCHHHHHHHHHHHHHHHHEEEEEEEEECCCCEEEEEECCCEEECCCCCCEEEECCCCCCC
MEFVQFHPTGIYGSGCLMTEGCRGEGGYLVNSQGEKFMERYAPKAKDLASRDVVSRAMTI
CCEEEEECCCEECCCCEEECCCCCCCCEEECCCCHHHHHHHCCCHHHHHHHHHHHHEEEE
EIREGRGVGPKKDHMYLNISHLDPEVIKLRLPGISETAKTFAGVDVTKDPIPVIPTVHYN
EEECCCCCCCCCCEEEEEEECCCCEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCEEEEC
MGGIPTNYHGEVITLQKGKEEVVEGLFAIGEAACVSVHGANRLGSNSLLDLVVFGRAAAL
CCCCCCCCCCCEEEECCCHHHHHHHHHHHCCHHEEEEECCCCCCCCHHHHHHHHHHHHHH
RAKEKLKPDTPHKKLHSDCTDWIVDRFNKMRFASGEFKVAKIRSEMQHTMQKYASVFRVA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
EVLEEGKKAIKEVAKMMPNIAVEDRSMIWNSDLVEALELANMIPQAVITMECAANREESR
HHHHHHHHHHHHHHHHCCCCEECCCHHHCCHHHHHHHHHHHHHHHHHEEHHHHCCCCHHC
GAHAREDFPERDDKNWMKHTIAWLKEEKSQVSVEIDYKKVAEKTLSDEIDFIAPEKRIY
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHCCCCEECCCCCCC
>Mature Secondary Structure
MDKSAYEIIEHEYDVVIVGAGGAGLRATLGMAATNFSVACISKIFPTRSHTVAAQGGISA
CCCHHHHHHCCCCCEEEEECCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCEEEECCCHHH
ALSNIAEDDWRWHAYDTIKGSDWLGDQDAIEYMCKNAAKAVIELENFGVPFSRTEDGKIY
HHHHHHCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCHHH
QRAFGGMTTHFGKGKSAQRTCAAADKTGHAILHTLYQQCLKFNAEFFVEYFVIDLIMDKG
HHHHCCCCEECCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCC
TCCGVIAWSLCDGTLHRFRAHFVVIATGGYGRVYFSATSAHTCTGDGNGMVVRAGLPLED
CCHHHHHHHHHHHHHHHHEEEEEEEEECCCCEEEEEECCCEEECCCCCCEEEECCCCCCC
MEFVQFHPTGIYGSGCLMTEGCRGEGGYLVNSQGEKFMERYAPKAKDLASRDVVSRAMTI
CCEEEEECCCEECCCCEEECCCCCCCCEEECCCCHHHHHHHCCCHHHHHHHHHHHHEEEE
EIREGRGVGPKKDHMYLNISHLDPEVIKLRLPGISETAKTFAGVDVTKDPIPVIPTVHYN
EEECCCCCCCCCCEEEEEEECCCCEEEEEECCCCCHHHHHHCCCCCCCCCCCCCCEEEEC
MGGIPTNYHGEVITLQKGKEEVVEGLFAIGEAACVSVHGANRLGSNSLLDLVVFGRAAAL
CCCCCCCCCCCEEEECCCHHHHHHHHHHHCCHHEEEEECCCCCCCCHHHHHHHHHHHHHH
RAKEKLKPDTPHKKLHSDCTDWIVDRFNKMRFASGEFKVAKIRSEMQHTMQKYASVFRVA
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEECCCCCHHHHHHHHHHHHHHHHHHHHHHH
EVLEEGKKAIKEVAKMMPNIAVEDRSMIWNSDLVEALELANMIPQAVITMECAANREESR
HHHHHHHHHHHHHHHHCCCCEECCCHHHCCHHHHHHHHHHHHHHHHHEEHHHHCCCCHHC
GAHAREDFPERDDKNWMKHTIAWLKEEKSQVSVEIDYKKVAEKTLSDEIDFIAPEKRIY
CCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA