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The map label for this gene is fabD [H]

Identifier: 190571076

GI number: 190571076

Start: 738423

End: 739388

Strand: Reverse

Name: fabD [H]

Synonym: WPa_0671

Alternate gene names: 190571076

Gene position: 739388-738423 (Counterclockwise)

Preceding gene: 190571086

Following gene: 190571075

Centisome position: 49.88

GC content: 37.47

Gene sequence:

>966_bases
ATGATTTTTGCTTTTCCTGGTCAGGGCTCCCAATTTGTAGGAATGGGAAAGAGCTTATATGATGAATTTTCAGTTGCAAG
GAACGTATTTGATGAAGTAGATGACATATTGGGTAGAAAGCTGTCTCATTTGATTTTCAATGGCCCTATTGAGAAATTAA
CCATCACGGAAAACGCTCAGCCAGCTATAATGGCAGTGTCAATTGCAACGCTACGTGTTATGAAGCACGTATTTGGTGAA
TCTCTTTACAGCGTTCAGTATGTTTGTGGGCATTCAGTTGGCGAGTATACAGCGCTGTGTGCTGCAGGGGCATTGACGCT
TGAGTCTGCAGTCAAGTTGCTAAAAGTTCGTAGCGAAGCAATGCATGAAGCTTCACTAAAATGCAAAGGTGGAATGTTTG
CTCTACTTGGAGCAGAAATAAGTGAAGTAGAAGGTATATTAAAATCAGCTCAAATTGATTGTGAAATTGCAAACGATAAT
GGTGGTGGGCAGGTAGTGGTGAGTGGTACTGCAGAGGCTCTTGAGGTCTTACCTGATTTATTCAAAAACTCAAGTGTCAA
GAAAATGATAAAATTACAAGTTAGTGGGCCTTTTCATTCATCTTTTATGAAACCTGCTGATGAAAAACTTCTGGAATTTT
TAAAAAGCATCAACATAACTCGCCCTTCGATTCCTTTTGTATCAAACGTTACAGCTAAGGAAGAAAGTGATCCAGAGATC
ATAAGAGCTTTGCTCGCTAAGCAAGTTGTAAGTAGAGTAAGATGGAGAGAGATGGTTTTATATATGACAAGCCATGGCAC
TAATAAGTTTGTTGAAGTTGGCCCTAACAAAGTTTTATCTAATCTAGTTAAAAGAATTGACCAATCTATCAATACAAAAA
GCATAGGTAGCATTAGTGATGCTGATAACTTCTTTAATGAATCATTAATGTTGACAGCAAAAAATTTAAAAATAAAAAGC
TTATAA

Upstream 100 bases:

>100_bases
AAGATTTTAGTGAATCTGGTTCATTTGGTCAATCATTATTGTGAAATATTGACAAAAAATAAATAAAGTAGTATTATCAA
TGAAGAATGAAAAACTTTTT

Downstream 100 bases:

>100_bases
CTAACATAAAGTAAAATTTGTACTATTTTTTGCTTTGATTATTGATAGCAGCGGAATGTCAAACATCGACACTAAAGAAT
ATGATCTAGCGTTGGGTGAT

Product: malonyl CoA-acyl carrier protein transacylase

Products: NA

Alternate protein names: MCT [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MIFAFPGQGSQFVGMGKSLYDEFSVARNVFDEVDDILGRKLSHLIFNGPIEKLTITENAQPAIMAVSIATLRVMKHVFGE
SLYSVQYVCGHSVGEYTALCAAGALTLESAVKLLKVRSEAMHEASLKCKGGMFALLGAEISEVEGILKSAQIDCEIANDN
GGGQVVVSGTAEALEVLPDLFKNSSVKKMIKLQVSGPFHSSFMKPADEKLLEFLKSINITRPSIPFVSNVTAKEESDPEI
IRALLAKQVVSRVRWREMVLYMTSHGTNKFVEVGPNKVLSNLVKRIDQSINTKSIGSISDADNFFNESLMLTAKNLKIKS
L

Sequences:

>Translated_321_residues
MIFAFPGQGSQFVGMGKSLYDEFSVARNVFDEVDDILGRKLSHLIFNGPIEKLTITENAQPAIMAVSIATLRVMKHVFGE
SLYSVQYVCGHSVGEYTALCAAGALTLESAVKLLKVRSEAMHEASLKCKGGMFALLGAEISEVEGILKSAQIDCEIANDN
GGGQVVVSGTAEALEVLPDLFKNSSVKKMIKLQVSGPFHSSFMKPADEKLLEFLKSINITRPSIPFVSNVTAKEESDPEI
IRALLAKQVVSRVRWREMVLYMTSHGTNKFVEVGPNKVLSNLVKRIDQSINTKSIGSISDADNFFNESLMLTAKNLKIKS
L
>Mature_321_residues
MIFAFPGQGSQFVGMGKSLYDEFSVARNVFDEVDDILGRKLSHLIFNGPIEKLTITENAQPAIMAVSIATLRVMKHVFGE
SLYSVQYVCGHSVGEYTALCAAGALTLESAVKLLKVRSEAMHEASLKCKGGMFALLGAEISEVEGILKSAQIDCEIANDN
GGGQVVVSGTAEALEVLPDLFKNSSVKKMIKLQVSGPFHSSFMKPADEKLLEFLKSINITRPSIPFVSNVTAKEESDPEI
IRALLAKQVVSRVRWREMVLYMTSHGTNKFVEVGPNKVLSNLVKRIDQSINTKSIGSISDADNFFNESLMLTAKNLKIKS
L

Specific function: Fatty acid biosynthesis. [C]

COG id: COG0331

COG function: function code I; (acyl-carrier-protein) S-malonyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fabD family [H]

Homologues:

Organism=Homo sapiens, GI51243059, Length=318, Percent_Identity=35.2201257861635, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI27477045, Length=104, Percent_Identity=37.5, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1787334, Length=300, Percent_Identity=35.6666666666667, Blast_Score=177, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI71984332, Length=293, Percent_Identity=32.0819112627986, Blast_Score=141, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17550940, Length=337, Percent_Identity=27.299703264095, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24665753, Length=312, Percent_Identity=32.6923076923077, Blast_Score=151, Evalue=7e-37,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001227
- InterPro:   IPR014043
- InterPro:   IPR016035
- InterPro:   IPR004410
- InterPro:   IPR016036 [H]

Pfam domain/function: PF00698 Acyl_transf_1 [H]

EC number: =2.3.1.39 [H]

Molecular weight: Translated: 35024; Mature: 35024

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFAFPGQGSQFVGMGKSLYDEFSVARNVFDEVDDILGRKLSHLIFNGPIEKLTITENAQ
CEEECCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
PAIMAVSIATLRVMKHVFGESLYSVQYVCGHSVGEYTALCAAGALTLESAVKLLKVRSEA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MHEASLKCKGGMFALLGAEISEVEGILKSAQIDCEIANDNGGGQVVVSGTAEALEVLPDL
HHHHCCCCCCCEEEECCCCHHHHHHHHHHCCEEEEEECCCCCCEEEECCCHHHHHHHHHH
FKNSSVKKMIKLQVSGPFHSSFMKPADEKLLEFLKSINITRPSIPFVSNVTAKEESDPEI
HCCCCHHEEEEEEECCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHH
IRALLAKQVVSRVRWREMVLYMTSHGTNKFVEVGPNKVLSNLVKRIDQSINTKSIGSISD
HHHHHHHHHHHHHHHHHHHHHEECCCCCCEEECCHHHHHHHHHHHHHHCCCCCCCCCCCH
ADNFFNESLMLTAKNLKIKSL
HHHHHCCCCEEEEECEEEECC
>Mature Secondary Structure
MIFAFPGQGSQFVGMGKSLYDEFSVARNVFDEVDDILGRKLSHLIFNGPIEKLTITENAQ
CEEECCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCC
PAIMAVSIATLRVMKHVFGESLYSVQYVCGHSVGEYTALCAAGALTLESAVKLLKVRSEA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MHEASLKCKGGMFALLGAEISEVEGILKSAQIDCEIANDNGGGQVVVSGTAEALEVLPDL
HHHHCCCCCCCEEEECCCCHHHHHHHHHHCCEEEEEECCCCCCEEEECCCHHHHHHHHHH
FKNSSVKKMIKLQVSGPFHSSFMKPADEKLLEFLKSINITRPSIPFVSNVTAKEESDPEI
HCCCCHHEEEEEEECCCHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHH
IRALLAKQVVSRVRWREMVLYMTSHGTNKFVEVGPNKVLSNLVKRIDQSINTKSIGSISD
HHHHHHHHHHHHHHHHHHHHHEECCCCCCEEECCHHHHHHHHHHHHHHCCCCCCCCCCCH
ADNFFNESLMLTAKNLKIKSL
HHHHHCCCCEEEEECEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8759840; 9534248; 9384377 [H]