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The map label for this gene is ltrA [H]

Identifier: 190570780

GI number: 190570780

Start: 356283

End: 357584

Strand: Direct

Name: ltrA [H]

Synonym: WPa_0338

Alternate gene names: 190570780

Gene position: 356283-357584 (Clockwise)

Preceding gene: 190570779

Following gene: 190570781

Centisome position: 24.03

GC content: 36.94

Gene sequence:

>1302_bases
ATGCAAGATAAACTAAACCAGATAGCAGTAAGAGCAAAGCAAGATAAGCGACTGAAATTCACATCGCTAATACATCTAAT
AAATGTAGGAAACCTTGCAGAGTGTTATAAAGAGCTAAAGCGTAACAAGGCTTGTGGAATAGACTGGGTAACAGTGGAAG
CTTACGGAGAAAATCTAAAAGAGCGACTGGAAGGACTAGTGGATAGTATGAAGGGAAAGCAATATCAACCACAACCGGTG
AGGAGGGTGTATATACCAAAAGCCGGAAGTAAAGAGAAACGCGGACTCGGAATACCATCAACTGAGGATAAGTTGGTACA
GATTATGCTGAAGAAGATATTAGAAAATATTTACGAGGCAAACTTTCTGGACAGCTCATATGGATTTCGACCTGGAAGAA
ACTGTCATCAAACGGTAAATGCACTAGATAAAGCAGTTATGTACAAACCAATAAACTACATTGTAGAAGTGGATATCAAG
AAGTTCTACGATAATATACAGCATAAATGGCTAATGAGATGTCTAAGGGAACGAATAACTGACCCAAATTTACTGTGGTT
AATAAAGCGTTTTCTTAAGGCAGGGATAGTTGAAGCTGGATATTATGAAGCAACAAAACAAGGTACACCCCAAGGTGGTA
TAGTAAGTCCTGTATTAGCAAATATATACTTACATTATGTGTTGGATTTATGGCTTGAAAAGAAATTTAAACCAAGATCC
AGAGGATATATACAACTAATAAGGTTTTGCGACGATTTTGTGGTTTGTTGCGAAAGTAAGGTAGACGCGGAAGAATTTCT
GGAATTACTGAAACAAAGGTTAAATAAATTCGGGTTGGAAGTATCTGAAAACAAGACCAGAGTAGTAAAGTTTGGCAAGA
GGGAGTGGCAACAAGCGATAAGAGAGAAACGAAGGACGGAAAGTTTCAATTTTCTGGGGTTTACGCACTATGGTGCAAAA
AGTCGTCTTGGTAGATTAATGATGGGACATAAAACCTCAAAGTTAAATCTAGCCAGAAAACTAAAAGAAATCAAAGAGTG
GTTGGAAAAAGTCCGCGGAAGTATTCGACTTAAAGATTGGTGGCAAGTACTGAAGGCTAAATTAACAGGACACTATAACT
ACTTTGGTATTAGCGGAAATTATTGGTGTTTAAAACAATTTTATACATCAGTAAGAAAGCTAGCATTTAAATGGATAAAT
CGGCGTAGTCAGAAAAAGAGTATGACCTGGGAACAGTTTGTACACTACGTAGAAGTAAATCCATTACCAAAGCCAAAAAT
ACATTTTTCTTTATATGCATAA

Upstream 100 bases:

>100_bases
GTACTCGGAGTGTGGGAAAGCCACGTACAAGGGGAAGCGATCAGCAATATAGTAACTGGTATAGGGATTGCTATGCCAAT
ACAACGGAGGTTGGAATAAC

Downstream 100 bases:

>100_bases
GAGGGACGACTGTGAAAACTAATATTGATGAGCCGTGTGCGGGAAATCTGCAAGCACGGTTCTTTAGGGGGAGTTGTAGT
AATAAAACTCAAACGAGAGG

Product: reverse transcriptase

Products: NA

Alternate protein names: Reverse-transcriptase; RNA maturase; DNA endonuclease [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MQDKLNQIAVRAKQDKRLKFTSLIHLINVGNLAECYKELKRNKACGIDWVTVEAYGENLKERLEGLVDSMKGKQYQPQPV
RRVYIPKAGSKEKRGLGIPSTEDKLVQIMLKKILENIYEANFLDSSYGFRPGRNCHQTVNALDKAVMYKPINYIVEVDIK
KFYDNIQHKWLMRCLRERITDPNLLWLIKRFLKAGIVEAGYYEATKQGTPQGGIVSPVLANIYLHYVLDLWLEKKFKPRS
RGYIQLIRFCDDFVVCCESKVDAEEFLELLKQRLNKFGLEVSENKTRVVKFGKREWQQAIREKRRTESFNFLGFTHYGAK
SRLGRLMMGHKTSKLNLARKLKEIKEWLEKVRGSIRLKDWWQVLKAKLTGHYNYFGISGNYWCLKQFYTSVRKLAFKWIN
RRSQKKSMTWEQFVHYVEVNPLPKPKIHFSLYA

Sequences:

>Translated_433_residues
MQDKLNQIAVRAKQDKRLKFTSLIHLINVGNLAECYKELKRNKACGIDWVTVEAYGENLKERLEGLVDSMKGKQYQPQPV
RRVYIPKAGSKEKRGLGIPSTEDKLVQIMLKKILENIYEANFLDSSYGFRPGRNCHQTVNALDKAVMYKPINYIVEVDIK
KFYDNIQHKWLMRCLRERITDPNLLWLIKRFLKAGIVEAGYYEATKQGTPQGGIVSPVLANIYLHYVLDLWLEKKFKPRS
RGYIQLIRFCDDFVVCCESKVDAEEFLELLKQRLNKFGLEVSENKTRVVKFGKREWQQAIREKRRTESFNFLGFTHYGAK
SRLGRLMMGHKTSKLNLARKLKEIKEWLEKVRGSIRLKDWWQVLKAKLTGHYNYFGISGNYWCLKQFYTSVRKLAFKWIN
RRSQKKSMTWEQFVHYVEVNPLPKPKIHFSLYA
>Mature_433_residues
MQDKLNQIAVRAKQDKRLKFTSLIHLINVGNLAECYKELKRNKACGIDWVTVEAYGENLKERLEGLVDSMKGKQYQPQPV
RRVYIPKAGSKEKRGLGIPSTEDKLVQIMLKKILENIYEANFLDSSYGFRPGRNCHQTVNALDKAVMYKPINYIVEVDIK
KFYDNIQHKWLMRCLRERITDPNLLWLIKRFLKAGIVEAGYYEATKQGTPQGGIVSPVLANIYLHYVLDLWLEKKFKPRS
RGYIQLIRFCDDFVVCCESKVDAEEFLELLKQRLNKFGLEVSENKTRVVKFGKREWQQAIREKRRTESFNFLGFTHYGAK
SRLGRLMMGHKTSKLNLARKLKEIKEWLEKVRGSIRLKDWWQVLKAKLTGHYNYFGISGNYWCLKQFYTSVRKLAFKWIN
RRSQKKSMTWEQFVHYVEVNPLPKPKIHFSLYA

Specific function: Multifunctional protein that promotes group II intron splicing and mobility by acting both on RNA and DNA. It has three activities:reverse transcriptase (RT) for intron duplication, maturase to promote splicing, and DNA endonuclease for site- specific cle

COG id: COG3344

COG function: function code L; Retron-type reverse transcriptase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 reverse transcriptase domain [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6226521, Length=202, Percent_Identity=35.6435643564356, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6226520, Length=310, Percent_Identity=26.4516129032258, Blast_Score=100, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003615
- InterPro:   IPR002866
- InterPro:   IPR000477 [H]

Pfam domain/function: PF01348 Intron_maturas2; PF00078 RVT_1 [H]

EC number: =2.7.7.49 [H]

Molecular weight: Translated: 51083; Mature: 51083

Theoretical pI: Translated: 10.38; Mature: 10.38

Prosite motif: PS00559 MOLYBDOPTERIN_EUK ; PS50878 RT_POL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQDKLNQIAVRAKQDKRLKFTSLIHLINVGNLAECYKELKRNKACGIDWVTVEAYGENLK
CCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEHHHHHHHHH
ERLEGLVDSMKGKQYQPQPVRRVYIPKAGSKEKRGLGIPSTEDKLVQIMLKKILENIYEA
HHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
NFLDSSYGFRPGRNCHQTVNALDKAVMYKPINYIVEVDIKKFYDNIQHKWLMRCLRERIT
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHEEHHHHHHHHHHHHHHHHHHHHHHCC
DPNLLWLIKRFLKAGIVEAGYYEATKQGTPQGGIVSPVLANIYLHYVLDLWLEKKFKPRS
CCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
RGYIQLIRFCDDFVVCCESKVDAEEFLELLKQRLNKFGLEVSENKTRVVKFGKREWQQAI
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHHH
REKRRTESFNFLGFTHYGAKSRLGRLMMGHKTSKLNLARKLKEIKEWLEKVRGSIRLKDW
HHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHH
WQVLKAKLTGHYNYFGISGNYWCLKQFYTSVRKLAFKWINRRSQKKSMTWEQFVHYVEVN
HHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
PLPKPKIHFSLYA
CCCCCCEEEEEEC
>Mature Secondary Structure
MQDKLNQIAVRAKQDKRLKFTSLIHLINVGNLAECYKELKRNKACGIDWVTVEAYGENLK
CCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCEEEEHHHHHHHHH
ERLEGLVDSMKGKQYQPQPVRRVYIPKAGSKEKRGLGIPSTEDKLVQIMLKKILENIYEA
HHHHHHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHC
NFLDSSYGFRPGRNCHQTVNALDKAVMYKPINYIVEVDIKKFYDNIQHKWLMRCLRERIT
CCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHEEHHHHHHHHHHHHHHHHHHHHHHCC
DPNLLWLIKRFLKAGIVEAGYYEATKQGTPQGGIVSPVLANIYLHYVLDLWLEKKFKPRS
CCHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCC
RGYIQLIRFCDDFVVCCESKVDAEEFLELLKQRLNKFGLEVSENKTRVVKFGKREWQQAI
CHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHHH
REKRRTESFNFLGFTHYGAKSRLGRLMMGHKTSKLNLARKLKEIKEWLEKVRGSIRLKDW
HHHHHCCCCCEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHH
WQVLKAKLTGHYNYFGISGNYWCLKQFYTSVRKLAFKWINRRSQKKSMTWEQFVHYVEVN
HHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
PLPKPKIHFSLYA
CCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655550; 11157264; 10488339; 9353259; 10413481; 11731786 [H]