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The map label for this gene is fumC [H]

Identifier: 190570666

GI number: 190570666

Start: 221716

End: 223104

Strand: Reverse

Name: fumC [H]

Synonym: WPa_0216

Alternate gene names: 190570666

Gene position: 223104-221716 (Counterclockwise)

Preceding gene: 190570667

Following gene: 190570665

Centisome position: 15.05

GC content: 38.37

Gene sequence:

>1389_bases
ATGGATAAAAAAATTAGGATAGAATCAGATAGCTTAGGAGAAGTAAAAGTACCAAGTGAACGTTACTGGGGAGCTCAGAC
TCAGCGTTCTTTGGAAAATTTCAAAATTGGTACAGAGAAAATGCCAGAGCCCCTGATTAAAGCGCTAGCAATAGTAAAAC
TTGCAGCAGCACGTGTTAACATGAAACAGGGTAGCATAGATAATAGAGTAGGGGATGCAATCTGCACAGCGGCACAGGAG
GTAATAGACGGTAAATTTAATAATCAATTTCCGCTTGTTGTTTGGCAAACCGGTTCTGGAACGCAGACCAATATGAATGT
GAATGAAGTGATCAGCAATCGTGCAATAGAAATTTTGGGCGGTGATTTAGGTAGTAAGTCTCCAGTGCATCCAAATGATC
ATGTAAACTGTGGTCAGTCATCAAATGACACTTTTCCAACAGCAATGCATATAGCAGTAGCAGAGCAAATAAACCGCTTG
CTTATTCCCAATCTTGAAGAATTATATAAAGCGCTAAATAATAAGGTTCATGAATTTAAAGATATAATAAAAGTAGGGCG
TACTCATCTGCAAGATGCAACTCCTCTAACACTTGGGCAGGAATTTTCTGGCTATGCAGTTCAGATTAAAAAGGGAATAG
AGAGAGTAAAGTCAACTCTAAGCAATGTATATGAACTTGCACAAGGTGGTACCGCGGTTGGCACGGGAATCAATACTAAA
AAGGGTTTTGCTGAGGATTTTGCTAAAGAAGTGGCAAAAATCACTAATTTTCCATTTATTTCAGCAAAAAATAAGTTTGA
AGCACTAGCAGCAAATGATGCTTTAGTTGAGCTCAGTGGAGCACTCAATACAGTAGCAGTAAGCTTGATGAAAATTGCAA
ATGATATAAGGCTACTTGGTTCTGGTCCAAGATGCGGGATTGGAGAAATAATGTTACCAGAAAATGAGCCTGGCTCTTCA
ATCATGCCGGGTAAGGTGAATCCAACTCAATGCGAAGCAGTGACTATGGTATGTGCTCAAGTTATGGGAAATCATGTTGC
CGTGACAATTGGTGGCTCAAATGGTCACTTTGAATTGAACGTGTTTAAGCCGGTGATAATTTACAATGTTTTGCAGTCTA
TAAGACTTTTAGCTGATACAAGTTTAAATTTTGCAGAGAAATGCGTAGTTGATATTAAAGCAAACGAAGAAAGAATAAAG
GATTTACTAAATCAGTCGTTAATGCTAGTTACTATATTAAATACGCATATAGGATATGACAATGCAGCAAAAATAGCGAA
GCTTGCTTATAAAGAAAATATCACTCTAAAGGAAGCAGCAGCAAAACTTCAACTGCTCACTGAGGAGGAGTTTGAAAGGA
TAGTGAAACCAGAGGAGATGGTAGGTTAA

Upstream 100 bases:

>100_bases
CTAAGGTCTTCACTAAAAATGTCTCAACTTGACACTGAAATACAATTTGATTTAATTAATTCATATATGTAGGTAACGTC
AAGCACTAGAAGGAGGAAAT

Downstream 100 bases:

>100_bases
ACTACCACCTTTTTTTGTCCCTAGTTAATTGTGGTAATATGTATGGAACTTTGCTGGTTGCTCTACATATACCTCTTCTA
AATCACTTAGAGCGTGGTCA

Product: fumarate hydratase

Products: NA

Alternate protein names: Fumarase C 1 [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MDKKIRIESDSLGEVKVPSERYWGAQTQRSLENFKIGTEKMPEPLIKALAIVKLAAARVNMKQGSIDNRVGDAICTAAQE
VIDGKFNNQFPLVVWQTGSGTQTNMNVNEVISNRAIEILGGDLGSKSPVHPNDHVNCGQSSNDTFPTAMHIAVAEQINRL
LIPNLEELYKALNNKVHEFKDIIKVGRTHLQDATPLTLGQEFSGYAVQIKKGIERVKSTLSNVYELAQGGTAVGTGINTK
KGFAEDFAKEVAKITNFPFISAKNKFEALAANDALVELSGALNTVAVSLMKIANDIRLLGSGPRCGIGEIMLPENEPGSS
IMPGKVNPTQCEAVTMVCAQVMGNHVAVTIGGSNGHFELNVFKPVIIYNVLQSIRLLADTSLNFAEKCVVDIKANEERIK
DLLNQSLMLVTILNTHIGYDNAAKIAKLAYKENITLKEAAAKLQLLTEEEFERIVKPEEMVG

Sequences:

>Translated_462_residues
MDKKIRIESDSLGEVKVPSERYWGAQTQRSLENFKIGTEKMPEPLIKALAIVKLAAARVNMKQGSIDNRVGDAICTAAQE
VIDGKFNNQFPLVVWQTGSGTQTNMNVNEVISNRAIEILGGDLGSKSPVHPNDHVNCGQSSNDTFPTAMHIAVAEQINRL
LIPNLEELYKALNNKVHEFKDIIKVGRTHLQDATPLTLGQEFSGYAVQIKKGIERVKSTLSNVYELAQGGTAVGTGINTK
KGFAEDFAKEVAKITNFPFISAKNKFEALAANDALVELSGALNTVAVSLMKIANDIRLLGSGPRCGIGEIMLPENEPGSS
IMPGKVNPTQCEAVTMVCAQVMGNHVAVTIGGSNGHFELNVFKPVIIYNVLQSIRLLADTSLNFAEKCVVDIKANEERIK
DLLNQSLMLVTILNTHIGYDNAAKIAKLAYKENITLKEAAAKLQLLTEEEFERIVKPEEMVG
>Mature_462_residues
MDKKIRIESDSLGEVKVPSERYWGAQTQRSLENFKIGTEKMPEPLIKALAIVKLAAARVNMKQGSIDNRVGDAICTAAQE
VIDGKFNNQFPLVVWQTGSGTQTNMNVNEVISNRAIEILGGDLGSKSPVHPNDHVNCGQSSNDTFPTAMHIAVAEQINRL
LIPNLEELYKALNNKVHEFKDIIKVGRTHLQDATPLTLGQEFSGYAVQIKKGIERVKSTLSNVYELAQGGTAVGTGINTK
KGFAEDFAKEVAKITNFPFISAKNKFEALAANDALVELSGALNTVAVSLMKIANDIRLLGSGPRCGIGEIMLPENEPGSS
IMPGKVNPTQCEAVTMVCAQVMGNHVAVTIGGSNGHFELNVFKPVIIYNVLQSIRLLADTSLNFAEKCVVDIKANEERIK
DLLNQSLMLVTILNTHIGYDNAAKIAKLAYKENITLKEAAAKLQLLTEEEFERIVKPEEMVG

Specific function: Tricarboxylic acid cycle [C]

COG id: COG0114

COG function: function code C; Fumarase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II fumarase/aspartase family. Fumarase subfamily [H]

Homologues:

Organism=Homo sapiens, GI19743875, Length=460, Percent_Identity=68.0434782608696, Blast_Score=639, Evalue=0.0,
Organism=Homo sapiens, GI266458395, Length=63, Percent_Identity=65.0793650793651, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1787896, Length=458, Percent_Identity=60.2620087336244, Blast_Score=561, Evalue=1e-161,
Organism=Escherichia coli, GI87082375, Length=465, Percent_Identity=40.2150537634409, Blast_Score=337, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI17553882, Length=461, Percent_Identity=67.4620390455531, Blast_Score=648, Evalue=0.0,
Organism=Caenorhabditis elegans, GI32565146, Length=324, Percent_Identity=68.5185185185185, Blast_Score=468, Evalue=1e-132,
Organism=Saccharomyces cerevisiae, GI6324993, Length=464, Percent_Identity=62.5, Blast_Score=583, Evalue=1e-167,
Organism=Drosophila melanogaster, GI24640179, Length=463, Percent_Identity=65.658747300216, Blast_Score=629, Evalue=1e-180,
Organism=Drosophila melanogaster, GI24640177, Length=463, Percent_Identity=65.658747300216, Blast_Score=629, Evalue=1e-180,
Organism=Drosophila melanogaster, GI78710009, Length=462, Percent_Identity=65.3679653679654, Blast_Score=622, Evalue=1e-178,
Organism=Drosophila melanogaster, GI24662684, Length=461, Percent_Identity=60.5206073752712, Blast_Score=576, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24583245, Length=461, Percent_Identity=54.6637744034707, Blast_Score=508, Evalue=1e-144,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005677
- InterPro:   IPR018951
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF10415 FumaraseC_C; PF00206 Lyase_1 [H]

EC number: =4.2.1.2 [H]

Molecular weight: Translated: 50297; Mature: 50297

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKKIRIESDSLGEVKVPSERYWGAQTQRSLENFKIGTEKMPEPLIKALAIVKLAAARVN
CCCCEEECCCCCCCEECCHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHC
MKQGSIDNRVGDAICTAAQEVIDGKFNNQFPLVVWQTGSGTQTNMNVNEVISNRAIEILG
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCEEEEC
GDLGSKSPVHPNDHVNCGQSSNDTFPTAMHIAVAEQINRLLIPNLEELYKALNNKVHEFK
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
DIIKVGRTHLQDATPLTLGQEFSGYAVQIKKGIERVKSTLSNVYELAQGGTAVGTGINTK
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCC
KGFAEDFAKEVAKITNFPFISAKNKFEALAANDALVELSGALNTVAVSLMKIANDIRLLG
CCHHHHHHHHHHHHHCCCEEECCCCHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHEEC
SGPRCGIGEIMLPENEPGSSIMPGKVNPTQCEAVTMVCAQVMGNHVAVTIGGSNGHFELN
CCCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEE
VFKPVIIYNVLQSIRLLADTSLNFAEKCVVDIKANEERIKDLLNQSLMLVTILNTHIGYD
EHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEECCCHHHHHHHHCCCEEEEEEHHHHCCCC
NAAKIAKLAYKENITLKEAAAKLQLLTEEEFERIVKPEEMVG
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCC
>Mature Secondary Structure
MDKKIRIESDSLGEVKVPSERYWGAQTQRSLENFKIGTEKMPEPLIKALAIVKLAAARVN
CCCCEEECCCCCCCEECCHHHHCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHC
MKQGSIDNRVGDAICTAAQEVIDGKFNNQFPLVVWQTGSGTQTNMNVNEVISNRAIEILG
CCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCHHHHHHCCCEEEEC
GDLGSKSPVHPNDHVNCGQSSNDTFPTAMHIAVAEQINRLLIPNLEELYKALNNKVHEFK
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
DIIKVGRTHLQDATPLTLGQEFSGYAVQIKKGIERVKSTLSNVYELAQGGTAVGTGINTK
HHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCC
KGFAEDFAKEVAKITNFPFISAKNKFEALAANDALVELSGALNTVAVSLMKIANDIRLLG
CCHHHHHHHHHHHHHCCCEEECCCCHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHEEC
SGPRCGIGEIMLPENEPGSSIMPGKVNPTQCEAVTMVCAQVMGNHVAVTIGGSNGHFELN
CCCCCCCCCEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCEEEEE
VFKPVIIYNVLQSIRLLADTSLNFAEKCVVDIKANEERIKDLLNQSLMLVTILNTHIGYD
EHHHHHHHHHHHHHHHHHHCCCCCHHHEEEEECCCHHHHHHHHCCCEEEEEEHHHHCCCC
NAAKIAKLAYKENITLKEAAAKLQLLTEEEFERIVKPEEMVG
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1856685; 12597275 [H]