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The map label for this gene is ubiB [H]

Identifier: 190570609

GI number: 190570609

Start: 153236

End: 154657

Strand: Direct

Name: ubiB [H]

Synonym: WPa_0147

Alternate gene names: 190570609

Gene position: 153236-154657 (Clockwise)

Preceding gene: 190570608

Following gene: 190570619

Centisome position: 10.34

GC content: 32.77

Gene sequence:

>1422_bases
ATGATTCAAAATATTCTACGTCTTCTGCAAATAACTACAGTGCTAACACGCTACAATGTGTTACCTTATTTACTTCCACC
ATCAAAAAAATCAATAAATAAAATACAAGGTCATAAACTAAAGCGTGCTCTTGAAAGATTAGGTCCGGTGTTCATTAAAT
TTGGGCAATCCATTTCATCACGCACTGATATTTTAAATGAGGACATAACAAATAACTTGCTATTGATATGTGATAGATTG
CCATCATTTTCGTATAAAATAGCAGTTAAAACTATAGAAAGTGAGTTTAATTGTAAATTAAGCGATATTTTTTCAAGTTT
TTCTGAAAAGCCAATTGCAGCAGCATCAATTTCTCAGGTGCATAGAGCAGTTACAATTGAGGGTAAGGAAGTTGCTGTAA
AGGTTTTGAGGCCAAATATTGAGAAAACATTCTCAAGGGATATAAAAATGCTTTCTTGGCTTGCAGAAATTGCAGAAAAA
TTTAGTGAACAATCAAAAAGGCTGAAGCCAGTTGAATTAGTCAAAACTTTTGCTGAAATTTGCCGATTAGAGTTAGATCT
ACGCTTTGAGGCTGCCCACTCTTCGGAACTGAAGGAAAATACTAAACATGACAGAGGTTTCTACGTACCTGAAATAGATT
GGAGTAGAACTTCAAAAAAGGTTTTAACATTAGAATGGATGGAAGCTATACCAATATACGAAGTTGAAAAGCTGAATAAC
CGAAAGCAAATAGCTATCAATCTTATAGAATCTTTTTGTAATCAGGTATATAGGGATTGTTTTTTTCATGCTGATATGCA
TCCTGGAAATTTAATGATCGATAGTAATAACAATATTATTGCCCTGGATTGTGGAATCATGGGTAGAATAGATCGTGAGA
CATGCTATTACGTTATAGAGATACTCAAAGGCTTTTTAAATAGGGATTATGATCACGTTGCAAAAATGCACTTTAGAGCC
GGTTATGTTCCATCACAGCATAGAAATTTTGTTACAGCTTGCAGAGCAATAGGTGAGCCCATTGTTGGACAGCCTATACA
GAAGATTTCATTTGCTCGATTACTTACTCAGCTACTAAAAATAACTGGTGATTTTGATATGAAAGTTCAAACACAATTGT
TATTGCTGCAGAAAACTATGATTTTATTAGAAGGAACATGTAGGAAAGTCTATCCAGAAATCAATATGTGGAAAGTAGTT
GAAACATGGATAAACAATCAACATGAAAGTAAAATAGGGTATAGGGAAAAAATTAAAAGCTCTTATCCCATAAAAGCAAT
TCAGGGAATATTTAGCCTTATAGAAAAATTAAACCTAATAGCTGACAAAAAATTACAGGTGAAAAATAAATCAAATGGAA
AAGCCTACTTTTTACTTTGGTCTGTAATTATAATTCTCATCGTTAAACTTTTAATTTCTTGA

Upstream 100 bases:

>100_bases
CCTCAGATTACATAATTTGCATAAATAATACTATCTATTATCAAGGTAAACCTGATGAAATTATGGAGATAAATGAAATA
TTTGGCAGTTACGCAGCGAA

Downstream 100 bases:

>100_bases
ACTAAAAGATAATAGAAGCAAGTTTACAATCAACTATTTAAGTCTTGAAACCACTCAGGTTTACATTCACTCGAATTATC
AAGGTATTTTCAGGATGTAC

Product: ubiquinone biosynthesis protein ubiB

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 473; Mature: 473

Protein sequence:

>473_residues
MIQNILRLLQITTVLTRYNVLPYLLPPSKKSINKIQGHKLKRALERLGPVFIKFGQSISSRTDILNEDITNNLLLICDRL
PSFSYKIAVKTIESEFNCKLSDIFSSFSEKPIAAASISQVHRAVTIEGKEVAVKVLRPNIEKTFSRDIKMLSWLAEIAEK
FSEQSKRLKPVELVKTFAEICRLELDLRFEAAHSSELKENTKHDRGFYVPEIDWSRTSKKVLTLEWMEAIPIYEVEKLNN
RKQIAINLIESFCNQVYRDCFFHADMHPGNLMIDSNNNIIALDCGIMGRIDRETCYYVIEILKGFLNRDYDHVAKMHFRA
GYVPSQHRNFVTACRAIGEPIVGQPIQKISFARLLTQLLKITGDFDMKVQTQLLLLQKTMILLEGTCRKVYPEINMWKVV
ETWINNQHESKIGYREKIKSSYPIKAIQGIFSLIEKLNLIADKKLQVKNKSNGKAYFLLWSVIIILIVKLLIS

Sequences:

>Translated_473_residues
MIQNILRLLQITTVLTRYNVLPYLLPPSKKSINKIQGHKLKRALERLGPVFIKFGQSISSRTDILNEDITNNLLLICDRL
PSFSYKIAVKTIESEFNCKLSDIFSSFSEKPIAAASISQVHRAVTIEGKEVAVKVLRPNIEKTFSRDIKMLSWLAEIAEK
FSEQSKRLKPVELVKTFAEICRLELDLRFEAAHSSELKENTKHDRGFYVPEIDWSRTSKKVLTLEWMEAIPIYEVEKLNN
RKQIAINLIESFCNQVYRDCFFHADMHPGNLMIDSNNNIIALDCGIMGRIDRETCYYVIEILKGFLNRDYDHVAKMHFRA
GYVPSQHRNFVTACRAIGEPIVGQPIQKISFARLLTQLLKITGDFDMKVQTQLLLLQKTMILLEGTCRKVYPEINMWKVV
ETWINNQHESKIGYREKIKSSYPIKAIQGIFSLIEKLNLIADKKLQVKNKSNGKAYFLLWSVIIILIVKLLIS
>Mature_473_residues
MIQNILRLLQITTVLTRYNVLPYLLPPSKKSINKIQGHKLKRALERLGPVFIKFGQSISSRTDILNEDITNNLLLICDRL
PSFSYKIAVKTIESEFNCKLSDIFSSFSEKPIAAASISQVHRAVTIEGKEVAVKVLRPNIEKTFSRDIKMLSWLAEIAEK
FSEQSKRLKPVELVKTFAEICRLELDLRFEAAHSSELKENTKHDRGFYVPEIDWSRTSKKVLTLEWMEAIPIYEVEKLNN
RKQIAINLIESFCNQVYRDCFFHADMHPGNLMIDSNNNIIALDCGIMGRIDRETCYYVIEILKGFLNRDYDHVAKMHFRA
GYVPSQHRNFVTACRAIGEPIVGQPIQKISFARLLTQLLKITGDFDMKVQTQLLLLQKTMILLEGTCRKVYPEINMWKVV
ETWINNQHESKIGYREKIKSSYPIKAIQGIFSLIEKLNLIADKKLQVKNKSNGKAYFLLWSVIIILIVKLLIS

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=276, Percent_Identity=27.536231884058, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI40254938, Length=254, Percent_Identity=26.3779527559055, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI34147522, Length=306, Percent_Identity=27.1241830065359, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI217035081, Length=228, Percent_Identity=25.8771929824561, Blast_Score=90, Evalue=5e-18,
Organism=Homo sapiens, GI27363457, Length=269, Percent_Identity=26.7657992565056, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI217416386, Length=269, Percent_Identity=26.7657992565056, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI2367309, Length=409, Percent_Identity=36.6748166259169, Blast_Score=271, Evalue=5e-74,
Organism=Caenorhabditis elegans, GI17559152, Length=249, Percent_Identity=32.1285140562249, Blast_Score=128, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6325148, Length=502, Percent_Identity=21.9123505976096, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6323282, Length=267, Percent_Identity=23.2209737827715, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24662575, Length=263, Percent_Identity=31.1787072243346, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI22024280, Length=384, Percent_Identity=24.4791666666667, Blast_Score=104, Evalue=2e-22,
Organism=Drosophila melanogaster, GI18859849, Length=312, Percent_Identity=22.4358974358974, Blast_Score=68, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 54585; Mature: 54585

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQNILRLLQITTVLTRYNVLPYLLPPSKKSINKIQGHKLKRALERLGPVFIKFGQSISS
CHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCCHHH
RTDILNEDITNNLLLICDRLPSFSYKIAVKTIESEFNCKLSDIFSSFSEKPIAAASISQV
HHHHHHHHHCCCEEEEEECCCCCEEEEEEEEECCHHCCCHHHHHHHHCCCCCHHHHHHHH
HRAVTIEGKEVAVKVLRPNIEKTFSRDIKMLSWLAEIAEKFSEQSKRLKPVELVKTFAEI
HHHEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
CRLELDLRFEAAHSSELKENTKHDRGFYVPEIDWSRTSKKVLTLEWMEAIPIYEVEKLNN
HHHHHCEEEECCCHHHHHHCCCCCCCEECCCCCCCCCCCCEEEEEHHHCCCCHHHHHCCC
RKQIAINLIESFCNQVYRDCFFHADMHPGNLMIDSNNNIIALDCGIMGRIDRETCYYVIE
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEECCCCCCCCHHHHHHHHH
ILKGFLNRDYDHVAKMHFRAGYVPSQHRNFVTACRAIGEPIVGQPIQKISFARLLTQLLK
HHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ITGDFDMKVQTQLLLLQKTMILLEGTCRKVYPEINMWKVVETWINNQHESKIGYREKIKS
HCCCCCCHHHHHHHHHHHHHHHHHCHHHHHCCCCHHHHHHHHHHCCCCHHCCCHHHHHCC
SYPIKAIQGIFSLIEKLNLIADKKLQVKNKSNGKAYFLLWSVIIILIVKLLIS
CCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEEHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIQNILRLLQITTVLTRYNVLPYLLPPSKKSINKIQGHKLKRALERLGPVFIKFGQSISS
CHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHCHHHHHHCCCHHH
RTDILNEDITNNLLLICDRLPSFSYKIAVKTIESEFNCKLSDIFSSFSEKPIAAASISQV
HHHHHHHHHCCCEEEEEECCCCCEEEEEEEEECCHHCCCHHHHHHHHCCCCCHHHHHHHH
HRAVTIEGKEVAVKVLRPNIEKTFSRDIKMLSWLAEIAEKFSEQSKRLKPVELVKTFAEI
HHHEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
CRLELDLRFEAAHSSELKENTKHDRGFYVPEIDWSRTSKKVLTLEWMEAIPIYEVEKLNN
HHHHHCEEEECCCHHHHHHCCCCCCCEECCCCCCCCCCCCEEEEEHHHCCCCHHHHHCCC
RKQIAINLIESFCNQVYRDCFFHADMHPGNLMIDSNNNIIALDCGIMGRIDRETCYYVIE
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCEEEEECCCCCCCCHHHHHHHHH
ILKGFLNRDYDHVAKMHFRAGYVPSQHRNFVTACRAIGEPIVGQPIQKISFARLLTQLLK
HHHHHHCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
ITGDFDMKVQTQLLLLQKTMILLEGTCRKVYPEINMWKVVETWINNQHESKIGYREKIKS
HCCCCCCHHHHHHHHHHHHHHHHHCHHHHHCCCCHHHHHHHHHHCCCCHHCCCHHHHHCC
SYPIKAIQGIFSLIEKLNLIADKKLQVKNKSNGKAYFLLWSVIIILIVKLLIS
CCCHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEEHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA