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The map label for this gene is dxr

Identifier: 189499092

GI number: 189499092

Start: 90804

End: 91952

Strand: Reverse

Name: dxr

Synonym: Cphamn1_0098

Alternate gene names: 189499092

Gene position: 91952-90804 (Counterclockwise)

Preceding gene: 189499093

Following gene: 189499091

Centisome position: 3.36

GC content: 52.57

Gene sequence:

>1149_bases
ATGAAATCACTATCTATCCTTGGCAGTACCGGATCAATCGGATTAAGCACGCTTGATGTTGTCCGTCAACACCCGGAGAA
ATTTAACGTAACCGGTCTGGCCGAAGGCCATGATATCAATCTGCTTGCCGAACAGATCAAGGAGTTCCGACCGGACATTG
TCTCTGTGAGGGATAAAGCATCTGCAGGACTCCTGCGTGAACAGCTCGGCTCCGAAAAACCTGAAATACTCTGGGGCATT
GAGGGCGCTGCCGCTGTTGGCGCTGCTGAAGGCTCGGAAATGGTTGTCTCGGCTATTGTCGGAGCGGCAGGGCTTGTGCC
CACAGTGAGCGCAATCAAGGCGGGTAAGGACATCGCCCTTGCAAACAAGGAAACGCTGGTTGTCGCAGGACAGCTTGTCT
CGGATCTTGTGAAAGAACATAAGGTGACGCTTCTGCCTGTCGATAGTGAACATTCAGCAATTTTTCAATCACTCTCCGGC
CACAGAAAAGAGGACATCGAGCGTATCATCCTGACCGCTTCAGGAGGACCTTTCAGACATACGTCCGCCGAAGACCTTCG
TCATGTCGGTCCTGAAAAAGCCCTGAAACATCCCCAATGGACGATGGGAGCGAAAATAACCATCGATTCCGCAACGCTCA
TGAACAAGGGGCTGGAAGTTATCGAGGCCCACTGGCTGTTCGATATGCCGGCAGACAAAATAGGTGTTGTCGTTCATCCG
CAAAGCATTATTCACTCTATGGTAGAGTATATCGACGGCTGCGTTATGGCCCAGCTCGGGGCGCCCGACATGCGGGCACC
GATAGCCTACGCACTGGCATGGCCTGAACGGTGCGAAAGCGGCATCAAAAAACTTGACCTGACACAGATAGGAACCTTGA
CTTTTGAGCAACCTGACATGGAAAGGTTCCCCGCGCTTCGCCTGGCGTTTGACGCACTCAAAGCCGGCCAGACGTTTCCT
GCCGTGCTGAACGCGGCCAACGAAATTGCCGTCGCCGCTTTCCTGGACAAAAAAATAGGTTTTACCGATATCCCTGCTAT
TGCAGACAGAACCATGCAGGCTCACGATCCTTACACTCCTTCCGGTCTTGATGAATATCTTGCCGCTGACAGGTGGGCCC
GTGATACCGCGAAAACAATGACGAATTAA

Upstream 100 bases:

>100_bases
GTCAACAATGGCCTGACCTTAATTTGTAAGCCGAGCTGAAAAAGTATAAATTCATGCCGGAAAACAAGAGGTGTACCACG
CAATTTGCCGTAATAAAAAC

Downstream 100 bases:

>100_bases
GAGATAGGTGCCCCTCAGGGGCTTTCGACACAGTTTGTAGAGAAGGAAACAGAGAATATTATGGACTTTATCAGTACGAC
GTTTTACTTTATTTTAGCGA

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MKSLSILGSTGSIGLSTLDVVRQHPEKFNVTGLAEGHDINLLAEQIKEFRPDIVSVRDKASAGLLREQLGSEKPEILWGI
EGAAAVGAAEGSEMVVSAIVGAAGLVPTVSAIKAGKDIALANKETLVVAGQLVSDLVKEHKVTLLPVDSEHSAIFQSLSG
HRKEDIERIILTASGGPFRHTSAEDLRHVGPEKALKHPQWTMGAKITIDSATLMNKGLEVIEAHWLFDMPADKIGVVVHP
QSIIHSMVEYIDGCVMAQLGAPDMRAPIAYALAWPERCESGIKKLDLTQIGTLTFEQPDMERFPALRLAFDALKAGQTFP
AVLNAANEIAVAAFLDKKIGFTDIPAIADRTMQAHDPYTPSGLDEYLAADRWARDTAKTMTN

Sequences:

>Translated_382_residues
MKSLSILGSTGSIGLSTLDVVRQHPEKFNVTGLAEGHDINLLAEQIKEFRPDIVSVRDKASAGLLREQLGSEKPEILWGI
EGAAAVGAAEGSEMVVSAIVGAAGLVPTVSAIKAGKDIALANKETLVVAGQLVSDLVKEHKVTLLPVDSEHSAIFQSLSG
HRKEDIERIILTASGGPFRHTSAEDLRHVGPEKALKHPQWTMGAKITIDSATLMNKGLEVIEAHWLFDMPADKIGVVVHP
QSIIHSMVEYIDGCVMAQLGAPDMRAPIAYALAWPERCESGIKKLDLTQIGTLTFEQPDMERFPALRLAFDALKAGQTFP
AVLNAANEIAVAAFLDKKIGFTDIPAIADRTMQAHDPYTPSGLDEYLAADRWARDTAKTMTN
>Mature_382_residues
MKSLSILGSTGSIGLSTLDVVRQHPEKFNVTGLAEGHDINLLAEQIKEFRPDIVSVRDKASAGLLREQLGSEKPEILWGI
EGAAAVGAAEGSEMVVSAIVGAAGLVPTVSAIKAGKDIALANKETLVVAGQLVSDLVKEHKVTLLPVDSEHSAIFQSLSG
HRKEDIERIILTASGGPFRHTSAEDLRHVGPEKALKHPQWTMGAKITIDSATLMNKGLEVIEAHWLFDMPADKIGVVVHP
QSIIHSMVEYIDGCVMAQLGAPDMRAPIAYALAWPERCESGIKKLDLTQIGTLTFEQPDMERFPALRLAFDALKAGQTFP
AVLNAANEIAVAAFLDKKIGFTDIPAIADRTMQAHDPYTPSGLDEYLAADRWARDTAKTMTN

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=390, Percent_Identity=51.2820512820513, Blast_Score=383, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_CHLPB (B3EK13)

Other databases:

- EMBL:   CP001101
- RefSeq:   YP_001958562.1
- ProteinModelPortal:   B3EK13
- SMR:   B3EK13
- GeneID:   6373741
- GenomeReviews:   CP001101_GR
- KEGG:   cpb:Cphamn1_0098
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- ProtClustDB:   PRK05447
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 41105; Mature: 41105

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: BINDING 123-123 BINDING 150-150 BINDING 174-174 BINDING 197-197 BINDING 219-219

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKSLSILGSTGSIGLSTLDVVRQHPEKFNVTGLAEGHDINLLAEQIKEFRPDIVSVRDKA
CCCCEEECCCCCCCHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHCCHHHHHHHHH
SAGLLREQLGSEKPEILWGIEGAAAVGAAEGSEMVVSAIVGAAGLVPTVSAIKAGKDIAL
HHHHHHHHHCCCCCCEEEECCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
ANKETLVVAGQLVSDLVKEHKVTLLPVDSEHSAIFQSLSGHRKEDIERIILTASGGPFRH
CCCCEEEEHHHHHHHHHHHCCEEEEEECCHHHHHHHHHCCCCHHHHEEEEEEECCCCCCC
TSAEDLRHVGPEKALKHPQWTMGAKITIDSATLMNKGLEVIEAHWLFDMPADKIGVVVHP
CCHHHHHHCCHHHHHCCCCCCCCCEEEECHHHHHHHCHHHHHHHHEEECCCCCEEEEECC
QSIIHSMVEYIDGCVMAQLGAPDMRAPIAYALAWPERCESGIKKLDLTQIGTLTFEQPDM
HHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHCHHHHHHHHHHCCHHHHCEEEECCCCH
ERFPALRLAFDALKAGQTFPAVLNAANEIAVAAFLDKKIGFTDIPAIADRTMQAHDPYTP
HHHHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHCCCCCCCCCHHHHCCHHCCCCCCC
SGLDEYLAADRWARDTAKTMTN
CCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKSLSILGSTGSIGLSTLDVVRQHPEKFNVTGLAEGHDINLLAEQIKEFRPDIVSVRDKA
CCCCEEECCCCCCCHHHHHHHHHCCCCCCEEECCCCCCHHHHHHHHHHHCCHHHHHHHHH
SAGLLREQLGSEKPEILWGIEGAAAVGAAEGSEMVVSAIVGAAGLVPTVSAIKAGKDIAL
HHHHHHHHHCCCCCCEEEECCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEE
ANKETLVVAGQLVSDLVKEHKVTLLPVDSEHSAIFQSLSGHRKEDIERIILTASGGPFRH
CCCCEEEEHHHHHHHHHHHCCEEEEEECCHHHHHHHHHCCCCHHHHEEEEEEECCCCCCC
TSAEDLRHVGPEKALKHPQWTMGAKITIDSATLMNKGLEVIEAHWLFDMPADKIGVVVHP
CCHHHHHHCCHHHHHCCCCCCCCCEEEECHHHHHHHCHHHHHHHHEEECCCCCEEEEECC
QSIIHSMVEYIDGCVMAQLGAPDMRAPIAYALAWPERCESGIKKLDLTQIGTLTFEQPDM
HHHHHHHHHHHCCHHHHHCCCCCCCCCHHHHHHCHHHHHHHHHHCCHHHHCEEEECCCCH
ERFPALRLAFDALKAGQTFPAVLNAANEIAVAAFLDKKIGFTDIPAIADRTMQAHDPYTP
HHHHHHHHHHHHHHCCCCCHHHHHCHHHHHHHHHHHCCCCCCCCCHHHHCCHHCCCCCCC
SGLDEYLAADRWARDTAKTMTN
CCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA