Click here to switch to the map view.

The map label for this gene is nhaK [H]

Identifier: 189352347

GI number: 189352347

Start: 397482

End: 399065

Strand: Direct

Name: nhaK [H]

Synonym: BMULJ_03566

Alternate gene names: 189352347

Gene position: 397482-399065 (Clockwise)

Preceding gene: 189352346

Following gene: 189352348

Centisome position: 16.07

GC content: 69.7

Gene sequence:

>1584_bases
ATGTCCCCCGTGTCGGCATTCAAGCTGATTCTGTTGTCATTCCTTGCGATCGTTGCGCTCGAATACGTGGCAAAGCGGCT
GCGGCTGCCGCCGGCGGCCGCGCTGCTGGTCGGCGGCATCGGCATCGCGTTCATTCCGGGCTTGCCGCCGATCAACCTCG
ATCCTGACCTCGTGCTCGTCGTGTTCCTGCCGCCGCTGCTGATGGACGGCGCGTACTTCTCGGTATGGCAGGAGTTCAAG
CGCAACGTCGGCGGGATCCTGCTGCTCGCGATCGGCGCGGTCGTGTTCACGACCTTCGCGGTCGGCGTCGCCGTGCACTG
GGCCGTGCCGTCGTTGCCGTGGGCCGCCTGTTTCGCGCTCGGCGCGATCGTGTCGCCGCCCGACGCGGTGGCGGCGAAAG
CGGTGCTCGAACGCGTCGCGCTGCCGCGCCGGCTGATGGTGCTGCTCGAAGGCGAAAGCCTGCTGAACGACGCGGCGGGG
CTCGTGCTGTTCCGCTTCGCGGTGGCCGCCGCGCTGACCGGCGCGTTCAGCCTGCAGCATGCGCTGATCGGCTTCGCGGA
GCTCGGGCTCGGCGGCGTCGTGGTCGGCTTCGTGATCGGCCGGCTCGTCGTGTGTTTCCTGAAGCTGCTCGACGACGACT
ATCTCGTGATCACGGTCGCCGTGCTCGCCGGCTGGATCGCCTATATCGCCGGCGAGATGGTCGAGGTGTCGGGCGTGATC
GCCACCGTCACGGCCGGGATGATCGTCGGCTGGCATCAGCACGAGGTGTTTTCCGCGGCGGTGCGCACGCGCGGCACGGC
GTTCTGGCAGGTGATCGTATTCCTGCTCGAGGCGCTCGTGTTCGTGCTGATCGGCCTGTCGCTGCGCGGCGCGATGCTGC
GGCTCGGCGGCCTCGACCAGGTGATCGCGACGATGCTGCCGCCCGTCGGCGCCGTGCTGGTCGCGGTCGTGCTGTCGCGC
TTCGCCTGGATCTATGCAGTCGAAGCGCTGAAATGGCCGGTGCGCGGCATCACGCGGCGCGGCGACGCGCCCGACTGGAA
AGCGGCGACCGTGATGAGCTGGGCCGGGATGCGCGGCGTCGTCACGCTCGCGATCGCGCTGTCGCTGCCGGACGCGATGC
CGGGCCGCGACGTCATTCTCGTCGCCGCCTTCGCGGTGATTCTCGTGACGGTACTGTTGCAGGGCACGACGATCGGCCCG
CTGATCCGGCTGCTGCGGCTGCCGCAGCGCCACGAGCGCGCCGCGCATCATCTGACCGAGCCGCAAGCGTGGGCGCGCGT
CGAGGCCGCGCAGCTCGCGGCGATCCAGCCGCTCGTGCACGACGAGAACGGGGTCGTGATCCATCCGCGGCTGCTCGAAC
AGTACACCTACCGCGCGGCGCTGACCGAGCGGCTGAAGGACGAGCCCGCGTTCCCCGACAGCGCACGCGCCGCGCACTAC
GACGTCGTGCTGGCCGCGATCGCGGCGGGCCGGGCAGAGCTGCTGCGCCTGCATCGCTCGGATCGCATCCACGACGAAAT
GCTGCACGCGCTCGAACGCGATCTCGATCTGCAGGAAGTGGCGGCCTACCACGCGCGCGGCTGA

Upstream 100 bases:

>100_bases
ACCTCGACTGCGCGCGGCGGTCATGTTGTAATCGCGCGCAACGGCCGCCCGGGGTACGACACCGGCGGTTCCGCCGATTC
CTTCCTCGAGAGGTCGATTC

Downstream 100 bases:

>100_bases
TTTGCGCCGCGCGCGTGGGGGGAGCCGCCCGCCCGTACCGCGGTGGCGCCGCGCGCAGGTCGCGCCGCACCGCGCGTTTC
GCCGGCCGCCGCAACGGCCG

Product: CPA1 family monovalent cation:H+ antiporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 527; Mature: 526

Protein sequence:

>527_residues
MSPVSAFKLILLSFLAIVALEYVAKRLRLPPAAALLVGGIGIAFIPGLPPINLDPDLVLVVFLPPLLMDGAYFSVWQEFK
RNVGGILLLAIGAVVFTTFAVGVAVHWAVPSLPWAACFALGAIVSPPDAVAAKAVLERVALPRRLMVLLEGESLLNDAAG
LVLFRFAVAAALTGAFSLQHALIGFAELGLGGVVVGFVIGRLVVCFLKLLDDDYLVITVAVLAGWIAYIAGEMVEVSGVI
ATVTAGMIVGWHQHEVFSAAVRTRGTAFWQVIVFLLEALVFVLIGLSLRGAMLRLGGLDQVIATMLPPVGAVLVAVVLSR
FAWIYAVEALKWPVRGITRRGDAPDWKAATVMSWAGMRGVVTLAIALSLPDAMPGRDVILVAAFAVILVTVLLQGTTIGP
LIRLLRLPQRHERAAHHLTEPQAWARVEAAQLAAIQPLVHDENGVVIHPRLLEQYTYRAALTERLKDEPAFPDSARAAHY
DVVLAAIAAGRAELLRLHRSDRIHDEMLHALERDLDLQEVAAYHARG

Sequences:

>Translated_527_residues
MSPVSAFKLILLSFLAIVALEYVAKRLRLPPAAALLVGGIGIAFIPGLPPINLDPDLVLVVFLPPLLMDGAYFSVWQEFK
RNVGGILLLAIGAVVFTTFAVGVAVHWAVPSLPWAACFALGAIVSPPDAVAAKAVLERVALPRRLMVLLEGESLLNDAAG
LVLFRFAVAAALTGAFSLQHALIGFAELGLGGVVVGFVIGRLVVCFLKLLDDDYLVITVAVLAGWIAYIAGEMVEVSGVI
ATVTAGMIVGWHQHEVFSAAVRTRGTAFWQVIVFLLEALVFVLIGLSLRGAMLRLGGLDQVIATMLPPVGAVLVAVVLSR
FAWIYAVEALKWPVRGITRRGDAPDWKAATVMSWAGMRGVVTLAIALSLPDAMPGRDVILVAAFAVILVTVLLQGTTIGP
LIRLLRLPQRHERAAHHLTEPQAWARVEAAQLAAIQPLVHDENGVVIHPRLLEQYTYRAALTERLKDEPAFPDSARAAHY
DVVLAAIAAGRAELLRLHRSDRIHDEMLHALERDLDLQEVAAYHARG
>Mature_526_residues
SPVSAFKLILLSFLAIVALEYVAKRLRLPPAAALLVGGIGIAFIPGLPPINLDPDLVLVVFLPPLLMDGAYFSVWQEFKR
NVGGILLLAIGAVVFTTFAVGVAVHWAVPSLPWAACFALGAIVSPPDAVAAKAVLERVALPRRLMVLLEGESLLNDAAGL
VLFRFAVAAALTGAFSLQHALIGFAELGLGGVVVGFVIGRLVVCFLKLLDDDYLVITVAVLAGWIAYIAGEMVEVSGVIA
TVTAGMIVGWHQHEVFSAAVRTRGTAFWQVIVFLLEALVFVLIGLSLRGAMLRLGGLDQVIATMLPPVGAVLVAVVLSRF
AWIYAVEALKWPVRGITRRGDAPDWKAATVMSWAGMRGVVTLAIALSLPDAMPGRDVILVAAFAVILVTVLLQGTTIGPL
IRLLRLPQRHERAAHHLTEPQAWARVEAAQLAAIQPLVHDENGVVIHPRLLEQYTYRAALTERLKDEPAFPDSARAAHYD
VVLAAIAAGRAELLRLHRSDRIHDEMLHALERDLDLQEVAAYHARG

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=427, Percent_Identity=24.824355971897, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI148727259, Length=429, Percent_Identity=23.7762237762238, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI41872703, Length=401, Percent_Identity=23.4413965087282, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI27777632, Length=411, Percent_Identity=25.5474452554745, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI4759144, Length=389, Percent_Identity=26.9922879177378, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI14211919, Length=397, Percent_Identity=24.4332493702771, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI27734935, Length=419, Percent_Identity=22.1957040572792, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI110227626, Length=406, Percent_Identity=25.1231527093596, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI294997330, Length=406, Percent_Identity=24.8768472906404, Blast_Score=97, Evalue=5e-20,
Organism=Homo sapiens, GI194239733, Length=431, Percent_Identity=23.2018561484919, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI5454070, Length=403, Percent_Identity=24.8138957816377, Blast_Score=96, Evalue=8e-20,
Organism=Escherichia coli, GI1790501, Length=506, Percent_Identity=31.4229249011858, Blast_Score=171, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71999817, Length=446, Percent_Identity=23.9910313901345, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71999819, Length=446, Percent_Identity=23.9910313901345, Blast_Score=122, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI71999821, Length=446, Percent_Identity=23.9910313901345, Blast_Score=122, Evalue=5e-28,
Organism=Caenorhabditis elegans, GI71987537, Length=408, Percent_Identity=23.2843137254902, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI71987535, Length=408, Percent_Identity=23.2843137254902, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI71980847, Length=379, Percent_Identity=22.4274406332454, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI25147678, Length=443, Percent_Identity=23.9277652370203, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI71990932, Length=376, Percent_Identity=22.8723404255319, Blast_Score=103, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI71990924, Length=381, Percent_Identity=22.5721784776903, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI25150332, Length=401, Percent_Identity=24.1895261845387, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71992107, Length=374, Percent_Identity=22.7272727272727, Blast_Score=92, Evalue=9e-19,
Organism=Caenorhabditis elegans, GI71992101, Length=374, Percent_Identity=22.7272727272727, Blast_Score=92, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71987559, Length=426, Percent_Identity=21.3615023474178, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71993590, Length=376, Percent_Identity=25, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71993582, Length=376, Percent_Identity=25, Blast_Score=82, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI71987545, Length=419, Percent_Identity=21.4797136038186, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6320663, Length=348, Percent_Identity=23.5632183908046, Blast_Score=74, Evalue=5e-14,
Organism=Drosophila melanogaster, GI221510734, Length=377, Percent_Identity=24.9336870026525, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI221510738, Length=377, Percent_Identity=24.9336870026525, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI281364513, Length=398, Percent_Identity=23.3668341708543, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI221473222, Length=398, Percent_Identity=23.3668341708543, Blast_Score=102, Evalue=7e-22,
Organism=Drosophila melanogaster, GI221510736, Length=377, Percent_Identity=24.9336870026525, Blast_Score=100, Evalue=3e-21,
Organism=Drosophila melanogaster, GI221510732, Length=377, Percent_Identity=24.9336870026525, Blast_Score=100, Evalue=4e-21,
Organism=Drosophila melanogaster, GI221473212, Length=390, Percent_Identity=23.3333333333333, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI221510740, Length=377, Percent_Identity=24.9336870026525, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24585580, Length=377, Percent_Identity=24.9336870026525, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24585578, Length=377, Percent_Identity=24.9336870026525, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI221473215, Length=390, Percent_Identity=23.3333333333333, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI281360447, Length=378, Percent_Identity=24.0740740740741, Blast_Score=94, Evalue=3e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705
- InterPro:   IPR002014 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 56611; Mature: 56480

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHCCC
>Mature Secondary Structure 
SPVSAFKLILLSFLAIVALEYVAKRLRLPPAAALLVGGIGIAFIPGLPPINLDPDLVLV
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHCCCCCCCCCCCHHHHH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HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA