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The map label for this gene is mdmC [H]

Identifier: 189352265

GI number: 189352265

Start: 311350

End: 312018

Strand: Direct

Name: mdmC [H]

Synonym: BMULJ_03484

Alternate gene names: 189352265

Gene position: 311350-312018 (Clockwise)

Preceding gene: 189352263

Following gene: 189352268

Centisome position: 12.59

GC content: 68.61

Gene sequence:

>669_bases
ATGGATCAGGATCAGTGGAACCGTGTGGACGCGTATTTCTCGGCGACGCTCGTGCCGTCCGACGACGTGCTCGATGCCGC
GCTGGCGGCGAGCGAGGCGGCCGGGCTGCCGGCGATCAACGTCGCGCCGAATCAGGGCAAGCTGCTGCAACTGCTCGCGA
CGATCCGCGGCGCGCGGCGCATTCTCGAGGTCGGCACGCTCGGCGGCTACAGCACGATCTGGCTGGCGCGCGCGTTGCCG
CCCGGCGGCCGGCTCGTGACGCTCGAGCTCAATCCGGCGCACGCGGCGGTCGCGACGCAGAACATCGCGCGCGCGGGCTT
CGCGGATGTCGTGTCGGTCGTCGTCGGCAGCGCGAAGGACAGTCTCGCGCGGCTCATTGCCGAGGGCGAGGCGCCGTTCG
ATTTCATCTTCATCGACGCGGACAAGGACAACAACCGCGCTTATCTCGATGCGGCGCTGAAGTTGTCGCGGCCGGGCACG
GTGATCGTCGTGGACAACGTTGTGCGGCGCGGGCGCGTGGCCGATCCGGACAATCGCGATCCGGATGTCGTCGGCGTGCG
CGAAGGGTTCGCGCGCATCGTCGCCGAGCCGAAGCTGACGACGACGGCCGTGCAGACGGTCGGGCAGAAGGGGTGGGACG
GGTTTTCGATTTCGATTGTGGGGGAGTGA

Upstream 100 bases:

>100_bases
ATTATAGGAGCGCAGCGCGCGCGAAGCTTAGAACGAATGGTGCGTTGCTTATCGGCGCAGCGCGCATAGAATGCATTTTT
CCGCAGACGAAAGGTGTGCG

Downstream 100 bases:

>100_bases
CGCGATCACAGCGTGCCGGCCCGGCGCGCATCGCGCGGCCGTTCACACACGACAAATCGCGATGATCTCCACACTCGTCG
CGTCGTCGAACGACGCGCCT

Product: O-methyltransferase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 222; Mature: 222

Protein sequence:

>222_residues
MDQDQWNRVDAYFSATLVPSDDVLDAALAASEAAGLPAINVAPNQGKLLQLLATIRGARRILEVGTLGGYSTIWLARALP
PGGRLVTLELNPAHAAVATQNIARAGFADVVSVVVGSAKDSLARLIAEGEAPFDFIFIDADKDNNRAYLDAALKLSRPGT
VIVVDNVVRRGRVADPDNRDPDVVGVREGFARIVAEPKLTTTAVQTVGQKGWDGFSISIVGE

Sequences:

>Translated_222_residues
MDQDQWNRVDAYFSATLVPSDDVLDAALAASEAAGLPAINVAPNQGKLLQLLATIRGARRILEVGTLGGYSTIWLARALP
PGGRLVTLELNPAHAAVATQNIARAGFADVVSVVVGSAKDSLARLIAEGEAPFDFIFIDADKDNNRAYLDAALKLSRPGT
VIVVDNVVRRGRVADPDNRDPDVVGVREGFARIVAEPKLTTTAVQTVGQKGWDGFSISIVGE
>Mature_222_residues
MDQDQWNRVDAYFSATLVPSDDVLDAALAASEAAGLPAINVAPNQGKLLQLLATIRGARRILEVGTLGGYSTIWLARALP
PGGRLVTLELNPAHAAVATQNIARAGFADVVSVVVGSAKDSLARLIAEGEAPFDFIFIDADKDNNRAYLDAALKLSRPGT
VIVVDNVVRRGRVADPDNRDPDVVGVREGFARIVAEPKLTTTAVQTVGQKGWDGFSISIVGE

Specific function: 4-O-methyltransferase for the lactone ring of midecamycin and other macrolide antibiotics [H]

COG id: COG4122

COG function: function code R; Predicted O-methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. Type 3 family [H]

Homologues:

Organism=Homo sapiens, GI6466450, Length=140, Percent_Identity=35.7142857142857, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI205830453, Length=140, Percent_Identity=35.7142857142857, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI205830451, Length=140, Percent_Identity=35.7142857142857, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI4502969, Length=140, Percent_Identity=35.7142857142857, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI31542747, Length=151, Percent_Identity=36.4238410596026, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI223718169, Length=82, Percent_Identity=46.3414634146341, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI223718164, Length=82, Percent_Identity=46.3414634146341, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI223718159, Length=82, Percent_Identity=46.3414634146341, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI72001127, Length=157, Percent_Identity=36.3057324840764, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI25148771, Length=192, Percent_Identity=32.8125, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17565612, Length=157, Percent_Identity=35.6687898089172, Blast_Score=79, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI72001028, Length=207, Percent_Identity=30.9178743961353, Blast_Score=77, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002935 [H]

Pfam domain/function: PF01596 Methyltransf_3 [H]

EC number: NA

Molecular weight: Translated: 23470; Mature: 23470

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQDQWNRVDAYFSATLVPSDDVLDAALAASEAAGLPAINVAPNQGKLLQLLATIRGARR
CCCCHHHHEEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHH
ILEVGTLGGYSTIWLARALPPGGRLVTLELNPAHAAVATQNIARAGFADVVSVVVGSAKD
HHHHCCCCCHHHEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
SLARLIAEGEAPFDFIFIDADKDNNRAYLDAALKLSRPGTVIVVDNVVRRGRVADPDNRD
HHHHHHHCCCCCEEEEEEECCCCCCEEEEEEEEEECCCCEEEEECCHHHCCCCCCCCCCC
PDVVGVREGFARIVAEPKLTTTAVQTVGQKGWDGFSISIVGE
CCEEEHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEEC
>Mature Secondary Structure
MDQDQWNRVDAYFSATLVPSDDVLDAALAASEAAGLPAINVAPNQGKLLQLLATIRGARR
CCCCHHHHEEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHH
ILEVGTLGGYSTIWLARALPPGGRLVTLELNPAHAAVATQNIARAGFADVVSVVVGSAKD
HHHHCCCCCHHHEEEEECCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHH
SLARLIAEGEAPFDFIFIDADKDNNRAYLDAALKLSRPGTVIVVDNVVRRGRVADPDNRD
HHHHHHHCCCCCEEEEEEECCCCCCEEEEEEEEEECCCCEEEEECCHHHCCCCCCCCCCC
PDVVGVREGFARIVAEPKLTTTAVQTVGQKGWDGFSISIVGE
CCEEEHHHHHHHHHCCCCHHHHHHHHHHCCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1629172 [H]