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The map label for this gene is paaH [H]

Identifier: 189352232

GI number: 189352232

Start: 272574

End: 273584

Strand: Direct

Name: paaH [H]

Synonym: BMULJ_03450

Alternate gene names: 189352232

Gene position: 272574-273584 (Clockwise)

Preceding gene: 189352231

Following gene: 189352241

Centisome position: 11.02

GC content: 71.61

Gene sequence:

>1011_bases
ATGATGCCGGCCGCCGAACTGACGCGCGTGCACGTGCTCGGTGCGGGCCGCATGGGGCAGGGCATCGCGCTCGCCTTCGC
GTTCGCGGGGCTCGAGGTGACGCTGATCGACTTCAAGGCGCGCGATGCGGCGGGCCGGCTTGCATTCGATCGGCGTACGC
GCGACGAACTCGCGCGGCCGCTGCACGCGCAGGTCGCGCTCGGCCGCATCGATGCCGCGCAGGCCGACGCCGCGCTCGCG
CGGATCGCGCACGTCGCGCGCGACGGCGCGGCCGACGCGATCCGCGATGCGCAGGTCGTCTTCGAAGCGTTGCCTGAAGT
GCTCGACGCGAAGGCCGACGCGTTGCGCTGGCTCGATGCGCACGTCGATGCCGACGCGACGATTGCGTCGACGACGTCGA
CGTTCGTCGTCACCGAACTGCAGCGCCACGTCGCGCGGCCGGCGCGTGTGCTGAACGCGCACTGGCTGAACCCGGCGCTG
CTGATGCCGCTCGTCGAGATCAGTCGCAGCGACGCGACCGCGCAGCACGTCGTCGATGAACTCGCCGCGCTGCTCGTGCG
GATCGGCAAGAAGCCCGTGATCTGCGGGCCGGCGCCCGGCTATATCGTGCCGCGCATCCAGGCGCTCGCGATGAACGAGG
CCGCGCGGATGGTCGACGAAGGCGTGGCGAGCGCGGCGGACATCGATACCGCGATCCGCACGGGCTTCGGCCCGCGCTTC
GCGGTGCTCGGCCTGCTCGAGTTCATCGATTGGGGCGGCTGCGACATCCTGTACTACGCATCGACGTATCTGGCGGGCGA
GATCGGGCCGCGCTTCGCTCCGGCCGACGGCGTCGTGCGCAACATGAACGCCGGCCGCGACGGCGTGCGCACGGGTGCCG
GCTTTCACGACTACGCGGACGTCGACGTCGCGGCCTACATGCGGCAGCGGCTCGGCGAGTTCGCGCGGCTGCTCGAACAC
CTCGGCCTCGCACCGACGTTCGACGGCGCGCGGCGTCGCCCGAGCGCATGA

Upstream 100 bases:

>100_bases
CGCGCGACCTGTATGCGGAGGGCCGCACGCTGGAGCGGCTCGGGCTCGCGGCGCTGTCGCGCGACGCGATGCGCACGCTG
CTCGAGACGGGAGACGCCGC

Downstream 100 bases:

>100_bases
TCGGCTAACCGCACGACCGACGCAGCCGCCGCGGCGCGCGACGTACGACCGCACCATCATGCGTCGCCGCCGCGCGCGCC
CCCGGCGCGCACGATGCGCG

Product: 3-hydroxybutyryl-CoA dehydrogenase

Products: NA

Alternate protein names: Beta-hydroxybutyryl-CoA dehydrogenase; BHBD [H]

Number of amino acids: Translated: 336; Mature: 336

Protein sequence:

>336_residues
MMPAAELTRVHVLGAGRMGQGIALAFAFAGLEVTLIDFKARDAAGRLAFDRRTRDELARPLHAQVALGRIDAAQADAALA
RIAHVARDGAADAIRDAQVVFEALPEVLDAKADALRWLDAHVDADATIASTTSTFVVTELQRHVARPARVLNAHWLNPAL
LMPLVEISRSDATAQHVVDELAALLVRIGKKPVICGPAPGYIVPRIQALAMNEAARMVDEGVASAADIDTAIRTGFGPRF
AVLGLLEFIDWGGCDILYYASTYLAGEIGPRFAPADGVVRNMNAGRDGVRTGAGFHDYADVDVAAYMRQRLGEFARLLEH
LGLAPTFDGARRRPSA

Sequences:

>Translated_336_residues
MMPAAELTRVHVLGAGRMGQGIALAFAFAGLEVTLIDFKARDAAGRLAFDRRTRDELARPLHAQVALGRIDAAQADAALA
RIAHVARDGAADAIRDAQVVFEALPEVLDAKADALRWLDAHVDADATIASTTSTFVVTELQRHVARPARVLNAHWLNPAL
LMPLVEISRSDATAQHVVDELAALLVRIGKKPVICGPAPGYIVPRIQALAMNEAARMVDEGVASAADIDTAIRTGFGPRF
AVLGLLEFIDWGGCDILYYASTYLAGEIGPRFAPADGVVRNMNAGRDGVRTGAGFHDYADVDVAAYMRQRLGEFARLLEH
LGLAPTFDGARRRPSA
>Mature_336_residues
MMPAAELTRVHVLGAGRMGQGIALAFAFAGLEVTLIDFKARDAAGRLAFDRRTRDELARPLHAQVALGRIDAAQADAALA
RIAHVARDGAADAIRDAQVVFEALPEVLDAKADALRWLDAHVDADATIASTTSTFVVTELQRHVARPARVLNAHWLNPAL
LMPLVEISRSDATAQHVVDELAALLVRIGKKPVICGPAPGYIVPRIQALAMNEAARMVDEGVASAADIDTAIRTGFGPRF
AVLGLLEFIDWGGCDILYYASTYLAGEIGPRFAPADGVVRNMNAGRDGVRTGAGFHDYADVDVAAYMRQRLGEFARLLEH
LGLAPTFDGARRRPSA

Specific function: Butyrate/butanol-producing pathway. Phenylacetic acid aerobic catabolism. [C]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Mitochondria or Peroxisomes [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI296179429, Length=296, Percent_Identity=29.0540540540541, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI115430219, Length=258, Percent_Identity=27.1317829457364, Blast_Score=105, Evalue=8e-23,
Organism=Homo sapiens, GI296179427, Length=313, Percent_Identity=27.4760383386581, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI20127408, Length=302, Percent_Identity=26.4900662251656, Blast_Score=90, Evalue=3e-18,
Organism=Escherichia coli, GI1787661, Length=291, Percent_Identity=32.3024054982818, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1788682, Length=242, Percent_Identity=30.1652892561983, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI1790281, Length=247, Percent_Identity=27.1255060728745, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17553560, Length=297, Percent_Identity=27.9461279461279, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17563036, Length=298, Percent_Identity=29.1946308724832, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17549919, Length=302, Percent_Identity=26.8211920529801, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI25144276, Length=332, Percent_Identity=29.2168674698795, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17508951, Length=323, Percent_Identity=28.7925696594427, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17508953, Length=323, Percent_Identity=28.7925696594427, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17558304, Length=321, Percent_Identity=28.3489096573209, Blast_Score=101, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI71985923, Length=293, Percent_Identity=24.2320819112628, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI193203623, Length=200, Percent_Identity=28, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI115533614, Length=193, Percent_Identity=27.979274611399, Blast_Score=82, Evalue=5e-16,
Organism=Drosophila melanogaster, GI45549573, Length=246, Percent_Identity=32.9268292682927, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI20129993, Length=244, Percent_Identity=31.9672131147541, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19921000, Length=298, Percent_Identity=29.1946308724832, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24583077, Length=298, Percent_Identity=29.1946308724832, Blast_Score=92, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24583079, Length=298, Percent_Identity=29.1946308724832, Blast_Score=92, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022694
- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N [H]

EC number: =1.1.1.157 [H]

Molecular weight: Translated: 35958; Mature: 35958

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMPAAELTRVHVLGAGRMGQGIALAFAFAGLEVTLIDFKARDAAGRLAFDRRTRDELARP
CCCHHHHHEEEEEECCCCCCHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHCCHHHHHCC
LHAQVALGRIDAAQADAALARIAHVARDGAADAIRDAQVVFEALPEVLDAKADALRWLDA
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
HVDADATIASTTSTFVVTELQRHVARPARVLNAHWLNPALLMPLVEISRSDATAQHVVDE
HCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHH
LAALLVRIGKKPVICGPAPGYIVPRIQALAMNEAARMVDEGVASAADIDTAIRTGFGPRF
HHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AVLGLLEFIDWGGCDILYYASTYLAGEIGPRFAPADGVVRNMNAGRDGVRTGAGFHDYAD
HHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCH
VDVAAYMRQRLGEFARLLEHLGLAPTFDGARRRPSA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MMPAAELTRVHVLGAGRMGQGIALAFAFAGLEVTLIDFKARDAAGRLAFDRRTRDELARP
CCCHHHHHEEEEEECCCCCCHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHCCHHHHHCC
LHAQVALGRIDAAQADAALARIAHVARDGAADAIRDAQVVFEALPEVLDAKADALRWLDA
HHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
HVDADATIASTTSTFVVTELQRHVARPARVLNAHWLNPALLMPLVEISRSDATAQHVVDE
HCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHH
LAALLVRIGKKPVICGPAPGYIVPRIQALAMNEAARMVDEGVASAADIDTAIRTGFGPRF
HHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
AVLGLLEFIDWGGCDILYYASTYLAGEIGPRFAPADGVVRNMNAGRDGVRTGAGFHDYAD
HHHHHHHHHCCCCCEEHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCCH
VDVAAYMRQRLGEFARLLEHLGLAPTFDGARRRPSA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]