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The map label for this gene is lepB [H]

Identifier: 189184859

GI number: 189184859

Start: 1989484

End: 1990224

Strand: Reverse

Name: lepB [H]

Synonym: OTT_1952

Alternate gene names: 189184859

Gene position: 1990224-1989484 (Counterclockwise)

Preceding gene: 189184861

Following gene: 189184858

Centisome position: 99.07

GC content: 28.74

Gene sequence:

>741_bases
ATGTCAGAAGTTAGGTCCTTTCTTAAAGAATTTAGTGTATTGATGATGATAGTAGTTTTAGTCAGAGTAACAGTTTTTGA
TTTAAACTATATTCCTACTCCTTCTATGGCTACTAATTTATTACCTGGTGATTATATTATTGCAACCAAATATAGTTATG
GATACAGTAAATATTCCATACCATTTAATTTACCAATTTTTGAAGGTAAGATTTTTGCTTCTAAACCTGAACGTGGTGAT
GTAATAGTGTTTCAACCACCCCATGATCCATTATCTGAGAAATATATTAAAAGGTTAATCGGATTGCCTGGTGACACTAT
TAAAATTATAGACGGGCAGCAAGTTTTTATTAATGATATTCCACTTAATAGAGAATATATTGGCAAATATGTAAATGAGA
AAGGAGTAGAATATGACCAGTACTTTGAAACATTACCTAATAATGTTAAATATTTAACTCAATTTATAGCAAAAAAGCAT
CGCGAAATACGACATATTTCTGTTTTTCATGTACCAGAGAATCATTACTTTTTTCTAGGTGATAATAGAGATAACTCAGC
AGATAGTAGATTTGATATAGGTTATGTACATCTTAACAATTTAGTTTCCAAAGCTAGATTTATTTGGTTCTCAACAGCAA
AAGAAATTTGGTCAGAGAGTAATAATATTTTGCATGCAGTATTAAATGTAATACCTTGGATTAAATCAATAAGGTATAAT
AGGTTATTGAAAAAAATATAA

Upstream 100 bases:

>100_bases
TTAAAAGTAATTATTTTTTGTGTTTTTGTAGAAGTGCTTGCAGTATTAGTTTAGATTTTTAGATTTTTAGATTTATAGTA
TTTATTATCTAGTATAATTT

Downstream 100 bases:

>100_bases
TCGAGTACATTTGACAAATGTACTTAATATTTAATATAAATACTAGTCAATAACATGAGAGATACTAATAATGAACATAA
TAAACTATATAAAGTTGATT

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 246; Mature: 245

Protein sequence:

>246_residues
MSEVRSFLKEFSVLMMIVVLVRVTVFDLNYIPTPSMATNLLPGDYIIATKYSYGYSKYSIPFNLPIFEGKIFASKPERGD
VIVFQPPHDPLSEKYIKRLIGLPGDTIKIIDGQQVFINDIPLNREYIGKYVNEKGVEYDQYFETLPNNVKYLTQFIAKKH
REIRHISVFHVPENHYFFLGDNRDNSADSRFDIGYVHLNNLVSKARFIWFSTAKEIWSESNNILHAVLNVIPWIKSIRYN
RLLKKI

Sequences:

>Translated_246_residues
MSEVRSFLKEFSVLMMIVVLVRVTVFDLNYIPTPSMATNLLPGDYIIATKYSYGYSKYSIPFNLPIFEGKIFASKPERGD
VIVFQPPHDPLSEKYIKRLIGLPGDTIKIIDGQQVFINDIPLNREYIGKYVNEKGVEYDQYFETLPNNVKYLTQFIAKKH
REIRHISVFHVPENHYFFLGDNRDNSADSRFDIGYVHLNNLVSKARFIWFSTAKEIWSESNNILHAVLNVIPWIKSIRYN
RLLKKI
>Mature_245_residues
SEVRSFLKEFSVLMMIVVLVRVTVFDLNYIPTPSMATNLLPGDYIIATKYSYGYSKYSIPFNLPIFEGKIFASKPERGDV
IVFQPPHDPLSEKYIKRLIGLPGDTIKIIDGQQVFINDIPLNREYIGKYVNEKGVEYDQYFETLPNNVKYLTQFIAKKHR
EIRHISVFHVPENHYFFLGDNRDNSADSRFDIGYVHLNNLVSKARFIWFSTAKEIWSESNNILHAVLNVIPWIKSIRYNR
LLKKI

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=247, Percent_Identity=29.5546558704453, Blast_Score=99, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 28733; Mature: 28601

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS00760 SPASE_I_2 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVRSFLKEFSVLMMIVVLVRVTVFDLNYIPTPSMATNLLPGDYIIATKYSYGYSKYSI
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEEEEECCCEEECC
PFNLPIFEGKIFASKPERGDVIVFQPPHDPLSEKYIKRLIGLPGDTIKIIDGQQVFINDI
EECCCEECCEEEECCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCCEEEEECC
PLNREYIGKYVNEKGVEYDQYFETLPNNVKYLTQFIAKKHREIRHISVFHVPENHYFFLG
CCCHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEE
DNRDNSADSRFDIGYVHLNNLVSKARFIWFSTAKEIWSESNNILHAVLNVIPWIKSIRYN
CCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RLLKKI
HHHHCC
>Mature Secondary Structure 
SEVRSFLKEFSVLMMIVVLVRVTVFDLNYIPTPSMATNLLPGDYIIATKYSYGYSKYSI
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCEEEEEEEECCCEEECC
PFNLPIFEGKIFASKPERGDVIVFQPPHDPLSEKYIKRLIGLPGDTIKIIDGQQVFINDI
EECCCEECCEEEECCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCEEEEECCCEEEEECC
PLNREYIGKYVNEKGVEYDQYFETLPNNVKYLTQFIAKKHREIRHISVFHVPENHYFFLG
CCCHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHEEEEEEEECCCCEEEEE
DNRDNSADSRFDIGYVHLNNLVSKARFIWFSTAKEIWSESNNILHAVLNVIPWIKSIRYN
CCCCCCCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
RLLKKI
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA