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The map label for this gene is rnc [H]

Identifier: 189184858

GI number: 189184858

Start: 1988689

End: 1989429

Strand: Reverse

Name: rnc [H]

Synonym: OTT_1951

Alternate gene names: 189184858

Gene position: 1989429-1988689 (Counterclockwise)

Preceding gene: 189184859

Following gene: 189184856

Centisome position: 99.03

GC content: 28.88

Gene sequence:

>741_bases
ATGAGAGATACTAATAATGAACATAATAAACTATATAAAGTTGATTATACTAAACTAGATACCTTACAGTCTGAAATTGG
CTATAATTTTAATAGTATTGATTTGTTAATTGAAGCATTAACTCATCCTTCTATTAATCAATATGGATATACTAAAAATT
ATCAAAGGTTAGAGTTCTTAGGTGATGTAATACTTAATCTTGTAATCTCAGAAACGTTATTTAAAAATTTTAGTCACTAT
AACGAAGGAAAATTAGCTAAAAGTAGAGCTTTTTTAGTATGCAATGAGTCAATTTGCTTAATTGCTCAGAAAATTAATTT
GCATAAATATATCATAATGACTGCAAATGAGGAAAAATGCGGAGGAAGAAGTAATAAAAACAATATTGAAAATACAATGG
AAGCCGTTATTGGCGCTGTTTATCTAGATGGTGGTATTCACGTTATAAAAGACATTGTAAATTCGTTATGGAAGGTATTA
ATCAAAGACCATGAATTATATTTAATTGCTGATCCAAAAAGCGCTTTACAAGAATGGTCTCAAAGTAAAAATTTTGGTAT
TCCAACTTATACACTGTCATCTAAAACTGGACAGTCTCATAGCCCTTTATTTGAAGTGATGGTTAAAGTTGGAAGATTAG
AACCTCAATATGGTAAAGGTACAACAATTAAAACAGCTCAAAAAAACGCAGCACAACTTATGTTATCTACTGTTTTAGCA
AATTCAAAACTTGAAGCATAG

Upstream 100 bases:

>100_bases
TTGGATTAAATCAATAAGGTATAATAGGTTATTGAAAAAAATATAATCGAGTACATTTGACAAATGTACTTAATATTTAA
TATAAATACTAGTCAATAAC

Downstream 100 bases:

>100_bases
CATTGTATGTTGAAAATATGTGAAATTGCAATAAAATAAAAGTTATAGCAACAGTACAAAAGAAAGCTAGTATACAGTAT
TAATCTTAAGTCTAATAGCC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MRDTNNEHNKLYKVDYTKLDTLQSEIGYNFNSIDLLIEALTHPSINQYGYTKNYQRLEFLGDVILNLVISETLFKNFSHY
NEGKLAKSRAFLVCNESICLIAQKINLHKYIIMTANEEKCGGRSNKNNIENTMEAVIGAVYLDGGIHVIKDIVNSLWKVL
IKDHELYLIADPKSALQEWSQSKNFGIPTYTLSSKTGQSHSPLFEVMVKVGRLEPQYGKGTTIKTAQKNAAQLMLSTVLA
NSKLEA

Sequences:

>Translated_246_residues
MRDTNNEHNKLYKVDYTKLDTLQSEIGYNFNSIDLLIEALTHPSINQYGYTKNYQRLEFLGDVILNLVISETLFKNFSHY
NEGKLAKSRAFLVCNESICLIAQKINLHKYIIMTANEEKCGGRSNKNNIENTMEAVIGAVYLDGGIHVIKDIVNSLWKVL
IKDHELYLIADPKSALQEWSQSKNFGIPTYTLSSKTGQSHSPLFEVMVKVGRLEPQYGKGTTIKTAQKNAAQLMLSTVLA
NSKLEA
>Mature_246_residues
MRDTNNEHNKLYKVDYTKLDTLQSEIGYNFNSIDLLIEALTHPSINQYGYTKNYQRLEFLGDVILNLVISETLFKNFSHY
NEGKLAKSRAFLVCNESICLIAQKINLHKYIIMTANEEKCGGRSNKNNIENTMEAVIGAVYLDGGIHVIKDIVNSLWKVL
IKDHELYLIADPKSALQEWSQSKNFGIPTYTLSSKTGQSHSPLFEVMVKVGRLEPQYGKGTTIKTAQKNAAQLMLSTVLA
NSKLEA

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030234, Length=221, Percent_Identity=29.4117647058824, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI155030236, Length=221, Percent_Identity=29.4117647058824, Blast_Score=85, Evalue=8e-17,
Organism=Escherichia coli, GI1788920, Length=212, Percent_Identity=32.5471698113208, Blast_Score=119, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17506883, Length=238, Percent_Identity=27.3109243697479, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI193202651, Length=238, Percent_Identity=27.3109243697479, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17552834, Length=205, Percent_Identity=29.2682926829268, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17137682, Length=232, Percent_Identity=28.8793103448276, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI22026807, Length=91, Percent_Identity=39.5604395604396, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 27768; Mature: 27768

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: PS50137 DS_RBD ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDTNNEHNKLYKVDYTKLDTLQSEIGYNFNSIDLLIEALTHPSINQYGYTKNYQRLEFL
CCCCCCCCCEEEEECHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
GDVILNLVISETLFKNFSHYNEGKLAKSRAFLVCNESICLIAQKINLHKYIIMTANEEKC
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEEEEEEECCCEEEEEEECCCHHC
GGRSNKNNIENTMEAVIGAVYLDGGIHVIKDIVNSLWKVLIKDHELYLIADPKSALQEWS
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHH
QSKNFGIPTYTLSSKTGQSHSPLFEVMVKVGRLEPQYGKGTTIKTAQKNAAQLMLSTVLA
HCCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHH
NSKLEA
CCCCCC
>Mature Secondary Structure
MRDTNNEHNKLYKVDYTKLDTLQSEIGYNFNSIDLLIEALTHPSINQYGYTKNYQRLEFL
CCCCCCCCCEEEEECHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
GDVILNLVISETLFKNFSHYNEGKLAKSRAFLVCNESICLIAQKINLHKYIIMTANEEKC
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCEEEEEEECCCEEEEEEECCCHHC
GGRSNKNNIENTMEAVIGAVYLDGGIHVIKDIVNSLWKVLIKDHELYLIADPKSALQEWS
CCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHH
QSKNFGIPTYTLSSKTGQSHSPLFEVMVKVGRLEPQYGKGTTIKTAQKNAAQLMLSTVLA
HCCCCCCCEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHH
NSKLEA
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA