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The map label for this gene is rsh [H]

Identifier: 189184754

GI number: 189184754

Start: 1879128

End: 1879721

Strand: Reverse

Name: rsh [H]

Synonym: OTT_1847

Alternate gene names: 189184754

Gene position: 1879721-1879128 (Counterclockwise)

Preceding gene: 189184755

Following gene: 189184749

Centisome position: 93.57

GC content: 30.3

Gene sequence:

>594_bases
ATGATAGACTTTTATAGCGAGAGCTTACTAAATAAGCTGTTTGAAACCAACGTAAGATTTAACACTAAAATTGATCTTGA
TAAAGTTGAAAAAGCAATATTTTATGCCAAAAAATATCATAGCAATCAAAAGCGAGAGACAGGAGAACCTTATTATATGC
ATCCATTAGAAGTAGCTTATATGGTATCAGACTACAGCTTTGAAACAGATACGATTATTACAGCAATACTACATGATACC
ATCGAAGACACAACACTAACCAAAGAAAAGATTGTTAAGGTATTTGGTAAAAAAATTGCAGAACAGGTTTCAGAACTCAC
AAGGATTAAGGATAATAAAAAAATCAGTTCTAGAGAAATGATTCAAACATTTTATAAGCAAAATAAAACAGAACTATTAT
TAATTAAGCTTTTCGACCGATTCCATAATATTCAAACCATACACATAAAACCTTATGAAAAAAGACAAAAAATCGTCATT
GAAACTCAGCAAGAATTTATACCTCTTGCTAAGTATAGCAATAACGTAGGAAATAGGTACAATCAGATAAACTGCATTAC
GTGTGCTACAGCAATGCTAATATCTTTGAATTGA

Upstream 100 bases:

>100_bases
ACAATTTAATTTACTTCTTTCCGAGACTTTATTTGAGATTGGAGTATATAAAAAGTTTAAATTATGGTATAATTTATTAA
AGATTATTTAGAGATGGAAA

Downstream 100 bases:

>100_bases
CCAATAACTTTTCTTATTTCGTTCTTAATCTTAAACCAATAATGTTCTATAGGATTTAAATCTGGACTATATGTAGGTAA
GAATAGAATACTGCAGCCAA

Product: RelA/SpoT-related protein

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase [H]

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MIDFYSESLLNKLFETNVRFNTKIDLDKVEKAIFYAKKYHSNQKRETGEPYYMHPLEVAYMVSDYSFETDTIITAILHDT
IEDTTLTKEKIVKVFGKKIAEQVSELTRIKDNKKISSREMIQTFYKQNKTELLLIKLFDRFHNIQTIHIKPYEKRQKIVI
ETQQEFIPLAKYSNNVGNRYNQINCITCATAMLISLN

Sequences:

>Translated_197_residues
MIDFYSESLLNKLFETNVRFNTKIDLDKVEKAIFYAKKYHSNQKRETGEPYYMHPLEVAYMVSDYSFETDTIITAILHDT
IEDTTLTKEKIVKVFGKKIAEQVSELTRIKDNKKISSREMIQTFYKQNKTELLLIKLFDRFHNIQTIHIKPYEKRQKIVI
ETQQEFIPLAKYSNNVGNRYNQINCITCATAMLISLN
>Mature_197_residues
MIDFYSESLLNKLFETNVRFNTKIDLDKVEKAIFYAKKYHSNQKRETGEPYYMHPLEVAYMVSDYSFETDTIITAILHDT
IEDTTLTKEKIVKVFGKKIAEQVSELTRIKDNKKISSREMIQTFYKQNKTELLLIKLFDRFHNIQTIHIKPYEKRQKIVI
ETQQEFIPLAKYSNNVGNRYNQINCITCATAMLISLN

Specific function: Functions as a (p)ppGpp synthase. In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. Plays a role in ada

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Escherichia coli, GI1790082, Length=169, Percent_Identity=32.5443786982249, Blast_Score=94, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI25143118, Length=129, Percent_Identity=30.2325581395349, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 23281; Mature: 23281

Theoretical pI: Translated: 9.15; Mature: 9.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDFYSESLLNKLFETNVRFNTKIDLDKVEKAIFYAKKYHSNQKRETGEPYYMHPLEVAY
CCCHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHHCCCCCCCCCCCEEECHHHEEE
MVSDYSFETDTIITAILHDTIEDTTLTKEKIVKVFGKKIAEQVSELTRIKDNKKISSREM
EEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
IQTFYKQNKTELLLIKLFDRFHNIQTIHIKPYEKRQKIVIETQQEFIPLAKYSNNVGNRY
HHHHHHCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCEEEECHHHHHHHHHHCCCCCCCC
NQINCITCATAMLISLN
CEEHHHHHHHHHHHCCC
>Mature Secondary Structure
MIDFYSESLLNKLFETNVRFNTKIDLDKVEKAIFYAKKYHSNQKRETGEPYYMHPLEVAY
CCCHHHHHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHHCCCCCCCCCCCEEECHHHEEE
MVSDYSFETDTIITAILHDTIEDTTLTKEKIVKVFGKKIAEQVSELTRIKDNKKISSREM
EEECCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
IQTFYKQNKTELLLIKLFDRFHNIQTIHIKPYEKRQKIVIETQQEFIPLAKYSNNVGNRY
HHHHHHCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCEEEECHHHHHHHHHHCCCCCCCC
NQINCITCATAMLISLN
CEEHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA