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The map label for this gene is nlpI [C]

Identifier: 189184574

GI number: 189184574

Start: 1693887

End: 1694960

Strand: Reverse

Name: nlpI [C]

Synonym: OTT_1667

Alternate gene names: 189184574

Gene position: 1694960-1693887 (Counterclockwise)

Preceding gene: 189184575

Following gene: 189184573

Centisome position: 84.37

GC content: 29.05

Gene sequence:

>1074_bases
ATGCTAACAGACAAATATTTTAATAAAGGGAATTCATTTTTTCAGTTAAGAAAATATCAAGAAGCAATAAAGAAGTTTAA
TTTAGCTATTAAGTGTAATCCATATTCAGCAGAAGCTTATATTAATAAAGGAATTGCTTTAGACAAATTAGGGCAACATC
AAGAAGCAATAGAGAATTATGATATAGCTATTAAGTATAAACCAGATTCGGTAGAAGCTTATATTAATAAAGGAATTTCT
TTGAAGCAATTAGGACAATATCAAGATGCAATAAAGAATTATGATATAGCTATTAAGTATAAACCAGATTCGGCGGAAGC
TTATATTAATAAAGGAGCAGCTTTGAACGAATTAGGTCAATATCAAGAAGCAATAGAGAATTATGATATAGCTATTAAGT
ATAAACCAGATTCGGCGGAAGCTTATATTAATAAAGGAAATACTTTGATGCAATTATGGCAATATCAAGAAGCAATAGAG
AATTATGATATAGCTATTCGATGTAACCCAAATGATGTAAACGCTTACTATAATAAAGGAATTGCTTTGAACGAATTAGG
TCGATATCAAGAAGCAATAGATAATTATGATATAGCTATTAAGTATAAACCAGATTTGGCAAAAGCTTATATTAATAAAG
GAAATGCTTTGAATGAATTAGGTCGATATCAAGAAGCAATAGAGAATTTTGATACAGGTATTCGATACAACCCAAATGAT
GAAAAGGCTTACTATAATAAAGGAATTTCTTTATACCAATTAGTGCAATATCAAGAAGCAATAGAGAATTGTGATATAGC
TATTAAGCATAAACCAGATCTGGCAGAAGCTTATATGAATAAAGGAGTTGCTTTGAGTAAATTAGGACAACATCAAGAAG
CAATAAAGAAGTTTAATTTAGCTATTAAGTATAAACCAGGTTTTGCAGAAGCTTATCTTAATAAAGGAGAGAGTTTGAAG
CAATTAGGACAACGTGAAAAGGCAATAAAGAATTTTGAGTTAGCTATTAAGTATAAACCAGGTTTAATAGCACCTTATAT
TAGAGATATTTTAAAAAAGGTAGAAATGCAATAG

Upstream 100 bases:

>100_bases
TATAAATCATATAAAATATATGACAGTATTATTAATACAGTTACATCTGTTGCATCAAAATAATCTGCTCATATAACACT
ATTTAATTCAGGATAAAGAT

Downstream 100 bases:

>100_bases
AAAAAGTTGTAACCTGGCTATCAAATATGATTCTGATAATGTGTACGCATACCAGTTAGCAAATGAACTTGCAAAAAAAA
TTAAAAAAAGCAATCTCCGC

Product: TPR repeat-containing protein 08

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 357; Mature: 357

Protein sequence:

>357_residues
MLTDKYFNKGNSFFQLRKYQEAIKKFNLAIKCNPYSAEAYINKGIALDKLGQHQEAIENYDIAIKYKPDSVEAYINKGIS
LKQLGQYQDAIKNYDIAIKYKPDSAEAYINKGAALNELGQYQEAIENYDIAIKYKPDSAEAYINKGNTLMQLWQYQEAIE
NYDIAIRCNPNDVNAYYNKGIALNELGRYQEAIDNYDIAIKYKPDLAKAYINKGNALNELGRYQEAIENFDTGIRYNPND
EKAYYNKGISLYQLVQYQEAIENCDIAIKHKPDLAEAYMNKGVALSKLGQHQEAIKKFNLAIKYKPGFAEAYLNKGESLK
QLGQREKAIKNFELAIKYKPGLIAPYIRDILKKVEMQ

Sequences:

>Translated_357_residues
MLTDKYFNKGNSFFQLRKYQEAIKKFNLAIKCNPYSAEAYINKGIALDKLGQHQEAIENYDIAIKYKPDSVEAYINKGIS
LKQLGQYQDAIKNYDIAIKYKPDSAEAYINKGAALNELGQYQEAIENYDIAIKYKPDSAEAYINKGNTLMQLWQYQEAIE
NYDIAIRCNPNDVNAYYNKGIALNELGRYQEAIDNYDIAIKYKPDLAKAYINKGNALNELGRYQEAIENFDTGIRYNPND
EKAYYNKGISLYQLVQYQEAIENCDIAIKHKPDLAEAYMNKGVALSKLGQHQEAIKKFNLAIKYKPGFAEAYLNKGESLK
QLGQREKAIKNFELAIKYKPGLIAPYIRDILKKVEMQ
>Mature_357_residues
MLTDKYFNKGNSFFQLRKYQEAIKKFNLAIKCNPYSAEAYINKGIALDKLGQHQEAIENYDIAIKYKPDSVEAYINKGIS
LKQLGQYQDAIKNYDIAIKYKPDSAEAYINKGAALNELGQYQEAIENYDIAIKYKPDSAEAYINKGNTLMQLWQYQEAIE
NYDIAIRCNPNDVNAYYNKGIALNELGRYQEAIDNYDIAIKYKPDLAKAYINKGNALNELGRYQEAIENFDTGIRYNPND
EKAYYNKGISLYQLVQYQEAIENCDIAIKHKPDLAEAYMNKGVALSKLGQHQEAIKKFNLAIKYKPGFAEAYLNKGESLK
QLGQREKAIKNFELAIKYKPGLIAPYIRDILKKVEMQ

Specific function: May Be Involved In Cell Division. Overexpression Of Nlpi Results In The Loss Of The Rod Morphology And The Formation Of Single Prolate Ellipsoids And Pairs Of Prolate Ellipsoids Joined By Partial Constrictions. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Attached To The Membrane By A Lipid Anchor [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 9 TPR repeats [H]

Homologues:

Organism=Homo sapiens, GI32307150, Length=363, Percent_Identity=30.5785123966942, Blast_Score=158, Evalue=8e-39,
Organism=Homo sapiens, GI32307148, Length=363, Percent_Identity=30.5785123966942, Blast_Score=158, Evalue=9e-39,
Organism=Homo sapiens, GI310123097, Length=292, Percent_Identity=27.7397260273973, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI310110582, Length=292, Percent_Identity=27.7397260273973, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI310131789, Length=292, Percent_Identity=27.7397260273973, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI170784867, Length=253, Percent_Identity=29.2490118577075, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI83415184, Length=321, Percent_Identity=26.1682242990654, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI301336134, Length=321, Percent_Identity=26.1682242990654, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI224809432, Length=338, Percent_Identity=25.4437869822485, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI296531396, Length=212, Percent_Identity=27.8301886792453, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI262206280, Length=318, Percent_Identity=22.9559748427673, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI22749211, Length=326, Percent_Identity=26.6871165644172, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI118766330, Length=263, Percent_Identity=25.4752851711027, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI118766328, Length=263, Percent_Identity=25.4752851711027, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI25952122, Length=278, Percent_Identity=27.3381294964029, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI54607135, Length=202, Percent_Identity=29.7029702970297, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI5803181, Length=232, Percent_Identity=24.5689655172414, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI224028289, Length=386, Percent_Identity=26.6839378238342, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI225735593, Length=255, Percent_Identity=26.2745098039216, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI225735591, Length=255, Percent_Identity=26.2745098039216, Blast_Score=66, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI115532690, Length=395, Percent_Identity=29.1139240506329, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI115532692, Length=371, Percent_Identity=29.3800539083558, Blast_Score=137, Evalue=8e-33,
Organism=Caenorhabditis elegans, GI25147174, Length=252, Percent_Identity=22.6190476190476, Blast_Score=74, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319387, Length=271, Percent_Identity=25.4612546125461, Blast_Score=84, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17647755, Length=363, Percent_Identity=30.3030303030303, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24585827, Length=363, Percent_Identity=30.3030303030303, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24585829, Length=363, Percent_Identity=30.3030303030303, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI161076610, Length=320, Percent_Identity=28.125, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI19920486, Length=320, Percent_Identity=28.125, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24647123, Length=264, Percent_Identity=25.7575757575758, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24656717, Length=344, Percent_Identity=26.453488372093, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI18110006, Length=344, Percent_Identity=26.453488372093, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI17137540, Length=405, Percent_Identity=22.962962962963, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI281364285, Length=326, Percent_Identity=23.6196319018405, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24581187, Length=326, Percent_Identity=23.6196319018405, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008940
- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF00515 TPR_1 [H]

EC number: NA

Molecular weight: Translated: 40970; Mature: 40970

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: PS50005 TPR ; PS50293 TPR_REGION

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTDKYFNKGNSFFQLRKYQEAIKKFNLAIKCNPYSAEAYINKGIALDKLGQHQEAIENY
CCCCHHHCCCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHCCCCHHHHCCHHHHHCCC
DIAIKYKPDSVEAYINKGISLKQLGQYQDAIKNYDIAIKYKPDSAEAYINKGAALNELGQ
CEEEEECCCHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHCCCHHHHHHH
YQEAIENYDIAIKYKPDSAEAYINKGNTLMQLWQYQEAIENYDIAIRCNPNDVNAYYNKG
HHHHHCCCCEEEEECCCCCHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHCCC
IALNELGRYQEAIDNYDIAIKYKPDLAKAYINKGNALNELGRYQEAIENFDTGIRYNPND
EEHHHHHHHHHHHCCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEECCCC
EKAYYNKGISLYQLVQYQEAIENCDIAIKHKPDLAEAYMNKGVALSKLGQHQEAIKKFNL
CHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHCE
AIKYKPGFAEAYLNKGESLKQLGQREKAIKNFELAIKYKPGLIAPYIRDILKKVEMQ
EEEECCCHHHHHHCCCHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MLTDKYFNKGNSFFQLRKYQEAIKKFNLAIKCNPYSAEAYINKGIALDKLGQHQEAIENY
CCCCHHHCCCCHHHHHHHHHHHHHHCCEEEEECCCCCHHHHHCCCCHHHHCCHHHHHCCC
DIAIKYKPDSVEAYINKGISLKQLGQYQDAIKNYDIAIKYKPDSAEAYINKGAALNELGQ
CEEEEECCCHHHHHHHCCCCHHHHHHHHHHHCCCCEEEEECCCCHHHHHHCCCHHHHHHH
YQEAIENYDIAIKYKPDSAEAYINKGNTLMQLWQYQEAIENYDIAIRCNPNDVNAYYNKG
HHHHHCCCCEEEEECCCCCHHHHCCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHCCC
IALNELGRYQEAIDNYDIAIKYKPDLAKAYINKGNALNELGRYQEAIENFDTGIRYNPND
EEHHHHHHHHHHHCCCEEEEEECCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCEECCCC
EKAYYNKGISLYQLVQYQEAIENCDIAIKHKPDLAEAYMNKGVALSKLGQHQEAIKKFNL
CHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHCCCCHHHHHHHHHHHHHHHCE
AIKYKPGFAEAYLNKGESLKQLGQREKAIKNFELAIKYKPGLIAPYIRDILKKVEMQ
EEEECCCHHHHHHCCCHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8688087; 9697413 [H]