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The map label for this gene is hemC [H]

Identifier: 189184545

GI number: 189184545

Start: 1667750

End: 1668646

Strand: Reverse

Name: hemC [H]

Synonym: OTT_1638

Alternate gene names: 189184545

Gene position: 1668646-1667750 (Counterclockwise)

Preceding gene: 189184548

Following gene: 189184544

Centisome position: 83.06

GC content: 32.66

Gene sequence:

>897_bases
ATGATTATTAGAGTAGGTAGTAGAGCAAGCAGATTGGCATTGATACAGGCGCAAGCAGTAGTTCAAAAAATTAATGATTT
ACTTGGGTTAAATGCTATAATAATTCCTATTAAAACTACTGGTGATTTAATTCAGAATAAAAACCTTTATGATATAGGAG
GCAAGGGCCTATTTTTAAAAGAAATAGAGTATGCTTTATTAAATAATACTATTGATATTGCTGTTCATTCCTTAAAAGAT
GTACCAGCTTATTTACCTGATGGATTACAACTTGCAGCTGTACTAGAAAGGGGGAATGTTGGCGATATGCTTGTATCTAA
AATAGCAAATAAAATTACTGACTTACCTTTAGGGGCTAGAGTTGGCACTTCTTCTGTACGAAGACGAATACAGCTATTAA
GGCTTCGGCCTGATCTTAATATCGTGTTATTTAGAGGTAATGTTGATACTAGATGGAATAAAATTTTCAATAATGAGGTA
GATGCAACAGTTTTGGCTGCTGCTGGACTACAGAGATTGAATTATGATACTAGCCGTTTTTGTAATATTATTTCTCAAGA
TGAGATGTTGCCAGCAATTGGGCAAGGCGTAATTGCAATCGAAGCTAGAAAAGATGATAAACTAATAATGCCATTATGTG
CTAAAATTAATCATCAGTTAACTTGGCAATTAATACAAGTTGAAAGAGGTTATTTAAAAACTTTAAATGCCGATTGTAAC
GTTCCAATAGGTGGGCTTGCAAACTATATTGGTAATAATAATTTTGAGGCTAAATTTATGCTTGGAGATTATAATATGAG
ATATTTTTTTTATTCTGAGGTGTGTGGAAAGTTACAGCATGGTTACGATATTGGAGTTGAAGCAGCAAAAAACTTTCAAA
AAAAATTATTTGTCTGA

Upstream 100 bases:

>100_bases
GAAAAGCTATTTTTTATACTAATTTATGAATTTATATAGTTTAAATATACACTTATTCAGTGTGGAATAATAAGTCAGTG
AAAGTAGTAATATCAAGTTT

Downstream 100 bases:

>100_bases
ATTTTTTTTCTTAATTAGAAGATCTATTTAGTAACTATATGTCTATGGTATACTCTCTAACATCTAATAATTAGGAAGAG
CTTTAGCCAAAATACATATA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 298; Mature: 298

Protein sequence:

>298_residues
MIIRVGSRASRLALIQAQAVVQKINDLLGLNAIIIPIKTTGDLIQNKNLYDIGGKGLFLKEIEYALLNNTIDIAVHSLKD
VPAYLPDGLQLAAVLERGNVGDMLVSKIANKITDLPLGARVGTSSVRRRIQLLRLRPDLNIVLFRGNVDTRWNKIFNNEV
DATVLAAAGLQRLNYDTSRFCNIISQDEMLPAIGQGVIAIEARKDDKLIMPLCAKINHQLTWQLIQVERGYLKTLNADCN
VPIGGLANYIGNNNFEAKFMLGDYNMRYFFYSEVCGKLQHGYDIGVEAAKNFQKKLFV

Sequences:

>Translated_298_residues
MIIRVGSRASRLALIQAQAVVQKINDLLGLNAIIIPIKTTGDLIQNKNLYDIGGKGLFLKEIEYALLNNTIDIAVHSLKD
VPAYLPDGLQLAAVLERGNVGDMLVSKIANKITDLPLGARVGTSSVRRRIQLLRLRPDLNIVLFRGNVDTRWNKIFNNEV
DATVLAAAGLQRLNYDTSRFCNIISQDEMLPAIGQGVIAIEARKDDKLIMPLCAKINHQLTWQLIQVERGYLKTLNADCN
VPIGGLANYIGNNNFEAKFMLGDYNMRYFFYSEVCGKLQHGYDIGVEAAKNFQKKLFV
>Mature_298_residues
MIIRVGSRASRLALIQAQAVVQKINDLLGLNAIIIPIKTTGDLIQNKNLYDIGGKGLFLKEIEYALLNNTIDIAVHSLKD
VPAYLPDGLQLAAVLERGNVGDMLVSKIANKITDLPLGARVGTSSVRRRIQLLRLRPDLNIVLFRGNVDTRWNKIFNNEV
DATVLAAAGLQRLNYDTSRFCNIISQDEMLPAIGQGVIAIEARKDDKLIMPLCAKINHQLTWQLIQVERGYLKTLNADCN
VPIGGLANYIGNNNFEAKFMLGDYNMRYFFYSEVCGKLQHGYDIGVEAAKNFQKKLFV

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI66933009, Length=248, Percent_Identity=39.5161290322581, Blast_Score=163, Evalue=2e-40,
Organism=Homo sapiens, GI20149500, Length=247, Percent_Identity=39.6761133603239, Blast_Score=163, Evalue=2e-40,
Organism=Escherichia coli, GI48994974, Length=292, Percent_Identity=40.7534246575342, Blast_Score=197, Evalue=9e-52,
Organism=Saccharomyces cerevisiae, GI6319996, Length=269, Percent_Identity=36.4312267657993, Blast_Score=149, Evalue=5e-37,
Organism=Drosophila melanogaster, GI20130425, Length=257, Percent_Identity=38.1322957198444, Blast_Score=164, Evalue=1e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 33188; Mature: 33188

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIRVGSRASRLALIQAQAVVQKINDLLGLNAIIIPIKTTGDLIQNKNLYDIGGKGLFLK
CEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHCCCCEEEECCCEEEHH
EIEYALLNNTIDIAVHSLKDVPAYLPDGLQLAAVLERGNVGDMLVSKIANKITDLPLGAR
HHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCC
VGTSSVRRRIQLLRLRPDLNIVLFRGNVDTRWNKIFNNEVDATVLAAAGLQRLNYDTSRF
CCHHHHHHHHHHHEECCCCEEEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHH
CNIISQDEMLPAIGQGVIAIEARKDDKLIMPLCAKINHQLTWQLIQVERGYLKTLNADCN
HHHHCCCCCCHHHCCCEEEEEECCCCCCHHHHHHHCCHHHEEEEEEHHCCHHHCCCCCCC
VPIGGLANYIGNNNFEAKFMLGDYNMRYFFYSEVCGKLQHGYDIGVEAAKNFQKKLFV
CCHHHHHHHHCCCCCEEEEEEECCCEEEEEHHHHHHHHHCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MIIRVGSRASRLALIQAQAVVQKINDLLGLNAIIIPIKTTGDLIQNKNLYDIGGKGLFLK
CEEEECCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCHHHCCCCEEEECCCEEEHH
EIEYALLNNTIDIAVHSLKDVPAYLPDGLQLAAVLERGNVGDMLVSKIANKITDLPLGAR
HHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCC
VGTSSVRRRIQLLRLRPDLNIVLFRGNVDTRWNKIFNNEVDATVLAAAGLQRLNYDTSRF
CCHHHHHHHHHHHEECCCCEEEEEECCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHH
CNIISQDEMLPAIGQGVIAIEARKDDKLIMPLCAKINHQLTWQLIQVERGYLKTLNADCN
HHHHCCCCCCHHHCCCEEEEEECCCCCCHHHHHHHCCHHHEEEEEEHHCCHHHCCCCCCC
VPIGGLANYIGNNNFEAKFMLGDYNMRYFFYSEVCGKLQHGYDIGVEAAKNFQKKLFV
CCHHHHHHHHCCCCCEEEEEEECCCEEEEEHHHHHHHHHCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA