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The map label for this gene is virB11 [H]

Identifier: 189184475

GI number: 189184475

Start: 1595867

End: 1596856

Strand: Reverse

Name: virB11 [H]

Synonym: OTT_1568

Alternate gene names: 189184475

Gene position: 1596856-1595867 (Counterclockwise)

Preceding gene: 189184476

Following gene: 189184474

Centisome position: 79.49

GC content: 32.53

Gene sequence:

>990_bases
ATGAAGAATAATATTGCACTTGAAACCTATTTAACTCCTTTTAAATTAATTTTTGATGAAGCAGGAGTAAATGAGGTGAT
GATTAACCGCCCTGGTGAGGTTTGGGTTGAAAAAAAGGGAAGCTATCGTCAAGAATTAATGAAAGATCTAGATTTTAGTC
ATTTAGCTGCTTTAGCTAGGTTAATAGCTCAGTCAACTGAACAAGTTATTTCTGAAGAAAAACCATTACTTTCAGCTACT
CTACCTAATGGCTATAGAGTGCAGGTAGTTTTTCCACCAGCTTGTGAAGTTGGATCAATAGGTATAGCTATTAGAAAAGT
ATCTTCTTTAAATATGACTTTAGAAGATTATAATAAAACAGGAGCATTTGATTACACGGCGATTGATGAAGTAATTGATG
AAAATGATAAAATACTTAGTGAATACCTTATTAATAAACAATTCAAAAATTTTTTGCAGCATGCAATAAAGTCCAAAAAA
AATATTATTATTAGCGGTGGTACCTCTAGTGGTAAAACAACTTTTACTAATTCAGCTTTATTAGAAGTTCCGCATACAGA
AAGACTAATTACTGTTGAAGATGCTAGAGAAATTAGCATACCTAATCATCCAAATCGCTTGCATTTATTAGCTTCAAAAG
GAAATCAAGGACGAGCAAAGGTTACTACTCAAGATTTAATTGAAGCTTGTTTAAGGCTAAGGCCTGATAGAATAATAATT
GGTGAGTTGCGAGGAGCAGAAGCATTTAGTTTTTTACGTGCTATTAATACAGGGCATCCAGGATCAATATCAACTTTACA
TGCAGATACTACTGCAATGGCTTTGGAGCAGTTAAAATTAATGGTAATGCAAGCTGGACTAGGAATGCCGCCAGATGAAA
TCAAAAACTATATTAATGCAGTAATTGATATAGTAGTGCAATTGAAGCGTGGTGATCGTGGAATTAGATATATTTCTGAA
ATATATTTTAAAAAAATGAGAAAAAAATAA

Upstream 100 bases:

>100_bases
ATAGAACTATTACTCTTAATCAAGGACAGAATATTAAAATATATGTTAACAAGGATTATTTGTTTCCAACAAAAGCAGTT
AGTGGAGTAAGAGTACTCTG

Downstream 100 bases:

>100_bases
TGAATGAGAATGCATTTTTAACTAAGATTAGAAATCTAGTTATAAAGATAATGGTTCATTGTATTGGAGTAATATTAGTA
GTTTTCATTATTAAATTTTT

Product: type IV secretion system ATPase VirB11

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MKNNIALETYLTPFKLIFDEAGVNEVMINRPGEVWVEKKGSYRQELMKDLDFSHLAALARLIAQSTEQVISEEKPLLSAT
LPNGYRVQVVFPPACEVGSIGIAIRKVSSLNMTLEDYNKTGAFDYTAIDEVIDENDKILSEYLINKQFKNFLQHAIKSKK
NIIISGGTSSGKTTFTNSALLEVPHTERLITVEDAREISIPNHPNRLHLLASKGNQGRAKVTTQDLIEACLRLRPDRIII
GELRGAEAFSFLRAINTGHPGSISTLHADTTAMALEQLKLMVMQAGLGMPPDEIKNYINAVIDIVVQLKRGDRGIRYISE
IYFKKMRKK

Sequences:

>Translated_329_residues
MKNNIALETYLTPFKLIFDEAGVNEVMINRPGEVWVEKKGSYRQELMKDLDFSHLAALARLIAQSTEQVISEEKPLLSAT
LPNGYRVQVVFPPACEVGSIGIAIRKVSSLNMTLEDYNKTGAFDYTAIDEVIDENDKILSEYLINKQFKNFLQHAIKSKK
NIIISGGTSSGKTTFTNSALLEVPHTERLITVEDAREISIPNHPNRLHLLASKGNQGRAKVTTQDLIEACLRLRPDRIII
GELRGAEAFSFLRAINTGHPGSISTLHADTTAMALEQLKLMVMQAGLGMPPDEIKNYINAVIDIVVQLKRGDRGIRYISE
IYFKKMRKK
>Mature_329_residues
MKNNIALETYLTPFKLIFDEAGVNEVMINRPGEVWVEKKGSYRQELMKDLDFSHLAALARLIAQSTEQVISEEKPLLSAT
LPNGYRVQVVFPPACEVGSIGIAIRKVSSLNMTLEDYNKTGAFDYTAIDEVIDENDKILSEYLINKQFKNFLQHAIKSKK
NIIISGGTSSGKTTFTNSALLEVPHTERLITVEDAREISIPNHPNRLHLLASKGNQGRAKVTTQDLIEACLRLRPDRIII
GELRGAEAFSFLRAINTGHPGSISTLHADTTAMALEQLKLMVMQAGLGMPPDEIKNYINAVIDIVVQLKRGDRGIRYISE
IYFKKMRKK

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG0630

COG function: function code NU; Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis

Gene ontology:

Cell location: Cell inner membrane (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP E family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR014155
- InterPro:   IPR001482 [H]

Pfam domain/function: PF00437 GSPII_E [H]

EC number: NA

Molecular weight: Translated: 36798; Mature: 36798

Theoretical pI: Translated: 8.93; Mature: 8.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNNIALETYLTPFKLIFDEAGVNEVMINRPGEVWVEKKGSYRQELMKDLDFSHLAALAR
CCCCEEEEECCCHHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHHCCHHHHHHHHH
LIAQSTEQVISEEKPLLSATLPNGYRVQVVFPPACEVGSIGIAIRKVSSLNMTLEDYNKT
HHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCCCCCCHHEEEEHHHCCCCHHHCCCC
GAFDYTAIDEVIDENDKILSEYLINKQFKNFLQHAIKSKKNIIISGGTSSGKTTFTNSAL
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEECCCEE
LEVPHTERLITVEDAREISIPNHPNRLHLLASKGNQGRAKVTTQDLIEACLRLRPDRIII
EECCCCCEEEEECCCCEECCCCCCCEEEEEECCCCCCCEEECHHHHHHHHHHCCCCEEEE
GELRGAEAFSFLRAINTGHPGSISTLHADTTAMALEQLKLMVMQAGLGMPPDEIKNYINA
EECCCHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
VIDIVVQLKRGDRGIRYISEIYFKKMRKK
HHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNNIALETYLTPFKLIFDEAGVNEVMINRPGEVWVEKKGSYRQELMKDLDFSHLAALAR
CCCCEEEEECCCHHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHHCCHHHHHHHHH
LIAQSTEQVISEEKPLLSATLPNGYRVQVVFPPACEVGSIGIAIRKVSSLNMTLEDYNKT
HHHHHHHHHHHCCCCEEEEECCCCEEEEEEECCCCCCCCCHHEEEEHHHCCCCHHHCCCC
GAFDYTAIDEVIDENDKILSEYLINKQFKNFLQHAIKSKKNIIISGGTSSGKTTFTNSAL
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCEEECCCEE
LEVPHTERLITVEDAREISIPNHPNRLHLLASKGNQGRAKVTTQDLIEACLRLRPDRIII
EECCCCCEEEEECCCCEECCCCCCCEEEEEECCCCCCCEEECHHHHHHHHHHCCCCEEEE
GELRGAEAFSFLRAINTGHPGSISTLHADTTAMALEQLKLMVMQAGLGMPPDEIKNYINA
EECCCHHHHHHHHHHCCCCCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
VIDIVVQLKRGDRGIRYISEIYFKKMRKK
HHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]