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The map label for this gene is mazG [H]

Identifier: 189026003

GI number: 189026003

Start: 846174

End: 847085

Strand: Reverse

Name: mazG [H]

Synonym: TPASS_0778

Alternate gene names: 189026003

Gene position: 847085-846174 (Counterclockwise)

Preceding gene: 189026004

Following gene: 189026002

Centisome position: 74.34

GC content: 53.95

Gene sequence:

>912_bases
GTGATGAGCACGTGTGCGCAGGCTTTTTATCGCTTGTATGAAATAATTGTGCGGTTGCGTGCGCCGGACGGGTGTGCGTG
GGATTTGGCACAAACGCCGGTAAGTATGTGTTCGTCCTTTTTGGAGGAGACGTATGAAGCGCTTGAGGCTATCCTCGAAG
AGGGCGAGGCACAGCATTCGTCGTATGCTCACGTTCAGGAGGAGTTGGGGGACGTGCTGATGAATGTGTGTATGATTGCA
TACATGTATGAACAGCGAGGGGTGTTCTCGCTTGCAGATGTTGTAACTGCATTAACGGAAAAGTTAATTCGACGTCACCC
CCACGTATTTGGGCAAACAGAAGGATTTCCTGGACCGGAAAATCCGAAGCGAGCACAAACAGCACAGGAGGTGTTTGATC
AGTGGGAACGGATTAAAACACAGGTGGAGCGTCGCCGTGCAGCTTCTCCGTTAGAGGGCATTCCTCGAACGGTTCCTCCC
CTCATGCGCGCGTCCAAAATGCAAAAAAACGCGTCGCGTGCGCGTCTTTTTTGTCCAACACGCACGGAGGTGGTACGAGA
ATGTGCGCGTACCTTTCGTGCACTCCGTGCGATGTCAGAGAATTCTGCCGAACAATCCGCCACTCAAGCAGCGCATGTTG
CAGTAGGTGCGCTGTTGACTGCAGTGATATCGTTTGCACATCTTGTGGGGGTAGATCCGGTGCTCGCCCTTATCCGCGCA
AATGCGGACTTCGTGCGCCGCTTTTCGTGTGCCTGTTCTATACCTGCCATTTCTGGAGGTACTTCTGTATTTTTGTCTCG
CGCGTGCCATAAACCACGTCGCGCACGCACGCGGGCGTCTGCGGTGCGCAGGCGCGCACGGTCACGGCGACTGTTTTTTA
CTCGACACAAGCTGGGGAATATGCTACGGTAG

Upstream 100 bases:

>100_bases
CGGTGCTGGGTATACGGGTGTTGATTGGCCGCCGGCAGAAAACCACAGGGGATGGAGTGAGAATTACACACGATGACGTA
CAAACTAATGTAGGAGTGAG

Downstream 100 bases:

>100_bases
GACGCGTCCCTGTCTCCGTGTGTAAATTGTTAGCACGGGCAGGGTGCGTGTTGAAGAAGAGGGGGCTTATGAAGACGTTG
CAGTGTGATATTTGTCGGAA

Product: protein MazG

Products: NA

Alternate protein names: NTP-PPase [H]

Number of amino acids: Translated: 303; Mature: 303

Protein sequence:

>303_residues
MMSTCAQAFYRLYEIIVRLRAPDGCAWDLAQTPVSMCSSFLEETYEALEAILEEGEAQHSSYAHVQEELGDVLMNVCMIA
YMYEQRGVFSLADVVTALTEKLIRRHPHVFGQTEGFPGPENPKRAQTAQEVFDQWERIKTQVERRRAASPLEGIPRTVPP
LMRASKMQKNASRARLFCPTRTEVVRECARTFRALRAMSENSAEQSATQAAHVAVGALLTAVISFAHLVGVDPVLALIRA
NADFVRRFSCACSIPAISGGTSVFLSRACHKPRRARTRASAVRRRARSRRLFFTRHKLGNMLR

Sequences:

>Translated_303_residues
MMSTCAQAFYRLYEIIVRLRAPDGCAWDLAQTPVSMCSSFLEETYEALEAILEEGEAQHSSYAHVQEELGDVLMNVCMIA
YMYEQRGVFSLADVVTALTEKLIRRHPHVFGQTEGFPGPENPKRAQTAQEVFDQWERIKTQVERRRAASPLEGIPRTVPP
LMRASKMQKNASRARLFCPTRTEVVRECARTFRALRAMSENSAEQSATQAAHVAVGALLTAVISFAHLVGVDPVLALIRA
NADFVRRFSCACSIPAISGGTSVFLSRACHKPRRARTRASAVRRRARSRRLFFTRHKLGNMLR
>Mature_303_residues
MMSTCAQAFYRLYEIIVRLRAPDGCAWDLAQTPVSMCSSFLEETYEALEAILEEGEAQHSSYAHVQEELGDVLMNVCMIA
YMYEQRGVFSLADVVTALTEKLIRRHPHVFGQTEGFPGPENPKRAQTAQEVFDQWERIKTQVERRRAASPLEGIPRTVPP
LMRASKMQKNASRARLFCPTRTEVVRECARTFRALRAMSENSAEQSATQAAHVAVGALLTAVISFAHLVGVDPVLALIRA
NADFVRRFSCACSIPAISGGTSVFLSRACHKPRRARTRASAVRRRARSRRLFFTRHKLGNMLR

Specific function: Involved in the regulation of bacterial cell survival under conditions of nutritional stress. Regulates the MazEF toxin- antitoxin (TA) module that mediates programmed cell death (PCD). This is achieved by lowering the cellular concentration of (p)ppGpp p

COG id: COG1694

COG function: function code R; Predicted pyrophosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nucleoside triphosphate pyrophosphohydrolase family [H]

Homologues:

Organism=Escherichia coli, GI1789144, Length=253, Percent_Identity=35.9683794466403, Blast_Score=130, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004518
- InterPro:   IPR011551 [H]

Pfam domain/function: PF03819 MazG [H]

EC number: =3.6.1.8 [H]

Molecular weight: Translated: 34017; Mature: 34017

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
3.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSTCAQAFYRLYEIIVRLRAPDGCAWDLAQTPVSMCSSFLEETYEALEAILEEGEAQHS
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
SYAHVQEELGDVLMNVCMIAYMYEQRGVFSLADVVTALTEKLIRRHPHVFGQTEGFPGPE
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
NPKRAQTAQEVFDQWERIKTQVERRRAASPLEGIPRTVPPLMRASKMQKNASRARLFCPT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHHEEECCC
RTEVVRECARTFRALRAMSENSAEQSATQAAHVAVGALLTAVISFAHLVGVDPVLALIRA
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NADFVRRFSCACSIPAISGGTSVFLSRACHKPRRARTRASAVRRRARSRRLFFTRHKLGN
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MLR
CCC
>Mature Secondary Structure
MMSTCAQAFYRLYEIIVRLRAPDGCAWDLAQTPVSMCSSFLEETYEALEAILEEGEAQHS
CCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
SYAHVQEELGDVLMNVCMIAYMYEQRGVFSLADVVTALTEKLIRRHPHVFGQTEGFPGPE
HHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
NPKRAQTAQEVFDQWERIKTQVERRRAASPLEGIPRTVPPLMRASKMQKNASRARLFCPT
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCHHHHHHHHHHHHHHHHEEECCC
RTEVVRECARTFRALRAMSENSAEQSATQAAHVAVGALLTAVISFAHLVGVDPVLALIRA
HHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NADFVRRFSCACSIPAISGGTSVFLSRACHKPRRARTRASAVRRRARSRRLFFTRHKLGN
CHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
MLR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]