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The map label for this gene is mutM [H]

Identifier: 188586505

GI number: 188586505

Start: 1982099

End: 1982986

Strand: Reverse

Name: mutM [H]

Synonym: Nther_1891

Alternate gene names: 188586505

Gene position: 1982986-1982099 (Counterclockwise)

Preceding gene: 188586506

Following gene: 188586504

Centisome position: 62.64

GC content: 36.15

Gene sequence:

>888_bases
GTGCCCGAATTACCTGAGGTAGAAACAATTAAAAAGAGTCTCCTTTCGGATCTGACCGGTGATAGAATAAGTCGGGTAGA
AATATATTTTCCAGGAATGTTACAAAACATGAGTCCCGAGGATTTTAAGGAAAGTGTAATTTCTAATCAGATTAAAGATG
TAAAGAGGCGGGGAAAATATCTTCTGATTTATGTGTCATGTAATGGCAAAATGAAGGATCAAGTAAAAGTGATAATTATA
CACTTGCGAATGACTGGTAGATTGATCTTAAAAAACAACGAGGTCGAGAAGTCTCACAATCATTTAGATGATGAGGAAAT
CATCCAAGAATACCGGCATCTTCGATGTTTATTTCAATTACAATCTGGTATTACTTTAGAATTCCATGATCAAAGAAAGT
TCGGTACTATGGCTCTAGTTAATCAAGGAGAAGAATTCTACTGGAAAGGTTTGGCTAACTTAGGACCTGAACCCTTAAGT
GAAGAGTTTGATTACGAGGACTTTTATAAAGGTGTGAAAAAATCAAAAAAGCCCATTAAAGGTATTCTCTTAGACCAAAA
ACTAGTGGCAGGTATAGGAAATATTTATGCGGATGAAGTCTTATTTGCATCTGGGATTCATCCGGCTCGAAAGGGCGAAG
AGTTAACAGAACAGGAAGTTGGGAGTTTGTATAAAACAATAATACAAATATTAGAACTGGGAATAAAATATCGTGGAACA
ACTTTTAGCGACTACCGTGATTCGGAAGGTAATAAGGGTAATTTTCAGGACCTATTAAAGGTTTTTAATAGGAACAAAGA
AGAATGCCTGATTTGCCGTAGAGAAGTTCAAAAAACAAAAGTTGCCAATAGAGGCACCTATTATTGTCCAAACTGCCAAC
CCCTTTAA

Upstream 100 bases:

>100_bases
TGGAAAATATCATTGAATTAAAAGTCCCTCTAACCGTTGATCTAAAAACTGGACCAAACTGGTACGATTTAAATCCTTAT
CAATCAGGAGAGTGATTTTC

Downstream 100 bases:

>100_bases
ACAGAATAAAGGACATGCACTCCGGCTTTGTTCCTCCCATATATTATTATTAACTGTCTAGTTTTAGGGGGGAAACAAAT
GCCGGAGCTTTTTCCTTTAG

Product: formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MPELPEVETIKKSLLSDLTGDRISRVEIYFPGMLQNMSPEDFKESVISNQIKDVKRRGKYLLIYVSCNGKMKDQVKVIII
HLRMTGRLILKNNEVEKSHNHLDDEEIIQEYRHLRCLFQLQSGITLEFHDQRKFGTMALVNQGEEFYWKGLANLGPEPLS
EEFDYEDFYKGVKKSKKPIKGILLDQKLVAGIGNIYADEVLFASGIHPARKGEELTEQEVGSLYKTIIQILELGIKYRGT
TFSDYRDSEGNKGNFQDLLKVFNRNKEECLICRREVQKTKVANRGTYYCPNCQPL

Sequences:

>Translated_295_residues
MPELPEVETIKKSLLSDLTGDRISRVEIYFPGMLQNMSPEDFKESVISNQIKDVKRRGKYLLIYVSCNGKMKDQVKVIII
HLRMTGRLILKNNEVEKSHNHLDDEEIIQEYRHLRCLFQLQSGITLEFHDQRKFGTMALVNQGEEFYWKGLANLGPEPLS
EEFDYEDFYKGVKKSKKPIKGILLDQKLVAGIGNIYADEVLFASGIHPARKGEELTEQEVGSLYKTIIQILELGIKYRGT
TFSDYRDSEGNKGNFQDLLKVFNRNKEECLICRREVQKTKVANRGTYYCPNCQPL
>Mature_294_residues
PELPEVETIKKSLLSDLTGDRISRVEIYFPGMLQNMSPEDFKESVISNQIKDVKRRGKYLLIYVSCNGKMKDQVKVIIIH
LRMTGRLILKNNEVEKSHNHLDDEEIIQEYRHLRCLFQLQSGITLEFHDQRKFGTMALVNQGEEFYWKGLANLGPEPLSE
EFDYEDFYKGVKKSKKPIKGILLDQKLVAGIGNIYADEVLFASGIHPARKGEELTEQEVGSLYKTIIQILELGIKYRGTT
FSDYRDSEGNKGNFQDLLKVFNRNKEECLICRREVQKTKVANRGTYYCPNCQPL

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Homo sapiens, GI157388969, Length=138, Percent_Identity=35.5072463768116, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1790066, Length=294, Percent_Identity=35.7142857142857, Blast_Score=163, Evalue=1e-41,
Organism=Escherichia coli, GI1786932, Length=308, Percent_Identity=25, Blast_Score=78, Evalue=8e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 34095; Mature: 33964

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETIKKSLLSDLTGDRISRVEIYFPGMLQNMSPEDFKESVISNQIKDVKRRGKY
CCCCCHHHHHHHHHHHHCCCCCEEEEEEEECHHHCCCCHHHHHHHHHHHHHHHHHHCCCE
LLIYVSCNGKMKDQVKVIIIHLRMTGRLILKNNEVEKSHNHLDDEEIIQEYRHLRCLFQL
EEEEEECCCCCCCCEEEEEEEEEECCEEEEECCCHHHHHCCCCHHHHHHHHHHHHHHHHH
QSGITLEFHDQRKFGTMALVNQGEEFYWKGLANLGPEPLSEEFDYEDFYKGVKKSKKPIK
HCCCEEEECCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHH
GILLDQKLVAGIGNIYADEVLFASGIHPARKGEELTEQEVGSLYKTIIQILELGIKYRGT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TFSDYRDSEGNKGNFQDLLKVFNRNKEECLICRREVQKTKVANRGTYYCPNCQPL
CCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCC
>Mature Secondary Structure 
PELPEVETIKKSLLSDLTGDRISRVEIYFPGMLQNMSPEDFKESVISNQIKDVKRRGKY
CCCCHHHHHHHHHHHHCCCCCEEEEEEEECHHHCCCCHHHHHHHHHHHHHHHHHHCCCE
LLIYVSCNGKMKDQVKVIIIHLRMTGRLILKNNEVEKSHNHLDDEEIIQEYRHLRCLFQL
EEEEEECCCCCCCCEEEEEEEEEECCEEEEECCCHHHHHCCCCHHHHHHHHHHHHHHHHH
QSGITLEFHDQRKFGTMALVNQGEEFYWKGLANLGPEPLSEEFDYEDFYKGVKKSKKPIK
HCCCEEEECCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCHH
GILLDQKLVAGIGNIYADEVLFASGIHPARKGEELTEQEVGSLYKTIIQILELGIKYRGT
HHHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TFSDYRDSEGNKGNFQDLLKVFNRNKEECLICRREVQKTKVANRGTYYCPNCQPL
CCCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA