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The map label for this gene is tyrS [H]

Identifier: 188586426

GI number: 188586426

Start: 1879599

End: 1880837

Strand: Reverse

Name: tyrS [H]

Synonym: Nther_1811

Alternate gene names: 188586426

Gene position: 1880837-1879599 (Counterclockwise)

Preceding gene: 188586428

Following gene: 188586425

Centisome position: 59.42

GC content: 34.22

Gene sequence:

>1239_bases
GTGGTGCTACAAAACTATAGTTTAGAACGACAAATGGAAATCTTTTCCCATGGTACCGAAGAAATAATTTCTAAAGAAGA
ATTGCAGAATAAGATTCAAAAGTCCATTGATAGTAATGAGCCATTACGGTTGAAACTAGGTTTGGACCCTTCGGCTCCTG
ACATTCATTTGGGGCACACTGTAGTATTGCGTAAACTAAAACAGATTCAAGAGATGGGACATAATGTTACCATTATTATT
GGTGACTTTACTGGTAAAATTGGTGATCCTACAGGAAGAAGTGAAACAAGAAAACAAATGACAACAGAAGAAATATTGGA
AAATGCCGAAACCTATAAGGAACAAATTTTTAAAATTTTGTATTCTGATAAAACCGACGTAAGATTTAACTCAGAATGGC
TATCTAACTTGAAGTTTGAAGATATCATAGAACTATCTAGCAAGGTAACAGTTGCACGAATGTTAGAAAGAGAAGACTTT
AATTGGAGGTATAAGAAAAATCGTCCAATTAGTTTACATGAATTCTTTTACCCAATTATGCAGGGTTATGATTCAGTATT
CTTGGATTCCGATGTGGAATTTGGAGCAACAGAACAAAAGTTTAATTTATTAATGGGAAGGCAACTGCAAAAAGAAAAAG
GTAACACACCTCAAATTGCTCTGATGCTTCCTATATTAGTGGGGACTGATGGCGAGAAAAAGATGAGCAAAAGTTTGGGT
AATTATATAGGTATAGAAGAAAAACCATATGATATGTACGGAAAAACTATGTCTATCCCTGATGAATTAATAATTGATTA
CTTTACACTAACTACCGATCTATTACCAGAAGAAGTTGATGAAATAGAAAAAGCTTTAAATGAAGGGAAAAATCCCAGAG
ATATAAAAATGAAGCTTGCCCGTGAAATTGTAACACTTTATCATGGGAAAGAAGAGGCCGAAAAGGCTGAACAGGAATTT
TTGAAGGTGTTTCAACAGCGCCAATTGCCAGAAGATATCCCTGAATACTCTTTAGAAACTATTAAAAAAGATATGACTGA
TGAACATAAGATACCTATTGTAAAACTACTGCAAAACTGTGAATTGGTAAGCAGTAATAGTGAAGGTCGTAGAATGGTTA
AACAAGGAGCAGTAAAACTAGAAGGTGAAAAAGTGACTGATAAAAACGCGGAAGTAGAAATTTCACCAGGTGCTATTATT
CAAGTAGGAAAAAGAAAGTTTGCGAAGATAACAGAATAA

Upstream 100 bases:

>100_bases
ACTAATAAAATTTGTCAAATATAATATCCTGCGGGAATTCCTTTGATAATAAAATTAATTTATCAAAAGTTAATAAAATT
TACAGTAGGGGGATTGGAAA

Downstream 100 bases:

>100_bases
AATACAGGACTTTAGATTCAATATATAAACAAAAGTATCCACCCTCTTTATAAAGGGTGGATTTTTTTTATCACATAAAA
TAAGGCTAACACATAGGGTG

Product: tyrosyl-tRNA synthetase

Products: NA

Alternate protein names: Tyrosine--tRNA ligase; TyrRS [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MVLQNYSLERQMEIFSHGTEEIISKEELQNKIQKSIDSNEPLRLKLGLDPSAPDIHLGHTVVLRKLKQIQEMGHNVTIII
GDFTGKIGDPTGRSETRKQMTTEEILENAETYKEQIFKILYSDKTDVRFNSEWLSNLKFEDIIELSSKVTVARMLEREDF
NWRYKKNRPISLHEFFYPIMQGYDSVFLDSDVEFGATEQKFNLLMGRQLQKEKGNTPQIALMLPILVGTDGEKKMSKSLG
NYIGIEEKPYDMYGKTMSIPDELIIDYFTLTTDLLPEEVDEIEKALNEGKNPRDIKMKLAREIVTLYHGKEEAEKAEQEF
LKVFQQRQLPEDIPEYSLETIKKDMTDEHKIPIVKLLQNCELVSSNSEGRRMVKQGAVKLEGEKVTDKNAEVEISPGAII
QVGKRKFAKITE

Sequences:

>Translated_412_residues
MVLQNYSLERQMEIFSHGTEEIISKEELQNKIQKSIDSNEPLRLKLGLDPSAPDIHLGHTVVLRKLKQIQEMGHNVTIII
GDFTGKIGDPTGRSETRKQMTTEEILENAETYKEQIFKILYSDKTDVRFNSEWLSNLKFEDIIELSSKVTVARMLEREDF
NWRYKKNRPISLHEFFYPIMQGYDSVFLDSDVEFGATEQKFNLLMGRQLQKEKGNTPQIALMLPILVGTDGEKKMSKSLG
NYIGIEEKPYDMYGKTMSIPDELIIDYFTLTTDLLPEEVDEIEKALNEGKNPRDIKMKLAREIVTLYHGKEEAEKAEQEF
LKVFQQRQLPEDIPEYSLETIKKDMTDEHKIPIVKLLQNCELVSSNSEGRRMVKQGAVKLEGEKVTDKNAEVEISPGAII
QVGKRKFAKITE
>Mature_412_residues
MVLQNYSLERQMEIFSHGTEEIISKEELQNKIQKSIDSNEPLRLKLGLDPSAPDIHLGHTVVLRKLKQIQEMGHNVTIII
GDFTGKIGDPTGRSETRKQMTTEEILENAETYKEQIFKILYSDKTDVRFNSEWLSNLKFEDIIELSSKVTVARMLEREDF
NWRYKKNRPISLHEFFYPIMQGYDSVFLDSDVEFGATEQKFNLLMGRQLQKEKGNTPQIALMLPILVGTDGEKKMSKSLG
NYIGIEEKPYDMYGKTMSIPDELIIDYFTLTTDLLPEEVDEIEKALNEGKNPRDIKMKLAREIVTLYHGKEEAEKAEQEF
LKVFQQRQLPEDIPEYSLETIKKDMTDEHKIPIVKLLQNCELVSSNSEGRRMVKQGAVKLEGEKVTDKNAEVEISPGAII
QVGKRKFAKITE

Specific function: Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction:tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) [H]

COG id: COG0162

COG function: function code J; Tyrosyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S4 RNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI94681057, Length=405, Percent_Identity=24.9382716049383, Blast_Score=125, Evalue=7e-29,
Organism=Escherichia coli, GI1787925, Length=365, Percent_Identity=26.8493150684932, Blast_Score=129, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI25145802, Length=375, Percent_Identity=25.6, Blast_Score=96, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6325160, Length=414, Percent_Identity=24.1545893719807, Blast_Score=110, Evalue=4e-25,
Organism=Drosophila melanogaster, GI20130383, Length=401, Percent_Identity=23.4413965087282, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: 892 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002305
- InterPro:   IPR014729
- InterPro:   IPR002942
- InterPro:   IPR002307 [H]

Pfam domain/function: PF01479 S4; PF00579 tRNA-synt_1b [H]

EC number: =6.1.1.1 [H]

Molecular weight: Translated: 47488; Mature: 47488

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS50889 S4 ; PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLQNYSLERQMEIFSHGTEEIISKEELQNKIQKSIDSNEPLRLKLGLDPSAPDIHLGHT
CCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEECCHH
VVLRKLKQIQEMGHNVTIIIGDFTGKIGDPTGRSETRKQMTTEEILENAETYKEQIFKIL
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSDKTDVRFNSEWLSNLKFEDIIELSSKVTVARMLEREDFNWRYKKNRPISLHEFFYPIM
HCCCCCCEECHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHH
QGYDSVFLDSDVEFGATEQKFNLLMGRQLQKEKGNTPQIALMLPILVGTDGEKKMSKSLG
HCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEHHCCCCCHHHHHHHHH
NYIGIEEKPYDMYGKTMSIPDELIIDYFTLTTDLLPEEVDEIEKALNEGKNPRDIKMKLA
HHCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHH
REIVTLYHGKEEAEKAEQEFLKVFQQRQLPEDIPEYSLETIKKDMTDEHKIPIVKLLQNC
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCC
ELVSSNSEGRRMVKQGAVKLEGEKVTDKNAEVEISPGAIIQVGKRKFAKITE
HHHCCCCHHHHHHHHCCEEECCCEECCCCCEEEECCCCEEECCCHHHHCCCC
>Mature Secondary Structure
MVLQNYSLERQMEIFSHGTEEIISKEELQNKIQKSIDSNEPLRLKLGLDPSAPDIHLGHT
CCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCEECCHH
VVLRKLKQIQEMGHNVTIIIGDFTGKIGDPTGRSETRKQMTTEEILENAETYKEQIFKIL
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YSDKTDVRFNSEWLSNLKFEDIIELSSKVTVARMLEREDFNWRYKKNRPISLHEFFYPIM
HCCCCCCEECHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHH
QGYDSVFLDSDVEFGATEQKFNLLMGRQLQKEKGNTPQIALMLPILVGTDGEKKMSKSLG
HCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEHHCCCCCHHHHHHHHH
NYIGIEEKPYDMYGKTMSIPDELIIDYFTLTTDLLPEEVDEIEKALNEGKNPRDIKMKLA
HHCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHHHCCCCCHHHHHHHH
REIVTLYHGKEEAEKAEQEFLKVFQQRQLPEDIPEYSLETIKKDMTDEHKIPIVKLLQNC
HHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCC
ELVSSNSEGRRMVKQGAVKLEGEKVTDKNAEVEISPGAIIQVGKRKFAKITE
HHHCCCCHHHHHHHHCCEEECCCEECCCCCEEEECCCCEEECCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA