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The map label for this gene is hrcA

Identifier: 188585807

GI number: 188585807

Start: 1252629

End: 1253660

Strand: Direct

Name: hrcA

Synonym: Nther_1181

Alternate gene names: 188585807

Gene position: 1252629-1253660 (Clockwise)

Preceding gene: 188585806

Following gene: 188585808

Centisome position: 39.57

GC content: 38.08

Gene sequence:

>1032_bases
ATGAGCCTTAATTGGCGTAAGCAAAAAATTTTAAAGACTATTATTTCAGATTATATTAAACGTGCAGAACCCGTCGGGTC
TAGAACCCTGACAAAAAGATATGAATTTGATTTAAGTCCCGCTACTATCAGAAATGAAATGGCAGACTTAGAAGATATGG
GCTTTTTGGAGCAACCGCATACTTCAGCCGGGCGTATTCCTACGGAAAGAGGATATCGTTTCTTTGTTGATGAGTTGATA
ACTCGCTGTTTATCAGTTCCACAGCAAGAGTTGCTCTTAAAAAAATTAACCAAATTCAAGGCTCTAGAAATAAATGAAAT
AGTGCAAGTAACAGCTCGGGCTCTGGCTGAAATGACAGATTATACTTCTTTAGTTTTAGGTCCGCAAACAAGTAAAAGTG
CTTTTCAGGAAATTCAAGTTTTTCCTATTGATCAACAAAGGGTATTAATGGTTCTAACAACAGATACAGGAATTATAGAA
AGCAAACCGGTGCCAGTTTCTGGTAACTTATCAAAACAAGAGCTTAGTAACATAGTTCAACATCTAAACAAACGACTGAA
AGGTTTAACTATAGATGATATCACCCCTAGCCTATTAAAGGAGTTGCGGACAGATTTAATTAAAGAAGTGGATTTAGTGG
AAAAAGCCATGCATATCTTGGCTGATTCCTTTAGACACAGTAGTGCCAACGTGGCTTTAGGCGGGACAAAGAATATTTTA
AATCAGCCTGAATTTAATGATCTTAAAAAGGTGAAAGAGTTACTATCATTTTTTGAGAATGAAGAGGTCTTGGCTGAATT
GCTTTCTGAATCGGAAGGCATTGTTGTGCGAATTGGGAAGGAAAACCCCAGGGATGAAGTGAAAGATTGCAGTCTAGTAA
CTGCTAGTTACGAATTAAATGGACGCCCCCTGGGTACTATAGGTGTTTTAGGTCCTACCAGGATGGATTACTCCAGGGTG
ATTGCCATAGTGGCTCAAATTGCCAATGAACTTACAATGGCATTGGATAAAAAGAAAATTACTGAGGAGTAG

Upstream 100 bases:

>100_bases
CCTACCTCATCTTGACAAATAACTTGGCTAGTGTTATTTTTTAACTGGATCAATTAGCACTCTTGTTTTAAGAGTGCTAA
TAACTTTCAGGGGTGATTTG

Downstream 100 bases:

>100_bases
GTGATGATTATGAAAAAAGAAAATAATCAAAATATCACAGAAGAACAAAAGCAATCGGCCAACCAAAAGAAAGAACAAAA
TCAAAAAGATACAGAAACAA

Product: heat-inducible transcription repressor HrcA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MSLNWRKQKILKTIISDYIKRAEPVGSRTLTKRYEFDLSPATIRNEMADLEDMGFLEQPHTSAGRIPTERGYRFFVDELI
TRCLSVPQQELLLKKLTKFKALEINEIVQVTARALAEMTDYTSLVLGPQTSKSAFQEIQVFPIDQQRVLMVLTTDTGIIE
SKPVPVSGNLSKQELSNIVQHLNKRLKGLTIDDITPSLLKELRTDLIKEVDLVEKAMHILADSFRHSSANVALGGTKNIL
NQPEFNDLKKVKELLSFFENEEVLAELLSESEGIVVRIGKENPRDEVKDCSLVTASYELNGRPLGTIGVLGPTRMDYSRV
IAIVAQIANELTMALDKKKITEE

Sequences:

>Translated_343_residues
MSLNWRKQKILKTIISDYIKRAEPVGSRTLTKRYEFDLSPATIRNEMADLEDMGFLEQPHTSAGRIPTERGYRFFVDELI
TRCLSVPQQELLLKKLTKFKALEINEIVQVTARALAEMTDYTSLVLGPQTSKSAFQEIQVFPIDQQRVLMVLTTDTGIIE
SKPVPVSGNLSKQELSNIVQHLNKRLKGLTIDDITPSLLKELRTDLIKEVDLVEKAMHILADSFRHSSANVALGGTKNIL
NQPEFNDLKKVKELLSFFENEEVLAELLSESEGIVVRIGKENPRDEVKDCSLVTASYELNGRPLGTIGVLGPTRMDYSRV
IAIVAQIANELTMALDKKKITEE
>Mature_342_residues
SLNWRKQKILKTIISDYIKRAEPVGSRTLTKRYEFDLSPATIRNEMADLEDMGFLEQPHTSAGRIPTERGYRFFVDELIT
RCLSVPQQELLLKKLTKFKALEINEIVQVTARALAEMTDYTSLVLGPQTSKSAFQEIQVFPIDQQRVLMVLTTDTGIIES
KPVPVSGNLSKQELSNIVQHLNKRLKGLTIDDITPSLLKELRTDLIKEVDLVEKAMHILADSFRHSSANVALGGTKNILN
QPEFNDLKKVKELLSFFENEEVLAELLSESEGIVVRIGKENPRDEVKDCSLVTASYELNGRPLGTIGVLGPTRMDYSRVI
AIVAQIANELTMALDKKKITEE

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_NATTJ (B2A1M7)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001917352.1
- GeneID:   6315803
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_1181
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF01628 HrcA

EC number: NA

Molecular weight: Translated: 38612; Mature: 38481

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLNWRKQKILKTIISDYIKRAEPVGSRTLTKRYEFDLSPATIRNEMADLEDMGFLEQPH
CCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCC
TSAGRIPTERGYRFFVDELITRCLSVPQQELLLKKLTKFKALEINEIVQVTARALAEMTD
CCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YTSLVLGPQTSKSAFQEIQVFPIDQQRVLMVLTTDTGIIESKPVPVSGNLSKQELSNIVQ
HHHEEECCCCCHHHHHHCEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHH
HLNKRLKGLTIDDITPSLLKELRTDLIKEVDLVEKAMHILADSFRHSSANVALGGTKNIL
HHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHC
NQPEFNDLKKVKELLSFFENEEVLAELLSESEGIVVRIGKENPRDEVKDCSLVTASYELN
CCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCEEEEEEEEC
GRPLGTIGVLGPTRMDYSRVIAIVAQIANELTMALDKKKITEE
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLNWRKQKILKTIISDYIKRAEPVGSRTLTKRYEFDLSPATIRNEMADLEDMGFLEQPH
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCC
TSAGRIPTERGYRFFVDELITRCLSVPQQELLLKKLTKFKALEINEIVQVTARALAEMTD
CCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YTSLVLGPQTSKSAFQEIQVFPIDQQRVLMVLTTDTGIIESKPVPVSGNLSKQELSNIVQ
HHHEEECCCCCHHHHHHCEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHH
HLNKRLKGLTIDDITPSLLKELRTDLIKEVDLVEKAMHILADSFRHSSANVALGGTKNIL
HHHHHHCCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHC
NQPEFNDLKKVKELLSFFENEEVLAELLSESEGIVVRIGKENPRDEVKDCSLVTASYELN
CCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCEEEEEEEEC
GRPLGTIGVLGPTRMDYSRVIAIVAQIANELTMALDKKKITEE
CCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA