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The map label for this gene is rocD [H]

Identifier: 188585776

GI number: 188585776

Start: 1216117

End: 1217313

Strand: Direct

Name: rocD [H]

Synonym: Nther_1150

Alternate gene names: 188585776

Gene position: 1216117-1217313 (Clockwise)

Preceding gene: 188585775

Following gene: 188585779

Centisome position: 38.42

GC content: 38.51

Gene sequence:

>1197_bases
ATGAAAGACGAAAATCAAATTGTTGAATTAACCGAGAAGTATAGTGCCCACAATTATAAGCCACTTCCTGTCGTGTTATC
TGAAGGGGAAGGGGTATGGGTAAAGGATGTCAATGGTAATTACTATCTCGATATGCTGGCTAGTTATTCTGCATTAAATC
AGGGCCATAGGCATCCCAAAATAATTAATGCCTTATTTGAACAGGCAAAAAAATTAACTATAACTTCACGTGCCTTCCAC
AATGATATTTTAGGAGAATTTTGTCAAAAAGTCGCAGAGACAACATCTAAAGATAAGGCCCTACCTATGAATACTGGAGC
AGAAGCTGTTGAAACAGCCCTGAAAGCTGCAAGAAGATGGGGCTATCGCAAGAAAAAAGTGGACACCGATAAAGCTGAAA
TAATAGCCTGTGAAAGTAATTTTCACGGCAGAACAATGTTTCCGGTATCTCTATCCACCAGTGAATCAGCCACACAAGAT
TATGGACCTATGATACCTGAAATCAAAAAGATTCCTTTTGGTGACCTCGAAGCATTAAAAGGTGCTATTGGACCTAATAC
TGTCGGATTTTTATTTGAACCGATCCAAGGCGAGGGTGGAGTTGTAATACCACCGGAAGGATATCTTAAAAAAGCTTTTG
ATATATGTAAAGAAAATAATGTCTTATTTATTGCCGATGAAATTCAAACCGGGTTAGGAAGAACGGGAAAACTGTTTGCT
TGTGATTGGGAAGGAGTCCAGCCCGACATTTATATTTTAGGAAAGGCACTGGGTGGAGGAGTATACCCTGTTTCATGTAT
AGCAGCTGATGACGAGGTTATGGACGTCTTTGAGCCTGGTTCTCACGGATCAACCTTTGGAGGTAATCCACTTGCTTGTG
TTGTGGGTAAGGCATCTTTAGATGTGATAATGGACGAGGACTTGCCTGCTAGATCTAAGGAATTAGGAGAATACTTTTAT
AATAAGTTAGCGGAAATTAATAGTCCAGTTATTAAAGAAGTTAGAGGAAAAGGCTTGTTTATTGGTATGGAACTAACAGA
ACCAGCAAGACCGTATTGTTTATCCTTGAAAGAACAAGGAATTTTATGTAAGGAAACGAGAGATTATGTAATAAGATTTG
CACCTCCTCTAGTCATTGAAAAAGAAACCTTGGATGAAGCTATCCAAACCATTAAAGAAATTTTTGAAAAACAGTAA

Upstream 100 bases:

>100_bases
TTTTAATTTTTGATAATTAAAAATGTAGGGGGGTTTTTTAAAAAGTATAATAATTCTTTAATCAAAAAAATTGAAAAAGA
TGAAAAAGGAGGTTGTGTTT

Downstream 100 bases:

>100_bases
TAATCATTTTTAAAAGTCAAGATAGTAGTAGCGAGAAGTAAAATAAATTAAATGGCCGAAGCTTGACAAGTTTATCAGGC
TTCGGCCATTTATATCTACA

Product: aminotransferase

Products: NA

Alternate protein names: OAT; Ornithine--oxo-acid aminotransferase [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MKDENQIVELTEKYSAHNYKPLPVVLSEGEGVWVKDVNGNYYLDMLASYSALNQGHRHPKIINALFEQAKKLTITSRAFH
NDILGEFCQKVAETTSKDKALPMNTGAEAVETALKAARRWGYRKKKVDTDKAEIIACESNFHGRTMFPVSLSTSESATQD
YGPMIPEIKKIPFGDLEALKGAIGPNTVGFLFEPIQGEGGVVIPPEGYLKKAFDICKENNVLFIADEIQTGLGRTGKLFA
CDWEGVQPDIYILGKALGGGVYPVSCIAADDEVMDVFEPGSHGSTFGGNPLACVVGKASLDVIMDEDLPARSKELGEYFY
NKLAEINSPVIKEVRGKGLFIGMELTEPARPYCLSLKEQGILCKETRDYVIRFAPPLVIEKETLDEAIQTIKEIFEKQ

Sequences:

>Translated_398_residues
MKDENQIVELTEKYSAHNYKPLPVVLSEGEGVWVKDVNGNYYLDMLASYSALNQGHRHPKIINALFEQAKKLTITSRAFH
NDILGEFCQKVAETTSKDKALPMNTGAEAVETALKAARRWGYRKKKVDTDKAEIIACESNFHGRTMFPVSLSTSESATQD
YGPMIPEIKKIPFGDLEALKGAIGPNTVGFLFEPIQGEGGVVIPPEGYLKKAFDICKENNVLFIADEIQTGLGRTGKLFA
CDWEGVQPDIYILGKALGGGVYPVSCIAADDEVMDVFEPGSHGSTFGGNPLACVVGKASLDVIMDEDLPARSKELGEYFY
NKLAEINSPVIKEVRGKGLFIGMELTEPARPYCLSLKEQGILCKETRDYVIRFAPPLVIEKETLDEAIQTIKEIFEKQ
>Mature_398_residues
MKDENQIVELTEKYSAHNYKPLPVVLSEGEGVWVKDVNGNYYLDMLASYSALNQGHRHPKIINALFEQAKKLTITSRAFH
NDILGEFCQKVAETTSKDKALPMNTGAEAVETALKAARRWGYRKKKVDTDKAEIIACESNFHGRTMFPVSLSTSESATQD
YGPMIPEIKKIPFGDLEALKGAIGPNTVGFLFEPIQGEGGVVIPPEGYLKKAFDICKENNVLFIADEIQTGLGRTGKLFA
CDWEGVQPDIYILGKALGGGVYPVSCIAADDEVMDVFEPGSHGSTFGGNPLACVVGKASLDVIMDEDLPARSKELGEYFY
NKLAEINSPVIKEVRGKGLFIGMELTEPARPYCLSLKEQGILCKETRDYVIRFAPPLVIEKETLDEAIQTIKEIFEKQ

Specific function: Catalyzes the interconversion of ornithine to glutamate semialdehyde [H]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=394, Percent_Identity=49.238578680203, Blast_Score=389, Evalue=1e-108,
Organism=Homo sapiens, GI284507298, Length=296, Percent_Identity=47.972972972973, Blast_Score=278, Evalue=6e-75,
Organism=Homo sapiens, GI13994255, Length=459, Percent_Identity=27.4509803921569, Blast_Score=165, Evalue=8e-41,
Organism=Homo sapiens, GI24119277, Length=415, Percent_Identity=28.433734939759, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI37574042, Length=425, Percent_Identity=27.0588235294118, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI226442709, Length=380, Percent_Identity=28.1578947368421, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI226442705, Length=425, Percent_Identity=26.5882352941176, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1789759, Length=385, Percent_Identity=36.1038961038961, Blast_Score=244, Evalue=6e-66,
Organism=Escherichia coli, GI145693181, Length=375, Percent_Identity=33.6, Blast_Score=230, Evalue=1e-61,
Organism=Escherichia coli, GI1788044, Length=370, Percent_Identity=35.4054054054054, Blast_Score=228, Evalue=6e-61,
Organism=Escherichia coli, GI1787560, Length=397, Percent_Identity=32.7455919395466, Blast_Score=183, Evalue=2e-47,
Organism=Escherichia coli, GI1789016, Length=409, Percent_Identity=29.8288508557457, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1786991, Length=419, Percent_Identity=26.9689737470167, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1786349, Length=349, Percent_Identity=27.5071633237822, Blast_Score=105, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI25144271, Length=400, Percent_Identity=49, Blast_Score=389, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI25144274, Length=294, Percent_Identity=44.2176870748299, Blast_Score=246, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI32564660, Length=425, Percent_Identity=32, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71981843, Length=177, Percent_Identity=47.4576271186441, Blast_Score=181, Evalue=6e-46,
Organism=Caenorhabditis elegans, GI71992977, Length=428, Percent_Identity=25.2336448598131, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17541228, Length=411, Percent_Identity=25.3041362530414, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6323470, Length=414, Percent_Identity=48.3091787439614, Blast_Score=383, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6324432, Length=394, Percent_Identity=32.741116751269, Blast_Score=207, Evalue=2e-54,
Organism=Saccharomyces cerevisiae, GI6324386, Length=424, Percent_Identity=24.7641509433962, Blast_Score=94, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6321456, Length=421, Percent_Identity=23.9904988123515, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI21357415, Length=384, Percent_Identity=50.78125, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI161085790, Length=447, Percent_Identity=30.8724832214765, Blast_Score=178, Evalue=7e-45,
Organism=Drosophila melanogaster, GI28574759, Length=430, Percent_Identity=31.1627906976744, Blast_Score=171, Evalue=6e-43,
Organism=Drosophila melanogaster, GI21356575, Length=427, Percent_Identity=25.5269320843091, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI281366494, Length=422, Percent_Identity=22.9857819905213, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24667139, Length=422, Percent_Identity=22.9857819905213, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24667143, Length=422, Percent_Identity=22.9857819905213, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR010164
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.13 [H]

Molecular weight: Translated: 43899; Mature: 43899

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDENQIVELTEKYSAHNYKPLPVVLSEGEGVWVKDVNGNYYLDMLASYSALNQGHRHPK
CCCCHHHHHHHHHHCCCCCCCCEEEEECCCEEEEEECCCCEEHHHHHHHHHHHCCCCCHH
IINALFEQAKKLTITSRAFHNDILGEFCQKVAETTSKDKALPMNTGAEAVETALKAARRW
HHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHC
GYRKKKVDTDKAEIIACESNFHGRTMFPVSLSTSESATQDYGPMIPEIKKIPFGDLEALK
CCCHHCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCHHCCCCCCHHHCCCCCCHHHHH
GAIGPNTVGFLFEPIQGEGGVVIPPEGYLKKAFDICKENNVLFIADEIQTGLGRTGKLFA
CCCCCCCEEEEEEEECCCCCEEECCCHHHHHHHHHHCCCCEEEEEECHHHCCCCCCCEEE
CDWEGVQPDIYILGKALGGGVYPVSCIAADDEVMDVFEPGSHGSTFGGNPLACVVGKASL
EECCCCCCCEEEEEEHHCCCCCEEEEEECCCHHHHHCCCCCCCCCCCCCCEEEEEECCEE
DVIMDEDLPARSKELGEYFYNKLAEINSPVIKEVRGKGLFIGMELTEPARPYCLSLKEQG
EEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEEEEECCCCCCCEECHHHCC
ILCKETRDYVIRFAPPLVIEKETLDEAIQTIKEIFEKQ
CEEECCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKDENQIVELTEKYSAHNYKPLPVVLSEGEGVWVKDVNGNYYLDMLASYSALNQGHRHPK
CCCCHHHHHHHHHHCCCCCCCCEEEEECCCEEEEEECCCCEEHHHHHHHHHHHCCCCCHH
IINALFEQAKKLTITSRAFHNDILGEFCQKVAETTSKDKALPMNTGAEAVETALKAARRW
HHHHHHHHHHHEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHC
GYRKKKVDTDKAEIIACESNFHGRTMFPVSLSTSESATQDYGPMIPEIKKIPFGDLEALK
CCCHHCCCCCCEEEEEECCCCCCCEEEEEEECCCCCCCHHCCCCCCHHHCCCCCCHHHHH
GAIGPNTVGFLFEPIQGEGGVVIPPEGYLKKAFDICKENNVLFIADEIQTGLGRTGKLFA
CCCCCCCEEEEEEEECCCCCEEECCCHHHHHHHHHHCCCCEEEEEECHHHCCCCCCCEEE
CDWEGVQPDIYILGKALGGGVYPVSCIAADDEVMDVFEPGSHGSTFGGNPLACVVGKASL
EECCCCCCCEEEEEEHHCCCCCEEEEEECCCHHHHHCCCCCCCCCCCCCCEEEEEECCEE
DVIMDEDLPARSKELGEYFYNKLAEINSPVIKEVRGKGLFIGMELTEPARPYCLSLKEQG
EEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHCCCEEEEEEEECCCCCCCEECHHHCC
ILCKETRDYVIRFAPPLVIEKETLDEAIQTIKEIFEKQ
CEEECCCCEEEEECCCCEEEHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA