Click here to switch to the map view.

The map label for this gene is mntH [H]

Identifier: 188585770

GI number: 188585770

Start: 1208983

End: 1210203

Strand: Direct

Name: mntH [H]

Synonym: Nther_1144

Alternate gene names: 188585770

Gene position: 1208983-1210203 (Clockwise)

Preceding gene: 188585769

Following gene: 188585771

Centisome position: 38.19

GC content: 39.15

Gene sequence:

>1221_bases
ATGAATTTTGTTAAACGATTAAAAAATATTGGCCCTGGTGCTTTAGTAGCAGCAGCTTTTATTGGACCCGGAACAGTAAC
TACGGCTACTGTAACAGGAGCAGAATATGGGTACACATTATTATGGGCATTGGTATTTTCTATATTTGCAACTATAGTTT
TACAGGAAATGTCGATGAGAGTTGGAATTGTATCAAAAATGGAATTAGGAGAAGCACTTCGAAATGAATTTGAAAACCCT
ATAATTAAATGGTTCAGTATTATTCTTGTAGTTGTGGCCATAGGGGTTGGGGCAGCTGCCTTTGAAACCGGAAATATTTT
GGGTGGAGCCCTTGGAGTGGAAACTTTAACAGGTATACATGTTAACATAGTAGGACCTGTAATAGGTATAATAGCTGCAT
TTATACTTTGGTCAGGCAGTTATAAAATAGTTGAGAAATTTTTAATTGGTCTTGTAATTGTTATGAGTATGGCTTTTATA
ATCACAGCTTTAGTGGTGAGCCCAAATATGGGTGAAGTACTTTCTGGTATGTTTGTACCCGAAATACCTGAAGGAGGATT
GGCTTTTGCCATTGGTTTGATTGGAACTACAGTTGTTCCTTATAATTTATTTCTTCATGCTTCTGCTGTCCAAGAACGTT
GGACTGATCCCAAAGATTTACCCCAAGCCAGGTTTGACACTTTCTTTTCCATTATCTTAGGTGGAATAATAACCCTGGCA
ATTATTGTGACAGCTTCAGCTACATTTTATGGGACGGGTGTAGTTCCGGAAGATGGGGCAGCCATGGCAGAACAGTTATC
ACCGTTGTTAGGCGCTTGGGCCAAATGGTTTTTTGCCATAGGATTATTTGGTGCCGGACTATCATCGGCTGTAACAGCAC
CACTTGCGGGTGCTTATGCTACTGCTGGTGCCCTGGGTTGGAGAAGGGATTTGAAAGGTAGAAACTTTAGAATTGTACTA
ATGATTATACTTGCAATAGGTGTGGTAGGTTCTGGGATGGGTTACGATCCTGTTACCGTCATCTTAATTGCACAGATTGC
AAATGGAATCATGTTACCTATTGCTGCCTTTTTCTTAATCTGGATTAGTAATAACAAGAAACGTCTAGGAGCATGGACAA
ATGGCCCTATTCATAATGTTTTAGGTATAATTGTATTAATAGTTGCTGTTATCCTTGGTTTAAAATCCTTATACGATGCT
CTTACAGGGGTACTTCTGTAA

Upstream 100 bases:

>100_bases
ATATGTTACAAGAACATGGTATCACAGTTAAAAGTCTTGGGACCTGGTTTACAGGCTAGTTCGGTATATTACCGAGCTAA
ACAAGAAGGGAGGACACAAT

Downstream 100 bases:

>100_bases
GCTACTATTATTATAACTTGAGAATTCAAAGGGCCCCTGACAAGTTTAGGGGCCTTATTAATGTGGAGGGATAGCATGTC
AAAATTACAGATATTACCTG

Product: natural resistance-associated macrophage protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MNFVKRLKNIGPGALVAAAFIGPGTVTTATVTGAEYGYTLLWALVFSIFATIVLQEMSMRVGIVSKMELGEALRNEFENP
IIKWFSIILVVVAIGVGAAAFETGNILGGALGVETLTGIHVNIVGPVIGIIAAFILWSGSYKIVEKFLIGLVIVMSMAFI
ITALVVSPNMGEVLSGMFVPEIPEGGLAFAIGLIGTTVVPYNLFLHASAVQERWTDPKDLPQARFDTFFSIILGGIITLA
IIVTASATFYGTGVVPEDGAAMAEQLSPLLGAWAKWFFAIGLFGAGLSSAVTAPLAGAYATAGALGWRRDLKGRNFRIVL
MIILAIGVVGSGMGYDPVTVILIAQIANGIMLPIAAFFLIWISNNKKRLGAWTNGPIHNVLGIIVLIVAVILGLKSLYDA
LTGVLL

Sequences:

>Translated_406_residues
MNFVKRLKNIGPGALVAAAFIGPGTVTTATVTGAEYGYTLLWALVFSIFATIVLQEMSMRVGIVSKMELGEALRNEFENP
IIKWFSIILVVVAIGVGAAAFETGNILGGALGVETLTGIHVNIVGPVIGIIAAFILWSGSYKIVEKFLIGLVIVMSMAFI
ITALVVSPNMGEVLSGMFVPEIPEGGLAFAIGLIGTTVVPYNLFLHASAVQERWTDPKDLPQARFDTFFSIILGGIITLA
IIVTASATFYGTGVVPEDGAAMAEQLSPLLGAWAKWFFAIGLFGAGLSSAVTAPLAGAYATAGALGWRRDLKGRNFRIVL
MIILAIGVVGSGMGYDPVTVILIAQIANGIMLPIAAFFLIWISNNKKRLGAWTNGPIHNVLGIIVLIVAVILGLKSLYDA
LTGVLL
>Mature_406_residues
MNFVKRLKNIGPGALVAAAFIGPGTVTTATVTGAEYGYTLLWALVFSIFATIVLQEMSMRVGIVSKMELGEALRNEFENP
IIKWFSIILVVVAIGVGAAAFETGNILGGALGVETLTGIHVNIVGPVIGIIAAFILWSGSYKIVEKFLIGLVIVMSMAFI
ITALVVSPNMGEVLSGMFVPEIPEGGLAFAIGLIGTTVVPYNLFLHASAVQERWTDPKDLPQARFDTFFSIILGGIITLA
IIVTASATFYGTGVVPEDGAAMAEQLSPLLGAWAKWFFAIGLFGAGLSSAVTAPLAGAYATAGALGWRRDLKGRNFRIVL
MIILAIGVVGSGMGYDPVTVILIAQIANGIMLPIAAFFLIWISNNKKRLGAWTNGPIHNVLGIIVLIVAVILGLKSLYDA
LTGVLL

Specific function: H(+)-stimulated, highly selective, manganese uptake system [H]

COG id: COG1914

COG function: function code P; Mn2+ and Fe2+ transporters of the NRAMP family

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NRAMP family [H]

Homologues:

Organism=Homo sapiens, GI109255241, Length=362, Percent_Identity=25.6906077348066, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI295293178, Length=368, Percent_Identity=24.4565217391304, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI295293175, Length=359, Percent_Identity=24.5125348189415, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI295293173, Length=359, Percent_Identity=24.5125348189415, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI10835169, Length=359, Percent_Identity=24.5125348189415, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI295293167, Length=359, Percent_Identity=24.5125348189415, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI295293171, Length=368, Percent_Identity=24.4565217391304, Blast_Score=83, Evalue=4e-16,
Organism=Homo sapiens, GI295293169, Length=368, Percent_Identity=24.4565217391304, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1788736, Length=396, Percent_Identity=28.5353535353535, Blast_Score=135, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17569473, Length=383, Percent_Identity=25.065274151436, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI193210616, Length=434, Percent_Identity=25.3456221198157, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI71993856, Length=219, Percent_Identity=31.0502283105023, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71999499, Length=437, Percent_Identity=23.1121281464531, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323062, Length=400, Percent_Identity=26.5, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6324450, Length=431, Percent_Identity=25.754060324826, Blast_Score=91, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6321841, Length=416, Percent_Identity=24.0384615384615, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24648607, Length=428, Percent_Identity=25.7009345794392, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI281362176, Length=428, Percent_Identity=25.7009345794392, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24648609, Length=428, Percent_Identity=25.7009345794392, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI45553443, Length=422, Percent_Identity=25.8293838862559, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023056
- InterPro:   IPR001046 [H]

Pfam domain/function: PF01566 Nramp [H]

EC number: NA

Molecular weight: Translated: 42752; Mature: 42752

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFVKRLKNIGPGALVAAAFIGPGTVTTATVTGAEYGYTLLWALVFSIFATIVLQEMSMR
CCHHHHHHCCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VGIVSKMELGEALRNEFENPIIKWFSIILVVVAIGVGAAAFETGNILGGALGVETLTGIH
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHCCH
VNIVGPVIGIIAAFILWSGSYKIVEKFLIGLVIVMSMAFIITALVVSPNMGEVLSGMFVP
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCC
EIPEGGLAFAIGLIGTTVVPYNLFLHASAVQERWTDPKDLPQARFDTFFSIILGGIITLA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
IIVTASATFYGTGVVPEDGAAMAEQLSPLLGAWAKWFFAIGLFGAGLSSAVTAPLAGAYA
HHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
TAGALGWRRDLKGRNFRIVLMIILAIGVVGSGMGYDPVTVILIAQIANGIMLPIAAFFLI
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHH
WISNNKKRLGAWTNGPIHNVLGIIVLIVAVILGLKSLYDALTGVLL
HCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNFVKRLKNIGPGALVAAAFIGPGTVTTATVTGAEYGYTLLWALVFSIFATIVLQEMSMR
CCHHHHHHCCCCHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VGIVSKMELGEALRNEFENPIIKWFSIILVVVAIGVGAAAFETGNILGGALGVETLTGIH
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHCCH
VNIVGPVIGIIAAFILWSGSYKIVEKFLIGLVIVMSMAFIITALVVSPNMGEVLSGMFVP
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCC
EIPEGGLAFAIGLIGTTVVPYNLFLHASAVQERWTDPKDLPQARFDTFFSIILGGIITLA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
IIVTASATFYGTGVVPEDGAAMAEQLSPLLGAWAKWFFAIGLFGAGLSSAVTAPLAGAYA
HHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
TAGALGWRRDLKGRNFRIVLMIILAIGVVGSGMGYDPVTVILIAQIANGIMLPIAAFFLI
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHH
WISNNKKRLGAWTNGPIHNVLGIIVLIVAVILGLKSLYDALTGVLL
HCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]