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The map label for this gene is hgdC [H]

Identifier: 188584753

GI number: 188584753

Start: 128423

End: 129397

Strand: Direct

Name: hgdC [H]

Synonym: Nther_0111

Alternate gene names: 188584753

Gene position: 128423-129397 (Clockwise)

Preceding gene: 188584752

Following gene: 188584754

Centisome position: 4.06

GC content: 41.03

Gene sequence:

>975_bases
ATGAAGGCAATTTATTTAGGTGTAGATGTTGGTTCTGTTAGTACGAATTTTGTTGCTTTGGATGAAAATTATCAAGTCCT
AGCCAGCCAGTACTTGAGGACTAAAGGTGAACCTATTAAAGCTATTCAAACCGGACTTCGTAACATTGGGGAAGAACTGG
GAAACGATGTAGAAGTAAAAGGAGTAGGTAGTACAGGAAGTGCCCGAACTTTGGCCGGGGTCATTTTAGGTGCAGATACT
GTCAAAAATGAAATCACAGCTCATGCGGTGGCTGCTTCTCAACAAGTTCCCGAGGTTAAAACTGTTTTGGAAATTGGTGG
TCAGGATTCAAAAATTATTATTTTAAGAGAAGGTGTAGTTGTAGACTTTGCCATGAATACTGTATGCGCAGCTGGGACGG
GGTCTTTCCTTGATCATCAATCAGAGCGATTAGGGGTTCCCATTGAGGAATTTGGGGAAAAAGCTTTAATGTCAGATAGT
CCAGTACGCATTGCCGGGAGATGTTCTGTCTTTGCAGAGTCAGACATGATCCATAAACAGCAAATGGGGCATGAAACAAT
AGATATAATCCGAGGACTAAGTGAAGCATTAGTTCGAAATTATCTTAACAATGTAGGTAAAGGGAAAGAGATACTGTCAC
CAATTGTGTTTCAAGGTGGGGTAGCGGCAAATCGTGGTATTAAAGCTGCCTTTGAACAAGAACTTGAGTCGGAAGTGGTA
GTACCTAATTTTTTCAATGTTATGGGCGCCATAGGTGCTGCCATTTTAGCTAAGGATGCTTCCAAAGATAAAGGAGAAAC
AAGTTTCAGAGGTTTTCAAGCTAGTGATCTAAGATATCAGGCCTCAAGCTTTGAATGCAGCAGTTGTCCTAACATGTGTG
AAATTGTCAATATCAAAAGTGAAGAACAGTTATTGGCTCGATGGGGTGGGCGATGTGAAAAATGGGAAGTTTTAGAAACG
AATGTCAACACATGA

Upstream 100 bases:

>100_bases
TGTTTTTGGATGAACAAACTGGAAAGGCTGGAATCAAAACGAGACTGGAAGCCTTTGTTGACCTAATTAAAAAGAAACAA
TTGAATGAGGTGAGTTAAAA

Downstream 100 bases:

>100_bases
ACAAGATGAAGTTAGGAAAGCTAACTTTAGATAATTGCATCATTGTTGCACCTATGGCAGGAGTGACCGATTACCCTTAT
CGACGAATTTTGGCAAAATT

Product: CoA-substrate-specific enzyme activase

Products: NA

Alternate protein names: 2-hydroxyglutaryl-CoA dehydratase component A [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MKAIYLGVDVGSVSTNFVALDENYQVLASQYLRTKGEPIKAIQTGLRNIGEELGNDVEVKGVGSTGSARTLAGVILGADT
VKNEITAHAVAASQQVPEVKTVLEIGGQDSKIIILREGVVVDFAMNTVCAAGTGSFLDHQSERLGVPIEEFGEKALMSDS
PVRIAGRCSVFAESDMIHKQQMGHETIDIIRGLSEALVRNYLNNVGKGKEILSPIVFQGGVAANRGIKAAFEQELESEVV
VPNFFNVMGAIGAAILAKDASKDKGETSFRGFQASDLRYQASSFECSSCPNMCEIVNIKSEEQLLARWGGRCEKWEVLET
NVNT

Sequences:

>Translated_324_residues
MKAIYLGVDVGSVSTNFVALDENYQVLASQYLRTKGEPIKAIQTGLRNIGEELGNDVEVKGVGSTGSARTLAGVILGADT
VKNEITAHAVAASQQVPEVKTVLEIGGQDSKIIILREGVVVDFAMNTVCAAGTGSFLDHQSERLGVPIEEFGEKALMSDS
PVRIAGRCSVFAESDMIHKQQMGHETIDIIRGLSEALVRNYLNNVGKGKEILSPIVFQGGVAANRGIKAAFEQELESEVV
VPNFFNVMGAIGAAILAKDASKDKGETSFRGFQASDLRYQASSFECSSCPNMCEIVNIKSEEQLLARWGGRCEKWEVLET
NVNT
>Mature_324_residues
MKAIYLGVDVGSVSTNFVALDENYQVLASQYLRTKGEPIKAIQTGLRNIGEELGNDVEVKGVGSTGSARTLAGVILGADT
VKNEITAHAVAASQQVPEVKTVLEIGGQDSKIIILREGVVVDFAMNTVCAAGTGSFLDHQSERLGVPIEEFGEKALMSDS
PVRIAGRCSVFAESDMIHKQQMGHETIDIIRGLSEALVRNYLNNVGKGKEILSPIVFQGGVAANRGIKAAFEQELESEVV
VPNFFNVMGAIGAAILAKDASKDKGETSFRGFQASDLRYQASSFECSSCPNMCEIVNIKSEEQLLARWGGRCEKWEVLET
NVNT

Specific function: Required for the activation of (R)-2-hydroxyglutaryl-CoA dehydratase. This protein is extremely sensitive towards oxygen [H]

COG id: COG1924

COG function: function code I; Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To E.coli yjiL and M.jannaschii MJ0004 and MJ0800 [H]

Homologues:

Organism=Escherichia coli, GI87082426, Length=258, Percent_Identity=32.1705426356589, Blast_Score=101, Evalue=6e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002731
- InterPro:   IPR008275 [H]

Pfam domain/function: PF01869 BcrAD_BadFG [H]

EC number: NA

Molecular weight: Translated: 34805; Mature: 34805

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAIYLGVDVGSVSTNFVALDENYQVLASQYLRTKGEPIKAIQTGLRNIGEELGNDVEVK
CCEEEEEEEECCCCCCEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEE
GVGSTGSARTLAGVILGADTVKNEITAHAVAASQQVPEVKTVLEIGGQDSKIIILREGVV
ECCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEECCEE
VDFAMNTVCAAGTGSFLDHQSERLGVPIEEFGEKALMSDSPVRIAGRCSVFAESDMIHKQ
EEEHHHHHHHCCCCHHHHCCHHHCCCCHHHHCCHHHCCCCCEEEEEEEEEEECHHHHHHH
QMGHETIDIIRGLSEALVRNYLNNVGKGKEILSPIVFQGGVAANRGIKAAFEQELESEVV
HHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCC
VPNFFNVMGAIGAAILAKDASKDKGETSFRGFQASDLRYQASSFECSSCPNMCEIVNIKS
CCHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCEEECCCCCCCCCCCCEEEECCCC
EEQLLARWGGRCEKWEVLETNVNT
HHHHHHHHCCCCCCEEEEECCCCC
>Mature Secondary Structure
MKAIYLGVDVGSVSTNFVALDENYQVLASQYLRTKGEPIKAIQTGLRNIGEELGNDVEVK
CCEEEEEEEECCCCCCEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCEEEE
GVGSTGSARTLAGVILGADTVKNEITAHAVAASQQVPEVKTVLEIGGQDSKIIILREGVV
ECCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEEEEEECCEE
VDFAMNTVCAAGTGSFLDHQSERLGVPIEEFGEKALMSDSPVRIAGRCSVFAESDMIHKQ
EEEHHHHHHHCCCCHHHHCCHHHCCCCHHHHCCHHHCCCCCEEEEEEEEEEECHHHHHHH
QMGHETIDIIRGLSEALVRNYLNNVGKGKEILSPIVFQGGVAANRGIKAAFEQELESEVV
HHCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCC
VPNFFNVMGAIGAAILAKDASKDKGETSFRGFQASDLRYQASSFECSSCPNMCEIVNIKS
CCHHHHHHHHHHHHHHHCCCCCCCCCCHHCCCCCCCCEEECCCCCCCCCCCCEEEECCCC
EEQLLARWGGRCEKWEVLETNVNT
HHHHHHHHCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8365476; 2659350; 7607244; 11106419; 11243821 [H]