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The map label for this gene is nuoF2 [H]

Identifier: 188584741

GI number: 188584741

Start: 113355

End: 115148

Strand: Direct

Name: nuoF2 [H]

Synonym: Nther_0099

Alternate gene names: 188584741

Gene position: 113355-115148 (Clockwise)

Preceding gene: 188584740

Following gene: 188584742

Centisome position: 3.58

GC content: 40.97

Gene sequence:

>1794_bases
ATGGAAGTGTATCGATCTCATGTTTTGATATGCGGTGGTACTGGTTGTAGTTCATCCGGATGTCAACAAGTGCAAGATAA
GTTTAATGAAGAATTAGATAAACACAATCTTTCGAATGAAGTTAAGTTAATAATTACGGGCTGTCATGGACTATGTGAGC
TCGGTCCTATAGTTATCGTGTATCCTGAGGGAACTTCCTACTTTACCGTATCAGCAGAAGATGTGTCAGAAATAGTAGAA
GAACACCTTTTAAAAGGTCGCAAAGTAGAACGATTAATGTATCAAGATGAGGAAAGTGCGGAAAAGATTCCTTACTATAA
TGAAATTGGTTTTTATAAACAACAGGAGAGAATTGTCCTAAGCAATTGTGGTTATATCAATCCTGAAAGCATCGATGAAT
ACATTGCTAGAGGTGGGTATCAAGGCCTTGCCAGGGCTGTCACAGAATTTGACCCCCAAGGAGTTACCGAAGAAGTTATT
AATGCAAACCTAAGAGGACGCGGTGGTGCTGGCTTCCCTGCAGGCAAAAAATGGAAGTTTGCTAGTCAAGAACCTGAACC
AACAAAATACATGGTTTGTAATGCCGATGAAGGTGACCCGGGAGCCTTTATGGATAGAAGTATTTTAGAGGGTGATCCTC
ACAGTGTAATAGAAGGAATGGCCATTGCCAGCTATGCAATAGGTGCGGAAGTTGGGTATGTTTATATAAGGGCTGAATAT
CCCTTGGCGGTTCGTCGTTTAAAAGAAGCAATCCAGCAAGCAGAAGAACTGGGCCTTTTGGGAGAGAATATTCTTGGATC
AGGATTTAACTTTAAATTAAAAGTGAAAGAAGGTGCAGGAGCCTTTGTTTGTGGCGAGAGTACTGCCCTCACTAGGTCCA
TTGAAGGTAGAAGGGGGATGCCCAGACCAACTCCGCCACGATCTACAGAAAAAGGACTCTGGGGAAAACCAACAGTGCTG
AATAATGTAGAAACCTTAGCTTGTGTTTCCTTTATATTATCAAAGGGCGCCGAAGAATTTACTAAGTTCGGAACAGAACA
AAGTCCCGGTACTAAAGTTTTTGCCTTGACTGGTAAAGTGAATAATACAGGACTTGTTGAAGTTCCCATGGGAATAAGTA
TTAGAGATATTGTTTTTGACATTGGTGGAGGCATACAACACGGAAATAAAATCAAAGCTGTCCAAATTGGTGGTCCATCA
GGAGGTTGCCTTCCTGAAGACAAACTGGACTTATCAGTTGACTTTGATACATTAGATGATGCGGGCGCTATGATGGGCTC
TGGTGGACTGGTAGTAATGGACGAAGAGACCTGTGTCGTAGATGTATCTAAGTTTTTCCTTAAGTTTACTCAAGCCGAAT
CTTGTGGTAAATGTACACCATGTCGTGAAGGAACTAAGCGTATGTTAGAAATTCTTGAGCGCATAACCAAAGGACAGGGT
GAGCCTAAAGATATCGATCTCTTAAAAGAACTTGGAGAAATGATAATAAACACTTCTCTGTGTGGACTTGGGAAATCAGC
ACCAAATCCAGTACTAAGCACATTAAGATACTTTGAAGACGAATACAGAGAGCATATTGAAAAGGGTCGTTGTCCTGCCG
GAATTTGTGCTGATTTGGTTAAGTATAAAATTATTGCAGATAACTGTATCGGATGTACGGCTTGTGTCAAAGTTTGTCCA
GTTGACGCAATTTCTGGCGAGAAAAAACAAGCCCATGAAATTGATCCGGATAAGTGCATTGGCTGTGGTGAGTGCTATGA
AAAATGTAAATTTGAAGCAATAACTTTAGGCTAA

Upstream 100 bases:

>100_bases
TATACCCAGGATAGTAAATGATCACCTTATTAATGGCAAATTAGTCCAAGATTTAGTGATTGGTAAACCTAATCAGTAAT
TGGGAGAGGAGGGGATAAAA

Downstream 100 bases:

>100_bases
ATTAATTTAAAAACGGATTTTTATAATTAGGGATAATGTAGAAAGGGGAGAGGGTAAATGAGTCTTGTAACTGTAACCAT
TGATGGTCAAAGCATACAAG

Product: NADH dehydrogenase (quinone)

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 2; NDH-1 subunit F 2 [H]

Number of amino acids: Translated: 597; Mature: 597

Protein sequence:

>597_residues
MEVYRSHVLICGGTGCSSSGCQQVQDKFNEELDKHNLSNEVKLIITGCHGLCELGPIVIVYPEGTSYFTVSAEDVSEIVE
EHLLKGRKVERLMYQDEESAEKIPYYNEIGFYKQQERIVLSNCGYINPESIDEYIARGGYQGLARAVTEFDPQGVTEEVI
NANLRGRGGAGFPAGKKWKFASQEPEPTKYMVCNADEGDPGAFMDRSILEGDPHSVIEGMAIASYAIGAEVGYVYIRAEY
PLAVRRLKEAIQQAEELGLLGENILGSGFNFKLKVKEGAGAFVCGESTALTRSIEGRRGMPRPTPPRSTEKGLWGKPTVL
NNVETLACVSFILSKGAEEFTKFGTEQSPGTKVFALTGKVNNTGLVEVPMGISIRDIVFDIGGGIQHGNKIKAVQIGGPS
GGCLPEDKLDLSVDFDTLDDAGAMMGSGGLVVMDEETCVVDVSKFFLKFTQAESCGKCTPCREGTKRMLEILERITKGQG
EPKDIDLLKELGEMIINTSLCGLGKSAPNPVLSTLRYFEDEYREHIEKGRCPAGICADLVKYKIIADNCIGCTACVKVCP
VDAISGEKKQAHEIDPDKCIGCGECYEKCKFEAITLG

Sequences:

>Translated_597_residues
MEVYRSHVLICGGTGCSSSGCQQVQDKFNEELDKHNLSNEVKLIITGCHGLCELGPIVIVYPEGTSYFTVSAEDVSEIVE
EHLLKGRKVERLMYQDEESAEKIPYYNEIGFYKQQERIVLSNCGYINPESIDEYIARGGYQGLARAVTEFDPQGVTEEVI
NANLRGRGGAGFPAGKKWKFASQEPEPTKYMVCNADEGDPGAFMDRSILEGDPHSVIEGMAIASYAIGAEVGYVYIRAEY
PLAVRRLKEAIQQAEELGLLGENILGSGFNFKLKVKEGAGAFVCGESTALTRSIEGRRGMPRPTPPRSTEKGLWGKPTVL
NNVETLACVSFILSKGAEEFTKFGTEQSPGTKVFALTGKVNNTGLVEVPMGISIRDIVFDIGGGIQHGNKIKAVQIGGPS
GGCLPEDKLDLSVDFDTLDDAGAMMGSGGLVVMDEETCVVDVSKFFLKFTQAESCGKCTPCREGTKRMLEILERITKGQG
EPKDIDLLKELGEMIINTSLCGLGKSAPNPVLSTLRYFEDEYREHIEKGRCPAGICADLVKYKIIADNCIGCTACVKVCP
VDAISGEKKQAHEIDPDKCIGCGECYEKCKFEAITLG
>Mature_597_residues
MEVYRSHVLICGGTGCSSSGCQQVQDKFNEELDKHNLSNEVKLIITGCHGLCELGPIVIVYPEGTSYFTVSAEDVSEIVE
EHLLKGRKVERLMYQDEESAEKIPYYNEIGFYKQQERIVLSNCGYINPESIDEYIARGGYQGLARAVTEFDPQGVTEEVI
NANLRGRGGAGFPAGKKWKFASQEPEPTKYMVCNADEGDPGAFMDRSILEGDPHSVIEGMAIASYAIGAEVGYVYIRAEY
PLAVRRLKEAIQQAEELGLLGENILGSGFNFKLKVKEGAGAFVCGESTALTRSIEGRRGMPRPTPPRSTEKGLWGKPTVL
NNVETLACVSFILSKGAEEFTKFGTEQSPGTKVFALTGKVNNTGLVEVPMGISIRDIVFDIGGGIQHGNKIKAVQIGGPS
GGCLPEDKLDLSVDFDTLDDAGAMMGSGGLVVMDEETCVVDVSKFFLKFTQAESCGKCTPCREGTKRMLEILERITKGQG
EPKDIDLLKELGEMIINTSLCGLGKSAPNPVLSTLRYFEDEYREHIEKGRCPAGICADLVKYKIIADNCIGCTACVKVCP
VDAISGEKKQAHEIDPDKCIGCGECYEKCKFEAITLG

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI260656005, Length=432, Percent_Identity=37.2685185185185, Blast_Score=292, Evalue=5e-79,
Organism=Homo sapiens, GI20149568, Length=428, Percent_Identity=37.3831775700935, Blast_Score=291, Evalue=9e-79,
Organism=Escherichia coli, GI1788620, Length=403, Percent_Identity=40.6947890818859, Blast_Score=328, Evalue=5e-91,
Organism=Caenorhabditis elegans, GI17531727, Length=395, Percent_Identity=38.9873417721519, Blast_Score=288, Evalue=4e-78,
Organism=Drosophila melanogaster, GI19920794, Length=376, Percent_Identity=39.3617021276596, Blast_Score=287, Evalue=1e-77,
Organism=Drosophila melanogaster, GI45550452, Length=397, Percent_Identity=38.0352644836272, Blast_Score=276, Evalue=3e-74,
Organism=Drosophila melanogaster, GI24653819, Length=397, Percent_Identity=34.2569269521411, Blast_Score=226, Evalue=2e-59,
Organism=Drosophila melanogaster, GI24653817, Length=358, Percent_Identity=33.2402234636872, Blast_Score=201, Evalue=1e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 64867; Mature: 64867

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00645 COMPLEX1_51K_2 ; PS00198 4FE4S_FERREDOXIN ; PS00307 LECTIN_LEGUME_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
4.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEVYRSHVLICGGTGCSSSGCQQVQDKFNEELDKHNLSNEVKLIITGCHGLCELGPIVIV
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHCCEEEE
YPEGTSYFTVSAEDVSEIVEEHLLKGRKVERLMYQDEESAEKIPYYNEIGFYKQQERIVL
EECCCCEEEEEHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHCCCHHHCCCEECCCEEEE
SNCGYINPESIDEYIARGGYQGLARAVTEFDPQGVTEEVINANLRGRGGAGFPAGKKWKF
ECCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCC
ASQEPEPTKYMVCNADEGDPGAFMDRSILEGDPHSVIEGMAIASYAIGAEVGYVYIRAEY
CCCCCCCCEEEEEECCCCCCCCHHCCHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEEECC
PLAVRRLKEAIQQAEELGLLGENILGSGFNFKLKVKEGAGAFVCGESTALTRSIEGRRGM
CHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEEEECCCCEEEECCCHHHHHCCCCCCCC
PRPTPPRSTEKGLWGKPTVLNNVETLACVSFILSKGAEEFTKFGTEQSPGTKVFALTGKV
CCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHCCHHHHHHCCCCCCCCCEEEEEECCC
NNTGLVEVPMGISIRDIVFDIGGGIQHGNKIKAVQIGGPSGGCLPEDKLDLSVDFDTLDD
CCCCEEEECCCCCHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEECCCCCC
AGAMMGSGGLVVMDEETCVVDVSKFFLKFTQAESCGKCTPCREGTKRMLEILERITKGQG
CHHHCCCCCEEEECCCCEEEHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
EPKDIDLLKELGEMIINTSLCGLGKSAPNPVLSTLRYFEDEYREHIEKGRCPAGICADLV
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
KYKIIADNCIGCTACVKVCPVDAISGEKKQAHEIDPDKCIGCGECYEKCKFEAITLG
HEEEHHCCCCCHHHHHHHCCCCCCCCCCHHHCCCCHHHCCCCHHHHHHCCCEEEECC
>Mature Secondary Structure
MEVYRSHVLICGGTGCSSSGCQQVQDKFNEELDKHNLSNEVKLIITGCHGLCELGPIVIV
CCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHCCEEEE
YPEGTSYFTVSAEDVSEIVEEHLLKGRKVERLMYQDEESAEKIPYYNEIGFYKQQERIVL
EECCCCEEEEEHHHHHHHHHHHHHCCCHHHHHHHCCCCHHHHCCCHHHCCCEECCCEEEE
SNCGYINPESIDEYIARGGYQGLARAVTEFDPQGVTEEVINANLRGRGGAGFPAGKKWKF
ECCCCCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCC
ASQEPEPTKYMVCNADEGDPGAFMDRSILEGDPHSVIEGMAIASYAIGAEVGYVYIRAEY
CCCCCCCCEEEEEECCCCCCCCHHCCHHHCCCHHHHHHHHHHHHHHHCCCEEEEEEEECC
PLAVRRLKEAIQQAEELGLLGENILGSGFNFKLKVKEGAGAFVCGESTALTRSIEGRRGM
CHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEEEECCCCEEEECCCHHHHHCCCCCCCC
PRPTPPRSTEKGLWGKPTVLNNVETLACVSFILSKGAEEFTKFGTEQSPGTKVFALTGKV
CCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHCCHHHHHHCCCCCCCCCEEEEEECCC
NNTGLVEVPMGISIRDIVFDIGGGIQHGNKIKAVQIGGPSGGCLPEDKLDLSVDFDTLDD
CCCCEEEECCCCCHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEECCCCCC
AGAMMGSGGLVVMDEETCVVDVSKFFLKFTQAESCGKCTPCREGTKRMLEILERITKGQG
CHHHCCCCCEEEECCCCEEEHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCC
EPKDIDLLKELGEMIINTSLCGLGKSAPNPVLSTLRYFEDEYREHIEKGRCPAGICADLV
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
KYKIIADNCIGCTACVKVCPVDAISGEKKQAHEIDPDKCIGCGECYEKCKFEAITLG
HEEEHHCCCCCHHHHHHHCCCCCCCCCCHHHCCCCHHHCCCCHHHHHHCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481432 [H]