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The map label for this gene is dnaX [H]

Identifier: 188584680

GI number: 188584680

Start: 52041

End: 53003

Strand: Direct

Name: dnaX [H]

Synonym: Nther_0038

Alternate gene names: 188584680

Gene position: 52041-53003 (Clockwise)

Preceding gene: 188584679

Following gene: 188584681

Centisome position: 1.64

GC content: 34.68

Gene sequence:

>963_bases
ATGGAAACTACTCAAGAAACAATTAACTTTCAGACATGGAGTTTTGATAAGTTTATTGGTCAAGAAAAAATAGTGAAGAA
CTTATTAAGACAGTTGACTTCAGGTAATACCGGACATGCTTATATGTTTGTAGGTCCTGAAGGACAAGGAAAGGGGAGCC
TTGCTAGAATTTTTGCTGCAGGATTACTCTGTGAATCAGTGGACGAAAATTCAGGTCCATGTGGAATATGTTATTCCTGT
AGTAAATTGAAAAAGTCGATTCACCCTGATTTAGTGACGATTGGAAGTGAATCTAAATCAATTAAAATAGAAGAAGTTAG
AAAAGTAAAACAGTATATTAATTATCGCCCGACGGACTCAAAGAAAAAGATATATTTAATCGAAAGTGCTGAAAATATGA
CCCGGGAAGGTGCTAATAGCATTTTAAAGATGCTTGAAGAACCTCCTGAATACGTGGTGTTTTTATTGACAGTTAATGAA
CTTGAAAGAATGCTGCCCACGGTGATTTCGCGCTGCCAAATTCATCAATTTCTTCCTTTAACTGAGGAACAACTTTATAA
AGCGTTAAGTAATCGTACTCATGCAAGTCAGGAACAGCTTGAATTAGCCGTTTCATTGTCCGGTGGTATGATCGGAAGAG
GTTTAGCCATCTTACAAGACGAAAGTTATTATGATATGATAAAGAAAGCTCATAGCTTTGTAGAAAAATTTGAGAAGTTA
ACTTTACCTGAACTCCTTGATTGGGCAGAAAAAATAGATTCAATGGACAATTGTGAAGAGTTTTTAGAGCTTTTAAATAT
TGTATTTAAACAAAAACTTTCTGAAAACCAAACTTCTGATTCTATAAATAAATTGGCTAGAATAATGGAAATAATTCTCG
AAACCAAAGGTCAATTATTGACAAATGTGAATAGGCTTTTGGCTCTTGAAGCTATGATGGTCAAGATAAAGGAGGTGGAC
TAA

Upstream 100 bases:

>100_bases
ATAATTTCAAAGAACAAAAATAGTGGATATGTTGCTTTTTATTAACATAACTTGATATAATCAAAAAGAACCAAATAAAA
AATTAGGGTTGGGTGGCAAT

Downstream 100 bases:

>100_bases
TATTGGAAAAATATATCGTTGTTGGCGTAAGGTTTAAAAAAGCTGGGAAAATATATTATTTTGATCCCAATGATATAGAT
TTGGAAGTAGGTAATAAAGT

Product: DNA-directed DNA polymerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 320; Mature: 320

Protein sequence:

>320_residues
METTQETINFQTWSFDKFIGQEKIVKNLLRQLTSGNTGHAYMFVGPEGQGKGSLARIFAAGLLCESVDENSGPCGICYSC
SKLKKSIHPDLVTIGSESKSIKIEEVRKVKQYINYRPTDSKKKIYLIESAENMTREGANSILKMLEEPPEYVVFLLTVNE
LERMLPTVISRCQIHQFLPLTEEQLYKALSNRTHASQEQLELAVSLSGGMIGRGLAILQDESYYDMIKKAHSFVEKFEKL
TLPELLDWAEKIDSMDNCEEFLELLNIVFKQKLSENQTSDSINKLARIMEIILETKGQLLTNVNRLLALEAMMVKIKEVD

Sequences:

>Translated_320_residues
METTQETINFQTWSFDKFIGQEKIVKNLLRQLTSGNTGHAYMFVGPEGQGKGSLARIFAAGLLCESVDENSGPCGICYSC
SKLKKSIHPDLVTIGSESKSIKIEEVRKVKQYINYRPTDSKKKIYLIESAENMTREGANSILKMLEEPPEYVVFLLTVNE
LERMLPTVISRCQIHQFLPLTEEQLYKALSNRTHASQEQLELAVSLSGGMIGRGLAILQDESYYDMIKKAHSFVEKFEKL
TLPELLDWAEKIDSMDNCEEFLELLNIVFKQKLSENQTSDSINKLARIMEIILETKGQLLTNVNRLLALEAMMVKIKEVD
>Mature_320_residues
METTQETINFQTWSFDKFIGQEKIVKNLLRQLTSGNTGHAYMFVGPEGQGKGSLARIFAAGLLCESVDENSGPCGICYSC
SKLKKSIHPDLVTIGSESKSIKIEEVRKVKQYINYRPTDSKKKIYLIESAENMTREGANSILKMLEEPPEYVVFLLTVNE
LERMLPTVISRCQIHQFLPLTEEQLYKALSNRTHASQEQLELAVSLSGGMIGRGLAILQDESYYDMIKKAHSFVEKFEKL
TLPELLDWAEKIDSMDNCEEFLELLNIVFKQKLSENQTSDSINKLARIMEIILETKGQLLTNVNRLLALEAMMVKIKEVD

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786676, Length=167, Percent_Identity=36.5269461077844, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1787341, Length=311, Percent_Identity=25.4019292604502, Blast_Score=88, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 36329; Mature: 36329

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METTQETINFQTWSFDKFIGQEKIVKNLLRQLTSGNTGHAYMFVGPEGQGKGSLARIFAA
CCCCHHHHCCCCCCHHHHHCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHH
GLLCESVDENSGPCGICYSCSKLKKSIHPDLVTIGSESKSIKIEEVRKVKQYINYRPTDS
HHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCEEHHHHHHHHHHHCCCCCCC
KKKIYLIESAENMTREGANSILKMLEEPPEYVVFLLTVNELERMLPTVISRCQIHQFLPL
CCEEEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCC
TEEQLYKALSNRTHASQEQLELAVSLSGGMIGRGLAILQDESYYDMIKKAHSFVEKFEKL
CHHHHHHHHHCCCCCCHHHHHHHHEECCCCHHCCEEEEECCHHHHHHHHHHHHHHHHHHC
TLPELLDWAEKIDSMDNCEEFLELLNIVFKQKLSENQTSDSINKLARIMEIILETKGQLL
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
TNVNRLLALEAMMVKIKEVD
HHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
METTQETINFQTWSFDKFIGQEKIVKNLLRQLTSGNTGHAYMFVGPEGQGKGSLARIFAA
CCCCHHHHCCCCCCHHHHHCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHHHHH
GLLCESVDENSGPCGICYSCSKLKKSIHPDLVTIGSESKSIKIEEVRKVKQYINYRPTDS
HHHHHHCCCCCCCCCHHHHHHHHHHHCCCCEEEECCCCCCEEHHHHHHHHHHHCCCCCCC
KKKIYLIESAENMTREGANSILKMLEEPPEYVVFLLTVNELERMLPTVISRCQIHQFLPL
CCEEEEEECHHHHHHHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCCC
TEEQLYKALSNRTHASQEQLELAVSLSGGMIGRGLAILQDESYYDMIKKAHSFVEKFEKL
CHHHHHHHHHCCCCCCHHHHHHHHEECCCCHHCCEEEEECCHHHHHHHHHHHHHHHHHHC
TLPELLDWAEKIDSMDNCEEFLELLNIVFKQKLSENQTSDSINKLARIMEIILETKGQLL
CHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
TNVNRLLALEAMMVKIKEVD
HHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]